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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2decreases activityEXP 6480464CTDsulforaphane results in decreased activity of NR1I2 proteinPMID:29933105
NR1I2decreases expressionEXP 6480464CTDsulforaphane results in decreased expression of NR1I2 mRNAPMID:29933105
NR1I2multiple interactionsEXP 6480464CTDsulforaphane inhibits the reaction [3,3',4,5'-tetrahydroxystilbene results in increased activity of NR1I2 protein]; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein]; sulforaphane inhibits the reaction [alpha-methylepinine results in decreased expression of NR1I2 mRNA]; sulforaphane inhibits the reaction [Genistein results in increased activity of NR1I2 protein]; sulforaphane inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; sulforaphane inhibits the reaction [Resveratrol results in increased activity of NR1I2 protein]; sulforaphane inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]PMID:21871945 PMID:29356861 PMID:29933105
NR1I2decreases expressionISONr1i2 (Rattus norvegicus)6480464CTDsulforaphane results in decreased expression of NR1I2 mRNAPMID:21402137 PMID:21871945
NR1I2multiple interactionsISONr1i2 (Rattus norvegicus)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in decreased expression of NR1I2 mRNA]; sulforaphane inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NR1I2 mRNA]; sulforaphane inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]PMID:21402137 PMID:21871945
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