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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2affects bindingEXP 6480464CTDDexamethasone binds to NR1I2 proteinPMID:27071811
NR1I2increases activityEXP 6480464CTDDexamethasone results in increased activity of NR1I2 proteinPMID:12065438 PMID:21641981 PMID:23899473
NR1I2increases expressionEXP 6480464CTDDexamethasone results in increased expression of NR1I2 mRNA; Dexamethasone results in increased expression of NR1I2 proteinPMID:18332045 PMID:19022236
NR1I2multiple interactionsEXP 6480464CTDDexamethasone binds to and results in increased activity of NR1I2 protein; Dexamethasone promotes the reaction [NR1I2 protein binds to FGF21 promoter]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Dexamethasone results in increased expression of FGF21 mRNA]PMID:12695351 PMID:16054614 PMID:28088388
NR1I2affects bindingISONr1i2 (Rattus norvegicus)6480464CTDDexamethasone binds to NR1I2 proteinPMID:19562681
NR1I2increases activityISONr1i2 (Rattus norvegicus)6480464CTDDexamethasone results in increased activity of NR1I2 proteinPMID:23439660 PMID:23899473 PMID:27732639
NR1I2increases activityISONr1i2 (Mus musculus)6480464CTDDexamethasone results in increased activity of NR1I2 proteinPMID:23899473
NR1I2increases expressionISONr1i2 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of NR1I2 mRNA; Dexamethasone results in increased expression of NR1I2 proteinPMID:15102944 PMID:18332045 PMID:18473823 PMID:19562681 PMID:20035846 PMID:20599767 PMID:20888898 PMID:21146967 PMID:23770461 PMID:32599024
NR1I2multiple interactionsISONr1i2 (Rattus norvegicus)6480464CTDDactinomycin inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA]; NR1I2 gene mutant form inhibits the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 mRNA]; NR1I2 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Dexamethasone results in increased expression of NR1I2 protein]PMID:11752103 PMID:18473823 PMID:20599767 PMID:23770461
NR1I2multiple interactionsISONr1i2 (Mus musculus)6480464CTDDexamethasone binds to and results in increased activity of NR1I2 protein; Dexamethasone promotes the reaction [NR1I2 protein binds to FGF21 promoter]; NR1I2 affects the reaction [Dexamethasone results in increased activity of CYP3A4 protein]; NR1I2 protein affects the reaction [Dexamethasone results in increased expression of FGF21 mRNA]PMID:15630458 PMID:15919853 PMID:20361990 PMID:28088388
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