GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NR1I2 | increases activity | EXP | | 6480464 | CTD | Flutamide results in increased activity of NR1I2 protein | PMID:20041327 PMID:28728110 | NR1I2 | multiple interactions | EXP | | 6480464 | CTD | [Flutamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Flutamide binds to and results in increased activity of NR1I2 protein; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]]; NR1I2 protein promotes the reaction [Flutamide results in increased expression of and results in increased activity of ABCB1 protein] | PMID:18839173 PMID:20041327 PMID:32682830 PMID:33049310 | NR1I2 | decreases expression | ISO | Nr1i2 (Rattus norvegicus) | 6480464 | CTD | Flutamide results in decreased expression of NR1I2 mRNA | PMID:24793618 | NR1I2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | Flutamide binds to and results in increased activity of NR1I2 protein | PMID:33049310 | | ||||||||||||||||||||||
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