MPO (myeloperoxidase) - Rat Genome Database

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Gene: MPO (myeloperoxidase) Homo sapiens
Symbol: MPO
Name: myeloperoxidase
RGD ID: 1346384
Description: Enables heparin binding activity and peroxidase activity. Involved in low-density lipoprotein particle remodeling. Acts upstream of or within hydrogen peroxide catabolic process. Located in azurophil granule; extracellular space; and nucleoplasm. Implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of asthma (multiple); glomerulonephritis; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBI
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,IAGP,ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (EXP)
Alzheimer's disease  (EXP,IAGP)
Alzheimer's disease 1  (IAGP)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IEP)
asthma  (IAGP,IEP)
bacterial pneumonia  (IEP)
brain disease  (EXP)
Brain Injuries  (EXP)
Brain Injuries, Traumatic  (EXP)
brain ischemia  (EXP)
Burns  (EXP,ISO)
cardiovascular system disease  (EXP,IAGP)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
colitis  (EXP)
Contrast-Induced Nephropathy  (ISO)
cystic fibrosis  (IAGP,IDA)
cystitis  (ISO)
Drug Eruptions  (EXP)
end stage renal disease  (IDA)
Enteritis  (ISO)
Experimental Arthritis  (EXP)
Experimental Diabetes Mellitus  (EXP,ISO)
extrahepatic cholestasis  (EXP)
glomerulonephritis  (IEP,ISO)
Hemorrhagic Shock  (EXP)
hepatocellular carcinoma  (EXP,IAGP)
Hypoxia  (EXP)
Inflammation  (EXP)
interstitial lung disease  (IEP)
keratosis  (EXP,IAGP)
Kidney Calculi  (IEP)
kidney disease  (EXP)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (IAGP)
lung cancer  (IAGP)
lung disease  (EXP,IDA)
Lung Neoplasms  (EXP)
lupus nephritis  (IAGP)
major depressive disorder  (EXP)
Myeloperoxidase Deficiency  (IAGP)
Myocardial Ischemia  (IEP)
Occupational Diseases  (EXP)
pancreatic cancer  (IAGP)
pancreatitis  (EXP)
pleurisy  (ISO)
pre-malignant neoplasm  (EXP)
Prostatic Neoplasms  (EXP)
renovascular hypertension  (ISO)
Reperfusion Injury  (EXP,ISO)
rheumatoid arthritis  (EXP)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status asthmaticus  (IEP)
Systemic Candidiasis  (ISO)
trichuriasis  (EXP)
ulcerative colitis  (EXP)
urinary bladder cancer  (EXP)
urticaria  (EXP)
vasculitis  (IMP)
Viral Bronchiolitis  (IEP)
Wounds and Injuries  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-phenylenediamine  (EXP)
1,4-benzoquinone  (EXP)
1,7-dimethylxanthine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dichloroaniline  (EXP)
2,4-dimethylaniline  (EXP)
2,6-dihydroxybenzoic acid  (EXP)
2,6-dimethylaniline  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-bromohexadecanoic acid  (EXP)
2-naphthylamine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-dimethylaniline  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
3-aminobenzamide  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4'-hydroxydiclofenac  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-chloroaniline  (EXP)
4-fluoroaniline  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (EXP)
5,5-dimethyl-1-pyrroline N-oxide  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-hydroxydiclofenac  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
abacavir  (EXP)
acetaldehyde  (EXP)
acetic acid  (ISO)
acetohydrazide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
albuterol  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (EXP)
allopurinol  (ISO)
alloxan  (ISO)
alpha-amanitin  (ISO)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
ambroxol  (ISO)
amifostine  (ISO)
aminoglutethimide  (EXP)
aminoguanidine  (ISO)
amiodarone  (ISO)
ammonia  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (EXP)
astragaloside IV  (ISO)
atorvastatin calcium  (ISO)
baicalein  (ISO)
balsalazide  (ISO)
benzene  (EXP,ISO)
benzidine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzohydrazide  (EXP)
benzoic acid  (EXP)
Benzoyl peroxide  (ISO)
beraprost  (ISO)
berberine  (ISO)
Bergenin  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bivalirudin  (EXP)
bleomycin A2  (ISO)
Boldine  (ISO)
budesonide  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
camphor  (ISO)
candesartan  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carnosine  (ISO)
carrageenan  (ISO)
carvacrol  (ISO)
carvedilol  (EXP,ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP,ISO)
cerium trichloride  (EXP)
ceruletide  (ISO)
chalcones  (ISO)
chelerythrine  (ISO)
Chloralose  (ISO)
chlorogenic acid  (ISO)
chlorphenamine  (ISO)
chlorpyrifos  (ISO)
chondroitin sulfate  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarins  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyanides  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cysteamine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
dapagliflozin  (ISO)
deoxynivalenol  (ISO)
desmethylnaproxen  (EXP)
dexamethasone  (ISO)
dextran  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
Dibromoacetonitrile  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
docebenone  (ISO)
domperidone  (ISO)
donepezil hydrochloride  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
emodin  (ISO)
enalapril  (ISO)
erdosteine  (ISO)
eriodictyol  (ISO)
ethanol  (ISO)
etoposide  (EXP)
eugenol  (ISO)
famotidine  (ISO)
fasudil hydrochloride  (ISO)
fenoterol  (EXP)
ferroheme b  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flucloxacillin  (ISO)
fluconazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (EXP,ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
gliclazide  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glutathione disulfide  (EXP)
glyburide  (ISO)
GR 113808  (ISO)
granisetron  (ISO)
halothane  (ISO)
heme b  (ISO)
hemin  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hyaluronic acid  (ISO)
hydrazine  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxamic acid  (ISO)
hypochlorous acid  (EXP)
ibuprofen  (ISO)
imiquimod  (ISO)
indole-3-butyric acid  (ISO)
indometacin  (EXP,ISO)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isatin  (ISO)
isoflurane  (ISO)
isoniazide  (EXP)
isoorientin  (ISO)
isoprenaline  (ISO)
ketoprofen  (ISO)
ketorolac  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-leucine  (ISO)
L-threonine  (EXP)
Lafutidine  (ISO)
lansoprazole  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lisinopril dihydrate  (ISO)
loxoprofen  (ISO)
lupeol  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
mesalamine  (ISO)
Mesna  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylene blue  (ISO)
metoclopramide  (ISO)
mirtazapine  (ISO)
MK 571  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monotropein  (ISO)
montelukast  (ISO)
N'-acetylisoniazid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylformamide  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
n-propyl gallate  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naproxen  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicorandil  (ISO)
nicotine  (ISO)
nimesulide  (EXP,ISO)
nitric oxide  (ISO)
nitroflurbiprofen  (ISO)
nitrogen dioxide  (EXP)
nitroglycerin  (ISO)
nitrososulfamethoxazole  (EXP)
notoginsenoside R1  (ISO)
NSC 23766  (ISO)
o-anisidine  (EXP)
o-toluidine  (EXP)
octadecanoic acid  (ISO)
olaparib  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
p-toluidine  (EXP)
pantoprazole  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenol  (EXP)
phenol red  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium chloride  (EXP)
potassium cyanide  (EXP)
prednisolone  (ISO)
probenecid  (ISO)
procainamide  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP)
prostaglandin E2  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
Rebamipide  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (EXP,ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rifaximin  (ISO)
rolipram  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
ruthenium red  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (EXP)
saxagliptin  (ISO)
SB 203580  (ISO)
Scalaradial  (ISO)
serotonin  (EXP,ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
Sinomenine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP)
sodium cyanide  (EXP)
sodium fluoride  (ISO)
sodium hypochlorite  (EXP)
sodium nitrate  (ISO)
sodium thiosulfate pentahydrate  (ISO)
spironolactone  (ISO)
stattic  (ISO)
streptozocin  (ISO)
sulfamethoxazole  (EXP)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
superoxide  (EXP)
synephrine  (ISO)
syringic acid  (EXP)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
telmisartan  (ISO)
terbufos  (EXP)
terbutaline  (EXP)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
theophylline  (EXP,ISO)
thiabendazole  (EXP)
thiazolidines  (ISO)
thioacetamide  (ISO)
thiophenes  (EXP)
thymoquinone  (ISO)
tiquizium bromide  (ISO)
titanium dioxide  (EXP,ISO)
trans-caffeic acid  (EXP,ISO)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tropisetron  (ISO)
tungsten  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (ISO)
Vinpocetine  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)


References - curated
1. Abul H, etal., Mol Cell Biochem. 2001 Jan;217(1-2):107-12.
2. Ahsan H, etal., Cancer Lett. 2003 Nov 10;201(1):57-65.
3. Andersen GN, etal., Respir Med. 2007 Oct;101(10):2199-206. Epub 2007 Jul 20.
4. Aratani Y, etal., J Infect Dis. 2002 Jun 15;185(12):1833-7. doi: 10.1086/340635. Epub 2002 May 16.
5. Barlak A, etal., Ren Fail. 2010;32(8):992-9.
6. Bouali H, etal., J Rheumatol. 2007 Oct;34(10):2028-34. Epub 2007 Sep 15.
7. Brovkovych V, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L96-103. Epub 2008 Apr 18.
8. Cevik O, etal., Burns. 2012 Sep;38(6):861-71. doi: 10.1016/j.burns.2012.01.006. Epub 2012 Feb 20.
9. El Kebir D, etal., Am J Respir Crit Care Med. 2009 Aug 15;180(4):311-9. Epub 2009 May 29.
10. Ersahin M, etal., J Pineal Res. 2009 Aug;47(1):97-106. Epub 2009 Jun 22.
11. Ersahin M, etal., Prostaglandins Other Lipid Mediat. 2012 Sep 15. pii: S1098-8823(12)00119-0. doi: 10.1016/j.prostaglandins.2012.09.002.
12. Fiorini G, etal., Biomed Pharmacother. 2000 Jun;54(5):274-8.
13. Frode TS and Medeiros YS, Mediators Inflamm. 2001 Aug;10(4):223-7.
14. GOA_HUMAN data from the GO Consortium
15. Gu J, etal., Acta Anaesthesiol Scand. 2011 Nov;55(10):1272-8. doi: 10.1111/j.1399-6576.2011.02526.x. Epub 2011 Sep 26.
16. Guilpain P, etal., Eur Respir J. 2010 Nov 11.
17. Kalayci O, etal., Turk J Pediatr. 2000 Jan-Mar;42(1):9-16.
18. Kantarci OH, etal., J Neuroimmunol 2000 Jun 26;105(2):189-94.
19. Karakoyun B, etal., Drug Chem Toxicol. 2009;32(4):312-8.
20. Kawashima S, etal., Nihon Jinzo Gakkai Shi. 2009;51(1):56-67.
21. Linares-Fernandez B and Alfieri AB, Invest Clin. 2009 Mar;50(1):23-33.
22. Ma N, etal., Zhonghua Nei Ke Za Zhi. 1999 Aug;38(8):523-6.
23. Matthijsen RA, etal., Am J Pathol. 2007 Dec;171(6):1743-52. Epub 2007 Nov 30.
24. Menozzi A, etal., Eur J Pharmacol. 2011 Jan 10;650(1):378-83. Epub 2010 Oct 13.
25. Misaka S, etal., Eur J Pharm Sci. 2009 Jun 28;37(3-4):469-76. Epub 2009 Apr 10.
26. Nahon P, etal., Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.
27. Nahon P, etal., J Hepatol. 2012 Feb;56(2):426-32. doi: 10.1016/j.jhep.2011.08.010. Epub 2011 Sep 8.
28. Odobasic D, etal., J Am Soc Nephrol. 2007 Mar;18(3):760-70. Epub 2007 Jan 31.
29. OMIM Disease Annotation Pipeline
30. Pecoits-Filho R, etal., Kidney Int Suppl. 2003 May;(84):S172-6.
31. Perianayagam MC, etal., Kidney Int. 2012 Oct;82(8):909-19. doi: 10.1038/ki.2012.235. Epub 2012 Jun 27.
32. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. Pipeline to import SMPDB annotations from SMPDB into RGD
34. Polonikov AV, etal., J Asthma. 2009 Jun;46(5):523-8.
35. Reynolds WF, etal., Mediators Inflamm. 2006;2006(2):36735.
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
39. Sawicki M, etal., Eur J Clin Invest. 2011 Jan 12. doi: 10.1111/j.1365-2362.2010.02457.x.
40. Schabath MB, etal., Am J Epidemiol. 2005 Mar 1;161(5):412-22.
41. Sigurs N, etal., Acta Paediatr. 1994 Nov;83(11):1151-5.
42. Sommer SP, etal., J Heart Lung Transplant. 2011 Apr 4.
43. Tasdemir C, etal., Ren Fail. 2012;34(9):1144-9. doi: 10.3109/0886022X.2012.717490. Epub 2012 Sep 6.
44. Tsao KC, etal., J Clin Lab Anal. 2007;21(6):426-31.
45. Uluoglu C, etal., Gen Physiol Biophys. 2008 Mar;27(1):25-31.
46. Vasu VT, etal., Free Radic Res. 2011 Feb;45(2):165-76. Epub 2010 Oct 18.
47. Wang AY, etal., Am J Kidney Dis. 2010 Nov;56(5):937-46. Epub 2010 Jul 16.
48. Wheatley-Price P, etal., Cancer. 2008 Mar 1;112(5):1037-42.
49. Yamanishi Y, etal., Mod Rheumatol. 2012 Oct 21.
Additional References at PubMed
PMID:1320128   PMID:1334087   PMID:1703177   PMID:2154223   PMID:2444596   PMID:2552418   PMID:2820530   PMID:2829220   PMID:2884926   PMID:2903767   PMID:2981589   PMID:3029127  
PMID:3031585   PMID:3654979   PMID:7530510   PMID:7809065   PMID:7840679   PMID:7904599   PMID:8037771   PMID:8078496   PMID:8142659   PMID:8383257   PMID:8390465   PMID:8530055  
PMID:8621627   PMID:8718890   PMID:9097926   PMID:9175709   PMID:9354683   PMID:9637725   PMID:10766826   PMID:10772654   PMID:10777476   PMID:10801811   PMID:10828600   PMID:11087769  
PMID:11090610   PMID:11147929   PMID:11161635   PMID:11179831   PMID:11423389   PMID:11434421   PMID:11705390   PMID:11774269   PMID:11794452   PMID:11811524   PMID:11813987   PMID:11840286  
PMID:11861298   PMID:11895912   PMID:11907569   PMID:11943609   PMID:11956078   PMID:11960308   PMID:11981455   PMID:11986950   PMID:12027420   PMID:12052532   PMID:12057865   PMID:12089442  
PMID:12111688   PMID:12135010   PMID:12164325   PMID:12209361   PMID:12355548   PMID:12393699   PMID:12397651   PMID:12432558   PMID:12460800   PMID:12477932   PMID:12496042   PMID:12496043  
PMID:12515618   PMID:12565898   PMID:12606047   PMID:12707270   PMID:12729191   PMID:12773517   PMID:12782337   PMID:12792137   PMID:12800195   PMID:12810834   PMID:12818404   PMID:12861032  
PMID:12915675   PMID:12946561   PMID:12950060   PMID:12952835   PMID:12969520   PMID:14617020   PMID:14626895   PMID:14646692   PMID:14668325   PMID:14716779   PMID:14729580   PMID:14730210  
PMID:14761515   PMID:14972011   PMID:15006595   PMID:15023809   PMID:15031357   PMID:15068388   PMID:15108282   PMID:15159316   PMID:15184258   PMID:15196853   PMID:15199549   PMID:15203186  
PMID:15222689   PMID:15255951   PMID:15299090   PMID:15304260   PMID:15331175   PMID:15350145   PMID:15379210   PMID:15492293   PMID:15504976   PMID:15507752   PMID:15507753   PMID:15507754  
PMID:15507759   PMID:15507760   PMID:15507769   PMID:15507770   PMID:15507771   PMID:15536330   PMID:15538122   PMID:15600254   PMID:15661916   PMID:15705913   PMID:15714076   PMID:15734083  
PMID:15829318   PMID:15850382   PMID:15884126   PMID:15885363   PMID:15894800   PMID:15901995   PMID:15911707   PMID:15967795   PMID:15996936   PMID:16084535   PMID:16107886   PMID:16148002  
PMID:16157195   PMID:16170238   PMID:16195240   PMID:16221222   PMID:16267254   PMID:16289072   PMID:16297214   PMID:16326702   PMID:16335952   PMID:16385446   PMID:16430221   PMID:16476719  
PMID:16484808   PMID:16497665   PMID:16502470   PMID:16504169   PMID:16543247   PMID:16606792   PMID:16641309   PMID:16732739   PMID:16740002   PMID:16758302   PMID:16829688   PMID:16844322  
PMID:16901848   PMID:16956579   PMID:17017121   PMID:17042493   PMID:17119198   PMID:17145829   PMID:17149600   PMID:17159117   PMID:17161406   PMID:17178637   PMID:17209550   PMID:17259657  
PMID:17304047   PMID:17337886   PMID:17355643   PMID:17381162   PMID:17424838   PMID:17428572   PMID:17438335   PMID:17440118   PMID:17451207   PMID:17479404   PMID:17483704   PMID:17521322  
PMID:17549373   PMID:17582430   PMID:17595772   PMID:17601350   PMID:17613595   PMID:17650507   PMID:17701359   PMID:17704068   PMID:17726014   PMID:17767014   PMID:17855424   PMID:17869258  
PMID:17875305   PMID:17885617   PMID:17922231   PMID:17925548   PMID:17980933   PMID:18042261   PMID:18051367   PMID:18177875   PMID:18214807   PMID:18237195   PMID:18258609   PMID:18271379  
PMID:18273043   PMID:18280811   PMID:18296681   PMID:18314009   PMID:18322643   PMID:18331758   PMID:18340529   PMID:18344624   PMID:18359301   PMID:18435917   PMID:18440308   PMID:18441517  
PMID:18447907   PMID:18452102   PMID:18466756   PMID:18505072   PMID:18617697   PMID:18632753   PMID:18636124   PMID:18642288   PMID:18662591   PMID:18667997   PMID:18676680   PMID:18676870  
PMID:18778866   PMID:18784359   PMID:18836923   PMID:18854777   PMID:18930040   PMID:18976975   PMID:18977241   PMID:19012698   PMID:19030913   PMID:19031316   PMID:19056867   PMID:19059911  
PMID:19081093   PMID:19126404   PMID:19129321   PMID:19138806   PMID:19140875   PMID:19147137   PMID:19162321   PMID:19170196   PMID:19201174   PMID:19237222   PMID:19255063   PMID:19255975  
PMID:19322015   PMID:19339270   PMID:19345674   PMID:19362143   PMID:19410253   PMID:19420105   PMID:19423521   PMID:19423540   PMID:19479063   PMID:19490915   PMID:19505917   PMID:19524564  
PMID:19538950   PMID:19543083   PMID:19556446   PMID:19578796   PMID:19589271   PMID:19593802   PMID:19608745   PMID:19614918   PMID:19622717   PMID:19625176   PMID:19626395   PMID:19641039  
PMID:19646343   PMID:19651119   PMID:19651670   PMID:19692168   PMID:19726691   PMID:19729473   PMID:19729601   PMID:19735726   PMID:19752340   PMID:19758957   PMID:19761988   PMID:19788922  
PMID:19789190   PMID:19814685   PMID:19816870   PMID:19822138   PMID:19828014   PMID:19857655   PMID:19857676   PMID:19877306   PMID:19878569   PMID:19897513   PMID:19902075   PMID:19913121  
PMID:19916937   PMID:19963114   PMID:19995403   PMID:20007081   PMID:20026093   PMID:20032816   PMID:20043647   PMID:20064972   PMID:20080069   PMID:20091863   PMID:20136960   PMID:20146436  
PMID:20158910   PMID:20201999   PMID:20228064   PMID:20237496   PMID:20301340   PMID:20305551   PMID:20332087   PMID:20332596   PMID:20360068   PMID:20364045   PMID:20364135   PMID:20399194  
PMID:20406964   PMID:20413430   PMID:20418356   PMID:20437850   PMID:20438785   PMID:20485444   PMID:20536280   PMID:20568015   PMID:20592714   PMID:20598694   PMID:20628086   PMID:20636397  
PMID:20643115   PMID:20644561   PMID:20646231   PMID:20651370   PMID:20663217   PMID:20673159   PMID:20673504   PMID:20677014   PMID:20714866   PMID:20732340   PMID:20848159   PMID:20933108  
PMID:20951227   PMID:20974672   PMID:20974816   PMID:21126969   PMID:21176345   PMID:21204009   PMID:21292302   PMID:21327394   PMID:21331575   PMID:21407237   PMID:21461569   PMID:21540635  
PMID:21630459   PMID:21657847   PMID:21674360   PMID:21699462   PMID:21739466   PMID:21779191   PMID:21792769   PMID:21795425   PMID:21827295   PMID:21856025   PMID:21873635   PMID:21880315  
PMID:21880720   PMID:21884783   PMID:21917261   PMID:21934609   PMID:21950958   PMID:21967851   PMID:22014237   PMID:22094928   PMID:22097722   PMID:22126566   PMID:22140557   PMID:22145905  
PMID:22219194   PMID:22264587   PMID:22331023   PMID:22352991   PMID:22355012   PMID:22427832   PMID:22462773   PMID:22465269   PMID:22659527   PMID:22703762   PMID:22802447   PMID:22902565  
PMID:22912422   PMID:22949765   PMID:22959522   PMID:22985908   PMID:23016839   PMID:23059132   PMID:23066164   PMID:23100268   PMID:23124356   PMID:23167629   PMID:23260186   PMID:23268804  
PMID:23306200   PMID:23342893   PMID:23364307   PMID:23376485   PMID:23384293   PMID:23436245   PMID:23521574   PMID:23532856   PMID:23533145   PMID:23535901   PMID:23537682   PMID:23583798  
PMID:23620142   PMID:23624305   PMID:23666398   PMID:23691142   PMID:23707661   PMID:23734221   PMID:23746122   PMID:23773345   PMID:23832536   PMID:23840365   PMID:23893381   PMID:23908111  
PMID:23943392   PMID:23943394   PMID:23979979   PMID:23991124   PMID:24035742   PMID:24036021   PMID:24083736   PMID:24267244   PMID:24267251   PMID:24271323   PMID:24291125   PMID:24291281  
PMID:24330098   PMID:24338120   PMID:24340057   PMID:24355864   PMID:24385592   PMID:24391750   PMID:24436331   PMID:24457336   PMID:24530881   PMID:24534704   PMID:24567965   PMID:24583458  
PMID:24591758   PMID:24631066   PMID:24704632   PMID:24713525   PMID:24719228   PMID:24748187   PMID:24786234   PMID:24851620   PMID:24882572   PMID:24915973   PMID:24976018   PMID:24981860  
PMID:25002508   PMID:25056433   PMID:25141318   PMID:25261597   PMID:25394640   PMID:25482861   PMID:25530680   PMID:25614581   PMID:25637720   PMID:25645918   PMID:25697357   PMID:25701357  
PMID:25759391   PMID:25770662   PMID:25823564   PMID:25922506   PMID:26066543   PMID:26107902   PMID:26132583   PMID:26179062   PMID:26186194   PMID:26229458   PMID:26307104   PMID:26319155  
PMID:26323935   PMID:26386352   PMID:26392121   PMID:26431910   PMID:26541603   PMID:26567811   PMID:26576922   PMID:26697531   PMID:26714302   PMID:26797862   PMID:26833773   PMID:26841645  
PMID:26978734   PMID:27013444   PMID:27048452   PMID:27129797   PMID:27197583   PMID:27579896   PMID:27643667   PMID:27706591   PMID:27752292   PMID:27797335   PMID:27821628   PMID:27836774  
PMID:27884085   PMID:27903408   PMID:27928450   PMID:28013526   PMID:28058679   PMID:28069011   PMID:28131839   PMID:28135312   PMID:28167245   PMID:28187981   PMID:28260049   PMID:28279572  
PMID:28281453   PMID:28328864   PMID:28339364   PMID:28348079   PMID:28397206   PMID:28466093   PMID:28514442   PMID:28575531   PMID:28602123   PMID:28645072   PMID:28675297   PMID:28682877  
PMID:28764808   PMID:28905321   PMID:29041000   PMID:29114094   PMID:29212118   PMID:29306105   PMID:29306874   PMID:29383971   PMID:29453088   PMID:29467282   PMID:29496995   PMID:29509190  
PMID:29540402   PMID:29577557   PMID:29585927   PMID:29590135   PMID:29614255   PMID:29618370   PMID:29631687   PMID:29875311   PMID:29937309   PMID:29970677   PMID:29975476   PMID:30021884  
PMID:30056589   PMID:30207165   PMID:30237127   PMID:30266105   PMID:30278820   PMID:30300402   PMID:30343390   PMID:30448568   PMID:30456985   PMID:30539859   PMID:30626536   PMID:30641731  
PMID:30726210   PMID:30824926   PMID:30938436   PMID:31175983   PMID:31236695   PMID:31247619   PMID:31341419   PMID:31343991   PMID:31358527   PMID:31531730   PMID:31536960   PMID:31653520  
PMID:31754972   PMID:31864385   PMID:31991297   PMID:32050431   PMID:32277104   PMID:32314165   PMID:32383462   PMID:32674726   PMID:32758447   PMID:32758448   PMID:32761433   PMID:32794199  
PMID:32814053   PMID:32928076   PMID:33023023   PMID:33027796   PMID:33228505   PMID:33285335   PMID:33460291   PMID:33569703  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBI
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391187,684,610 - 87,695,238 (+)NCBIGRCm39mm39
GRCm39 Ensembl1187,684,407 - 87,695,239 (+)Ensembl
GRCm381187,793,784 - 87,804,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,793,581 - 87,804,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,607,286 - 87,617,914 (+)NCBIGRCm37mm9NCBIm37
MGSCv361187,609,776 - 87,620,592 (+)NCBImm8
Celera1197,389,547 - 97,400,150 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.22NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21072,594,458 - 72,608,862 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554514,743,744 - 4,753,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,743,744 - 4,753,358 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11757,189,654 - 57,212,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,201,073 - 57,212,111 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01752,333,882 - 52,357,838 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1932,927,483 - 32,938,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,927,483 - 32,937,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,164,643 - 32,175,070 (-)NCBI
ROS_Cfam_1.0933,734,267 - 33,744,696 (-)NCBI
UMICH_Zoey_3.1932,520,407 - 32,530,846 (-)NCBI
UNSW_CanFamBas_1.0932,803,860 - 32,814,324 (-)NCBI
UU_Cfam_GSD_1.0932,897,366 - 32,907,792 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560232,254,998 - 32,265,476 (-)NCBI
SpeTri2.0NW_0049364904,809,773 - 4,819,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1234,556,408 - 34,567,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,245,391 - 36,256,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11635,120,194 - 35,130,851 (+)NCBI
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)Ensembl
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_004624871121,026 - 131,433 (-)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,251 - 56,347,395UniSTSGRCh37
Build 361753,702,250 - 53,702,394RGDNCBI36
Celera1752,809,029 - 52,809,173RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,047 - 51,708,191UniSTS
GeneMap99-GB4 RH Map17371.55UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,643 - 56,348,060UniSTSGRCh37
Build 361753,702,642 - 53,703,059RGDNCBI36
Celera1752,809,421 - 52,809,838RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,439 - 51,708,856UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,357,310 - 56,357,854UniSTSGRCh37
Build 361753,712,309 - 53,712,853RGDNCBI36
Celera1752,819,080 - 52,819,624RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,717,980 - 51,718,524UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,348,149 - 56,348,482UniSTSGRCh37
Build 361753,703,148 - 53,703,481RGDNCBI36
Celera1752,809,927 - 52,810,260RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,945 - 51,709,278UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,693 - 56,347,997UniSTSGRCh37
Build 361753,702,692 - 53,702,996RGDNCBI36
Celera1752,809,471 - 52,809,775RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,489 - 51,708,793UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,954 - 56,348,130UniSTSGRCh37
Build 361753,702,953 - 53,703,129RGDNCBI36
Celera1752,809,732 - 52,809,908RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,750 - 51,708,926UniSTS
Whitehead-YAC Contig Map17 UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,923 - 56,348,151UniSTSGRCh37
Build 361753,702,922 - 53,703,150RGDNCBI36
Celera1752,809,701 - 52,809,929RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,719 - 51,708,947UniSTS
GeneMap99-GB4 RH Map17375.3UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,796 - 56,347,927UniSTSGRCh37
Build 361753,702,795 - 53,702,926RGDNCBI36
Celera1752,809,574 - 52,809,705RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,592 - 51,708,723UniSTS
Stanford-G3 RH Map172431.0UniSTS
NCBI RH Map17654.6UniSTS
GeneMap99-G3 RH Map172932.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2005
Count of miRNA genes:798
Interacting mature miRNAs:956
Transcripts:ENST00000225275, ENST00000340482, ENST00000577220, ENST00000578493, ENST00000580005, ENST00000581022
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 4 18 2
Medium 1 460 30 33 611 19 6 9 7 6 216 13 4 5
Low 477 1005 722 230 582 106 906 867 2626 63 627 725 126 1 462 671 4
Below cutoff 1854 1460 857 272 451 251 3160 1271 992 227 690 491 26 727 2013 1


Nucleotide Sequences
RefSeq Transcripts NG_009629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A08802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ088846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB659828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB659830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S65785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z37728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000225275   ⟹   ENSP00000225275
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)Ensembl
RefSeq Acc Id: ENST00000577220   ⟹   ENSP00000464668
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,270,729 - 58,273,492 (-)Ensembl
RefSeq Acc Id: ENST00000578493
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,275,571 - 58,278,119 (-)Ensembl
RefSeq Acc Id: ENST00000580005
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,279,876 - 58,280,687 (-)Ensembl
RefSeq Acc Id: ENST00000581022
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,278,837 - 58,279,399 (-)Ensembl
RefSeq Acc Id: NM_000250   ⟹   NP_000241
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh381758,269,855 - 58,280,935 (-)NCBI
GRCh371756,347,217 - 56,358,296 (-)ENTREZGENE
Build 361753,702,216 - 53,713,295 (-)NCBI Archive
HuRef1751,708,013 - 51,718,966 (-)ENTREZGENE
CHM1_11756,412,238 - 56,423,315 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_000241   ⟸   NM_000250
- Peptide Label: precursor
- UniProtKB: P05164 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000464668   ⟸   ENST00000577220
RefSeq Acc Id: ENSP00000225275   ⟸   ENST00000225275

RGD ID:6811257
Promoter ID:HG_ACW:35487
SO ACC ID:SO:0000170
Tissues & Cell Lines:NB4
Human AssemblyChrPosition (strand)Source
Build 361753,711,906 - 53,712,406 (-)MPROMDB
RGD ID:6794336
Promoter ID:HG_KWN:26678
SO ACC ID:SO:0000170
Tissues & Cell Lines:NB4
Transcripts:ENST00000340482,   NM_000250
Human AssemblyChrPosition (strand)Source
Build 361753,713,206 - 53,714,207 (-)MPROMDB
RGD ID:7235795
Promoter ID:EPDNEW_H23643
Type:initiation region
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh381758,280,935 - 58,280,995EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000250.2(MPO):c.1705C>T (p.Arg569Trp) single nucleotide variant Myeloperoxidase deficiency [RCV000003810]|not provided [RCV000366635] Chr17:58272835 [GRCh38]
Chr17:56350196 [GRCh37]
NM_000250.2(MPO):c.518A>G (p.Tyr173Cys) single nucleotide variant Myeloperoxidase deficiency [RCV000003811] Chr17:58279553 [GRCh38]
Chr17:56356914 [GRCh37]
NM_000250.2(MPO):c.752T>C (p.Met251Thr) single nucleotide variant Myeloperoxidase deficiency [RCV000003812] Chr17:58279141 [GRCh38]
Chr17:56356502 [GRCh37]
pathogenic|uncertain significance
NM_000250.2(MPO):c.1555_1568del (p.Met519fs) deletion Myeloperoxidase deficiency [RCV000003813]|not provided [RCV000274466] Chr17:58273467..58273480 [GRCh38]
Chr17:56350828..56350841 [GRCh37]
pathogenic|likely pathogenic|conflicting interpretations of pathogenicity
NM_000250.2(MPO):c.995C>T (p.Ala332Val) single nucleotide variant Myeloperoxidase deficiency [RCV000003814] Chr17:58278036 [GRCh38]
Chr17:56355397 [GRCh37]
pathogenic|conflicting interpretations of pathogenicity|uncertain significance
NM_000250.2(MPO):c.1715T>G (p.Leu572Trp) single nucleotide variant Myeloperoxidase deficiency [RCV000003815] Chr17:58272825 [GRCh38]
Chr17:56350186 [GRCh37]
NM_000250.2(MPO):c.2031-2A>C single nucleotide variant Myeloperoxidase deficiency [RCV000003816]|not provided [RCV000265536] Chr17:58270865 [GRCh38]
Chr17:56348226 [GRCh37]
pathogenic|likely pathogenic
NG_009629.1:g.4535G>A single nucleotide variant Alzheimer disease, susceptibility to [RCV000003817]|Lung cancer, protection against, in smokers [RCV000003818] Chr17:58281401 [GRCh38]
Chr17:56358762 [GRCh37]
risk factor|protective
NM_000250.2(MPO):c.1501G>A (p.Gly501Ser) single nucleotide variant Myeloperoxidase deficiency [RCV000003819] Chr17:58273534 [GRCh38]
Chr17:56350895 [GRCh37]
NM_000250.2(MPO):c.1495C>T (p.Arg499Cys) single nucleotide variant Myeloperoxidase deficiency [RCV000003820] Chr17:58273540 [GRCh38]
Chr17:56350901 [GRCh37]
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
NM_000250.2(MPO):c.1621+2T>C single nucleotide variant not provided [RCV000519053] Chr17:58273412 [GRCh38]
Chr17:56350773 [GRCh37]
likely pathogenic
NM_000250.2(MPO):c.110T>C (p.Leu37Pro) single nucleotide variant not provided [RCV000520642] Chr17:58280649 [GRCh38]
Chr17:56358010 [GRCh37]
uncertain significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
NM_000250.1(MPO):c.396C>T (p.Ser132=) single nucleotide variant Malignant melanoma [RCV000071582] Chr17:58279867 [GRCh38]
Chr17:56357228 [GRCh37]
Chr17:53712227 [NCBI36]
not provided
NM_000250.1(MPO):c.395C>T (p.Ser132Phe) single nucleotide variant Malignant melanoma [RCV000071583] Chr17:58279868 [GRCh38]
Chr17:56357229 [GRCh37]
Chr17:53712228 [NCBI36]
not provided
NM_001160102.1(LPO):c.1431C>T (p.Asp477=) single nucleotide variant Malignant melanoma [RCV000071581] Chr17:58266313 [GRCh38]
Chr17:56343674 [GRCh37]
Chr17:53698673 [NCBI36]
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
GRCh38/hg38 17q22-23.1(chr17:57418806-59735464)x1 copy number loss See cases [RCV000140211] Chr17:57418806..59735464 [GRCh38]
Chr17:55496167..57812825 [GRCh37]
Chr17:52851166..55167607 [NCBI36]
NM_000250.1(MPO):c.2031-2A>C single nucleotide variant Myeloperoxidase deficiency [RCV000169667] Chr17:58270865 [GRCh38]
Chr17:56348226 [GRCh37]
GRCh37/hg19 17q22(chr17:55916829-56770618)x1 copy number loss See cases [RCV000239996] Chr17:55916829..56770618 [GRCh37]
likely pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
NM_000250.2(MPO):c.1281del (p.Thr428fs) deletion not provided [RCV000519860] Chr17:58275626 [GRCh38]
Chr17:56352987 [GRCh37]
likely pathogenic
NM_000250.2(MPO):c.604G>T (p.Glu202Ter) single nucleotide variant not provided [RCV000578983] Chr17:58279371 [GRCh38]
Chr17:56356732 [GRCh37]
pathogenic|likely pathogenic
GRCh37/hg19 17q22(chr17:52189051-57477162)x3 copy number gain See cases [RCV000448801] Chr17:52189051..57477162 [GRCh37]
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
NM_000250.2(MPO):c.2031-6A>C single nucleotide variant not specified [RCV000455269] Chr17:58270869 [GRCh38]
Chr17:56348230 [GRCh37]
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
NM_000250.2(MPO):c.234G>A (p.Lys78=) single nucleotide variant not provided [RCV000973561] Chr17:58280380 [GRCh38]
Chr17:56357741 [GRCh37]
likely benign
NM_000250.2(MPO):c.1410G>A (p.Thr470=) single nucleotide variant not provided [RCV000972922] Chr17:58273625 [GRCh38]
Chr17:56350986 [GRCh37]
NM_000250.2(MPO):c.1365+7C>T single nucleotide variant not provided [RCV000901183] Chr17:58275535 [GRCh38]
Chr17:56352896 [GRCh37]
likely benign
NM_000250.2(MPO):c.1810C>T (p.Arg604Cys) single nucleotide variant not provided [RCV000901330] Chr17:58271875 [GRCh38]
Chr17:56349236 [GRCh37]
likely benign
NM_000250.2(MPO):c.696C>G (p.Asn232Lys) single nucleotide variant not provided [RCV000996587] Chr17:58279197 [GRCh38]
Chr17:56356558 [GRCh37]
uncertain significance
NM_000250.2(MPO):c.1377C>T (p.Tyr459=) single nucleotide variant not provided [RCV000962528] Chr17:58273658 [GRCh38]
Chr17:56351019 [GRCh37]
NM_000250.2(MPO):c.172G>A (p.Asp58Asn) single nucleotide variant not provided [RCV000906220] Chr17:58280442 [GRCh38]
Chr17:56357803 [GRCh37]
NM_000250.2(MPO):c.2133C>T (p.Thr711=) single nucleotide variant not provided [RCV000881823] Chr17:58270761 [GRCh38]
Chr17:56348122 [GRCh37]
NM_000250.2(MPO):c.315G>A (p.Pro105=) single nucleotide variant not provided [RCV000886886] Chr17:58279948 [GRCh38]
Chr17:56357309 [GRCh37]
likely benign
NM_000250.2(MPO):c.1379G>A (p.Arg460Gln) single nucleotide variant not provided [RCV000890999] Chr17:58273656 [GRCh38]
Chr17:56351017 [GRCh37]
likely benign
NM_000250.2(MPO):c.2187C>T (p.Asn729=) single nucleotide variant not provided [RCV000957639] Chr17:58270707 [GRCh38]
Chr17:56348068 [GRCh37]
NM_000250.2(MPO):c.1365+7C>G single nucleotide variant not provided [RCV000957967] Chr17:58275535 [GRCh38]
Chr17:56352896 [GRCh37]
NM_000250.2(MPO):c.1031G>A (p.Gly344Asp) single nucleotide variant Alzheimer disease [RCV001198130] Chr17:58278000 [GRCh38]
Chr17:56355361 [GRCh37]
uncertain significance
NM_000250.2(MPO):c.-56C>T single nucleotide variant Hereditary angioedema with normal C1Inh [RCV001027426] Chr17:58280814 [GRCh38]
Chr17:56358175 [GRCh37]
not provided
NM_000250.2(MPO):c.886-2A>G single nucleotide variant Myeloperoxidase deficiency [RCV001333310] Chr17:58278147 [GRCh38]
Chr17:56355508 [GRCh37]
NM_000250.2(MPO):c.249-2A>G single nucleotide variant Myeloperoxidase deficiency [RCV001292655] Chr17:58280016 [GRCh38]
Chr17:56357377 [GRCh37]
NM_000250.2(MPO):c.1783G>A (p.Gly595Ser) single nucleotide variant Myeloperoxidase deficiency [RCV001290209] Chr17:58272757 [GRCh38]
Chr17:56350118 [GRCh37]
NM_000250.2(MPO):c.308AGC[1] (p.Gln104del) microsatellite not provided [RCV001310373] Chr17:58279950..58279952 [GRCh38]
Chr17:56357311..56357313 [GRCh37]
uncertain significance
NM_000250.2(MPO):c.2047G>C (p.Glu683Gln) single nucleotide variant not provided [RCV001355756] Chr17:58270847 [GRCh38]
Chr17:56348208 [GRCh37]
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7218 AgrOrtholog
Ensembl Genes ENSG00000005381 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000225275 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000464668 UniProtKB/TrEMBL
Ensembl Transcript ENST00000225275 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000577220 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000005381 GTEx
Human Proteome Map MPO Human Proteome Map
InterPro Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4353 UniProtKB/Swiss-Prot
OMIM 104300 OMIM
  254600 OMIM
  606989 OMIM
PANTHER PTHR11475:SF108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P05164 ENTREZGENE, UniProtKB/Swiss-Prot
  Q16771_HUMAN UniProtKB/TrEMBL
UniProt Secondary A1L4B8 UniProtKB/Swiss-Prot
  Q14862 UniProtKB/Swiss-Prot
  Q4PJH5 UniProtKB/Swiss-Prot
  Q9UCL7 UniProtKB/Swiss-Prot