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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:16363
Term: alpha-santonin
Definition: A santonin that is 3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione substituted by methyl groups at positions 3, 5a and 9.
Chemical ID: MESH:D012500
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2increases activityEXP 6480464CTDSantonin results in increased activity of NR1I2 proteinPMID:25455453
NR1I2multiple interactionsEXP 6480464CTD[Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNAPMID:25455453
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