FGF2 (fibroblast growth factor 2) - Rat Genome Database

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Gene: FGF2 (fibroblast growth factor 2) Canis lupus familiaris
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Symbol: FGF2
Name: fibroblast growth factor 2
RGD ID: 12173826
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); chemokine binding (ortholog); cytokine activity (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Arteriovenous Fistula (ortholog); biliary tract disease (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: basic fibroblast growth factor; BFGF; fibroblast growth factor 2 (basic)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBI
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBI
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBI
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBI
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (ISO)
biliary tract disease  (ISO)
bladder disease  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
chronic ulcer of skin  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
decubitus ulcer  (ISO)
Delayed Hypersensitivity  (ISO)
demyelinating disease  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Epilepsy, Hearing Loss, and Mental Retardation Syndrome  (ISO)
esophageal cancer  (ISO)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Injuries  (ISO)
Eye Injuries, Penetrating  (ISO)
Femoral Fractures  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
high grade glioma  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypoglossal Nerve Injuries  (ISO)
impotence  (ISO)
Inflammation  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
Kaposiform Hemangioendothelioma  (ISO)
kidney disease  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
macular retinal edema  (ISO)
mental depression  (ISO)
Mesothelioma  (ISO)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
Optic Nerve Injuries  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinsonism  (ISO)
periapical periodontitis  (ISO)
polyarteritis nodosa  (ISO)
Pregnancy in Diabetics  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
pterygium  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal vein occlusion  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
transitional cell carcinoma  (ISO)
Tympanic Membrane Perforation  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urinary bladder cancer  (ISO)
visual epilepsy  (ISO)
Wound Infection  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
animal organ morphogenesis  (IBA)
brain development  (IEA)
branching involved in ureteric bud morphogenesis  (ISO)
cell differentiation  (IBA)
cell migration involved in sprouting angiogenesis  (ISO)
chondroblast differentiation  (ISO)
corticotropin hormone secreting cell differentiation  (ISO)
embryo development ending in birth or egg hatching  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,ISO)
glial cell differentiation  (ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (ISO)
hyaluronan catabolic process  (ISO)
inositol phosphate biosynthetic process  (ISO)
lung development  (IBA,ISO)
mammary gland epithelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of wound healing  (ISO)
organ induction  (ISO)
paracrine signaling  (ISO)
phosphatidylinositol biosynthetic process  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell fate specification  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
positive regulation of endothelial cell migration  (IBA,ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IBA,ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IBA,ISO)
positive regulation of lens fiber cell differentiation  (ISO)
positive regulation of MAP kinase activity  (IBA)
positive regulation of MAPK cascade  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (IBA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
regulation of cell cycle  (ISO)
regulation of cell migration  (IBA)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
regulation of retinal cell programmed cell death  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to axon injury  (ISO)
stem cell development  (ISO)
substantia nigra development  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
wound healing  (IBA,ISO)

Cellular Component
cytoplasm  (IBA,IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,ISO)
nucleus  (IBA,ISO)
spindle  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17099154   PMID:26523832   PMID:27632571   PMID:31789340  


Genomics

Comparative Map Data
FGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBI
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBI
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBI
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBI
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBI
FGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4122,826,708 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh384122,826,708 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,747,863 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBI
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
Fgf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBImm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
Fgf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22120,236,328 - 120,290,673 (+)NCBI
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
Fgf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
FGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0panPan3
FGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,878 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,089,394 - 70,157,423 (+)NCBI
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBI
Fgf2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006393   ⟹   ENSCAFP00000005918
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,053,625 - 17,371,334 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000006398   ⟹   ENSCAFP00000005923
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,402,932 - 17,463,151 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061643   ⟹   ENSCAFP00000052204
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,085,783 - 17,371,334 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076603   ⟹   ENSCAFP00000065643
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,053,785 - 17,371,334 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076622   ⟹   ENSCAFP00000044947
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,053,625 - 17,463,151 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081140   ⟹   ENSCAFP00000050397
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1916,994,661 - 17,371,334 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090319   ⟹   ENSCAFP00000052448
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,054,448 - 17,371,334 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000091794   ⟹   ENSCAFP00000060936
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1917,107,275 - 17,371,334 (-)Ensembl
RefSeq Acc Id: XM_003432481   ⟹   XP_003432529
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11917,403,288 - 17,463,143 (-)NCBI
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038425639   ⟹   XP_038281567
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBI
RefSeq Acc Id: XM_038502500   ⟹   XP_038358428
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBI
RefSeq Acc Id: XM_038565228   ⟹   XP_038421156
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBI
RefSeq Acc Id: XM_038629358   ⟹   XP_038485286
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_003432529   ⟸   XM_003432481
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSCAFP00000005923   ⟸   ENSCAFT00000006398
RefSeq Acc Id: ENSCAFP00000005918   ⟸   ENSCAFT00000006393
RefSeq Acc Id: ENSCAFP00000060936   ⟸   ENSCAFT00000091794
RefSeq Acc Id: ENSCAFP00000065643   ⟸   ENSCAFT00000076603
RefSeq Acc Id: ENSCAFP00000044947   ⟸   ENSCAFT00000076622
RefSeq Acc Id: ENSCAFP00000052448   ⟸   ENSCAFT00000090319
RefSeq Acc Id: ENSCAFP00000052204   ⟸   ENSCAFT00000061643
RefSeq Acc Id: ENSCAFP00000050397   ⟸   ENSCAFT00000081140
RefSeq Acc Id: XP_038358428   ⟸   XM_038502500
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038485286   ⟸   XM_038629358
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038281567   ⟸   XM_038425639
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038421156   ⟸   XM_038565228
- Peptide Label: isoform X4
Protein Domains
AAA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003988 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000005918 UniProtKB/TrEMBL
  ENSCAFP00000005923 UniProtKB/TrEMBL
  ENSCAFP00000044947 UniProtKB/TrEMBL
  ENSCAFP00000050397 UniProtKB/TrEMBL
  ENSCAFP00000052448 UniProtKB/TrEMBL
  ENSCAFP00000060936 UniProtKB/TrEMBL
  ENSCAFP00000065643 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006393 UniProtKB/TrEMBL
  ENSCAFT00000006398 UniProtKB/TrEMBL
  ENSCAFT00000076603 UniProtKB/TrEMBL
  ENSCAFT00000076622 UniProtKB/TrEMBL
  ENSCAFT00000081140 UniProtKB/TrEMBL
  ENSCAFT00000090319 UniProtKB/TrEMBL
  ENSCAFT00000091794 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  Asp_de-COase-like_dom_sf UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  FGF2 UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene FGF2 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF83 UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  FGF UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/TrEMBL
PROSITE AAA UniProtKB/TrEMBL
  HBGF_FGF UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
  FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
  SSF50692 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A5F4BT10_CANLF UniProtKB/TrEMBL
  A0A5F4C814_CANLF UniProtKB/TrEMBL
  A0A5F4CGC0_CANLF UniProtKB/TrEMBL
  A0A5F4D2H3_CANLF UniProtKB/TrEMBL
  A0A5F4DL02_CANLF UniProtKB/TrEMBL
  E2RC37_CANLF UniProtKB/TrEMBL
  F1P6K6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40847 ENTREZGENE