GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NR1I2 | decreases activity | EXP | | 6480464 | CTD | oxiconazole results in decreased activity of NR1I2 protein | PMID:17438109 | NR1I2 | decreases expression | EXP | | 6480464 | CTD | oxiconazole results in decreased expression of NR1I2 mRNA | PMID:17998298 | NR1I2 | multiple interactions | EXP | | 6480464 | CTD | oxiconazole binds to and results in increased activity of NR1I2 protein; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole results in increased expression of NR1I2 mRNA] | PMID:17438109 PMID:17998298 | |
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