NR1I2 (nuclear receptor subfamily 1 group I member 2) - Rat Genome Database

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Gene: NR1I2 (nuclear receptor subfamily 1 group I member 2) Canis lupus familiaris
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Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
RGD ID: 12257278
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); nuclear receptor activity (ortholog); nuclear receptor binding (ortholog); INVOLVED IN negative regulation of transcription, DNA-templated (ortholog); positive regulation of gene expression (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); Barrett's esophagus (ortholog); calcinosis (ortholog); FOUND IN intermediate filament cytoskeleton (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; Acetyl tributyl citrate
Type: protein-coding
RefSeq Status: MODEL
Also known as: pregnane X receptor; PXR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,444,367 - 23,456,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,432,690 - 23,455,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,474,457 - 23,486,487 (+)NCBI
ROS_Cfam_1.03323,682,177 - 23,694,192 (+)NCBI
UMICH_Zoey_3.13323,486,165 - 23,498,350 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:11981033   PMID:27732639  


Genomics

Comparative Map Data
NR1I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,444,367 - 23,456,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,432,690 - 23,455,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,474,457 - 23,486,487 (+)NCBI
ROS_Cfam_1.03323,682,177 - 23,694,192 (+)NCBI
UMICH_Zoey_3.13323,486,165 - 23,498,350 (+)NCBI
NR1I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3119,780,484 - 119,818,487 (+)EnsemblGRCh38hg38GRCh38
GRCh383119,782,101 - 119,818,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373119,500,948 - 119,537,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,982,021 - 121,020,022 (+)NCBINCBI36hg18NCBI36
Build 343120,982,020 - 121,020,021NCBI
Celera3117,908,432 - 117,946,438 (+)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3116,874,950 - 116,913,074 (+)NCBIHuRef
CHM1_13119,462,845 - 119,500,855 (+)NCBICHM1_1
Nr1i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,068,711 - 38,115,211 (-)NCBIGRCm39mm39
GRCm39 Ensembl1638,068,685 - 38,115,186 (-)Ensembl
GRCm381638,248,349 - 38,294,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,248,323 - 38,294,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv371638,248,435 - 38,294,910 (-)NCBIGRCm37mm9NCBIm37
MGSCv361638,167,590 - 38,214,062 (-)NCBImm8
Celera1638,657,356 - 38,703,953 (-)NCBICelera
Cytogenetic Map16B3NCBI
Nr1i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21162,460,213 - 62,496,665 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1162,460,213 - 62,496,658 (+)Ensembl
Rnor_6.01165,022,100 - 65,058,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,022,100 - 65,058,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,024,185 - 67,060,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,239,918 - 64,276,702 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11164,297,534 - 64,333,716 (+)NCBI
Celera1161,960,674 - 61,997,009 (+)NCBICelera
Cytogenetic Map11q21NCBI
Nr1i2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,459,936 - 19,487,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,459,936 - 19,487,276 (+)NCBIChiLan1.0ChiLan1.0
NR1I2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13123,815,135 - 123,853,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,815,135 - 123,853,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03116,901,579 - 116,940,366 (+)NCBIMhudiblu_PPA_v0panPan3
Nr1i2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,794,594 - 130,830,392 (-)NCBI
SpeTri2.0NW_0049365366,691,590 - 6,726,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,364,075 - 140,406,112 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,373,571 - 140,406,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,710,912 - 149,743,466 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR1I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,005,404 - 61,043,016 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,006,667 - 61,040,832 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041105,267,620 - 105,304,705 (+)NCBIVero_WHO_p1.0
Nr1i2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473128,371,707 - 28,405,327 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 6 6 6
Low 2 11 6 8 2
Below cutoff 5 5 6 6 6 6 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017654   ⟹   ENSCAFP00000016344
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3323,432,690 - 23,455,347 (+)Ensembl
RefSeq Acc Id: XM_038445374   ⟹   XP_038301302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03323,682,177 - 23,694,192 (+)NCBI
RefSeq Acc Id: XM_038462516   ⟹   XP_038318444
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3323,474,457 - 23,486,487 (+)NCBI
RefSeq Acc Id: XM_038519634   ⟹   XP_038375562
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13323,486,165 - 23,498,350 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038301302 (Get FASTA)   NCBI Sequence Viewer  
  XP_038318444 (Get FASTA)   NCBI Sequence Viewer  
  XP_038375562 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM10632 (Get FASTA)   NCBI Sequence Viewer  
  ATI96883 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSCAFP00000016344   ⟸   ENSCAFT00000017654
RefSeq Acc Id: XP_038375562   ⟸   XM_038519634
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038301302   ⟸   XM_038445374
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038318444   ⟸   XM_038462516
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011094 Ensembl
NCBI Gene NR1I2 ENTREZGENE
VGNC ID VGNC:53079 ENTREZGENE