FGF2 (fibroblast growth factor 2) - Rat Genome Database

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Gene: FGF2 (fibroblast growth factor 2) Homo sapiens
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Symbol: FGF2
Name: fibroblast growth factor 2
RGD ID: 70822
HGNC Page HGNC:3676
Description: Enables several functions, including identical protein binding activity; nuclear receptor coactivator activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and regulation of cell migration. Acts upstream of or within positive regulation of cell fate specification and positive regulation of cell population proliferation. Located in extracellular space. Implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Biomarker of several diseases, including artery disease (multiple); breast cancer (multiple); carcinoma (multiple); eye disease (multiple); and female reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: basic fibroblast growth factor bFGF; BFGF; FGF-2; FGFB; fibroblast growth factor 2 (basic); HBGF-2; heparin-binding growth factor 2; prostatropin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (ISO)
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (IEP)
biliary tract disease  (IEP)
bladder disease  (ISO)
bone disease  (IDA)
Bone Fractures  (IDA)
brain infarction  (EXP)
Brain Injuries  (EXP)
breast cancer  (IEP)
breast carcinoma  (IEP)
Cardiomegaly  (EXP,ISO)
cataract  (IEP)
cholangiocarcinoma  (IEP)
cholesteatoma of middle ear  (IEP)
Choroidal Neovascularization  (ISO)
chronic ulcer of skin  (IDA)
cleft lip  (EXP)
cleft palate  (EXP)
cocaine abuse  (ISO)
Cocaine-Related Disorders  (EXP)
cognitive disorder  (IDA)
corneal neovascularization  (EXP,IDA)
coronary artery disease  (IEP)
Coronary Disease  (IEP)
COVID-19  (IEP)
decubitus ulcer  (ISO)
Delayed Hypersensitivity  (IDA)
demyelinating disease  (ISO)
depressive disorder  (EXP)
dermatitis  (IDA)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (IDA)
diabetic retinopathy  (IAGP,IEP,ISO)
Diaphragmatic Hernia  (EXP)
Disease Progression  (EXP)
endometrial cancer  (IEP)
epilepsy with generalized tonic-clonic seizures  (EXP)
esophageal cancer  (IEP)
essential thrombocythemia  (EXP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Eye Injuries  (ISO)
Femoral Fractures  (ISO)
Gallbladder Neoplasms  (IEP)
gastric ulcer  (IDA)
gestational diabetes  (EXP)
Gliosis  (EXP)
high grade glioma  (EXP)
Hypercholesterolemia  (IEP)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypoglossal Nerve Injuries  (ISO)
impotence  (IDA)
Inflammation  (EXP,ISO)
Invasive Pulmonary Aspergillosis  (IDA)
Kaposiform Hemangioendothelioma  (IDA)
kidney disease  (EXP)
leiomyoma  (IEP)
liver cirrhosis  (EXP)
long QT syndrome  (IAGP)
macular retinal edema  (IEP)
Mesothelioma  (EXP)
middle cerebral artery infarction  (ISO)
multiple endocrine neoplasia type 1  (IEP)
Myocardial Ischemia  (EXP)
Nasal Polyps  (IEP)
Necrosis  (IDA)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (IEP)
nephrosclerosis  (EXP)
nephrotic syndrome  (EXP)
Nerve Degeneration  (EXP)
neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  (IAGP)
Neurodevelopmental Disorders  (IAGP)
Optic Nerve Injuries  (IMP)
oral submucous fibrosis  (EXP)
ovarian cancer  (IEP)
pancreatic cancer  (IDA,IEP)
pancreatic ductal carcinoma  (IEP)
Parkinsonism  (IDA)
Penetrating Eye Injuries  (ISO)
periapical periodontitis  (EXP)
polyarteritis nodosa  (IEP)
Pregnancy in Diabetics  (IEP)
Prenatal Exposure Delayed Effects  (EXP)
prostate adenocarcinoma  (IAGP)
Prostatic Neoplasms  (EXP)
Pseudomonas Infections  (IDA)
pterygium  (IEP)
pulmonary fibrosis  (EXP)
pulmonary hypertension  (IEP,ISO)
renal cell carcinoma  (IEP)
Reperfusion Injury  (EXP)
Retina Reperfusion Injury  (IDA,ISO)
retinal vein occlusion  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Surgical Wound  (ISO)
transitional cell carcinoma  (IEP)
Tympanic Membrane Perforation  (IDA,ISO)
type 2 diabetes mellitus  (IEP)
Ulcer  (ISO)
urinary bladder cancer  (IMP)
Wound Infection  (IDA)
Wounds and Injuries  (EXP,IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14,15-EET  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxyethyl methacrylate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Nitrobenzanthrone  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-fluorouracil  (EXP)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
albuterol  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alliin  (EXP)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
apigenin  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
Azoxymethane  (ISO)
bathocuproine disulfonic acid  (ISO)
BAY 60-6583  (ISO)
beclomethasone  (EXP)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
Calcitonin gene-related peptide 1  (ISO)
Calphostin C  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cerivastatin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
chondroitin sulfate  (EXP)
cilazapril monohydrate  (ISO)
cilnidipine  (ISO)
cisplatin  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
DDT  (EXP)
deguelin  (EXP)
dermatan sulfate  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazepam  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diprotium oxide  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
dobutamine  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
Erionite  (ISO)
ethanol  (ISO)
etoposide  (EXP)
famotidine  (EXP)
fenoldopam  (ISO)
fenpyroximate  (EXP)
finasteride  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
formoterol fumarate  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
galactose  (ISO)
gamma-tocopherol  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
gossypol  (EXP)
haloperidol  (ISO)
heparan sulfate  (EXP,ISO)
heparin  (EXP,ISO)
hexadecanoic acid  (EXP)
Hexadimethrine bromide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
iloprost  (EXP)
imiquimod  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
Isradipine  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
lansoprazole  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
leukotriene B4  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
manganese(II) chloride  (ISO)
Mecamylamine  (ISO)
melittin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
mitomycin C  (EXP)
MK-2206  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP)
Morroniside  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naloxone  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nitrofen  (ISO)
nitroprusside  (EXP,ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
olanzapine  (ISO)
Oxadiazon  (EXP)
oxilofrine  (EXP)
oxybenzone  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
permethrin  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP)
prostaglandin F2alpha  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
Rutecarpine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH772984  (ISO)
scutellarin  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
Sodium oleate  (EXP)
Soman  (ISO)
Sucralfate  (EXP)
sucrose  (EXP)
suramin  (EXP)
Swertiamarin  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP,ISO)
teniposide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thalidomide  (EXP,ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
trifluoroacetic acid  (EXP)
triphenylstannane  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
water  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiogenesis involved in coronary vascular morphogenesis  (IEA,ISO)
animal organ morphogenesis  (TAS)
behavioral response to ethanol  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IDA)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (IEA)
cell migration involved in sprouting angiogenesis  (IDA,IGI)
cell population proliferation  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cerebellar granule cell precursor proliferation  (IEA,ISO)
chemotaxis  (TAS)
chondroblast differentiation  (IDA)
corticotropin hormone secreting cell differentiation  (IEA,ISO)
embryo development ending in birth or egg hatching  (IEA,ISO)
embryonic morphogenesis  (TAS)
endothelial cell migration  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IDA,IEA,IGI,IPI)
glial cell differentiation  (IEA,ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (IMP)
hyaluronan catabolic process  (IDA)
inner ear auditory receptor cell differentiation  (IEA,ISO)
lung development  (IEA,ISO)
lymphatic endothelial cell migration  (IEA,ISO)
mammary gland epithelial cell differentiation  (IEA,ISO)
negative regulation of blood vessel endothelial cell migration  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (NAS)
negative regulation of fibroblast migration  (IDA)
negative regulation of gene expression  (NAS)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of stem cell proliferation  (IEA,ISO)
negative regulation of wound healing  (IDA)
nervous system development  (TAS)
neuroblast proliferation  (IEA,ISO)
neuroepithelial cell differentiation  (IEA,ISO)
neurogenesis  (IBA)
organ induction  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
paracrine signaling  (IEA,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IDA,IEA,IGI,ISO)
positive regulation of blood vessel branching  (IDA)
positive regulation of blood vessel endothelial cell migration  (IDA,IGI)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IDA,IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell fate specification  (IDA)
positive regulation of cell migration involved in sprouting angiogenesis  (IDA)
positive regulation of cell population proliferation  (IBA,IDA,IEA,IGI,ISO,TAS)
positive regulation of cerebellar granule cell precursor proliferation  (IEA,ISO)
positive regulation of DNA biosynthetic process  (IDA,IGI)
positive regulation of endothelial cell chemotaxis  (IGI)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (IDA)
positive regulation of endothelial cell migration  (IDA,IEA,ISO)
positive regulation of endothelial cell proliferation  (IDA,IEA,IMP,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of epithelial tube formation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inner ear auditory receptor cell differentiation  (IEA,ISO)
positive regulation of lens fiber cell differentiation  (IDA)
positive regulation of MAP kinase activity  (IDA)
positive regulation of MAPK cascade  (IBA,IDA,IEA,ISO)
positive regulation of miRNA transcription  (NAS)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of neuroepithelial cell differentiation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IEA,IGI,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of sprouting angiogenesis  (IDA,IMP)
positive regulation of stem cell differentiation  (IEA,ISO)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IGI)
positive regulation of vascular endothelial cell proliferation  (IGI)
Ras protein signal transduction  (TAS)
regulation of angiogenesis  (TAS)
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (NAS)
regulation of cell cycle  (IEA,ISO)
regulation of cell migration  (IBA)
regulation of cell migration involved in sprouting angiogenesis  (NAS)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (IDA,NAS)
regulation of retinal cell programmed cell death  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IDA)
response to axon injury  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to wortmannin  (IEA,ISO)
signal transduction  (IEA,NAS)
stem cell development  (IEA)
stem cell differentiation  (IEA,ISO)
stem cell proliferation  (IEA,ISO,NAS)
substantia nigra development  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
wound healing  (IDA,TAS)

Cellular Component
cytoplasm  (IBA)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEA,ISO,TAS)
nucleus  (IBA,IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. Ben-Ami R, etal., J Infect Dis. 2013 Apr;207(7):1066-74. doi: 10.1093/infdis/jis940. Epub 2013 Jan 9.
2. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. Beranek M, etal., Diabetes Res Clin Pract. 2008 Feb;79(2):362-7. Epub 2007 Nov 7.
3. Influence of maternal diabetes on placental fibroblast growth factor-2 expression, proliferation, and apoptosis. Burleigh DW, etal., J Soc Gynecol Investig. 2004 Jan;11(1):36-41.
4. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Cao W, etal., Exp Eye Res. 1997 Aug;65(2):241-8.
5. Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Cassidy L, etal., Br J Ophthalmol. 1998 Feb;82(2):181-5.
6. FGF2-Targeted adenovirus encoding platelet-derived growth factor-B enhances de novo tissue formation. Chandler LA, etal., Mol Ther. 2000 Aug;2(2):153-60. doi: 10.1006/mthe.2000.0102.
7. The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. Cho KS, etal., Am J Otolaryngol. 2010 Sep-Oct;31(5):309-14. doi: 10.1016/j.amjoto.2009.03.005. Epub 2009 Jun 4.
8. Growth factor expression in ophthalmic pterygia and normal conjunctiva. Detorakis ET, etal., Int J Mol Med. 2010 Apr;25(4):513-6.
9. Responses of reactive astrocytes containing S100beta protein and fibroblast growth factor-2 in the border and in the adjacent preserved tissue after a contusion injury of the spinal cord in rats: implications for wound repair and neuroregeneration. do Carmo Cunha J, etal., Wound Repair Regen. 2007 Jan-Feb;15(1):134-46.
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PMID:20672350   PMID:20673868   PMID:20681019   PMID:20713592   PMID:20817637   PMID:20819778   PMID:20850693   PMID:20857427   PMID:20886037   PMID:20926602   PMID:20945415   PMID:21029699  
PMID:21037114   PMID:21041608   PMID:21041986   PMID:21048031   PMID:21161264   PMID:21209880   PMID:21224050   PMID:21266348   PMID:21350328   PMID:21381082   PMID:21382096   PMID:21460777  
PMID:21471211   PMID:21501244   PMID:21506108   PMID:21506113   PMID:21515689   PMID:21528671   PMID:21539890   PMID:21572099   PMID:21678127   PMID:21693575   PMID:21695795   PMID:21699503  
PMID:21720547   PMID:21733164   PMID:21761458   PMID:21766497   PMID:21771176   PMID:21830216   PMID:21832283   PMID:21855631   PMID:21873635   PMID:21894939   PMID:21919032   PMID:21923031  
PMID:21942441   PMID:21996542   PMID:21997191   PMID:21998584   PMID:22009965   PMID:22016523   PMID:22102278   PMID:22125837   PMID:22158871   PMID:22174424   PMID:22193058   PMID:22228819  
PMID:22233184   PMID:22237711   PMID:22260074   PMID:22267482   PMID:22335910   PMID:22393273   PMID:22493287   PMID:22506349   PMID:22508498   PMID:22539306   PMID:22542539   PMID:22546563  
PMID:22577248   PMID:22599586   PMID:22680042   PMID:22730382   PMID:22732006   PMID:22804708   PMID:22836867   PMID:22895562   PMID:22927437   PMID:22932066   PMID:22962037   PMID:22967508  
PMID:23053181   PMID:23086340   PMID:23122986   PMID:23124902   PMID:23154434   PMID:23236888   PMID:23239497   PMID:23243019   PMID:23263626   PMID:23264596   PMID:23265436   PMID:23290762  
PMID:23301033   PMID:23322705   PMID:23331079   PMID:23335070   PMID:23352645   PMID:23385422   PMID:23435034   PMID:23443559   PMID:23448571   PMID:23457216   PMID:23463326   PMID:23469107  
PMID:23485603   PMID:23536707   PMID:23597562   PMID:23597563   PMID:23604117   PMID:23620752   PMID:23625726   PMID:23630597   PMID:23677479   PMID:23800732   PMID:23861152   PMID:23869761  
PMID:23872928   PMID:23891065   PMID:23918206   PMID:23951165   PMID:23970062   PMID:23988031   PMID:23990967   PMID:23991123   PMID:23998120   PMID:24014875   PMID:24021953   PMID:24063890  
PMID:24066673   PMID:24089521   PMID:24092775   PMID:24122792   PMID:24155149   PMID:24157794   PMID:24188024   PMID:24216509   PMID:24283919   PMID:24308692   PMID:24329908   PMID:24370903  
PMID:24385208   PMID:24398102   PMID:24405062   PMID:24463821   PMID:24481949   PMID:24490960   PMID:24503018   PMID:24552587   PMID:24560494   PMID:24578133   PMID:24639043   PMID:24647157  
PMID:24663037   PMID:24667757   PMID:24725364   PMID:24737684   PMID:24777337   PMID:24793757   PMID:24797007   PMID:24827991   PMID:24970903   PMID:24986796   PMID:24988442   PMID:25079902  
PMID:25088797   PMID:25122057   PMID:25130652   PMID:25190353   PMID:25204086   PMID:25248378   PMID:25256553   PMID:25263081   PMID:25267953   PMID:25287675   PMID:25299071   PMID:25361773  
PMID:25403884   PMID:25429350   PMID:25477183   PMID:25550544   PMID:25552245   PMID:25595970   PMID:25597785   PMID:25599736   PMID:25636512   PMID:25640183   PMID:25693804   PMID:25735814  
PMID:25790378   PMID:25853270   PMID:25872462   PMID:25890121   PMID:25894376   PMID:25909157   PMID:25999285   PMID:26030799   PMID:26032256   PMID:26042674   PMID:26056081   PMID:26078726  
PMID:26096243   PMID:26120833   PMID:26123869   PMID:26133673   PMID:26141457   PMID:26186194   PMID:26197710   PMID:26252425   PMID:26263555   PMID:26267536   PMID:26276817   PMID:26279296  
PMID:26282129   PMID:26314253   PMID:26332075   PMID:26403263   PMID:26451614   PMID:26461038   PMID:26464712   PMID:26465938   PMID:26465941   PMID:26493998   PMID:26496610   PMID:26518873  
PMID:26547859   PMID:26553652   PMID:26572749   PMID:26578364   PMID:26597457   PMID:26617686   PMID:26637527   PMID:26644005   PMID:26650737   PMID:26655277   PMID:26712576   PMID:26719333  
PMID:26729092   PMID:26731484   PMID:26749426   PMID:26760575   PMID:26762209   PMID:26798059   PMID:26816250   PMID:26823724   PMID:26824699   PMID:26833879   PMID:26879180   PMID:26888666  
PMID:26899709   PMID:27007053   PMID:27097071   PMID:27097314   PMID:27130666   PMID:27133199   PMID:27190997   PMID:27237708   PMID:27305863   PMID:27312585   PMID:27314542   PMID:27317650  
PMID:27321088   PMID:27324104   PMID:27350596   PMID:27362808   PMID:27382052   PMID:27411850   PMID:27481339   PMID:27511275   PMID:27521890   PMID:27558498   PMID:27566073   PMID:27572168  
PMID:27580376   PMID:27634335   PMID:27702660   PMID:27794612   PMID:27825029   PMID:27878407   PMID:27883224   PMID:27889473   PMID:27918462   PMID:27930387   PMID:27966750   PMID:28049184  
PMID:28167392   PMID:28209294   PMID:28219779   PMID:28298222   PMID:28302677   PMID:28317323   PMID:28342868   PMID:28363830   PMID:28373444   PMID:28378594   PMID:28423625   PMID:28433654  
PMID:28466272   PMID:28481872   PMID:28500362   PMID:28514442   PMID:28543663   PMID:28629469   PMID:28631381   PMID:28653999   PMID:28656882   PMID:28679560   PMID:28732140   PMID:28734240  
PMID:28746898   PMID:28765647   PMID:28869446   PMID:28871048   PMID:28916723   PMID:28924004   PMID:28935533   PMID:28967471   PMID:29016732   PMID:29042195   PMID:29121325   PMID:29168882  
PMID:29363574   PMID:29382571   PMID:29433373   PMID:29501879   PMID:29534588   PMID:29561195   PMID:29873400   PMID:29887238   PMID:29983388   PMID:29989583   PMID:30029518   PMID:30080932  
PMID:30099339   PMID:30129658   PMID:30144335   PMID:30159917   PMID:30168023   PMID:30236477   PMID:30372829   PMID:30475537   PMID:30679579   PMID:30720426   PMID:30764615   PMID:30799482  
PMID:30804659   PMID:30866584   PMID:30952770   PMID:31094056   PMID:31378921   PMID:31503014   PMID:31515454   PMID:31586073   PMID:31629466   PMID:31789423   PMID:31915155   PMID:31916307  
PMID:31958075   PMID:31980649   PMID:32196384   PMID:32214225   PMID:32229735   PMID:32283546   PMID:32383752   PMID:32474521   PMID:32500557   PMID:32557854   PMID:32585853   PMID:32613556  
PMID:32615335   PMID:32682018   PMID:32707033   PMID:32727671   PMID:32890968   PMID:32977766   PMID:33033110   PMID:33093168   PMID:33162101   PMID:33177072   PMID:33187467   PMID:33206726  
PMID:33285208   PMID:33381388   PMID:33445083   PMID:33545068   PMID:33565061   PMID:33706169   PMID:33800200   PMID:33961781   PMID:34072943   PMID:34224989   PMID:34360002   PMID:34437953  
PMID:34460152   PMID:34654466   PMID:34663382   PMID:34921695   PMID:35013556   PMID:35079927   PMID:35093168   PMID:35164915   PMID:35256949   PMID:35348113   PMID:35384245   PMID:35562616  
PMID:35662113   PMID:35716001   PMID:35754140   PMID:35767892   PMID:35859077   PMID:36113752   PMID:36163231   PMID:36189305   PMID:36225120   PMID:36273042   PMID:36717031   PMID:36736316  
PMID:36807118   PMID:37165492   PMID:37188903   PMID:37432067   PMID:37433992   PMID:37496999   PMID:37583315   PMID:37832794   PMID:37848720   PMID:37913587   PMID:37960778   PMID:37988847  
PMID:38247274   PMID:38253356   PMID:38355415   PMID:38479160   PMID:38518781   PMID:38811382   PMID:39119899  


Genomics

Comparative Map Data
FGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
Fgf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)EnsemblGRCm39 Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBIMGSCv36mm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
Fgf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
Fgf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
FGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,604,078 - 120,675,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,869,886 - 120,941,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
FGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBIUU_Cfam_GSD_1.0
FGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,089,394 - 70,157,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,268,953 - 3,321,145 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF2
33 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2		 pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2		 pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3		 pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3		 pathogenic
GRCh38/hg38 4q26-31.21(chr4:116630862-145429900)x1 copy number loss See cases [RCV000053321] Chr4:116630862..145429900 [GRCh38]
Chr4:117552018..146351052 [GRCh37]
Chr4:117771466..146570502 [NCBI36]
Chr4:4q26-31.21		 pathogenic
GRCh38/hg38 4q26-28.3(chr4:117351881-133565667)x1 copy number loss See cases [RCV000143207] Chr4:117351881..133565667 [GRCh38]
Chr4:118273037..134486822 [GRCh37]
Chr4:118492485..134706272 [NCBI36]
Chr4:4q26-28.3		 pathogenic
NM_001361665.2(FGF2):c.-74G>A single nucleotide variant Long QT syndrome [RCV000190152] Chr4:122827101 [GRCh38]
Chr4:123748256 [GRCh37]
Chr4:4q28.1		 likely benign
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2		 pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q26-28.2(chr4:116307857-129302960)x1 copy number loss not provided [RCV000682448] Chr4:116307857..129302960 [GRCh37]
Chr4:4q26-28.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_001361665.2(FGF2):c.99C>T (p.Tyr33=) single nucleotide variant not provided [RCV000916958] Chr4:122827273 [GRCh38]
Chr4:123748428 [GRCh37]
Chr4:4q28.1		 likely benign
Single allele deletion Neurodevelopmental disorder [RCV000787448] Chr4:116624547..126168646 [GRCh37]
Chr4:4q26-28.1		 likely pathogenic
NM_001361665.2(FGF2):c.183G>T (p.Lys61Asn) single nucleotide variant not provided [RCV000886527] Chr4:122876325 [GRCh38]
Chr4:123797480 [GRCh37]
Chr4:4q28.1		 likely benign
GRCh37/hg19 4q27-28.1(chr4:123666456-123851648)x1 copy number loss not provided [RCV001259312] Chr4:123666456..123851648 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
GRCh37/hg19 4q26-28.2(chr4:116833638-130232122) copy number loss Atypical behavior [RCV001352657] Chr4:116833638..130232122 [GRCh37]
Chr4:4q26-28.2		 pathogenic
NC_000004.11:g.(?_123663028)_(124235239_?)del deletion Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome [RCV001388944] Chr4:123663028..124235239 [GRCh37]
Chr4:4q27-28.1		 pathogenic
GRCh37/hg19 4q26-28.3(chr4:114872547-138005267)x1 copy number loss not provided [RCV001795851] Chr4:114872547..138005267 [GRCh37]
Chr4:4q26-28.3		 pathogenic
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595) copy number gain not specified [RCV002053446] Chr4:104715235..145252595 [GRCh37]
Chr4:4q24-31.21		 pathogenic
GRCh37/hg19 4q26-28.2(chr4:116888785-129649979) copy number loss not specified [RCV002053451] Chr4:116888785..129649979 [GRCh37]
Chr4:4q26-28.2		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q27-28.1(chr4:123730878-123891478)x1 copy number loss not provided [RCV001834323] Chr4:123730878..123891478 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
NC_000004.11:g.(?_123533865)_(124011880_?)dup duplication not provided [RCV001923176] Chr4:123533865..124011880 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
NC_000004.11:g.(?_121616266)_(124323706_?)dup duplication Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome [RCV003113657] Chr4:121616266..124323706 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
NC_000004.11:g.(?_123818759)_(124235219_?)del deletion Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome [RCV003113661] Chr4:123818759..124235219 [GRCh37]
Chr4:4q28.1		 pathogenic
NM_001361665.2(FGF2):c.337A>G (p.Asn113Asp) single nucleotide variant not specified [RCV004141496] Chr4:122892265 [GRCh38]
Chr4:123813420 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_007083.5(NUDT6):c.569G>A (p.Arg190Gln) single nucleotide variant not specified [RCV004170103] Chr4:122893210 [GRCh38]
Chr4:123814365 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-129G>A single nucleotide variant not specified [RCV004176360] Chr4:122827046 [GRCh38]
Chr4:123748201 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-162G>A single nucleotide variant not specified [RCV004173823] Chr4:122827013 [GRCh38]
Chr4:123748168 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.346C>T (p.Arg116Trp) single nucleotide variant not specified [RCV004171386] Chr4:122892274 [GRCh38]
Chr4:123813429 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-26G>A single nucleotide variant not specified [RCV004224614] Chr4:122827149 [GRCh38]
Chr4:123748304 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_007083.5(NUDT6):c.613G>T (p.Val205Phe) single nucleotide variant not specified [RCV004271273] Chr4:122893166 [GRCh38]
Chr4:123814321 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-66C>T single nucleotide variant not specified [RCV004261649] Chr4:122827109 [GRCh38]
Chr4:123748264 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-109C>G single nucleotide variant not provided [RCV003457124] Chr4:122827066 [GRCh38]
Chr4:123748221 [GRCh37]
Chr4:4q28.1		 likely benign
GRCh37/hg19 4q27-28.1(chr4:123654096-123996443)x3 copy number gain not provided [RCV003484202] Chr4:123654096..123996443 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
GRCh37/hg19 4q26-32.3(chr4:117518683-168174703)x3 copy number gain not provided [RCV003484198] Chr4:117518683..168174703 [GRCh37]
Chr4:4q26-32.3		 pathogenic
GRCh37/hg19 4q27-35.2(chr4:123399154-190957473)x3 copy number gain not specified [RCV003986533] Chr4:123399154..190957473 [GRCh37]
Chr4:4q27-35.2		 pathogenic
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3 copy number gain not specified [RCV003986496] Chr4:101203509..190957473 [GRCh37]
Chr4:4q24-35.2		 pathogenic
GRCh37/hg19 4q27-28.1(chr4:123302296-124083892)x3 copy number gain not specified [RCV003986536] Chr4:123302296..124083892 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
NM_007083.5(NUDT6):c.770C>T (p.Thr257Ile) single nucleotide variant NUDT6-related disorder [RCV003914587] Chr4:122893009 [GRCh38]
Chr4:123814164 [GRCh37]
Chr4:4q28.1		 benign
NM_007083.5(NUDT6):c.612C>T (p.Ser204=) single nucleotide variant NUDT6-related disorder [RCV003909525] Chr4:122893167 [GRCh38]
Chr4:123814322 [GRCh37]
Chr4:4q28.1		 likely benign
NM_007083.5(NUDT6):c.764C>T (p.Ala255Val) single nucleotide variant NUDT6-related disorder [RCV003954770] Chr4:122893015 [GRCh38]
Chr4:123814170 [GRCh37]
Chr4:4q28.1		 likely benign
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_007083.5(NUDT6):c.554-5C>A single nucleotide variant NUDT6-related disorder [RCV003973949] Chr4:122893230 [GRCh38]
Chr4:123814385 [GRCh37]
Chr4:4q28.1		 benign
NM_001361665.2(FGF2):c.-311A>G single nucleotide variant not specified [RCV004394047] Chr4:122826864 [GRCh38]
Chr4:123748019 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-219G>A single nucleotide variant not specified [RCV004394042] Chr4:122826956 [GRCh38]
Chr4:123748111 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_007083.5(NUDT6):c.702C>A (p.Phe234Leu) single nucleotide variant not specified [RCV004496219] Chr4:122893077 [GRCh38]
Chr4:123814232 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-198C>G single nucleotide variant not specified [RCV004394043] Chr4:122826977 [GRCh38]
Chr4:123748132 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.293C>T (p.Thr98Met) single nucleotide variant not specified [RCV004394045] Chr4:122892221 [GRCh38]
Chr4:123813376 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.460A>C (p.Lys154Gln) single nucleotide variant not specified [RCV004394046] Chr4:122892388 [GRCh38]
Chr4:123813543 [GRCh37]
Chr4:4q28.1		 uncertain significance
NC_000004.11:g.(?_121616266)_(124323706_?)del deletion not provided [RCV004580860] Chr4:121616266..124323706 [GRCh37]
Chr4:4q27-28.1		 uncertain significance
NC_000004.11:g.(?_123818759)_(123978463_?)del deletion Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome [RCV004580795] Chr4:123818759..123978463 [GRCh37]
Chr4:4q28.1		 pathogenic
NC_000004.11:g.(?_123813983)_(124177355_?)dup duplication Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome [RCV004580796] Chr4:123813983..124177355 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_007083.5(NUDT6):c.590G>T (p.Gly197Val) single nucleotide variant not specified [RCV004638837] Chr4:122893189 [GRCh38]
Chr4:123814344 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_007083.5(NUDT6):c.613G>A (p.Val205Ile) single nucleotide variant not specified [RCV004652652] Chr4:122893166 [GRCh38]
Chr4:123814321 [GRCh37]
Chr4:4q28.1		 uncertain significance
NM_001361665.2(FGF2):c.-176G>A single nucleotide variant not specified [RCV004623265] Chr4:122826999 [GRCh38]
Chr4:123748154 [GRCh37]
Chr4:4q28.1		 likely benign
NM_001361665.2(FGF2):c.-99G>C single nucleotide variant not specified [RCV004623266] Chr4:122827076 [GRCh38]
Chr4:123748231 [GRCh37]
Chr4:4q28.1		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR16-1hsa-miR-16-5pOncomiRDBexternal_infoNANA21532615
MIR15Ahsa-miR-15a-5pOncomiRDBexternal_infoNANA21532615
MIR16-2hsa-miR-16-5pOncomiRDBexternal_infoNANA21532615
MIR503hsa-miR-503-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23352645

Predicted Target Of
Summary Value
Count of predictions:2979
Count of miRNA genes:948
Interacting mature miRNAs:1144
Transcripts:ENST00000264498, ENST00000608478
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1643256BW127_HBody Weight QTL 127 (human)1.310.007Body weightbody mass index4106319694132319694Human
597019186GWAS1115260_Hbody mass index QTL GWAS1115260 (human)0.0000007body mass indexbody mass index (BMI) (CMO:0000105)4122841742122841743Human
597199711GWAS1295785_Hbone density QTL GWAS1295785 (human)2e-10bone mineral mass (VT:0005007)bone mineral density (CMO:0001226)4122897478122897479Human
597244944GWAS1341018_HBMI-adjusted waist-hip ratio QTL GWAS1341018 (human)5e-08body size trait (VT:0100005)4122860717122860718Human
597145081GWAS1241155_Hbody height QTL GWAS1241155 (human)4e-08body height (VT:0001253)body height (CMO:0000106)4122841742122841743Human
597047449GWAS1143523_HBMI-adjusted waist-hip ratio QTL GWAS1143523 (human)6e-09body size trait (VT:0100005)4122854222122854223Human
597223735GWAS1319809_HBMI-adjusted waist circumference QTL GWAS1319809 (human)5e-09body size trait (VT:0100005)4122858186122858187Human
407112502GWAS761478_Hwaist-hip ratio QTL GWAS761478 (human)4e-17waist-hip ratiowaist to hip ratio (WHR) (CMO:0000020)4122836593122836594Human
597070373GWAS1166447_Hmosquito bite reaction size measurement QTL GWAS1166447 (human)4e-08mosquito bite reaction size measurement4122852424122852425Human
597319785GWAS1415859_HX-24422 measurement QTL GWAS1415859 (human)3e-13X-24422 measurement4122894208122894209Human
597266605GWAS1362679_Hfibroblast growth factor 2 measurement QTL GWAS1362679 (human)9e-18fibroblast growth factor 2 measurement4122836593122836594Human
597297774GWAS1393848_Hfibroblast growth factor 2 measurement QTL GWAS1393848 (human)6e-39fibroblast growth factor 2 measurement4122836593122836594Human
597274732GWAS1370806_Hfibroblast growth factor 2 measurement QTL GWAS1370806 (human)6e-36fibroblast growth factor 2 measurement4122827461122827462Human
597177760GWAS1273834_Hfibroblast growth factor 2 measurement QTL GWAS1273834 (human)8e-667fibroblast growth factor 2 measurement4122827461122827462Human
597334211GWAS1430285_Hgluteofemoral adipose tissue measurement QTL GWAS1430285 (human)3e-08gluteofemoral adipose tissue measurement4122891032122891033Human
597352704GWAS1448778_Hbody height QTL GWAS1448778 (human)2e-96body height (VT:0001253)body height (CMO:0000106)4122830862122830863Human
597159787GWAS1255861_Hlipid measurement QTL GWAS1255861 (human)0.000008lipid measurementblood lipid measurement (CMO:0000050)4122878832122878833Human

Markers in Region
SHGC-105784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,758,257 - 123,758,553UniSTSGRCh37
Build 364123,977,707 - 123,978,003RGDNCBI36
Celera4121,141,101 - 121,141,397RGD
Cytogenetic Map4q26UniSTS
HuRef4119,484,680 - 119,484,976UniSTS
TNG Radiation Hybrid Map476848.0UniSTS
SHGC-59784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,819,099 - 123,819,197UniSTSGRCh37
Build 364124,038,549 - 124,038,647RGDNCBI36
Celera4121,201,943 - 121,202,041RGD
Cytogenetic Map4q26UniSTS
HuRef4119,545,526 - 119,545,624UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
SHGC-59517  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,818,907 - 123,819,134UniSTSGRCh37
Build 364124,038,357 - 124,038,584RGDNCBI36
Celera4121,201,751 - 121,201,978RGD
Cytogenetic Map4q26UniSTS
HuRef4119,545,334 - 119,545,561UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
SHGC-31504  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,813,560 - 123,813,776UniSTSGRCh37
Build 364124,033,010 - 124,033,226RGDNCBI36
Celera4121,196,404 - 121,196,620RGD
Cytogenetic Map4q26UniSTS
HuRef4119,539,987 - 119,540,203UniSTS
TNG Radiation Hybrid Map476869.0UniSTS
Stanford-G3 RH Map46929.0UniSTS
GeneMap99-GB4 RH Map4557.24UniSTS
Whitehead-RH Map4609.0UniSTS
GeneMap99-G3 RH Map46875.0UniSTS
D15S1390  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map15q23UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map7p13UniSTS
SHGC-67307  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map18pter-p11.3UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map4q13.1UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map8q21.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map1q32.2-q41UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map5p13.3UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map5q22.1UniSTS
Cytogenetic Map1p36.12UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map1p36.21UniSTS
TNG Radiation Hybrid Map41213.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2381 2788 2243 4968 1718 2330 4 617 1830 458 2266 7136 6348 50 3732 848 1735 1603 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA256481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI276765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY820133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE439775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP292299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU501243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN315083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF506888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM015593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S47380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000264498   ⟹   ENSP00000264498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)Ensembl
Ensembl Acc Id: ENST00000608478   ⟹   ENSP00000477134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4122,826,831 - 122,895,464 (+)Ensembl
Ensembl Acc Id: ENST00000644866   ⟹   ENSP00000494222
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4122,826,831 - 122,898,236 (+)Ensembl
RefSeq Acc Id: NM_001361665   ⟹   NP_001348594
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,826,831 - 122,898,236 (+)NCBI
T2T-CHM13v2.04126,130,930 - 126,202,343 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002006   ⟹   NP_001997
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,826,682 - 122,898,236 (+)NCBI
GRCh374123,747,568 - 123,819,390 (+)NCBI
Build 364123,967,313 - 124,038,840 (+)NCBI Archive
HuRef4119,474,437 - 119,545,817 (+)ENTREZGENE
CHM1_14123,724,372 - 123,795,895 (+)NCBI
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001997   ⟸   NM_002006
- Peptide Label: isoform 34 kDa
- UniProtKB: P09038 (UniProtKB/Swiss-Prot),   Q9UCS5 (UniProtKB/Swiss-Prot),   Q9UC54 (UniProtKB/Swiss-Prot),   Q7KZ72 (UniProtKB/Swiss-Prot),   Q7KZ11 (UniProtKB/Swiss-Prot),   Q5PY50 (UniProtKB/Swiss-Prot),   Q16443 (UniProtKB/Swiss-Prot),   P78443 (UniProtKB/Swiss-Prot),   O00527 (UniProtKB/Swiss-Prot),   A4LBB8 (UniProtKB/Swiss-Prot),   Q9UCS6 (UniProtKB/Swiss-Prot),   A0A0A0MQV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001348594   ⟸   NM_001361665
- Peptide Label: isoform 18 kDa
- UniProtKB: D9ZGF5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000494222   ⟸   ENST00000644866
Ensembl Acc Id: ENSP00000264498   ⟸   ENST00000264498
Ensembl Acc Id: ENSP00000477134   ⟸   ENST00000608478

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09038-F1-model_v2 AlphaFold P09038 1-288 view protein structure

Promoters
RGD ID:6868424
Promoter ID:EPDNEW_H7377
Type:initiation region
Name:FGF2_1
Description:fibroblast growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,826,831 - 122,826,891EPDNEW
RGD ID:6802313
Promoter ID:HG_KWN:49062
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_002006
Position:
Human AssemblyChrPosition (strand)Source
Build 364123,967,396 - 123,967,917 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3676 AgrOrtholog
COSMIC FGF2 COSMIC
Ensembl Genes ENSG00000138685 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000264498 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000264498.9 UniProtKB/Swiss-Prot
  ENST00000608478.1 UniProtKB/Swiss-Prot
  ENST00000644866 ENTREZGENE
  ENST00000644866.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000138685 GTEx
HGNC ID HGNC:3676 ENTREZGENE
Human Proteome Map FGF2 Human Proteome Map
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2247 UniProtKB/Swiss-Prot
NCBI Gene 2247 ENTREZGENE
OMIM 134920 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28115 PharmGKB
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQV6 ENTREZGENE, UniProtKB/TrEMBL
  A4LBB8 ENTREZGENE
  D9ZGF5 ENTREZGENE, UniProtKB/TrEMBL
  FGF2_HUMAN UniProtKB/Swiss-Prot
  O00527 ENTREZGENE
  P09038 ENTREZGENE
  P78443 ENTREZGENE
  Q16443 ENTREZGENE
  Q5PY50 ENTREZGENE
  Q7KZ11 ENTREZGENE
  Q7KZ72 ENTREZGENE
  Q9UC54 ENTREZGENE
  Q9UCS5 ENTREZGENE
  Q9UCS6 ENTREZGENE
UniProt Secondary A4LBB8 UniProtKB/Swiss-Prot
  O00527 UniProtKB/Swiss-Prot
  P78443 UniProtKB/Swiss-Prot
  Q16443 UniProtKB/Swiss-Prot
  Q5PY50 UniProtKB/Swiss-Prot
  Q7KZ11 UniProtKB/Swiss-Prot
  Q7KZ72 UniProtKB/Swiss-Prot
  Q9UC54 UniProtKB/Swiss-Prot
  Q9UCS5 UniProtKB/Swiss-Prot
  Q9UCS6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 FGF2  fibroblast growth factor 2  FGF2  fibroblast growth factor 2 (basic)  Symbol and/or name change 5135510 APPROVED