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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2decreases expressionISONr1i2 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of NR1I2 mRNAPMID:15312234 PMID:15617534 PMID:15976188
NR1I2multiple interactionsISONr1i2 (Mus musculus)6480464CTDMelatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA]; phenyl-N-tert-butylnitrone inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA]PMID:15617534 PMID:15976188
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