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Gene: MPO (myeloperoxidase) Homo sapiens
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Symbol: MPO
Name: myeloperoxidase
Description: Exhibits heparin binding activity and peroxidase activity. Involved in hydrogen peroxide catabolic process; low-density lipoprotein particle remodeling; and oxidation-reduction process. Localizes to azurophil granule; extracellular space; and nucleoplasm. Implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of asthma (multiple); glomerulonephritis; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Orthologs:
Mus musculus (house mouse) : Mpo (myeloperoxidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mpo (myeloperoxidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mpo (myeloperoxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : MPO (myeloperoxidase)
Canis lupus familiaris (dog) : MPO (myeloperoxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mpo (myeloperoxidase)
Sus scrofa (pig) : MPO (myeloperoxidase)
Chlorocebus sabaeus (African green monkey) : MPO (myeloperoxidase)
Heterocephalus glaber (naked mole-rat) : Mpo (myeloperoxidase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371756,347,217 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBI
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MPO
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346384
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.