ACTA2 (actin alpha 2, smooth muscle) - Rat Genome Database

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Gene: ACTA2 (actin alpha 2, smooth muscle) Homo sapiens
Analyze
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
RGD ID: 1348351
HGNC Page HGNC
Description: Predicted to enable protein kinase binding activity. Involved in glomerular mesangial cell development and response to virus. Located in cytoplasm. Part of protein-containing complex. Implicated in Moyamoya disease and thoracic aortic aneurysm. Biomarker of lymphedema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT6; actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; ACTSA; alpha 2 actin; alpha-actin-2; alpha-cardiac actin; cell growth-inhibiting gene 46 protein; growth-inhibiting gene 46; MYMY5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1088,935,074 - 88,991,339 (-)EnsemblGRCh38hg38GRCh38
GRCh381088,935,074 - 88,991,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,694,831 - 90,751,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,684,811 - 90,702,491 (-)NCBINCBI36hg18NCBI36
Build 341090,684,810 - 90,702,491NCBI
Celera1084,441,676 - 84,497,934 (-)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,329,337 - 84,385,614 (-)NCBIHuRef
CHM1_11090,976,918 - 91,033,207 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acetaldehyde  (ISO)
acrylamide  (ISO)
acteoside  (EXP)
aflatoxin B1  (EXP)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
AM-251  (EXP)
andrographolide  (EXP,ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arecoline  (EXP)
argatroban  (ISO)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP,ISO)
ATP  (EXP)
atrazine  (EXP)
baicalein  (EXP)
benazepril  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (ISO)
beryllium sulfate  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (EXP,ISO)
captan  (ISO)
captopril  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carvedilol  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
ceruletide  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorothalonil  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
Clofop  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (EXP,ISO)
cystamine  (ISO)
cytochalasin D  (EXP,ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
DAPT  (EXP)
DDT  (ISO)
delphinidin  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
Diacetylmonoxime  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethyl malate  (ISO)
dihydrolipoic acid  (ISO)
diisononyl phthalate  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
disulfiram  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (EXP)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
eplerenone  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fasudil hydrochloride  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
formoterol fumarate  (EXP)
fructose  (ISO)
gadolinium trichloride  (ISO)
gamma-mangostin  (EXP,ISO)
Ganoderic acid A  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
Ginkgoic acid  (ISO)
Ginkgolide A  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP)
graphene oxide  (ISO)
heparin  (ISO)
heptachlor  (EXP)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
homocysteine  (ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (ISO)
ICI 118551  (EXP)
imperatorin  (ISO)
indole-3-methanol  (ISO)
irbesartan  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoorientin  (ISO)
isoprenaline  (ISO)
isorhamnetin  (EXP,ISO)
ivermectin  (EXP)
jaspamide  (EXP,ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lamivudine  (EXP)
lapatinib  (EXP)
latrunculin B  (ISO)
leukotriene B4  (EXP,ISO)
limonene  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP,ISO)
lovastatin  (EXP)
lucanthone  (EXP)
luteolin  (ISO)
LY 364947  (ISO)
LY294002  (EXP)
malonaldehyde  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercaptoethanol  (EXP)
mesalamine  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (EXP)
mirtazapine  (ISO)
mitogen  (ISO)
MK-2206  (EXP)
ML-7  (EXP,ISO)
monocrotaline  (ISO)
montelukast  (ISO)
morin  (ISO)
myricitrin  (ISO)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nitrofen  (ISO)
nocodazole  (EXP)
NS-398  (EXP)
ochratoxin A  (EXP,ISO)
octreotide  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP)
olmesartan  (ISO)
ouabain  (EXP)
Pachymic acid  (EXP)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
Pentoxifylline  (EXP,ISO)
perindopril  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
PhIP  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
poly(guanylic acid)  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (ISO)
probucol  (EXP)
progesterone  (EXP,ISO)
propanal  (EXP)
prostaglandin E2  (EXP)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
radon atom  (EXP,ISO)
radon(0)  (EXP,ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ridaforolimus  (EXP)
rifaximin  (EXP)
rimonabant  (ISO)
rivaroxaban  (ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
saroglitazar  (EXP)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
SCH772984  (ISO)
serpentine asbestos  (EXP)
Shikonin  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sorbinil  (EXP)
spironolactone  (ISO)
SR 144528  (ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP,ISO)
Swertiamarin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP,ISO)
taurine  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thioacetamide  (EXP,ISO)
thymidine  (EXP)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
TRAM-34  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (EXP,ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (ISO)
vildagliptin  (ISO)
vinclozolin  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
vitamin K  (ISO)
vorinostat  (EXP)
warfarin  (ISO)
WIN 55212-2  (EXP,ISO)
XL147  (ISO)
Y-27632  (EXP,ISO)
zileuton  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal aortic aneurysm  (IAGP)
Abnormal cerebral vascular morphology  (IAGP)
Abnormal left ventricular function  (IAGP)
Abnormal sternum morphology  (IAGP)
Abnormality iris morphology  (IAGP)
Aortic regurgitation  (IAGP)
Aortic root aneurysm  (IAGP)
Arachnodactyly  (IAGP)
Arterial tortuosity  (IAGP)
Ascending aortic dissection  (IAGP)
Ascending tubular aorta aneurysm  (IAGP)
Autosomal dominant inheritance  (IAGP)
Bicuspid aortic valve  (IAGP)
Bruising susceptibility  (IAGP)
Cardiomegaly  (IAGP)
Carotid artery dilatation  (IAGP)
Chest pain  (IAGP)
Coronary artery atherosclerosis  (IAGP)
Cryptorchidism  (IAGP)
Cutis marmorata  (IAGP)
Descending aortic dissection  (IAGP)
Descending thoracic aorta aneurysm  (IAGP)
Dilatation of the cerebral artery  (IAGP)
Dural ectasia  (IAGP)
Exertional dyspnea  (IAGP)
Hemoptysis  (IAGP)
High, narrow palate  (IAGP)
Hyperperistalsis  (IAGP)
Hypertelorism  (IAGP)
Hypertension  (IAGP)
Hypovolemia  (IAGP)
Inguinal hernia  (IAGP)
Intellectual disability  (IAGP)
Intestinal malrotation  (IAGP)
Iris flocculi  (IAGP)
Ischemic stroke  (IAGP)
Livedo reticularis  (IAGP)
Moyamoya phenomenon  (IAGP)
Mucoid extracellular matrix accumulation  (IAGP)
Mydriasis  (IAGP)
Paroxysmal dyspnea  (IAGP)
Patent ductus arteriosus  (IAGP)
Peripheral arterial stenosis  (IAGP)
Periventricular white matter hyperdensities  (IAGP)
Pes planus  (IAGP)
Pneumothorax  (IAGP)
Premature coronary artery atherosclerosis  (IAGP)
Prenatal maternal abnormality  (IAGP)
Pulmonary arterial hypertension  (IAGP)
Retinal infarction  (IAGP)
Retrognathia  (IAGP)
Scoliosis  (IAGP)
Seizure  (IAGP)
Subarachnoid hemorrhage  (IAGP)
Tachypnea  (IAGP)
Tall stature  (IAGP)
Telangiectasia  (IAGP)
Thoracic aortic aneurysm  (IAGP)
Transient ischemic attack  (IAGP)
Ventriculomegaly  (IAGP)
References

Additional References at PubMed
PMID:1540415   PMID:1555776   PMID:1907279   PMID:1939373   PMID:1969628   PMID:1991513   PMID:2022339   PMID:2295650   PMID:2612915   PMID:2701935   PMID:3842206   PMID:6330528  
PMID:6725286   PMID:7780165   PMID:8138584   PMID:8609175   PMID:8661406   PMID:8892894   PMID:8997639   PMID:9512352   PMID:9546431   PMID:9841925   PMID:9971772   PMID:10049817  
PMID:10074138   PMID:10341211   PMID:10556093   PMID:10628374   PMID:11037796   PMID:11580270   PMID:11707283   PMID:11709093   PMID:11812134   PMID:11927518   PMID:12009869   PMID:12119014  
PMID:12355421   PMID:12477932   PMID:12777385   PMID:14530271   PMID:14627618   PMID:14694110   PMID:15032605   PMID:15164054   PMID:15342556   PMID:15489334   PMID:15555551   PMID:15588509  
PMID:15618548   PMID:15703204   PMID:15862967   PMID:16051665   PMID:16115228   PMID:16289162   PMID:16385451   PMID:16526095   PMID:16548883   PMID:16573163   PMID:17360745   PMID:17379189  
PMID:17411366   PMID:17464107   PMID:17504171   PMID:17626241   PMID:17786474   PMID:17994018   PMID:18443296   PMID:18468998   PMID:18775311   PMID:19261809   PMID:19285011   PMID:19409525  
PMID:19531499   PMID:19639585   PMID:19654303   PMID:19683985   PMID:19745835   PMID:19788615   PMID:19883584   PMID:19913121   PMID:20128380   PMID:20132408   PMID:20147394   PMID:20237496  
PMID:20301299   PMID:20381122   PMID:20618440   PMID:20628086   PMID:20628268   PMID:20689142   PMID:20694011   PMID:20734336   PMID:20876399   PMID:20970362   PMID:21131735   PMID:21145461  
PMID:21233699   PMID:21248741   PMID:21288906   PMID:21343850   PMID:21477997   PMID:21496259   PMID:21530503   PMID:21553326   PMID:21612641   PMID:21617610   PMID:21815248   PMID:21873635  
PMID:21917091   PMID:21923909   PMID:21937134   PMID:21937873   PMID:21996542   PMID:22001912   PMID:22004035   PMID:22133903   PMID:22138123   PMID:22232431   PMID:22395512   PMID:22460095  
PMID:22465675   PMID:22479424   PMID:22535526   PMID:22543453   PMID:22619371   PMID:22640593   PMID:22721673   PMID:22790431   PMID:22810585   PMID:22831780   PMID:22939629   PMID:22946110  
PMID:22960022   PMID:22989508   PMID:23017337   PMID:23020218   PMID:23068445   PMID:23071112   PMID:23116162   PMID:23178941   PMID:23182716   PMID:23246001   PMID:23260110   PMID:23294842  
PMID:23443559   PMID:23533145   PMID:23575248   PMID:23580065   PMID:23770605   PMID:23788249   PMID:23794425   PMID:23811015   PMID:23874603   PMID:23875777   PMID:23879759   PMID:23973329  
PMID:23982059   PMID:23995859   PMID:24020716   PMID:24024919   PMID:24189400   PMID:24243736   PMID:24244333   PMID:24292274   PMID:24322015   PMID:24332808   PMID:24353327   PMID:24446247  
PMID:24614064   PMID:24715163   PMID:24742657   PMID:24755837   PMID:24793577   PMID:24840563   PMID:24877105   PMID:24945657   PMID:24966580   PMID:24981860   PMID:24998021   PMID:25190485  
PMID:25225139   PMID:25314063   PMID:25406900   PMID:25476248   PMID:25611270   PMID:25759435   PMID:25798074   PMID:25852190   PMID:25853442   PMID:25921136   PMID:25954927   PMID:25963833  
PMID:26028530   PMID:26034244   PMID:26153420   PMID:26186194   PMID:26217791   PMID:26447986   PMID:26470744   PMID:26496610   PMID:26506232   PMID:26569118   PMID:26701730   PMID:26816005  
PMID:26835993   PMID:26927700   PMID:26934405   PMID:27012699   PMID:27064749   PMID:27082296   PMID:27431987   PMID:27551047   PMID:27560372   PMID:28074631   PMID:28117838   PMID:28302793  
PMID:28328125   PMID:28343608   PMID:28347704   PMID:28378594   PMID:28514442   PMID:28581483   PMID:28652363   PMID:28808903   PMID:29049801   PMID:29053956   PMID:29074464   PMID:29202781  
PMID:29229926   PMID:29300374   PMID:29563501   PMID:29721663   PMID:29845934   PMID:29875232   PMID:29970531   PMID:30001387   PMID:30135315   PMID:30466735   PMID:30526509   PMID:30535478  
PMID:30559450   PMID:30654940   PMID:30833792   PMID:30940648   PMID:31322276   PMID:31501420   PMID:31760702   PMID:31761395   PMID:32023084   PMID:32051585   PMID:32093627   PMID:32115750  
PMID:32464348   PMID:32711434   PMID:33179077   PMID:33199432   PMID:33275213   PMID:34028731   PMID:34079125  


Genomics

Comparative Map Data
ACTA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1088,935,074 - 88,991,339 (-)EnsemblGRCh38hg38GRCh38
GRCh381088,935,074 - 88,991,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,694,831 - 90,751,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,684,811 - 90,702,491 (-)NCBINCBI36hg18NCBI36
Build 341090,684,810 - 90,702,491NCBI
Celera1084,441,676 - 84,497,934 (-)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,329,337 - 84,385,614 (-)NCBIHuRef
CHM1_11090,976,918 - 91,033,207 (-)NCBICHM1_1
Acta2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,217,736 - 34,232,985 (-)NCBIGRCm39mm39
GRCm39 Ensembl1934,218,490 - 34,232,990 (-)Ensembl
GRCm381934,240,336 - 34,255,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,241,090 - 34,255,590 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,315,581 - 34,329,826 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,307,088 - 34,321,333 (-)NCBImm8
Celera1935,018,279 - 35,032,476 (-)NCBICelera
Cytogenetic Map19C1NCBI
Acta2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,746,527 - 231,759,307 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1231,746,548 - 231,759,554 (-)Ensembl
Rnor_6.01252,537,614 - 252,550,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,537,615 - 252,550,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,760,521 - 259,773,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1228,860,239 - 228,873,019 (-)NCBICelera
Cytogenetic Map1q52NCBI
Acta2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554254,026,430 - 4,040,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554254,023,001 - 4,039,980 (+)NCBIChiLan1.0ChiLan1.0
ACTA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11089,164,344 - 89,182,131 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,164,344 - 89,182,080 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01085,660,983 - 85,678,729 (-)NCBIMhudiblu_PPA_v0panPan3
ACTA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,700,434 - 38,714,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,700,480 - 38,711,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,451,228 - 38,465,187 (-)NCBI
ROS_Cfam_1.02640,285,064 - 40,299,518 (-)NCBI
UMICH_Zoey_3.12638,154,857 - 38,169,070 (-)NCBI
UNSW_CanFamBas_1.02637,720,236 - 37,734,291 (-)NCBI
UU_Cfam_GSD_1.02638,990,553 - 39,005,038 (-)NCBI
Acta2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,509,060 - 78,526,056 (-)NCBI
SpeTri2.0NW_004936735266,918 - 283,858 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14100,867,733 - 100,886,713 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114100,868,145 - 100,886,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214109,852,854 - 109,871,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,358,937 - 82,376,289 (-)NCBI
ChlSab1.1 Ensembl982,359,086 - 82,372,446 (-)Ensembl
Vero_WHO_p1.0NW_02366604843,037,005 - 43,054,486 (-)NCBI
Acta2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479115,243,074 - 15,259,362 (-)NCBI

Position Markers
GDB:193855  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,708,261 - 90,708,376UniSTSGRCh37
Build 361090,698,241 - 90,698,356RGDNCBI36
Celera1084,455,106 - 84,455,221RGD
Cytogenetic Map10q23.3UniSTS
HuRef1084,342,767 - 84,342,882UniSTS
SHGC-145404  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,701,424 - 90,701,696UniSTSGRCh37
Build 361090,691,404 - 90,691,676RGDNCBI36
Celera1084,448,269 - 84,448,541RGD
Cytogenetic Map10q23.3UniSTS
HuRef1084,335,930 - 84,336,202UniSTS
TNG Radiation Hybrid Map171712.0UniSTS
RH44176  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,694,869 - 90,695,067UniSTSGRCh37
Build 361090,684,849 - 90,685,047RGDNCBI36
Celera1084,441,714 - 84,441,912RGD
Cytogenetic Map10q23.31UniSTS
Cytogenetic Map10q23.3UniSTS
HuRef1084,329,375 - 84,329,573UniSTS
GeneMap99-GB4 RH Map10428.76UniSTS
NCBI RH Map101035.6UniSTS
G65659  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,751,933 - 90,752,247UniSTSGRCh37
Build 361090,741,913 - 90,742,227RGDNCBI36
Celera1084,498,720 - 84,499,034RGD
Cytogenetic Map10q24.1UniSTS
Cytogenetic Map10q23.3UniSTS
HuRef1084,386,400 - 84,386,714UniSTS
ACTA2_(5)  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,694,878 - 90,695,079UniSTSGRCh37
Build 361090,684,858 - 90,685,059RGDNCBI36
Celera1084,441,723 - 84,441,924RGD
HuRef1084,329,384 - 84,329,585UniSTS
RH45184  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,702,544 - 90,702,755UniSTSGRCh37
Build 361090,692,524 - 90,692,735RGDNCBI36
Celera1084,449,389 - 84,449,600RGD
Cytogenetic Map10q23.3UniSTS
HuRef1084,337,050 - 84,337,261UniSTS
GeneMap99-GB4 RH Map10430.81UniSTS
NCBI RH Map101035.6UniSTS
D10S2177  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,694,950 - 90,695,067UniSTSGRCh37
Build 361090,684,930 - 90,685,047RGDNCBI36
Celera1084,441,795 - 84,441,912RGD
Cytogenetic Map10q23.31UniSTS
Cytogenetic Map10q23.3UniSTS
HuRef1084,329,456 - 84,329,573UniSTS
Whitehead-YAC Contig Map10 UniSTS
SHGC-30457  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3713111,516,798 - 111,516,904UniSTSGRCh37
GRCh371090,713,542 - 90,713,648UniSTSGRCh37
Build 361090,703,522 - 90,703,628RGDNCBI36
Celera1392,363,012 - 92,363,118UniSTS
Celera1084,460,387 - 84,460,493RGD
Cytogenetic Map13q34UniSTS
Cytogenetic Map10q23.3UniSTS
HuRef1392,115,194 - 92,115,300UniSTS
HuRef1084,348,059 - 84,348,165UniSTS
GeneMap99-G3 RH Map133633.0UniSTS
SHGC-30908  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371090,751,352 - 90,751,501UniSTSGRCh37
Build 361090,741,332 - 90,741,481RGDNCBI36
Celera1084,498,139 - 84,498,288RGD
Cytogenetic Map10q24.1UniSTS
Cytogenetic Map10q23.3UniSTS
HuRef1084,385,819 - 84,385,968UniSTS
TNG Radiation Hybrid Map1042781.0UniSTS
GeneMap99-G3 RH Map104188.0UniSTS
PMC23952P1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map7p22UniSTS
Cytogenetic Map10q23.3UniSTS
Cytogenetic Map1q42.13UniSTS
Cytogenetic Map14q11.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:986
Count of miRNA genes:483
Interacting mature miRNAs:521
Transcripts:ENST00000224784, ENST00000415557, ENST00000458159, ENST00000458208, ENST00000480297, ENST00000482085, ENST00000488967
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1396 1338 21 35 1 911 819 64 25 395 103 214 738
Medium 930 932 1562 555 1007 392 3233 1315 2007 366 964 1328 163 990 2034 2
Low 94 717 138 64 895 69 206 61 1635 27 92 161 8 16
Below cutoff 18 3 4 5 14 3 5 2 17 1 9 21 3 1 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001141945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL157394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY692464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP248338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP320140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP379410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ029841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC304647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC354672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC359878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC385559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU143396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000224784   ⟹   ENSP00000224784
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1088,935,074 - 88,952,773 (-)Ensembl
RefSeq Acc Id: ENST00000415557   ⟹   ENSP00000396730
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1088,941,785 - 88,991,339 (-)Ensembl
RefSeq Acc Id: ENST00000458159   ⟹   ENSP00000398239
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1088,941,785 - 88,991,288 (-)Ensembl
RefSeq Acc Id: ENST00000480297
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1088,941,001 - 88,952,747 (-)Ensembl
RefSeq Acc Id: ENST00000482085
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1088,948,242 - 88,952,773 (-)Ensembl
RefSeq Acc Id: ENST00000488967
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1088,946,820 - 88,952,773 (-)Ensembl
RefSeq Acc Id: NM_001141945   ⟹   NP_001135417
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,935,074 - 88,991,397 (-)NCBI
GRCh371090,694,831 - 90,751,147 (-)ENTREZGENE
HuRef1084,329,337 - 84,385,614 (-)ENTREZGENE
CHM1_11090,976,918 - 91,033,214 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001320855   ⟹   NP_001307784
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,935,074 - 88,991,397 (-)NCBI
CHM1_11090,976,918 - 91,033,214 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001613   ⟹   NP_001604
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,935,074 - 88,952,773 (-)NCBI
GRCh371090,694,831 - 90,751,147 (-)ENTREZGENE
Build 361090,684,811 - 90,702,491 (-)NCBI Archive
HuRef1084,329,337 - 84,385,614 (-)ENTREZGENE
CHM1_11090,976,918 - 90,994,666 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001135417   ⟸   NM_001141945
- UniProtKB: P62736 (UniProtKB/Swiss-Prot),   D2JYH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001604   ⟸   NM_001613
- UniProtKB: P62736 (UniProtKB/Swiss-Prot),   D2JYH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307784   ⟸   NM_001320855
- UniProtKB: P62736 (UniProtKB/Swiss-Prot),   D2JYH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000396730   ⟸   ENST00000415557
RefSeq Acc Id: ENSP00000398239   ⟸   ENST00000458159
RefSeq Acc Id: ENSP00000224784   ⟸   ENST00000224784

Promoters
RGD ID:7218083
Promoter ID:EPDNEW_H14787
Type:multiple initiation site
Name:ACTA2_1
Description:actin, alpha 2, smooth muscle, aorta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14792  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,952,773 - 88,952,833EPDNEW
RGD ID:7218093
Promoter ID:EPDNEW_H14792
Type:initiation region
Name:ACTA2_2
Description:actin, alpha 2, smooth muscle, aorta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14787  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,991,332 - 88,991,392EPDNEW
RGD ID:6851806
Promoter ID:EP73708
Type:single initiation site
Name:HS_ACTA2
Description:Actin, alpha 2, smooth muscle, aorta.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361090,702,510 - 90,702,570EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001613.4(ACTA2):c.129+4A>G single nucleotide variant Aortic aneurysm, familial thoracic 6 [RCV000543204] Chr10:88948798 [GRCh38]
Chr10:90708555 [GRCh37]
Chr10:10q23.31
uncertain significance
NM_001613.4(ACTA2):c.953A>G (p.Glu318Gly) single nucleotide variant not provided [RCV000723005] Chr10:88938098 [GRCh38]
Chr10:90697855 [GRCh37]
Chr10:10q23.31
uncertain significance
NM_001613.4(ACTA2):c.523dup (p.His175fs) duplication not provided [RCV000519122] Chr10:88941321..88941322 [GRCh38]
Chr10:90701078..90701079 [GRCh37]
Chr10:10q23.31
uncertain significance
NM_001613.4(ACTA2):c.1047C>T (p.Ala349=) single nucleotide variant Aortic aneurysm, familial thoracic 6 [RCV000544123]|Familial thoracic aortic aneurysm and aortic dissection [RCV001191098] Chr10:88935310 [GRCh38]
Chr10:90695067 [GRCh37]
Chr10:10q23.31
likely benign
NM_001613.4(ACTA2):c.536G>A (p.Arg179His) single nucleotide variant Aortic aneurysm, familial thoracic 6 [