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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:5078
Term: flavonol
Definition: A monohydroxyflavone that is the 3-hydroxy derivative of flavone.
Chemical ID: MESH:C041477
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2multiple interactionsEXP 6480464CTD3-hydroxyflavone binds to and results in increased activity of NR1I2 protein; 3-hydroxyflavone promotes the reaction [NCOA1 protein binds to NR1I2 protein]; 3-hydroxyflavone promotes the reaction [NCOA2 protein binds to NR1I2 protein]; 3-hydroxyflavone promotes the reaction [NCOA3 protein binds to NR1I2 protein]PMID:26238175
NR1I2increases activityISONr1i2 (Rattus norvegicus)6480464CTD3-hydroxyflavone results in increased activity of NR1I2 proteinPMID:26238175
NR1I2increases activityISONr1i2 (Mus musculus)6480464CTD3-hydroxyflavone results in increased activity of NR1I2 proteinPMID:26238175
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