Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2affects bindingEXP 6480464CTDDiethylhexyl Phthalate binds to NR1I2 proteinPMID:27071811 PMID:36893891
NR1I2decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of NR1I2 mRNAPMID:31163220
NR1I2increases activityEXP 6480464CTDDiethylhexyl Phthalate results in increased activity of NR1I2 proteinPMID:22206814 PMID:23899473 PMID:27551952
NR1I2multiple interactionsEXP 6480464CTDDiethylhexyl Phthalate binds to and results in increased activity of NR1I2 protein; Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Diethylhexyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of ABCB1 mRNA]; Diethylhexyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4]PMID:11581012 PMID:16054614 PMID:17003290 PMID:21227907 PMID:33049310 PMID:36893891
NR1I2increases activityISONr1i2 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased activity of NR1I2 proteinPMID:23899473
NR1I2increases activityISONr1i2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased activity of NR1I2 proteinPMID:23899473
NR1I2increases expressionISONr1i2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of NR1I2 mRNA; Diethylhexyl Phthalate results in increased expression of NR1I2 proteinPMID:17627975 PMID:36403809
NR1I2multiple interactionsISONr1i2 (Mus musculus)6480464CTDDiethylhexyl Phthalate binds to and results in increased activity of NR1I2 protein; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NR1I2 mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NR1I2 protein]PMID:33049310 PMID:36403809
Go Back to source page   Continue to Ontology report