RGD Reference Report - Expressions of the fibroblast growth factor family (FGF-1, -2 and -4) mRNA in endometrial cancers. - Rat Genome Database

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Expressions of the fibroblast growth factor family (FGF-1, -2 and -4) mRNA in endometrial cancers.

Authors: Fujimoto, J  Hori, M  Ichigo, S  Tamaya, T 
Citation: Fujimoto J, etal., Tumour Biol. 1996;17(4):226-33.
RGD ID: 2298516
Pubmed: PMID:8685603   (View Abstract at PubMed)

To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed. The levels of FGF-1 mRNA and FGF-2 and its mRNA tended to increase with dedifferentiation (especially grade G3), myometrial invasion (especially grade C) and staging (especially stages III and IV) in endometrial cancers were significantly (p < 0.05) higher than those in normal endometria. However, the levels of FGF-4 mRNA expression were significantly (p < 0.05) lower than those of FGF-1 and -2 mRNAs in both endometrial cancers and normal endometria. Therefore, endometrial cancers might mainly secrete FGF-1 and -2, which leads to neovascularization to provide nutrition, resulting in accelerated growth, invasion and metastasis. Apparently, the increased secretion parallels the progressive malignancy of endometrial cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial cancer disease_progressionIEP 2298516mRNA:increased expression:myometriumRGD 
endometrial cancer disease_progressionIEP 2298516mRNA and protein:increased expression:myometriumRGD 
endometrial cancer disease_progressionISOFGF1 (Homo sapiens)2298516; 2298516mRNA:increased expression:myometriumRGD 
endometrial cancer disease_progressionISOFGF2 (Homo sapiens)2298516; 2298516mRNA and protein:increased expression:myometriumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgf1  (fibroblast growth factor 1)
Fgf2  (fibroblast growth factor 2)

Genes (Mus musculus)
Fgf1  (fibroblast growth factor 1)
Fgf2  (fibroblast growth factor 2)

Genes (Homo sapiens)
FGF1  (fibroblast growth factor 1)
FGF2  (fibroblast growth factor 2)


Additional Information