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Gene: BAX (BCL2 associated X, apoptosis regulator) Homo sapiens
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Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulator BAX; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4; BCL2-associated X protein omega; BCL2-associated X protein transcript variant delta2; bcl2-L-4; BCL2L4
Orthologs:
Mus musculus (house mouse) : Bax (BCL2-associated X protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bax (BCL2 associated X, apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bax (BCL2 associated X, apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : BAX (BCL2 associated X, apoptosis regulator)
Canis lupus familiaris (dog) : BAX (BCL2 associated X, apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bax (BCL2 associated X, apoptosis regulator)
Sus scrofa (pig) : BAX (BCL2 associated X, apoptosis regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,954,825 - 48,961,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,458,117 - 49,465,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,149,929 - 54,156,867 (+)NCBINCBI36hg18NCBI36
Build 341954,149,928 - 54,156,866NCBI
Celera1946,325,480 - 46,332,409 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,835,055 - 45,841,975 (+)NCBIHuRef
CHM1_11949,460,326 - 49,467,266 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model