FGF2 (fibroblast growth factor 2) - Rat Genome Database

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Gene: FGF2 (fibroblast growth factor 2) Homo sapiens
Symbol: FGF2
Name: fibroblast growth factor 2
RGD ID: 70822
Description: Exhibits several functions, including identical protein binding activity; nuclear receptor coactivator activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and regulation of cell migration. Localizes to extracellular space. Implicated in several diseases, including corneal neovascularization; diabetic neuropathy; gastric ulcer; impotence; and prostate adenocarcinoma. Biomarker of several diseases, including artery disease (multiple); breast cancer (multiple); carcinoma (multiple); eye disease (multiple); and female reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic fibroblast growth factor bFGF; BFGF; FGF-2; FGFB; fibroblast growth factor 2 (basic); HBGF-2; heparin-binding growth factor 2; prostatropin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4122,826,708 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh384122,826,708 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,747,863 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBI
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (IEP)
biliary tract disease  (IEP)
bladder disease  (ISO)
bone disease  (IDA)
Bone Fractures  (IDA)
brain infarction  (EXP)
Brain Injuries  (EXP)
breast cancer  (IEP)
breast carcinoma  (IEP)
Cardiomegaly  (EXP,ISO)
cataract  (IEP)
cholangiocarcinoma  (IEP)
cholesteatoma of middle ear  (IEP)
Choroidal Neovascularization  (ISO)
chronic ulcer of skin  (IDA)
cleft lip  (EXP)
cleft palate  (EXP)
Cocaine-Related Disorders  (EXP)
cognitive disorder  (IDA)
corneal neovascularization  (EXP,IDA)
coronary artery disease  (IEP)
Coronary Disease  (IEP)
decubitus ulcer  (ISO)
Delayed Hypersensitivity  (IDA)
demyelinating disease  (ISO)
dermatitis  (IDA)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (IDA)
diabetic retinopathy  (IAGP,IEP,ISO)
Diaphragmatic Hernia  (EXP)
Disease Progression  (EXP)
endometrial cancer  (IEP)
epilepsy with generalized tonic-clonic seizures  (EXP)
esophageal cancer  (IEP)
essential thrombocythemia  (EXP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Eye Injuries  (ISO)
Eye Injuries, Penetrating  (ISO)
Femoral Fractures  (ISO)
Gallbladder Neoplasms  (IEP)
gastric ulcer  (IDA)
gestational diabetes  (EXP)
Gliosis  (EXP)
high grade glioma  (EXP)
Hypercholesterolemia  (IEP)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypoglossal Nerve Injuries  (ISO)
impotence  (IDA)
Inflammation  (EXP,ISO)
Invasive Pulmonary Aspergillosis  (IDA)
Kaposiform Hemangioendothelioma  (IDA)
kidney disease  (EXP)
leiomyoma  (IEP)
liver cirrhosis  (EXP)
long QT syndrome  (IAGP)
macular retinal edema  (IEP)
mental depression  (EXP)
Mesothelioma  (EXP)
multiple endocrine neoplasia type 1  (IEP)
Myocardial Ischemia  (EXP)
Nasal Polyps  (IEP)
Necrosis  (IDA)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (IEP)
nephrosclerosis  (EXP)
nephrotic syndrome  (EXP)
Nerve Degeneration  (EXP)
Neurodevelopmental Disorders  (IAGP)
Optic Nerve Injuries  (IMP)
oral submucous fibrosis  (EXP)
ovarian cancer  (IEP)
pancreatic cancer  (IDA,IEP)
pancreatic ductal carcinoma  (IEP)
Parkinsonism  (IDA)
periapical periodontitis  (EXP)
polyarteritis nodosa  (IEP)
Pregnancy in Diabetics  (IEP)
Prenatal Exposure Delayed Effects  (EXP)
prostate adenocarcinoma  (IAGP)
Prostatic Neoplasms  (EXP)
Pseudomonas Infections  (IDA)
pterygium  (IEP)
pulmonary fibrosis  (EXP)
pulmonary hypertension  (IEP,ISO)
renal cell carcinoma  (IEP)
Reperfusion Injury  (EXP)
Retina Reperfusion Injury  (IDA,ISO)
retinal vein occlusion  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
transitional cell carcinoma  (IEP)
Tympanic Membrane Perforation  (IDA,ISO)
type 2 diabetes mellitus  (IEP)
Ulcer  (ISO)
urinary bladder cancer  (IMP)
visual epilepsy  (EXP)
Wound Infection  (IDA)
Wounds and Injuries  (EXP,IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14,15-EET  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxyethyl methacrylate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-fluorouracil  (EXP)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
albuterol  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alliin  (EXP)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apigenin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
bathocuproine disulfonic acid  (ISO)
BAY 60-6583  (ISO)
beclomethasone  (EXP)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP)
beta-D-glucosamine  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bucladesine  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cerivastatin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
chondroitin sulfate  (EXP)
cilazapril monohydrate  (ISO)
cilnidipine  (ISO)
cisplatin  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
dermatan sulfate  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazepam  (EXP)
diazinon  (ISO)
dichlorine  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diprotium oxide  (EXP)
divanadium pentaoxide  (EXP)
dobutamine  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
Erionite  (ISO)
etoposide  (EXP)
famotidine  (EXP)
fenoldopam  (ISO)
finasteride  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
formoterol fumarate  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
galactose  (ISO)
gamma-tocopherol  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
gossypol  (EXP)
heparan sulfate  (EXP,ISO)
heparin  (EXP,ISO)
hexadecanoic acid  (EXP)
Hexadimethrine bromide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
iloprost  (EXP)
imiquimod  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
Isradipine  (EXP)
kainic acid  (ISO)
lansoprazole  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
manganese(II) chloride  (ISO)
Mecamylamine  (ISO)
melittin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
mitomycin C  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naloxone  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nitrofen  (ISO)
nitroprusside  (EXP,ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
olanzapine  (ISO)
Oxadiazon  (EXP)
oxilofrine  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
permethrin  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP)
prostaglandin F2alpha  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
rottlerin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH772984  (ISO)
scutellarin  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
Sodium oleate  (EXP)
Soman  (ISO)
Sucralfate  (EXP)
sucrose  (EXP)
suramin  (EXP)
Swertiamarin  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
teniposide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thalidomide  (EXP,ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
topotecan  (EXP)
trichostatin A  (EXP,ISO)
trifluoroacetic acid  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
water  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEA,ISO)
angiogenesis involved in coronary vascular morphogenesis  (IEA,ISO)
animal organ morphogenesis  (IBA)
branching involved in ureteric bud morphogenesis  (IDA)
cell differentiation  (IBA)
cell migration involved in sprouting angiogenesis  (IDA,IGI)
chemotaxis  (TAS)
chondroblast differentiation  (IDA)
corticotropin hormone secreting cell differentiation  (IEA,ISO)
cytokine-mediated signaling pathway  (TAS)
embryo development ending in birth or egg hatching  (IEA,ISO)
embryonic morphogenesis  (TAS)
extracellular matrix organization  (TAS)
fibroblast growth factor receptor signaling pathway  (IBA,IDA,IEA,IGI,IPI,TAS)
glial cell differentiation  (IEA,ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (IMP)
hyaluronan catabolic process  (IDA)
inositol phosphate biosynthetic process  (IDA)
lung development  (IBA,ISO)
mammary gland epithelial cell differentiation  (IEA,ISO)
MAPK cascade  (TAS)
negative regulation of blood vessel endothelial cell migration  (IDA)
negative regulation of cell death  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (NAS)
negative regulation of fibroblast migration  (IDA)
negative regulation of gene expression  (NAS)
negative regulation of wound healing  (IDA)
nervous system development  (TAS)
obsolete activation of MAPK activity  (TAS)
obsolete activation of MAPKK activity  (IEA)
organ induction  (IEA,ISO)
paracrine signaling  (ISS)
phosphatidylinositol biosynthetic process  (IDA)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IDA,IGI,ISO)
positive regulation of blood vessel endothelial cell migration  (IDA,IGI)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IDA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell fate specification  (IDA)
positive regulation of cell migration involved in sprouting angiogenesis  (IDA)
positive regulation of cell population proliferation  (IBA,IDA,IGI,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (IEA,ISO)
positive regulation of DNA biosynthetic process  (IDA,IGI)
positive regulation of endothelial cell chemotaxis  (IGI)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (IDA)
positive regulation of endothelial cell migration  (IBA,IDA,ISO)
positive regulation of endothelial cell proliferation  (IDA,IMP,ISO)
positive regulation of epithelial cell proliferation  (IBA,ISO)
positive regulation of epithelial tube formation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISO)
positive regulation of gene expression  (IBA,ISO)
positive regulation of lens fiber cell differentiation  (IDA)
positive regulation of MAP kinase activity  (IBA,IDA)
positive regulation of MAPK cascade  (IDA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IGI)
positive regulation of phospholipase C activity  (IDA)
positive regulation of pri-miRNA transcription by RNA polymerase II  (NAS)
positive regulation of protein kinase B signaling  (IDA,ISO,TAS)
positive regulation of protein phosphorylation  (IBA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sprouting angiogenesis  (IDA,IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IGI)
positive regulation of vascular endothelial cell proliferation  (IGI)
Ras protein signal transduction  (TAS)
regulation of angiogenesis  (TAS)
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (NAS)
regulation of cell cycle  (IEA,ISO)
regulation of cell migration  (IBA)
regulation of cell migration involved in sprouting angiogenesis  (NAS)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (IDA,NAS)
regulation of retinal cell programmed cell death  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IDA)
response to axon injury  (IEA,ISO)
signal transduction  (NAS)
somatic stem cell population maintenance  (TAS)
stem cell development  (IEA)
stem cell proliferation  (NAS)
substantia nigra development  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)
wound healing  (IBA,IDA,ISO,TAS)

Cellular Component
cytoplasm  (IBA,ISO)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,ISO)
nucleus  (IBA,IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

References - curated
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Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4122,826,708 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh384122,826,708 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,747,863 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBI
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBImm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22120,236,328 - 120,290,673 (+)NCBI
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBI
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBI
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBI
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBI
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8101,278,878 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1770,089,394 - 70,157,423 (+)NCBI
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,758,257 - 123,758,553UniSTSGRCh37
Build 364123,977,707 - 123,978,003RGDNCBI36
Celera4121,141,101 - 121,141,397RGD
Cytogenetic Map4q26UniSTS
HuRef4119,484,680 - 119,484,976UniSTS
TNG Radiation Hybrid Map476848.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,819,099 - 123,819,197UniSTSGRCh37
Build 364124,038,549 - 124,038,647RGDNCBI36
Celera4121,201,943 - 121,202,041RGD
Cytogenetic Map4q26UniSTS
HuRef4119,545,526 - 119,545,624UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,818,907 - 123,819,134UniSTSGRCh37
Build 364124,038,357 - 124,038,584RGDNCBI36
Celera4121,201,751 - 121,201,978RGD
Cytogenetic Map4q26UniSTS
HuRef4119,545,334 - 119,545,561UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,813,560 - 123,813,776UniSTSGRCh37
Build 364124,033,010 - 124,033,226RGDNCBI36
Celera4121,196,404 - 121,196,620RGD
Cytogenetic Map4q26UniSTS
HuRef4119,539,987 - 119,540,203UniSTS
TNG Radiation Hybrid Map476869.0UniSTS
Stanford-G3 RH Map46929.0UniSTS
GeneMap99-GB4 RH Map4557.24UniSTS
Whitehead-RH Map4609.0UniSTS
GeneMap99-G3 RH Map46875.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map15q23UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map7p13UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map18pter-p11.3UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map4q13.1UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map8q21.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map1q32.2-q41UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map5p13.3UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map5q22.1UniSTS
Cytogenetic Map1p36.12UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map1p36.21UniSTS
TNG Radiation Hybrid Map41213.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR503hsa-miR-503-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23352645

Predicted Target Of
Summary Value
Count of predictions:2979
Count of miRNA genes:948
Interacting mature miRNAs:1144
Transcripts:ENST00000264498, ENST00000608478
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
Medium 1580 1317 115 18 81 16 2168 886 1632 132 625 487 5 1080 1290 1
Low 745 922 1480 481 934 324 2095 1239 2091 259 778 1069 168 1 124 1431 2
Below cutoff 56 696 123 118 815 118 90 68 9 24 48 46 1 67 1


Nucleotide Sequences
RefSeq Transcripts NG_029067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA256481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI276765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY820133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE439775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP292299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU501243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN315083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF506888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM015593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S47380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264498   ⟹   ENSP00000264498
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,826,708 - 122,898,236 (+)Ensembl
RefSeq Acc Id: ENST00000608478   ⟹   ENSP00000477134
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,826,831 - 122,895,464 (+)Ensembl
RefSeq Acc Id: ENST00000644866   ⟹   ENSP00000494222
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,826,831 - 122,898,236 (+)Ensembl
RefSeq Acc Id: NM_001361665   ⟹   NP_001348594
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh384122,826,831 - 122,898,236 (+)NCBI
RefSeq Acc Id: NM_002006   ⟹   NP_001997
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh384122,826,708 - 122,898,236 (+)NCBI
GRCh374123,747,568 - 123,819,390 (+)NCBI
Build 364123,967,313 - 124,038,840 (+)NCBI Archive
HuRef4119,474,437 - 119,545,817 (+)ENTREZGENE
CHM1_14123,724,372 - 123,795,895 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001997   ⟸   NM_002006
- Peptide Label: isoform 34 kDa
- UniProtKB: P09038 (UniProtKB/Swiss-Prot),   A0A087WUF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001348594   ⟸   NM_001361665
- Peptide Label: isoform 18 kDa
RefSeq Acc Id: ENSP00000494222   ⟸   ENST00000644866
RefSeq Acc Id: ENSP00000264498   ⟸   ENST00000264498
RefSeq Acc Id: ENSP00000477134   ⟸   ENST00000608478

RGD ID:6868424
Promoter ID:EPDNEW_H7377
Type:initiation region
Description:fibroblast growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh384122,826,831 - 122,826,891EPDNEW
RGD ID:6802313
Promoter ID:HG_KWN:49062
SO ACC ID:SO:0000170
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Human AssemblyChrPosition (strand)Source
Build 364123,967,396 - 123,967,917 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
GRCh38/hg38 4q26-31.21(chr4:116630862-145429900)x1 copy number loss See cases [RCV000053321] Chr4:116630862..145429900 [GRCh38]
Chr4:117552018..146351052 [GRCh37]
Chr4:117771466..146570502 [NCBI36]
GRCh38/hg38 4q26-28.3(chr4:117351881-133565667)x1 copy number loss See cases [RCV000143207] Chr4:117351881..133565667 [GRCh38]
Chr4:118273037..134486822 [GRCh37]
Chr4:118492485..134706272 [NCBI36]
NM_001361665.2(FGF2):c.-74G>A single nucleotide variant Long QT syndrome [RCV000190152] Chr4:122827101 [GRCh38]
Chr4:123748256 [GRCh37]
likely benign
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
GRCh37/hg19 4q26-28.2(chr4:116307857-129302960)x1 copy number loss not provided [RCV000682448] Chr4:116307857..129302960 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
NM_001361665.2(FGF2):c.99C>T (p.Tyr33=) single nucleotide variant not provided [RCV000916958] Chr4:122827273 [GRCh38]
Chr4:123748428 [GRCh37]
likely benign
Single allele deletion Neurodevelopmental disorder [RCV000787448] Chr4:116624547..126168646 [GRCh37]
likely pathogenic
NM_001361665.2(FGF2):c.183G>T (p.Lys61Asn) single nucleotide variant not provided [RCV000886527] Chr4:122876325 [GRCh38]
Chr4:123797480 [GRCh37]
likely benign
GRCh37/hg19 4q27-28.1(chr4:123666456-123851648)x1 copy number loss not provided [RCV001259312] Chr4:123666456..123851648 [GRCh37]
uncertain significance
GRCh37/hg19 4q26-28.2(chr4:116833638-130232122) copy number loss Behavioral abnormality [RCV001352657] Chr4:116833638..130232122 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3676 AgrOrtholog
Ensembl Genes ENSG00000138685 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000264498 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000477134 UniProtKB/Swiss-Prot
  ENSP00000494222 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264498 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000608478 UniProtKB/Swiss-Prot
  ENST00000644866 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000138685 GTEx
Human Proteome Map FGF2 Human Proteome Map
InterPro FGF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2247 UniProtKB/Swiss-Prot
OMIM 134920 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF83 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28115 PharmGKB
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary A4LBB8 UniProtKB/Swiss-Prot
  O00527 UniProtKB/Swiss-Prot
  P78443 UniProtKB/Swiss-Prot
  Q16443 UniProtKB/Swiss-Prot
  Q5PY50 UniProtKB/Swiss-Prot
  Q7KZ11 UniProtKB/Swiss-Prot
  Q7KZ72 UniProtKB/Swiss-Prot
  Q9UC54 UniProtKB/Swiss-Prot
  Q9UCS5 UniProtKB/Swiss-Prot
  Q9UCS6 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 FGF2  fibroblast growth factor 2    fibroblast growth factor 2 (basic)  Symbol and/or name change 5135510 APPROVED
2011-08-16 FGF2  fibroblast growth factor 2 (basic)  FGF2  fibroblast growth factor 2 (basic)  Symbol and/or name change 5135510 APPROVED