RGD Reference Report - The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. - Rat Genome Database

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The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation.

Authors: Cho, KS  Lee, DG  Shin, DH  Park, YD  Chon, KM 
Citation: Cho KS, etal., Am J Otolaryngol. 2010 Sep-Oct;31(5):309-14. doi: 10.1016/j.amjoto.2009.03.005. Epub 2009 Jun 4.
RGD ID: 8655595
Pubmed: (View Article at PubMed) PMID:20015768
DOI: Full-text: DOI:10.1016/j.amjoto.2009.03.005

PURPOSE: The purpose of this study was to determine the more important growth factor expression between basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in the healing of acute tympanic membrane (TM) perforation. MATERIALS AND METHODS: Bilateral perforations of the TM were created in 12 rats. The TM perforations in the right ears were treated with dexamethasone, and left ears were designated as the control group. The TM was examined for the growth factor expression immunohistochemically in the epithelial and fibrous layers according to the rate of TM perforation healing. RESULTS: The mean spontaneous healing time of the TM perforations was 11.0 +/- 2.0 days. However, dexamethasone-treated group showed no evidence of closure. The bFGF and VEGF expression were significantly correlated with the rate of healing of acute TM perforations. The VEGF expression was decreased both in the epithelial and fibrous layers, but bFGF expression was decreased only in the epithelial layer in the dexamethasone-treated group. The VEGF was expressed to a lesser degree than bFGF in the dexamethasone-treated group. CONCLUSION: Vascular endothelial growth factor is the more specific and important growth factor than bFGF in the healing of acute TM perforation.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Fgf2  (fibroblast growth factor 2)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Fgf2  (fibroblast growth factor 2)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
FGF2  (fibroblast growth factor 2)
VEGFA  (vascular endothelial growth factor A)


Additional Information