RGD Reference Report - Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.

Authors: Su, WC  Shiesh, SC  Liu, HS  Chen, CY  Chow, NH  Lin, XZ 
Citation: Su WC, etal., Dig Dis Sci. 2001 Jul;46(7):1387-92.
RGD ID: 2317765
Pubmed: PMID:11478488   (View Abstract at PubMed)

The expression of several growth factors and K-ras gene mutation in bile were studied to better understand the pathogenesis and improve early diagnosis of bile duct cancers. Bile samples were collected from 12 cholangiocarcinomas (CLC), 10 ampullary cancers (APC), 3 gallbladder cancers (GBC), 7 pancreatic cancers (PNC), 9 biliary tract infection (BTI), 8 biliary stone disease (ST), and 5 normal controls (NC). The highest mean value of TGF-beta in bile was in patients with BTI; the mean levels of bFGF and PDGF were highest in CLC, and patients with APC and CLC had higher expression of HER2/Neu than other groups. In bile, a K-ras gene codon 12 mutation was found in 5 of 6 (83%) cases of CLC by the PCR-RFLP method. The results suggest overexpression of bFGF, PDGF, and HER2/Neu and the presence of K-ras mutation are important for carcinogenesis of bile duct cancers, and detection of the above abnormalities in bile is helpful for early diagnosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FGF2Humanbiliary tract disease  IEP protein:increased expression:bileRGD 
Fgf2Ratbiliary tract disease  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
Fgf2Mousebiliary tract disease  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
FGF2Humancholangiocarcinoma  IEP protein:increased expression:bileRGD 
Fgf2Ratcholangiocarcinoma  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
Fgf2Mousecholangiocarcinoma  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
FGF2HumanGallbladder Neoplasms  IEP protein:increased expression:bileRGD 
Fgf2RatGallbladder Neoplasms  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
Fgf2MouseGallbladder Neoplasms  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
FGF2Humanpancreatic cancer  IEP protein:increased expression:bileRGD 
Fgf2Ratpancreatic cancer  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 
Fgf2Mousepancreatic cancer  ISOFGF2 (Homo sapiens)protein:increased expression:bileRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgf2  (fibroblast growth factor 2)

Genes (Mus musculus)
Fgf2  (fibroblast growth factor 2)

Genes (Homo sapiens)
FGF2  (fibroblast growth factor 2)


Additional Information