GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NR1I2 | increases activity | EXP | | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether results in increased activity of NR1I2 protein | PMID:17324954 PMID:24218150 PMID:25680588 | NR1I2 | multiple interactions | EXP | | 6480464 | CTD | [2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,2',4,4',5-brominated diphenyl ether co-treated with pentabrominated diphenyl ether 100 co-treated with hexabrominated diphenyl ether 153 co-treated with hexabromodiphenyl ether 154] results in increased activity of NR1I2 protein | PMID:25680588 | NR1I2 | affects expression | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether affects the expression of NR1I2 mRNA | PMID:30294300 | NR1I2 | increases activity | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether results in increased activity of NR1I2 protein | PMID:17324954 | NR1I2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | NR1I2 protein promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B10 mRNA]; NR1I2 protein promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP3A11 mRNA] | PMID:17324954 | | ||||||||||||||||||||||
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