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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2increases activityEXP 6480464CTDkaempferol results in increased activity of NR1I2 proteinPMID:19034627 PMID:25455453 PMID:29933105
NR1I2increases expressionEXP 6480464CTDkaempferol results in increased expression of NR1I2 mRNAPMID:29933105
NR1I2multiple interactionsEXP 6480464CTD[kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; kaempferol binds to and results in increased activity of NR1I2 proteinPMID:25455453 PMID:33049310
NR1I2increases activityISONr1i2 (Mus musculus)6480464CTDkaempferol results in increased activity of NR1I2 proteinPMID:26238175
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