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Nanoparticles (NP) are increasingly being used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Nanoparticles with unusual properties that may translate into beneficial medical applications are cerium oxide NP or nanoceria (NC). Cerium (Ce), a rare earth lanthanide, can cycle between the cerous (III) and the ceric (IV) oxidation states. While the physico-chemical properties of nanoceria

Pathway Diagram:

Ariadne Genomics Inc. cerium oxide ---| cancer cells cancer cells NC differentially expressed genes PC12 cells gene expression cerium oxide ---- Fgf2 cerium oxide ---- heparin heparin BaF32 cells cell proliferation Fgf2 ---- Fgfr1 Fgfr1 Fgf2 cerium oxide cerium oxide --+> cell proliferation cerium oxide ---> NC differentially expressed genes cerium oxide ---> ROS modulation Ce(IV) oxide ---> hydrogen peroxide Ce(III) oxide ---> superoxide radical Ce(III) oxide Ce(IV) oxide hydrogen peroxide Diabetes Mellitus Macular Degeneration superoxide radical ROS generation senescence ROS modulation cerium oxide ---| Diabetes Mellitus cerium oxide ---| senescence cytotoxicity dopamine biosynthetic pathway ROS catabolism cerium oxide ---| Macular Degeneration cerium oxide --+> ROS catabolism cerium oxide --+> dopamine biosynthetic pathway cerium oxide ---> cytotoxicity cerium oxide ---| ROS generation cerium oxide ---> gene expression

Genes in Pathway:

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cerium oxide nanoparticle response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:23478040 RGD:7364779 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:23478040 RGD:7364779 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cerium oxide nanoparticle response pathway
Disease TermsGene Symbols
acoustic neuromaFgfr1
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesFgfr1
acute myeloid leukemiaFgfr1
Alzheimer's diseaseFgfr1
Animal Mammary NeoplasmsFgf2
Arteriovenous FistulaFgf2
atypical chronic myeloid leukemiaFgfr1
biliary tract diseaseFgf2
bladder diseaseFgf2
bone diseaseFgf2
Bone FracturesFgf2
brain infarctionFgf2
Brain InjuriesFgf2
breast cancerFgf2
breast carcinomaFgf2
Breast NeoplasmsFgfr1
cerebellar hypoplasiaFgfr1
cholesteatoma of middle earFgf2
Choroidal NeovascularizationFgf2
chronic ulcer of skinFgf2
cleft lipFgf2 , Fgfr1
cleft palateFgf2 , Fgfr1
Cocaine-Related DisordersFgf2
cognitive disorderFgf2
Congenital Foot DeformitiesFgfr1
corneal neovascularizationFgf2
coronary artery diseaseFgf2
Coronary DiseaseFgf2
Craniofacial AbnormalitiesFgfr1
Craniosynostosis Syndrome, Autosomal RecessiveFgfr1
decubitus ulcerFgf2
Delayed HypersensitivityFgf2
Delayed PubertyFgfr1
demyelinating diseaseFgf2 , Fgfr1
Diabetic NephropathiesFgf2
diabetic neuropathyFgf2
diabetic retinopathyFgf2
Diaphragmatic HerniaFgf2
disease of cellular proliferationFgfr1
Disease ProgressionFgf2
Encephalocraniocutaneous LipomatosisFgfr1
endometrial cancerFgf2
epilepsy with generalized tonic-clonic seizuresFgf2
esophageal cancerFgf2
essential thrombocythemiaFgf2
Experimental ArthritisFgfr1
Experimental Autoimmune EncephalomyelitisFgf2
Experimental Diabetes MellitusFgf2
Experimental LeukemiaFgfr1
Experimental Liver CirrhosisFgf2 , Fgfr1
Eye InjuriesFgf2
Eye Injuries, PenetratingFgf2
fatty liver diseaseFgfr1
Femoral FracturesFgf2 , Fgfr1
fibrolamellar carcinomaFgfr1
Gallbladder NeoplasmsFgf2
gastric adenocarcinomaFgfr1
gastric ulcerFgf2
genetic diseaseFgfr1
gestational diabetesFgf2
Head Injuries, PenetratingFgfr1
heart valve diseaseFgfr1
hepatocellular carcinomaFgfr1
high grade gliomaFgf2 , Fgfr1
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/PalateFgfr1
Hyperoxic Lung InjuryFgf2
Hypoglossal Nerve InjuriesFgf2 , Fgfr1
hypogonadotropic hypogonadism 2 with or without anosmiaFgfr1
hypogonadotropic hypogonadism 7 with or without anosmiaFgfr1
Hypogonadotropic Hypogonadism and Anosmia, Autosomal DominantFgfr1
Invasive Pulmonary AspergillosisFgf2
Jackson-Weiss syndromeFgfr1
Kallmann syndromeFgfr1
Kaposiform HemangioendotheliomaFgf2
kidney diseaseFgf2
Limb IschemiaFgfr1
liver cirrhosisFgf2
Liver MetastasisFgfr1
long QT syndromeFgf2
Lung NeoplasmsFgfr1
lung non-small cell carcinomaFgfr1
lung small cell carcinomaFgfr1
macular retinal edemaFgf2
malignant astrocytomaFgfr1
mental depressionFgf2 , Fgfr1
mesangial proliferative glomerulonephritisFgfr1
mouth diseaseFgfr1
multiple endocrine neoplasia type 1Fgf2
myeloid leukemiaFgfr1
myeloid neoplasmFgfr1
myocardial infarctionFgfr1
Myocardial IschemiaFgf2
Nasal PolypsFgf2
NeointimaFgf2 , Fgfr1
Neoplasm MetastasisFgfr1
neovascular inflammatory vitreoretinopathyFgf2
nephrotic syndromeFgf2
Nerve DegenerationFgf2
Neurodevelopmental DisordersFgf2
non-alcoholic fatty liver diseaseFgfr1
Nonsyndromic TrigonocephalyFgfr1
Optic Nerve InjuriesFgf2
oral submucous fibrosisFgf2
Osteoarthritis, ExperimentalFgfr1
osteoglophonic dysplasiaFgfr1
otitis mediaFgfr1
ovarian cancerFgf2
pancreatic cancerFgf2
pancreatic ductal carcinomaFgf2
periapical periodontitisFgf2
Pfeiffer syndromeFgfr1
polyarteritis nodosaFgf2
Pregnancy in DiabeticsFgf2
Prenatal Exposure Delayed EffectsFgf2
prostate adenocarcinomaFgf2 , Fgfr1
prostate cancerFgfr1
prostate carcinoma in situFgfr1
Prostatic NeoplasmsFgf2
pulmonary fibrosisFgf2
pulmonary hypertensionFgf2 , Fgfr1
renal cell carcinomaFgf2 , Fgfr1
Reperfusion InjuryFgf2
Retina Reperfusion InjuryFgf2
retinal detachmentFgfr1
retinal vein occlusionFgf2
sciatic neuropathyFgfr1
Spinal Cord CompressionFgf2
Spinal Cord InjuriesFgf2
squamous cell carcinomaFgfr1
Stargardt Disease 3Fgfr1
T-Cell LymphomaFgfr1
transient cerebral ischemiaFgfr1
transitional cell carcinomaFgf2 , Fgfr1
Trigonocephaly 1Fgfr1
Tympanic Membrane PerforationFgf2 , Fgfr1
type 2 diabetes mellitusFgf2 , Fgfr1
umbilical herniaFgfr1
urinary bladder cancerFgf2
vascular dementiaFgfr1
visual epilepsyFgf2 , Fgfr1
Wound InfectionFgf2
Wounds and InjuriesFgf2
Pathway Annotations Associated with Genes in the cerium oxide nanoparticle response pathway

References Associated with the cerium oxide nanoparticle response pathway:

Ontology Path Diagram:

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