FGF2 (fibroblast growth factor 2) - Rat Genome Database

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Gene: FGF2 (fibroblast growth factor 2) Homo sapiens
Analyze
Symbol: FGF2
Name: fibroblast growth factor 2
RGD ID: 70822
HGNC Page HGNC:3676
Description: Enables chemokine binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and regulation of cell migration. Acts upstream of or within positive regulation of cell fate specification and positive regulation of cell population proliferation. Located in extracellular space. Implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Biomarker of several diseases, including artery disease (multiple); breast cancer (multiple); carcinoma (multiple); eye disease (multiple); and female reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: basic fibroblast growth factor bFGF; BFGF; FGF-2; FGFB; fibroblast growth factor 2 (basic); HBGF-2; heparin-binding growth factor 2; prostatropin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
FGF2Humanalcohol use disorder  ISORGD:2609405855870 RGD 
FGF2Humanalcohol use disorder  ISORGD:2609405855874 RGD 
FGF2HumanAnimal Mammary Neoplasms  ISORGD:708238554853 RGD 
FGF2HumanArteriovenous Fistula  IEP 8655590 RGD 
FGF2Humanbiliary tract disease  IEP 2317765protein:increased expression:bileRGD 
FGF2Humanbladder disease  ISORGD:26092315846associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:urinary bladderRGD 
FGF2Humanbone disease  IDA 2315858associated with Diabetes Mellitus, ExperimentalRGD 
FGF2HumanBone Fractures  IDA 2315907associated with Diabetes Mellitus, ExperimentalRGD 
FGF2Humanbreast cancer disease_progressionIEP 8655549 RGD 
FGF2Humanbreast cancer susceptibilityIEP 8655587protein:increased expression:mammary gland fluid/secretionRGD 
FGF2Humanbreast carcinoma disease_progressionIEP 8655550 RGD 
FGF2HumanCardiomegaly  ISORGD:26092289364mRNA:increased expression:heartRGD 
FGF2Humancataract  IEP 8554856mRNA:increased expression:lens, epithelial cellRGD 
FGF2Humancholangiocarcinoma  IEP 2317765protein:increased expression:bileRGD 
FGF2Humancholesteatoma of middle ear  IEP 8547968 RGD 
FGF2HumanChoroidal Neovascularization treatmentISORGD:26098655568 RGD 
FGF2Humanchronic ulcer of skin  IDA 2315843associated with Diabetes MellitusRGD 
FGF2Humancocaine abuse  ISORGD:2609405855871mRNA:increased expression:nucleus accumbens (rat)RGD 
FGF2Humancognitive disorder  IDA 2315912 RGD 
FGF2Humancorneal neovascularization  IDA 8655668 RGD 
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FGF2Humanlong QT syndrome  IAGPRGD:103986038554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:26132555
FGF2Humanneurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  IAGPRGD:156443278|RGD:4058757988554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH HEARING LOSS, SEIZURES, AND BRAIN ABNORMALITIESClinVarPMID:28492532
FGF2Humanneurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  IAGPRGD:127267332|RGD:156443282|RGD:4058757978554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH HEARING LOSS, SEIZURES, AND BRAIN ABNORMALITIESClinVarPMID:26299366|PMID:28492532
FGF2HumanNeurodevelopmental Disorders  IAGPRGD:146988648554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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FGF2Humanbrain infarction  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:17524524
FGF2HumanBrain Injuries  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:21269288
FGF2HumanCardiomegaly  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:10491406
FGF2Humancleft lip  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17963255
FGF2Humancleft palate  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17963255
FGF2HumanCocaine-Related Disorders  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19014962
FGF2Humancorneal neovascularization  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:9301478
FGF2Humandepressive disorder  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16861106
FGF2HumanDiaphragmatic Hernia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:10646786
FGF2HumanDisease Progression  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12644816
FGF2Humanepilepsy with generalized tonic-clonic seizures  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16023256
FGF2Humanessential thrombocythemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15682418
FGF2HumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16116963
FGF2Humangestational diabetes  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20421132
FGF2HumanGliosis  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:21087489
FGF2Humanhigh grade glioma  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:10673511
FGF2HumanInflammation  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:21087489
FGF2Humankidney disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:8995747
FGF2Humanliver cirrhosis  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:17093919
FGF2HumanMesothelioma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15878867
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Original Reference(s)
FGF2Human(+)-pilocarpine multiple interactionsISORGD:26096480464FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]CTDPMID:21087489
FGF2Human(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of FGF2 mRNACTDPMID:16084531
FGF2Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FGF2 mRNACTDPMID:22079256
FGF2Human(R)-noradrenaline multiple interactionsISORGD:26096480464[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results more ...CTDPMID:11742803
FGF2Human(S)-colchicine affects expressionISORGD:26096480464Colchicine affects the expression of FGF2 proteinCTDPMID:7714246
FGF2Human(S)-nicotine decreases expressionISORGD:26096480464Nicotine results in decreased expression of FGF2 proteinCTDPMID:14732461
FGF2Human(S)-nicotine increases expressionISORGD:708236480464Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 more ...CTDPMID:31622651|PMID:32512034
FGF2Human(S)-nicotine increases expressionISORGD:26096480464Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 more ...CTDPMID:15465631|PMID:18190895|PMID:22198237|PMID:31622651|PMID:32512034|PMID:9503263|PMID:9832142
FGF2Human(S)-nicotine increases secretionEXP 6480464Nicotine results in increased secretion of FGF2 proteinCTDPMID:16365874|PMID:22198237
FGF2Human(S)-nicotine multiple interactionsEXP 6480464[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which more ...CTDPMID:22198237
FGF2Human(S)-nicotine multiple interactionsISORGD:26096480464Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the more ...CTDPMID:22198237|PMID:9832142
FGF2Human1,2-dimethylhydrazine multiple interactionsISORGD:26096480464p-coumaric acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of FGF2 protein]CTDPMID:29879413
FGF2Human1,2-dimethylhydrazine increases expressionISORGD:260964804641,2-Dimethylhydrazine results in increased expression of FGF2 proteinCTDPMID:29879413
FGF2Human1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactionsISORGD:260964804641-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein]CTDPMID:15654655
FGF2Human1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISORGD:7082364804641-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FGF2 mRNACTDPMID:28801915
FGF2Human1-naphthyl isothiocyanate multiple interactionsEXP 6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of FGF2 mRNACTDPMID:27344345
FGF2Human14,15-EET increases expressionEXP 648046414,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 proteinCTDPMID:16286479
FGF2Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of FGF2 mRNACTDPMID:21098263
FGF2Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol binds to ESR2 protein] which results in decreased expression of FGF2 mRNA; [Progesterone co-treated more ...CTDPMID:18692832|PMID:20404318
FGF2Human17beta-hydroxy-5alpha-androstan-3-one increases expressionEXP 6480464Dihydrotestosterone results in increased expression of FGF2 mRNA; Dihydrotestosterone results in increased expression of FGF2 more ...CTDPMID:20421132

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Biological Process
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Original Reference(s)
FGF2Humanangiogenesis involved_inIEAUniProtKB-KW:KW-0037150520179 UniProtGO_REF:0000043
FGF2Humanangiogenesis acts_upstream_ofIEAUniProtKB:P15655|ensembl:ENSMUSP00000143094150520179 EnsemblGO_REF:0000107
FGF2Humanangiogenesis involved in coronary vascular morphogenesis  ISORGD:26099068941 RGDPMID:11397779|REF_RGD_ID:8655634
FGF2Humanangiogenesis involved in coronary vascular morphogenesis involved_inIEAUniProtKB:P13109|ensembl:ENSRNOP00000023388150520179 EnsemblGO_REF:0000107
FGF2Humananimal organ morphogenesis involved_inTAS 150520179 PMID:10903182PINCPMID:10903182
FGF2Humanbehavioral response to ethanol  ISORGD:26099068941 RGDPMID:28821667|REF_RGD_ID:405855870
FGF2Humanbehavioral response to ethanol involved_inIEAUniProtKB:P13109|ensembl:ENSRNOP00000023388150520179 EnsemblGO_REF:0000107
FGF2Humanbranching involved in ureteric bud morphogenesis involved_inIDA 150520179 PMID:12631064UniProtPMID:12631064
FGF2Humancanonical Wnt signaling pathway acts_upstream_ofIEAUniProtKB:P15655|ensembl:ENSMUSP00000143094150520179 EnsemblGO_REF:0000107
FGF2Humancell differentiation involved_inIEAUniProtKB-KW:KW-0221150520179 UniProtGO_REF:0000043
FGF2Humancell migration involved in sprouting angiogenesis involved_inIDA 150520179 PMID:18059339BHF-UCLPMID:18059339
FGF2Humancell migration involved in sprouting angiogenesis involved_inIGIUniProtKB:Q9UQL6150520179 PMID:19351956BHF-UCLPMID:19351956
FGF2Humancell population proliferation acts_upstream_ofIEAUniProtKB:P15655|ensembl:ENSMUSP00000143094150520179 EnsemblGO_REF:0000107
FGF2Humancellular response to mechanical stimulus involved_inIEAUniProtKB:P13109|ensembl:ENSRNOP00000023388150520179 EnsemblGO_REF:0000107
FGF2Humancellular response to mechanical stimulus  ISORGD:26099068941 RGDPMID:19012730|REF_RGD_ID:8662390
FGF2Humancerebellar granule cell precursor proliferation acts_upstream_ofIEAUniProtKB:P15655|ensembl:ENSMUSP00000143094150520179 EnsemblGO_REF:0000107
FGF2Humanchemotaxis involved_inTAS 150520179 PMID:10848592PINCPMID:10848592
FGF2Humanchondroblast differentiation involved_inIDA 150520179 PMID:17167778UniProtPMID:17167778
FGF2Humanchromatin organization involved_inIEAGO:0062072150520179 GOCGO_REF:0000108
FGF2Humancorticotropin hormone secreting cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P15655|ensembl:ENSMUSP00000143094150520179 EnsemblGO_REF:0000107
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Cellular Component
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FGF2Humancytoplasm is_active_inIBAMGI:109178|MGI:109189|MGI:1914362|MGI:95517|MGI:95521|PANTHER:PTN000160075|RGD:2608|UniProtKB:P05230|UniProtKB:P48800|UniProtKB:Q92913|WB:WBGene00002881|ZFIN:ZDB-GENE-990415-72150520179 GO_CentralGO_REF:0000033
FGF2Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
FGF2Humanextracellular region located_inTAS 150520179 PMID:10490103ReactomePMID:10490103|Reactome:R-HSA-109699|Reactome:R-HSA-1839094|Reactome:R-HSA-1839098|Reactome:R-HSA-1839100|Reactome:R-HSA-190245|Reactome:R-HSA-190256|Reactome:R-HSA-190258|Reactome:R-HSA-190261|Reactome:R-HSA-190265|Reactome:R-HSA-190326|Reactome:R-HSA-190388|Reactome:R-HSA-190413|Reactome:R-HSA-190427|Reactome:R-HSA-190429|Reactome:R-HSA-2012073|Reactome:R-HSA-2012074|Reactome:R-HSA-2023451|Reactome:R-HSA-2023455|Reactome:R-HSA-2033472|Reactome:R-HSA-2033474|Reactome:R-HSA-2033486|Reactome:R-HSA-2033488|Reactome:R-HSA-2077420|Reactome:R-HSA-2077421|Reactome:R-HSA-2077424|Reactome:R-HSA-2316434|Reactome:R-HSA-2396337|Reactome:R-HSA-2400009|Reactome:R-HSA-2684507|Reactome:R-HSA-480515|Reactome:R-HSA-5654147|Reactome:R-HSA-5654148|Reactome:R-HSA-5654149|Reactome:R-HSA-5654151|Reactome:R-HSA-5654157|Reactome:R-HSA-5654159|Reactome:R-HSA-5654163|Reactome:R-HSA-5654165|Reactome:R-HSA-5654167|Reactome:R-HSA-5654169|Reactome:R-HSA-5654222|Reactome:R-HSA-5654224|Reactome:R-HSA-5654392|Reactome:R-HSA-5654397|Reactome:R-HSA-5654399|Reactome:R-HSA-5654402|Reactome:R-HSA-5654404|Reactome:R-HSA-5654406|Reactome:R-HSA-5654407|Reactome:R-HSA-5654408|Reactome:R-HSA-5654409|Reactome:R-HSA-5654413|Reactome:R-HSA-5654416|Reactome:R-HSA-5654418|Reactome:R-HSA-5654422|Reactome:R-HSA-5654423|Reactome:R-HSA-5654425|Reactome:R-HSA-5654426|Reactome:R-HSA-5654428|Reactome:R-HSA-5654560|Reactome:R-HSA-5654562|Reactome:R-HSA-5654565|Reactome:R-HSA-5654566|Reactome:R-HSA-5654569|Reactome:R-HSA-5654571|Reactome:R-HSA-5654573|Reactome:R-HSA-5654575|Reactome:R-HSA-5654578|Reactome:R-HSA-5654582|Reactome:R-HSA-5654584|Reactome:R-HSA-5654586|Reactome:R-HSA-5654587|Reactome:R-HSA-5654591|Reactome:R-HSA-5654592|Reactome:R-HSA-5654594|Reactome:R-HSA-5654596|Reactome:R-HSA-5654597|Reactome:R-HSA-5654600|Reactome:R-HSA-5654603|Reactome:R-HSA-5654605|Reactome:R-HSA-5654607|Reactome:R-HSA-5654608|Reactome:R-HSA-5654612|Reactome:R-HSA-5654614|Reactome:R-HSA-5654615|Reactome:R-HSA-5654618|Reactome:R-HSA-5654620|Reactome:R-HSA-5654622|Reactome:R-HSA-5654623|Reactome:R-HSA-5654625|Reactome:R-HSA-5654628|Reactome:R-HSA-5654631|Reactome:R-HSA-5654633|Reactome:R-HSA-5654634|Reactome:R-HSA-5654637|Reactome:R-HSA-5654640|Reactome:R-HSA-5654641|Reactome:R-HSA-5654643|Reactome:R-HSA-5654646|Reactome:R-HSA-5654647|Reactome:R-HSA-5654651|Reactome:R-HSA-5654653|Reactome:R-HSA-5654655|Reactome:R-HSA-5654658|Reactome:R-HSA-5654659|Reactome:R-HSA-5654662|Reactome:R-HSA-5654663|Reactome:R-HSA-5654664|Reactome:R-HSA-5654667|Reactome:R-HSA-5654669|Reactome:R-HSA-5654672|Reactome:R-HSA-5654673|Reactome:R-HSA-5654677|Reactome:R-HSA-5654679|Reactome:R-HSA-5654684|Reactome:R-HSA-5654690|Reactome:R-HSA-5654692|Reactome:R-HSA-5654697|Reactome:R-HSA-5654701|Reactome:R-HSA-5654705|Reactome:R-HSA-5654709|Reactome:R-HSA-5654714|Reactome:R-HSA-5654717|Reactome:R-HSA-5654729|Reactome:R-HSA-5654730|Reactome:R-HSA-5654734|Reactome:R-HSA-5654748|Reactome:R-HSA-5655233|Reactome:R-HSA-5655240|Reactome:R-HSA-5655241|Reactome:R-HSA-5655243|Reactome:R-HSA-5655244|Reactome:R-HSA-5655245|Reactome:R-HSA-5655247|Reactome:R-HSA-5655262|Reactome:R-HSA-5655263|Reactome:R-HSA-5655266|Reactome:R-HSA-5655268|Reactome:R-HSA-5655269|Reactome:R-HSA-5655270|Reactome:R-HSA-5655277|Reactome:R-HSA-5655278|Reactome:R-HSA-5655285|Reactome:R-HSA-5655289|Reactome:R-HSA-5655290|Reactome:R-HSA-5655295|Reactome:R-HSA-5655301|Reactome:R-HSA-5655315|Reactome:R-HSA-5655320|Reactome:R-HSA-5655323|Reactome:R-HSA-5655326|Reactome:R-HSA-5655339|Reactome:R-HSA-5655343|Reactome:R-HSA-5656064|Reactome:R-HSA-5656070|Reactome:R-HSA-5672965|Reactome:R-HSA-6789615|Reactome:R-HSA-9839379|Reactome:R-HSA-9839381|Reactome:R-NUL-8853328
FGF2Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
FGF2Humanextracellular space  ISORGD:26099068941 RGDPMID:21543745|REF_RGD_ID:25440477
FGF2Humanextracellular space is_active_inIBAMGI:1099809|MGI:1861377|MGI:1891427|MGI:95515|MGI:95516|PANTHER:PTN000160075|RGD:2609|RGD:61805|RGD:620175|RGD:620178|UniProtKB:E1BDA6|UniProtKB:O15520|UniProtKB:P05230|UniProtKB:P09038|UniProtKB:P31371|UniProtKB:P48800|UniProtKB:P55075|UniProtKB:Q9GZV9|WB:WBGene00001185|WB:WBGene00002881|ZFIN:ZDB-GENE-980526-178|ZFIN:ZDB-GENE-990415-72150520179 GO_CentralGO_REF:0000033
FGF2Humanextracellular space located_inIDA 150520179 PMID:2161540MGIPMID:2161540
FGF2Humanextracellular space located_inTAS 150520179 PMID:2435575PINCPMID:2435575
FGF2Humanextracellular space located_inIEAUniProtKB:P13109|UniProtKB:P15655|ensembl:ENSMUSP00000143094|ensembl:ENSRNOP00000023388150520179 EnsemblGO_REF:0000107
FGF2Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
FGF2Humannucleus is_active_inIBAPANTHER:PTN000896537|UniProtKB:P05230|UniProtKB:P48800150520179 GO_CentralGO_REF:0000033
FGF2Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
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Molecular Function
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FGF2Humanchemoattractant activity enablesIDA 150520179 PMID:18059339BHF-UCLPMID:18059339
FGF2Humanchemokine binding enablesIPIUniProtKB:O43927150520179 PMID:11708770BHF-UCLPMID:11708770
FGF2Humancytokine activity enablesIDA 150520179 PMID:18059339BHF-UCLPMID:18059339
FGF2Humanfibroblast growth factor receptor binding enablesIPIUniProtKB:P16092150520179 PMID:2161540MGIPMID:2161540
FGF2Humanfibroblast growth factor receptor binding enablesIBAFB:FBgn0014135|MGI:1891427|PANTHER:PTN000160075|RGD:2609|RGD:2610|RGD:61805|RGD:71052|RGD:71068|UniProtKB:O15520|UniProtKB:O60258|UniProtKB:O76093|UniProtKB:O95750|UniProtKB:P05230|UniProtKB:P09038|UniProtKB:P12034|UniProtKB:P55075|ZFIN:ZDB-GENE-980526-178150520179 GO_CentralGO_REF:0000033
FGF2Humanfibroblast growth factor receptor binding enablesIPIUniProtKB:P21802150520179 PMID:10830168MGIPMID:10830168
FGF2Humanfibroblast growth factor receptor binding enablesIEAUniProtKB:P13109|ensembl:ENSRNOP00000023388150520179 EnsemblGO_REF:0000107
FGF2Humangrowth factor activity enablesIEAInterPro:IPR002209150520179 InterProGO_REF:0000002
FGF2Humangrowth factor activity enablesIBAMGI:95516|PANTHER:PTN000160075|RGD:2605|RGD:2610|RGD:61805|RGD:620129|RGD:620165|RGD:71068|UniProtKB:O15520|UniProtKB:P05230|UniProtKB:P09038|UniProtKB:P55075|WB:WBGene00002881150520179 GO_CentralGO_REF:0000033
FGF2Humangrowth factor activity enablesIEAUniProtKB:P15655|ensembl:ENSMUSP00000143094150520179 EnsemblGO_REF:0000107
FGF2Humangrowth factor activity enablesIDA 150520179 PMID:18059339, PMID:26451614BHF-UCLPMID:18059339|PMID:26451614
FGF2Humangrowth factor activity enablesIEAUniProtKB-KW:KW-0339150520179 UniProtGO_REF:0000043
FGF2Humanheparin binding enablesIEAUniProtKB-KW:KW-0358150520179 UniProtGO_REF:0000043
FGF2Humanhistone H3K9me2/3 reader activity  ISORGD:26099068941 RGDPMID:25071177|PMID:27114539|REF_RGD_ID:405855871|REF_RGD_ID:405866182
FGF2Humanhistone H3K9me2/3 reader activity enablesIEAUniProtKB:P13109|ensembl:ENSRNOP00000023388150520179 EnsemblGO_REF:0000107
FGF2Humanidentical protein binding enablesIPIUniProtKB:P09038150520179 PMID:11708770BHF-UCLPMID:11708770
FGF2Humanintegrin binding enablesIDA 150520179 PMID:28302677UniProtPMID:28302677
FGF2Humanprotein binding  ISORGD:6207559068941 RGDPMID:12397076|REF_RGD_ID:634122
FGF2Humanprotein binding enablesIPIUniProtKB:P11362150520179 PMID:10490103, PMID:11030354, PMID:14613973, PMID:23597563IntActPMID:10490103|PMID:11030354|PMID:14613973|PMID:23597563
FGF2Humanprotein binding enablesIPIUniProtKB:P11362-7150520179 PMID:17086194IntActPMID:17086194
1 to 20 of 31 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FGF2Humancerium oxide nanoparticle response pathway   IDA 7364779 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FGF2Humanmelanoma pathway  IEA 6907045 KEGGhsa:05218
FGF2Humanmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGhsa:04010

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FGF2Humanfibroblast growth factor signaling pathway  EXP 6484113 PIDPID:200220
FGF2Humanglypican signaling pathway  EXP 6484113 PIDPID:200026
FGF2Humansyndecan signaling pathway  EXP 6484113 PIDPID:200134
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FGF2HumanProlonged QT interval  IAGPRGD:103986038554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:26132555

1 to 20 of 98 rows
#
Reference Title
Reference Citation
1. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. Ben-Ami R, etal., J Infect Dis. 2013 Apr;207(7):1066-74. doi: 10.1093/infdis/jis940. Epub 2013 Jan 9.
2. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. Beranek M, etal., Diabetes Res Clin Pract. 2008 Feb;79(2):362-7. Epub 2007 Nov 7.
3. Influence of maternal diabetes on placental fibroblast growth factor-2 expression, proliferation, and apoptosis. Burleigh DW, etal., J Soc Gynecol Investig. 2004 Jan;11(1):36-41.
4. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Cao W, etal., Exp Eye Res. 1997 Aug;65(2):241-8.
5. Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Cassidy L, etal., Br J Ophthalmol. 1998 Feb;82(2):181-5.
6. FGF2-Targeted adenovirus encoding platelet-derived growth factor-B enhances de novo tissue formation. Chandler LA, etal., Mol Ther. 2000 Aug;2(2):153-60. doi: 10.1006/mthe.2000.0102.
7. The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. Cho KS, etal., Am J Otolaryngol. 2010 Sep-Oct;31(5):309-14. doi: 10.1016/j.amjoto.2009.03.005. Epub 2009 Jun 4.
8. Growth factor expression in ophthalmic pterygia and normal conjunctiva. Detorakis ET, etal., Int J Mol Med. 2010 Apr;25(4):513-6.
9. Responses of reactive astrocytes containing S100beta protein and fibroblast growth factor-2 in the border and in the adjacent preserved tissue after a contusion injury of the spinal cord in rats: implications for wound repair and neuroregeneration. do Carmo Cunha J, etal., Wound Repair Regen. 2007 Jan-Feb;15(1):134-46.
10. Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway. Du Z, etal., Med Sci Monit. 2018 Dec 7;24:8860-8869. doi: 10.12659/MSM.913777.
11. Inhibition of FGF Receptor-1 Suppresses Alcohol Consumption: Role of PI3 Kinase Signaling in Dorsomedial Striatum. Even-Chen O and Barak S, J Neurosci. 2019 Oct 2;39(40):7947-7957. doi: 10.1523/JNEUROSCI.0805-19.2019. Epub 2019 Aug 2.
12. Fibroblast Growth Factor 2 in the Dorsomedial Striatum Is a Novel Positive Regulator of Alcohol Consumption. Even-Chen O, etal., J Neurosci. 2017 Sep 6;37(36):8742-8754. doi: 10.1523/JNEUROSCI.0890-17.2017. Epub 2017 Aug 8.
13. Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model. Faries PL, etal., J Vasc Surg. 1996 Sep;24(3):463-71.
14. A comparative study of recombinant human basic fibroblast growth factor (bFGF) and erythropoietin (EPO) in prevention of skin flap ischemic necrosis in rats. Fayazzadeh E, etal., Arch Iran Med. 2012 Sep;15(9):553-6. doi: 012159/AIM.008.
15. Keratinocyte growth factor-2 inhibits bacterial infection with Pseudomonas aeruginosa pneumonia in a mouse model. Feng N, etal., J Infect Chemother. 2016 Jan;22(1):44-52. doi: 10.1016/j.jiac.2015.10.005. Epub 2015 Nov 24.
16. Aortic coarctation hypertension induces fibroblast growth factor-2 immunoreactivity in the stimulated nucleus tractus solitarii. Fior-Chadi DR, etal., J Mol Histol. 2007 Aug;38(4):285-94. Epub 2007 Jun 12.
17. Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Flagel SB, etal., Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2861-70. doi: 10.1073/pnas.1520491113. Epub 2016 Apr 25.
18. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Florkiewicz RZ, etal., Biochem Biophys Res Commun. 2011 Jun 10;409(3):494-9. doi: 10.1016/j.bbrc.2011.05.033. Epub 2011 May 11.
19. Expressions of the fibroblast growth factor family (FGF-1, -2 and -4) mRNA in endometrial cancers. Fujimoto J, etal., Tumour Biol. 1996;17(4):226-33.
20. Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. Fujimoto K, etal., Biochem Biophys Res Commun. 1991 Oct 15;180(1):386-92.
1 to 20 of 98 rows
1 to 10 of 73 rows
PMID:1417798   PMID:1697263   PMID:1702556   PMID:1707542   PMID:1709094   PMID:1769963   PMID:1785797   PMID:1849658   PMID:1885605   PMID:2161540   PMID:2265560   PMID:2320377  
PMID:2435284   PMID:2435575   PMID:2538817   PMID:2726761   PMID:3472745   PMID:3579930   PMID:3732516   PMID:3780670   PMID:3964259   PMID:7520751   PMID:7532176   PMID:7691311  
PMID:7735329   PMID:7935812   PMID:7999082   PMID:8344959   PMID:8530375   PMID:8609172   PMID:8622701   PMID:8663044   PMID:8692946   PMID:8868466   PMID:8885834   PMID:9139660  
PMID:9174056   PMID:9266968   PMID:9342064   PMID:9553078   PMID:9558385   PMID:9576942   PMID:9700203   PMID:9712850   PMID:9826564   PMID:9858574   PMID:9925931   PMID:10358027  
PMID:10397733   PMID:10438928   PMID:10490103   PMID:10574949   PMID:10579907   PMID:10652299   PMID:10748122   PMID:10830168   PMID:10903182   PMID:10950949   PMID:11030354   PMID:11053263  
PMID:11066092   PMID:11075807   PMID:11141237   PMID:11276432   PMID:11294897   PMID:11390973   PMID:11418238   PMID:11509569   PMID:11598182   PMID:11708770   PMID:11716516   PMID:11742492  
PMID:11786412   PMID:11796824   PMID:11847221   PMID:11864711   PMID:11891198   PMID:11891801   PMID:11928807   PMID:11940567   PMID:11960370   PMID:11964307   PMID:11976347   PMID:11985797  
PMID:11986954   PMID:11999550   PMID:12000311   PMID:12006402   PMID:12008951   PMID:12020352   PMID:12032827   PMID:12054499   PMID:12057924   PMID:12080186   PMID:12087465   PMID:12145206  
PMID:12168799   PMID:12172783   PMID:12209593   PMID:12235165   PMID:12369790   PMID:12393937   PMID:12403780   PMID:12428103   PMID:12477932   PMID:12478660   PMID:12496364   PMID:12509902  
PMID:12517814   PMID:12538477   PMID:12545206   PMID:12571252   PMID:12574959   PMID:12590983   PMID:12607599   PMID:12623787   PMID:12631064   PMID:12631070   PMID:12651930   PMID:12659634  
1 to 10 of 73 rows



FGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
Fgf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)EnsemblGRCm39 Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBIMGSCv36mm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
Fgf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
Fgf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
FGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,604,078 - 120,675,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,869,886 - 120,941,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
FGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBIUU_Cfam_GSD_1.0
FGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,089,394 - 70,157,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,268,953 - 3,321,145 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in FGF2
37 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR16-1hsa-miR-16-5pOncomiRDBexternal_infoNANA21532615
MIR15Ahsa-miR-15a-5pOncomiRDBexternal_infoNANA21532615
MIR16-2hsa-miR-16-5pOncomiRDBexternal_infoNANA21532615
MIR503hsa-miR-503-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23352645

Predicted Target Of
Summary Value
Count of predictions:2979
Count of miRNA genes:948
Interacting mature miRNAs:1144
Transcripts:ENST00000264498, ENST00000608478
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1643256BW127_HBody Weight QTL 127 (human)1.310.007Body weightbody mass index4106319694132319694Human
407112502GWAS761478_Hwaist-hip ratio QTL GWAS761478 (human)4e-17waist-hip ratiowaist to hip ratio (WHR) (CMO:0000020)4122836593122836594Human
597070373GWAS1166447_Hmosquito bite reaction size measurement QTL GWAS1166447 (human)4e-08mosquito bite reaction size measurement4122852424122852425Human
597319785GWAS1415859_HX-24422 measurement QTL GWAS1415859 (human)3e-13X-24422 measurement4122894208122894209Human
597019186GWAS1115260_Hbody mass index QTL GWAS1115260 (human)0.0000007body mass indexbody mass index (BMI) (CMO:0000105)4122841742122841743Human
597244944GWAS1341018_HBMI-adjusted waist-hip ratio QTL GWAS1341018 (human)5e-08body size trait (VT:0100005)4122860717122860718Human
597334211GWAS1430285_Hgluteofemoral adipose tissue measurement QTL GWAS1430285 (human)3e-08gluteofemoral adipose tissue measurement4122891032122891033Human
597159787GWAS1255861_Hlipid measurement QTL GWAS1255861 (human)0.000008lipid measurementblood lipid measurement (CMO:0000050)4122878832122878833Human
597047449GWAS1143523_HBMI-adjusted waist-hip ratio QTL GWAS1143523 (human)6e-09body size trait (VT:0100005)4122854222122854223Human
597223735GWAS1319809_HBMI-adjusted waist circumference QTL GWAS1319809 (human)5e-09body size trait (VT:0100005)4122858186122858187Human

1 to 10 of 10 rows
SHGC-105784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,758,257 - 123,758,553UniSTSGRCh37
Build 364123,977,707 - 123,978,003RGDNCBI36
Celera4121,141,101 - 121,141,397RGD
Cytogenetic Map4q26UniSTS
HuRef4119,484,680 - 119,484,976UniSTS
TNG Radiation Hybrid Map476848.0UniSTS
SHGC-59784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,819,099 - 123,819,197UniSTSGRCh37
Build 364124,038,549 - 124,038,647RGDNCBI36
Celera4121,201,943 - 121,202,041RGD
Cytogenetic Map4q26UniSTS
HuRef4119,545,526 - 119,545,624UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
SHGC-59517  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,818,907 - 123,819,134UniSTSGRCh37
Build 364124,038,357 - 124,038,584RGDNCBI36
Celera4121,201,751 - 121,201,978RGD
Cytogenetic Map4q26UniSTS
HuRef4119,545,334 - 119,545,561UniSTS
GeneMap99-GB4 RH Map4560.59UniSTS
SHGC-31504  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,813,560 - 123,813,776UniSTSGRCh37
Build 364124,033,010 - 124,033,226RGDNCBI36
Celera4121,196,404 - 121,196,620RGD
Cytogenetic Map4q26UniSTS
HuRef4119,539,987 - 119,540,203UniSTS
TNG Radiation Hybrid Map476869.0UniSTS
Stanford-G3 RH Map46929.0UniSTS
GeneMap99-GB4 RH Map4557.24UniSTS
Whitehead-RH Map4609.0UniSTS
GeneMap99-G3 RH Map46875.0UniSTS
D15S1390  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map15q23UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map7p13UniSTS
SHGC-67307  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map18pter-p11.3UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map4q13.1UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map8q21.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map1q32.2-q41UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map5p13.3UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map5q22.1UniSTS
Cytogenetic Map1p36.12UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map1p36.21UniSTS
TNG Radiation Hybrid Map41213.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2381 2788 2243 4968 1718 2330 4 617 1830 458 2266 7136 6348 50 3732 848 1735 1603 174 1


1 to 27 of 27 rows
RefSeq Transcripts NG_029067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA256481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI276765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY820133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE439775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP292299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU501243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN315083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF506888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM015593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S47380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 27 of 27 rows

Ensembl Acc Id: ENST00000264498   ⟹   ENSP00000264498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)Ensembl
Ensembl Acc Id: ENST00000608478   ⟹   ENSP00000477134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4122,826,831 - 122,895,464 (+)Ensembl
Ensembl Acc Id: ENST00000644866   ⟹   ENSP00000494222
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4122,826,831 - 122,898,236 (+)Ensembl
RefSeq Acc Id: NM_001361665   ⟹   NP_001348594
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,826,831 - 122,898,236 (+)NCBI
T2T-CHM13v2.04126,130,930 - 126,202,343 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002006   ⟹   NP_001997
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,826,682 - 122,898,236 (+)NCBI
GRCh374123,747,568 - 123,819,390 (+)NCBI
Build 364123,967,313 - 124,038,840 (+)NCBI Archive
HuRef4119,474,437 - 119,545,817 (+)ENTREZGENE
CHM1_14123,724,372 - 123,795,895 (+)NCBI
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001997   ⟸   NM_002006
- Peptide Label: isoform 34 kDa
- UniProtKB: Q9UCS5 (UniProtKB/Swiss-Prot),   Q9UC54 (UniProtKB/Swiss-Prot),   Q7KZ72 (UniProtKB/Swiss-Prot),   Q7KZ11 (UniProtKB/Swiss-Prot),   Q5PY50 (UniProtKB/Swiss-Prot),   Q16443 (UniProtKB/Swiss-Prot),   P78443 (UniProtKB/Swiss-Prot),   O00527 (UniProtKB/Swiss-Prot),   A4LBB8 (UniProtKB/Swiss-Prot),   Q9UCS6 (UniProtKB/Swiss-Prot),   P09038 (UniProtKB/Swiss-Prot),   A0A0A0MQV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001348594   ⟸   NM_001361665
- Peptide Label: isoform 18 kDa
- UniProtKB: D9ZGF5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000494222   ⟸   ENST00000644866
Ensembl Acc Id: ENSP00000264498   ⟸   ENST00000264498
Ensembl Acc Id: ENSP00000477134   ⟸   ENST00000608478

Name Modeler Protein Id AA Range Protein Structure
AF-P09038-F1-model_v2 AlphaFold P09038 1-288 view protein structure

RGD ID:6868424
Promoter ID:EPDNEW_H7377
Type:initiation region
Name:FGF2_1
Description:fibroblast growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,826,831 - 122,826,891EPDNEW
RGD ID:6802313
Promoter ID:HG_KWN:49062
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_002006
Position:
Human AssemblyChrPosition (strand)Source
Build 364123,967,396 - 123,967,917 (+)MPROMDB


1 to 40 of 48 rows
Database
Acc Id
Source(s)
COSMIC FGF2 COSMIC
Ensembl Genes ENSG00000138685 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264498 ENTREZGENE
  ENST00000264498.9 UniProtKB/Swiss-Prot
  ENST00000608478.1 UniProtKB/Swiss-Prot
  ENST00000644866 ENTREZGENE
  ENST00000644866.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot
GTEx ENSG00000138685 GTEx
HGNC ID HGNC:3676 ENTREZGENE
Human Proteome Map FGF2 Human Proteome Map
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report hsa:2247 UniProtKB/Swiss-Prot
NCBI Gene 2247 ENTREZGENE
OMIM 134920 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot
Pfam FGF UniProtKB/Swiss-Prot
PharmGKB PA28115 PharmGKB
PRINTS HBGFFGF UniProtKB/Swiss-Prot
  IL1HBGF UniProtKB/Swiss-Prot
PROSITE HBGF_FGF UniProtKB/Swiss-Prot
SMART FGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt A0A0A0MQV6 ENTREZGENE, UniProtKB/TrEMBL
  A4LBB8 ENTREZGENE
  D9ZGF5 ENTREZGENE, UniProtKB/TrEMBL
  FGF2_HUMAN UniProtKB/Swiss-Prot
  O00527 ENTREZGENE
  P09038 ENTREZGENE
  P78443 ENTREZGENE
  Q16443 ENTREZGENE
  Q5PY50 ENTREZGENE
  Q7KZ11 ENTREZGENE
  Q7KZ72 ENTREZGENE
  Q9UC54 ENTREZGENE
  Q9UCS5 ENTREZGENE
  Q9UCS6 ENTREZGENE
UniProt Secondary A4LBB8 UniProtKB/Swiss-Prot
  O00527 UniProtKB/Swiss-Prot
1 to 40 of 48 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 FGF2  fibroblast growth factor 2  FGF2  fibroblast growth factor 2 (basic)  Symbol and/or name change 5135510 APPROVED