MPO (myeloperoxidase) - Rat Genome Database

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Gene: MPO (myeloperoxidase) Homo sapiens
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Symbol: MPO
Name: myeloperoxidase
RGD ID: 1346384
HGNC Page HGNC
Description: Enables heparin binding activity and peroxidase activity. Involved in low-density lipoprotein particle remodeling. Acts upstream of or within hydrogen peroxide catabolic process. Located in azurophil granule; extracellular space; and nucleoplasm. Implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of asthma (multiple); glomerulonephritis; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBI
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,IAGP,ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (EXP)
Alzheimer's disease  (EXP,IAGP)
Alzheimer's disease 1  (IAGP)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IEP)
asthma  (IAGP,IEP)
bacterial pneumonia  (IEP)
brain disease  (EXP)
Brain Injuries  (EXP)
Brain Injuries, Traumatic  (EXP)
brain ischemia  (EXP)
Burns  (EXP,ISO)
cardiovascular system disease  (EXP,IAGP)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
colitis  (EXP)
Contrast-Induced Nephropathy  (ISO)
cystic fibrosis  (IAGP,IDA)
cystitis  (ISO)
Drug Eruptions  (EXP)
end stage renal disease  (IDA)
Enteritis  (ISO)
Experimental Arthritis  (EXP)
Experimental Diabetes Mellitus  (EXP,ISO)
extrahepatic cholestasis  (EXP)
glomerulonephritis  (IEP,ISO)
Hemorrhagic Shock  (EXP)
hepatocellular carcinoma  (EXP,IAGP)
Hypoxia  (EXP)
Inflammation  (EXP)
interstitial lung disease  (IEP)
keratosis  (EXP,IAGP)
Kidney Calculi  (IEP)
kidney disease  (EXP)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (IAGP)
lung cancer  (IAGP)
lung disease  (EXP,IDA)
Lung Neoplasms  (EXP)
lupus nephritis  (IAGP)
major depressive disorder  (EXP)
Myeloperoxidase Deficiency  (IAGP)
Myocardial Ischemia  (IEP)
Occupational Diseases  (EXP)
pancreatic cancer  (IAGP)
pancreatitis  (EXP)
pleurisy  (ISO)
pre-malignant neoplasm  (EXP)
Prostatic Neoplasms  (EXP)
renovascular hypertension  (ISO)
Reperfusion Injury  (EXP,ISO)
rheumatoid arthritis  (EXP)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status asthmaticus  (IEP)
Systemic Candidiasis  (ISO)
trichuriasis  (EXP)
ulcerative colitis  (EXP)
urinary bladder cancer  (EXP)
urticaria  (EXP)
vasculitis  (IMP)
Viral Bronchiolitis  (IEP)
Wounds and Injuries  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-phenylenediamine  (EXP)
1,4-benzoquinone  (EXP)
1,7-dimethylxanthine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dichloroaniline  (EXP)
2,4-dimethylaniline  (EXP)
2,6-dihydroxybenzoic acid  (EXP)
2,6-dimethylaniline  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-bromohexadecanoic acid  (EXP)
2-naphthylamine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-dimethylaniline  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
3-aminobenzamide  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4'-hydroxydiclofenac  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-chloroaniline  (EXP)
4-fluoroaniline  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (EXP)
5,5-dimethyl-1-pyrroline N-oxide  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-hydroxydiclofenac  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
abacavir  (EXP)
acetaldehyde  (EXP)
acetic acid  (ISO)
acetohydrazide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
albuterol  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (EXP)
allopurinol  (ISO)
alloxan  (ISO)
alpha-amanitin  (ISO)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
ambroxol  (ISO)
amifostine  (ISO)
aminoglutethimide  (EXP)
aminoguanidine  (ISO)
amiodarone  (ISO)
ammonia  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (EXP)
astragaloside IV  (ISO)
atorvastatin calcium  (ISO)
baicalein  (ISO)
balsalazide  (ISO)
benzene  (EXP,ISO)
benzidine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzohydrazide  (EXP)
benzoic acid  (EXP)
Benzoyl peroxide  (ISO)
beraprost  (ISO)
berberine  (ISO)
Bergenin  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bivalirudin  (EXP)
bleomycin A2  (ISO)
Boldine  (ISO)
budesonide  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
camphor  (ISO)
candesartan  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carnosine  (ISO)
carrageenan  (ISO)
carvacrol  (ISO)
carvedilol  (EXP,ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP,ISO)
cerium trichloride  (EXP)
ceruletide  (ISO)
chalcones  (ISO)
chelerythrine  (ISO)
Chloralose  (ISO)
chlorogenic acid  (ISO)
chlorphenamine  (ISO)
chlorpyrifos  (ISO)
chondroitin sulfate  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarins  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyanides  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cysteamine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
dapagliflozin  (ISO)
deoxynivalenol  (ISO)
desmethylnaproxen  (EXP)
dexamethasone  (ISO)
dextran  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
Dibromoacetonitrile  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
docebenone  (ISO)
domperidone  (ISO)
donepezil hydrochloride  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
emodin  (ISO)
enalapril  (ISO)
erdosteine  (ISO)
eriodictyol  (ISO)
ethanol  (ISO)
etoposide  (EXP)
eugenol  (ISO)
famotidine  (ISO)
fasudil hydrochloride  (ISO)
fenoterol  (EXP)
ferroheme b  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flucloxacillin  (ISO)
fluconazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (EXP,ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
gliclazide  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glutathione disulfide  (EXP)
glyburide  (ISO)
GR 113808  (ISO)
granisetron  (ISO)
halothane  (ISO)
heme b  (ISO)
hemin  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hyaluronic acid  (ISO)
hydrazine  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxamic acid  (ISO)
hypochlorous acid  (EXP)
ibuprofen  (ISO)
imiquimod  (ISO)
IMP  (ISO)
indole-3-butyric acid  (ISO)
indometacin  (EXP,ISO)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isatin  (ISO)
isoflurane  (ISO)
isoniazide  (EXP)
isoorientin  (ISO)
isoprenaline  (ISO)
ketoprofen  (ISO)
ketorolac  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-leucine  (ISO)
L-threonine  (EXP)
Lafutidine  (ISO)
lansoprazole  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lisinopril dihydrate  (ISO)
loxoprofen  (ISO)
lupeol  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
mesalamine  (ISO)
Mesna  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylene blue  (ISO)
metoclopramide  (ISO)
mirtazapine  (ISO)
MK 571  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monotropein  (ISO)
montelukast  (ISO)
N'-acetylisoniazid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylformamide  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
n-propyl gallate  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naproxen  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicorandil  (ISO)
nicotine  (ISO)
nimesulide  (EXP,ISO)
nitric oxide  (ISO)
nitroflurbiprofen  (ISO)
nitrogen dioxide  (EXP)
nitroglycerin  (ISO)
nitrososulfamethoxazole  (EXP)
notoginsenoside R1  (ISO)
NSC 23766  (ISO)
o-anisidine  (EXP)
o-toluidine  (EXP)
octadecanoic acid  (ISO)
olaparib  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
p-toluidine  (EXP)
pantoprazole  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenol  (EXP)
phenol red  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium chloride  (EXP)
potassium cyanide  (EXP)
prednisolone  (ISO)
probenecid  (ISO)
procainamide  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP)
prostaglandin E2  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
Rebamipide  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (EXP,ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rifaximin  (ISO)
rolipram  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
ruthenium red  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (EXP)
saxagliptin  (ISO)
SB 203580  (ISO)
Scalaradial  (ISO)
serotonin  (EXP,ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
Sinomenine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP)
sodium cyanide  (EXP)
sodium fluoride  (ISO)
sodium hypochlorite  (EXP)
sodium nitrate  (ISO)
sodium thiosulfate pentahydrate  (ISO)
spironolactone  (ISO)
stattic  (ISO)
streptozocin  (ISO)
sulfamethoxazole  (EXP)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
superoxide  (EXP)
synephrine  (ISO)
syringic acid  (EXP)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
telmisartan  (ISO)
terbufos  (EXP)
terbutaline  (EXP)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
theophylline  (EXP,ISO)
thiabendazole  (EXP)
thiazolidines  (ISO)
thioacetamide  (ISO)
thiophenes  (EXP)
thymoquinone  (ISO)
tiquizium bromide  (ISO)
titanium dioxide  (EXP,ISO)
trans-caffeic acid  (EXP,ISO)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tropisetron  (ISO)
tungsten  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (ISO)
Vinpocetine  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

References

References - curated
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Additional References at PubMed
PMID:1320128   PMID:1334087   PMID:1703177   PMID:2154223   PMID:2444596   PMID:2552418   PMID:2820530   PMID:2829220   PMID:2884926   PMID:2903767   PMID:2981589   PMID:3029127  
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PMID:8621627   PMID:8718890   PMID:9097926   PMID:9175709   PMID:9354683   PMID:9637725   PMID:10766826   PMID:10772654   PMID:10777476   PMID:10801811   PMID:10828600   PMID:11087769  
PMID:11090610   PMID:11147929   PMID:11161635   PMID:11179831   PMID:11423389   PMID:11434421   PMID:11705390   PMID:11774269   PMID:11794452   PMID:11811524   PMID:11813987   PMID:11840286  
PMID:11861298   PMID:11895912   PMID:11907569   PMID:11943609   PMID:11956078   PMID:11960308   PMID:11981455   PMID:11986950   PMID:12027420   PMID:12052532   PMID:12057865   PMID:12089442  
PMID:12111688   PMID:12135010   PMID:12164325   PMID:12209361   PMID:12355548   PMID:12393699   PMID:12397651   PMID:12432558   PMID:12460800   PMID:12477932   PMID:12496042   PMID:12496043  
PMID:12515618   PMID:12565898   PMID:12606047   PMID:12707270   PMID:12729191   PMID:12773517   PMID:12782337   PMID:12792137   PMID:12800195   PMID:12810834   PMID:12818404   PMID:12861032  
PMID:12915675   PMID:12946561   PMID:12950060   PMID:12952835   PMID:12969520   PMID:14617020   PMID:14626895   PMID:14646692   PMID:14668325   PMID:14716779   PMID:14729580   PMID:14730210  
PMID:14761515   PMID:14972011   PMID:15006595   PMID:15023809   PMID:15031357   PMID:15068388   PMID:15108282   PMID:15159316   PMID:15184258   PMID:15196853   PMID:15199549   PMID:15203186  
PMID:15222689   PMID:15255951   PMID:15299090   PMID:15304260   PMID:15331175   PMID:15350145   PMID:15379210   PMID:15492293   PMID:15504976   PMID:15507752   PMID:15507753   PMID:15507754  
PMID:15507759   PMID:15507760   PMID:15507769   PMID:15507770   PMID:15507771   PMID:15536330   PMID:15538122   PMID:15600254   PMID:15661916   PMID:15705913   PMID:15714076   PMID:15734083  
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PMID:16484808   PMID:16497665   PMID:16502470   PMID:16504169   PMID:16543247   PMID:16606792   PMID:16641309   PMID:16732739   PMID:16740002   PMID:16758302   PMID:16829688   PMID:16844322  
PMID:16901848   PMID:16956579   PMID:17017121   PMID:17042493   PMID:17119198   PMID:17145829   PMID:17149600   PMID:17159117   PMID:17161406   PMID:17178637   PMID:17209550   PMID:17259657  
PMID:17304047   PMID:17337886   PMID:17355643   PMID:17381162   PMID:17424838   PMID:17428572   PMID:17438335   PMID:17440118   PMID:17451207   PMID:17479404   PMID:17483704   PMID:17521322  
PMID:17549373   PMID:17582430   PMID:17595772   PMID:17601350   PMID:17613595   PMID:17650507   PMID:17701359   PMID:17704068   PMID:17726014   PMID:17767014   PMID:17855424   PMID:17869258  
PMID:17875305   PMID:17885617   PMID:17922231   PMID:17925548   PMID:17980933   PMID:18042261   PMID:18051367   PMID:18177875   PMID:18214807   PMID:18237195   PMID:18258609   PMID:18271379  
PMID:18273043   PMID:18280811   PMID:18296681   PMID:18314009   PMID:18322643   PMID:18331758   PMID:18340529   PMID:18344624   PMID:18359301   PMID:18435917   PMID:18440308   PMID:18441517  
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PMID:19646343   PMID:19651119   PMID:19651670   PMID:19692168   PMID:19726691   PMID:19729473   PMID:19729601   PMID:19735726   PMID:19752340   PMID:19758957   PMID:19761988   PMID:19788922  
PMID:19789190   PMID:19814685   PMID:19816870   PMID:19822138   PMID:19828014   PMID:19857655   PMID:19857676   PMID:19877306   PMID:19878569   PMID:19897513   PMID:19902075   PMID:19913121  
PMID:19916937   PMID:19963114   PMID:19995403   PMID:20007081   PMID:20026093   PMID:20032816   PMID:20043647   PMID:20064972   PMID:20080069   PMID:20091863   PMID:20136960   PMID:20146436  
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PMID:28281453   PMID:28328864   PMID:28339364   PMID:28348079   PMID:28397206   PMID:28466093   PMID:28514442   PMID:28575531   PMID:28602123   PMID:28645072   PMID:28675297   PMID:28682877  
PMID:28764808   PMID:28905321   PMID:29041000   PMID:29114094   PMID:29212118   PMID:29306105   PMID:29306874   PMID:29383971   PMID:29453088   PMID:29467282   PMID:29496995   PMID:29509190  
PMID:29540402   PMID:29577557   PMID:29585927   PMID:29590135   PMID:29614255   PMID:29618370   PMID:29631687   PMID:29875311   PMID:29937309   PMID:29970677   PMID:29975476   PMID:30021884  
PMID:30056589   PMID:30207165   PMID:30237127   PMID:30266105   PMID:30278820   PMID:30300402   PMID:30343390   PMID:30448568   PMID:30456985   PMID:30539859   PMID:30626536   PMID:30641731  
PMID:30726210   PMID:30824926   PMID:30938436   PMID:31175983   PMID:31236695   PMID:31247619   PMID:31341419   PMID:31343991   PMID:31358527   PMID:31531730   PMID:31536960   PMID:31653520  
PMID:31754972   PMID:31864385   PMID:31991297   PMID:32050431   PMID:32277104   PMID:32314165   PMID:32383462   PMID:32674726   PMID:32758447   PMID:32758448   PMID:32761433   PMID:32794199  
PMID:32814053   PMID:32928076   PMID:33023023   PMID:33027796   PMID:33228505   PMID:33285335   PMID:33460291   PMID:33569703  


Genomics

Comparative Map Data
MPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBI
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
Mpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,684,610 - 87,695,238 (+)NCBIGRCm39mm39
GRCm39 Ensembl1187,684,407 - 87,695,239 (+)Ensembl
GRCm381187,793,784 - 87,804,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,793,581 - 87,804,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,607,286 - 87,617,914 (+)NCBIGRCm37mm9NCBIm37
MGSCv361187,609,776 - 87,620,592 (+)NCBImm8
Celera1197,389,547 - 97,400,150 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.22NCBI
Mpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21072,594,458 - 72,608,862 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
Mpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,743,744 - 4,753,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,743,744 - 4,753,358 (+)NCBIChiLan1.0ChiLan1.0
MPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11757,189,654 - 57,212,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,201,073 - 57,212,111 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01752,333,882 - 52,357,838 (-)NCBIMhudiblu_PPA_v0panPan3
MPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,927,483 - 32,938,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,927,483 - 32,937,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,164,643 - 32,175,070 (-)NCBI
ROS_Cfam_1.0933,734,267 - 33,744,696 (-)NCBI
UMICH_Zoey_3.1932,520,407 - 32,530,846 (-)NCBI
UNSW_CanFamBas_1.0932,803,860 - 32,814,324 (-)NCBI
UU_Cfam_GSD_1.0932,897,366 - 32,907,792 (-)NCBI
Mpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,254,998 - 32,265,476 (-)NCBI
SpeTri2.0NW_0049364904,809,773 - 4,819,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,556,408 - 34,567,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,245,391 - 36,256,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,120,194 - 35,130,851 (+)NCBI
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)Ensembl
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBI
Mpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624871121,026 - 131,433 (-)NCBI

Position Markers
RH45018  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,251 - 56,347,395UniSTSGRCh37
Build 361753,702,250 - 53,702,394RGDNCBI36
Celera1752,809,029 - 52,809,173RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,047 - 51,708,191UniSTS
GeneMap99-GB4 RH Map17371.55UniSTS
GDB:178575  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,643 - 56,348,060UniSTSGRCh37
Build 361753,702,642 - 53,703,059RGDNCBI36
Celera1752,809,421 - 52,809,838RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,439 - 51,708,856UniSTS
GDB:180938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,357,310 - 56,357,854UniSTSGRCh37
Build 361753,712,309 - 53,712,853RGDNCBI36
Celera1752,819,080 - 52,819,624RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,717,980 - 51,718,524UniSTS
GDB:191092  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,348,149 - 56,348,482UniSTSGRCh37
Build 361753,703,148 - 53,703,481RGDNCBI36
Celera1752,809,927 - 52,810,260RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,945 - 51,709,278UniSTS
GDB:196134  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,693 - 56,347,997UniSTSGRCh37
Build 361753,702,692 - 53,702,996RGDNCBI36
Celera1752,809,471 - 52,809,775RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,489 - 51,708,793UniSTS
D17S1716  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,954 - 56,348,130UniSTSGRCh37
Build 361753,702,953 - 53,703,129RGDNCBI36
Celera1752,809,732 - 52,809,908RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,750 - 51,708,926UniSTS
Whitehead-YAC Contig Map17 UniSTS
STS-M19507  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,923 - 56,348,151UniSTSGRCh37
Build 361753,702,922 - 53,703,150RGDNCBI36
Celera1752,809,701 - 52,809,929RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,719 - 51,708,947UniSTS
GeneMap99-GB4 RH Map17375.3UniSTS
D17S1975  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371756,347,796 - 56,347,927UniSTSGRCh37
Build 361753,702,795 - 53,702,926RGDNCBI36
Celera1752,809,574 - 52,809,705RGD
Cytogenetic Map17q23.1UniSTS
HuRef1751,708,592 - 51,708,723UniSTS
Stanford-G3 RH Map172431.0UniSTS
NCBI RH Map17654.6UniSTS
GeneMap99-G3 RH Map172932.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2005
Count of miRNA genes:798
Interacting mature miRNAs:956
Transcripts:ENST00000225275, ENST00000340482, ENST00000577220, ENST00000578493, ENST00000580005, ENST00000581022
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 4 18 2
Medium 1 460 30 33 611 19 6 9 7 6 216 13 4 5
Low 477 1005 722 230 582 106 906 867 2626 63 627 725 126 1 462 671 4
Below cutoff 1854 1460 857 272 451 251 3160 1271 992 227 690 491 26 727 2013 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_009629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A08802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ088846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB659828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB659830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY271122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S65785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z37728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000225275   ⟹   ENSP00000225275
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,269,855 - 58,280,935 (-)Ensembl
RefSeq Acc Id: ENST00000577220   ⟹   ENSP00000464668
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,270,729 - 58,273,492 (-)Ensembl
RefSeq Acc Id: ENST00000578493
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,275,571 - 58,278,119 (-)Ensembl
RefSeq Acc Id: ENST00000580005
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,279,876 - 58,280,687 (-)Ensembl
RefSeq Acc Id: ENST00000581022
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1758,278,837 - 58,279,399 (-)Ensembl
RefSeq Acc Id: NM_000250   ⟹   NP_000241
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381758,269,855 - 58,280,935 (-)NCBI
GRCh371756,347,217 - 56,358,296 (-)ENTREZGENE
Build 361753,702,216 - 53,713,295 (-)NCBI Archive
HuRef1751,708,013 - 51,718,966 (-)ENTREZGENE
CHM1_11756,412,238 - 56,423,315 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000241   ⟸   NM_000250
- Peptide Label: precursor
- UniProtKB: P05164 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000464668   ⟸   ENST00000577220
RefSeq Acc Id: ENSP00000225275   ⟸   ENST00000225275

Promoters
RGD ID:6811257
Promoter ID:HG_ACW:35487
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:MPO.BAPR07,   MPO.CAPR07,   MPO.FAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361753,711,906 - 53,712,406 (-)MPROMDB
RGD ID:6794336
Promoter ID:HG_KWN:26678
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000340482,   NM_000250
Position:
Human AssemblyChrPosition (strand)Source
Build 361753,713,206 - 53,714,207 (-)MPROMDB
RGD ID:7235795
Promoter ID:EPDNEW_H23643
Type:initiation region
Name:MPO_1
Description:myeloperoxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381758,280,935 - 58,280,995EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000250.2(MPO):c.1705C>T (p.Arg569Trp) single nucleotide variant Myeloperoxidase deficiency [RCV000003810]|not provided [RCV000366635] Chr17:58272835 [GRCh38]
Chr17:56350196 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.518A>G (p.Tyr173Cys) single nucleotide variant Myeloperoxidase deficiency [RCV000003811] Chr17:58279553 [GRCh38]
Chr17:56356914 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.752T>C (p.Met251Thr) single nucleotide variant Myeloperoxidase deficiency [RCV000003812] Chr17:58279141 [GRCh38]
Chr17:56356502 [GRCh37]
Chr17:17q22
pathogenic|uncertain significance
NM_000250.2(MPO):c.1555_1568del (p.Met519fs) deletion Myeloperoxidase deficiency [RCV000003813]|not provided [RCV000274466] Chr17:58273467..58273480 [GRCh38]
Chr17:56350828..56350841 [GRCh37]
Chr17:17q22
pathogenic|likely pathogenic|conflicting interpretations of pathogenicity
NM_000250.2(MPO):c.995C>T (p.Ala332Val) single nucleotide variant Myeloperoxidase deficiency [RCV000003814] Chr17:58278036 [GRCh38]
Chr17:56355397 [GRCh37]
Chr17:17q22
pathogenic|conflicting interpretations of pathogenicity|uncertain significance
NM_000250.2(MPO):c.1715T>G (p.Leu572Trp) single nucleotide variant Myeloperoxidase deficiency [RCV000003815] Chr17:58272825 [GRCh38]
Chr17:56350186 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.2031-2A>C single nucleotide variant Myeloperoxidase deficiency [RCV000003816]|not provided [RCV000265536] Chr17:58270865 [GRCh38]
Chr17:56348226 [GRCh37]
Chr17:17q22
pathogenic|likely pathogenic
NG_009629.1:g.4535G>A single nucleotide variant Alzheimer disease, susceptibility to [RCV000003817]|Lung cancer, protection against, in smokers [RCV000003818] Chr17:58281401 [GRCh38]
Chr17:56358762 [GRCh37]
Chr17:17q22
risk factor|protective
NM_000250.2(MPO):c.1501G>A (p.Gly501Ser) single nucleotide variant Myeloperoxidase deficiency [RCV000003819] Chr17:58273534 [GRCh38]
Chr17:56350895 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.1495C>T (p.Arg499Cys) single nucleotide variant Myeloperoxidase deficiency [RCV000003820] Chr17:58273540 [GRCh38]
Chr17:56350901 [GRCh37]
Chr17:17q22
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
NM_000250.2(MPO):c.1621+2T>C single nucleotide variant not provided [RCV000519053] Chr17:58273412 [GRCh38]
Chr17:56350773 [GRCh37]
Chr17:17q22
likely pathogenic
NM_000250.2(MPO):c.110T>C (p.Leu37Pro) single nucleotide variant not provided [RCV000520642] Chr17:58280649 [GRCh38]
Chr17:56358010 [GRCh37]
Chr17:17q22
uncertain significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
NM_000250.1(MPO):c.396C>T (p.Ser132=) single nucleotide variant Malignant melanoma [RCV000071582] Chr17:58279867 [GRCh38]
Chr17:56357228 [GRCh37]
Chr17:53712227 [NCBI36]
Chr17:17q22
not provided
NM_000250.1(MPO):c.395C>T (p.Ser132Phe) single nucleotide variant Malignant melanoma [RCV000071583] Chr17:58279868 [GRCh38]
Chr17:56357229 [GRCh37]
Chr17:53712228 [NCBI36]
Chr17:17q22
not provided
NM_001160102.1(LPO):c.1431C>T (p.Asp477=) single nucleotide variant Malignant melanoma [RCV000071581] Chr17:58266313 [GRCh38]
Chr17:56343674 [GRCh37]
Chr17:53698673 [NCBI36]
Chr17:17q22
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q22-23.1(chr17:57418806-59735464)x1 copy number loss See cases [RCV000140211] Chr17:57418806..59735464 [GRCh38]
Chr17:55496167..57812825 [GRCh37]
Chr17:52851166..55167607 [NCBI36]
Chr17:17q22-23.1
pathogenic
NM_000250.1(MPO):c.2031-2A>C single nucleotide variant Myeloperoxidase deficiency [RCV000169667] Chr17:58270865 [GRCh38]
Chr17:56348226 [GRCh37]
pathogenic
GRCh37/hg19 17q22(chr17:55916829-56770618)x1 copy number loss See cases [RCV000239996] Chr17:55916829..56770618 [GRCh37]
Chr17:17q22
likely pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3
pathogenic
NM_000250.2(MPO):c.1281del (p.Thr428fs) deletion not provided [RCV000519860] Chr17:58275626 [GRCh38]
Chr17:56352987 [GRCh37]
Chr17:17q22
likely pathogenic
NM_000250.2(MPO):c.604G>T (p.Glu202Ter) single nucleotide variant not provided [RCV000578983] Chr17:58279371 [GRCh38]
Chr17:56356732 [GRCh37]
Chr17:17q22
pathogenic|likely pathogenic
GRCh37/hg19 17q22(chr17:52189051-57477162)x3 copy number gain See cases [RCV000448801] Chr17:52189051..57477162 [GRCh37]
Chr17:17q22
pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
NM_000250.2(MPO):c.2031-6A>C single nucleotide variant not specified [RCV000455269] Chr17:58270869 [GRCh38]
Chr17:56348230 [GRCh37]
Chr17:17q22
benign
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_000250.2(MPO):c.234G>A (p.Lys78=) single nucleotide variant not provided [RCV000973561] Chr17:58280380 [GRCh38]
Chr17:56357741 [GRCh37]
Chr17:17q22
likely benign
NM_000250.2(MPO):c.1410G>A (p.Thr470=) single nucleotide variant not provided [RCV000972922] Chr17:58273625 [GRCh38]
Chr17:56350986 [GRCh37]
Chr17:17q22
benign
NM_000250.2(MPO):c.1365+7C>T single nucleotide variant not provided [RCV000901183] Chr17:58275535 [GRCh38]
Chr17:56352896 [GRCh37]
Chr17:17q22
likely benign
NM_000250.2(MPO):c.1810C>T (p.Arg604Cys) single nucleotide variant not provided [RCV000901330] Chr17:58271875 [GRCh38]
Chr17:56349236 [GRCh37]
Chr17:17q22
likely benign
NM_000250.2(MPO):c.696C>G (p.Asn232Lys) single nucleotide variant not provided [RCV000996587] Chr17:58279197 [GRCh38]
Chr17:56356558 [GRCh37]
Chr17:17q22
uncertain significance
NM_000250.2(MPO):c.1377C>T (p.Tyr459=) single nucleotide variant not provided [RCV000962528] Chr17:58273658 [GRCh38]
Chr17:56351019 [GRCh37]
Chr17:17q22
benign
NM_000250.2(MPO):c.172G>A (p.Asp58Asn) single nucleotide variant not provided [RCV000906220] Chr17:58280442 [GRCh38]
Chr17:56357803 [GRCh37]
Chr17:17q22
benign
NM_000250.2(MPO):c.2133C>T (p.Thr711=) single nucleotide variant not provided [RCV000881823] Chr17:58270761 [GRCh38]
Chr17:56348122 [GRCh37]
Chr17:17q22
benign
NM_000250.2(MPO):c.315G>A (p.Pro105=) single nucleotide variant not provided [RCV000886886] Chr17:58279948 [GRCh38]
Chr17:56357309 [GRCh37]
Chr17:17q22
likely benign
NM_000250.2(MPO):c.1379G>A (p.Arg460Gln) single nucleotide variant not provided [RCV000890999] Chr17:58273656 [GRCh38]
Chr17:56351017 [GRCh37]
Chr17:17q22
likely benign
NM_000250.2(MPO):c.2187C>T (p.Asn729=) single nucleotide variant not provided [RCV000957639] Chr17:58270707 [GRCh38]
Chr17:56348068 [GRCh37]
Chr17:17q22
benign
NM_000250.2(MPO):c.1365+7C>G single nucleotide variant not provided [RCV000957967] Chr17:58275535 [GRCh38]
Chr17:56352896 [GRCh37]
Chr17:17q22
benign
NM_000250.2(MPO):c.1031G>A (p.Gly344Asp) single nucleotide variant Alzheimer disease [RCV001198130] Chr17:58278000 [GRCh38]
Chr17:56355361 [GRCh37]
Chr17:17q22
uncertain significance
NM_000250.2(MPO):c.-56C>T single nucleotide variant Hereditary angioedema with normal C1Inh [RCV001027426] Chr17:58280814 [GRCh38]
Chr17:56358175 [GRCh37]
Chr17:17q22
not provided
NM_000250.2(MPO):c.886-2A>G single nucleotide variant Myeloperoxidase deficiency [RCV001333310] Chr17:58278147 [GRCh38]
Chr17:56355508 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.249-2A>G single nucleotide variant Myeloperoxidase deficiency [RCV001292655] Chr17:58280016 [GRCh38]
Chr17:56357377 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.1783G>A (p.Gly595Ser) single nucleotide variant Myeloperoxidase deficiency [RCV001290209] Chr17:58272757 [GRCh38]
Chr17:56350118 [GRCh37]
Chr17:17q22
pathogenic
NM_000250.2(MPO):c.308AGC[1] (p.Gln104del) microsatellite not provided [RCV001310373] Chr17:58279950..58279952 [GRCh38]
Chr17:56357311..56357313 [GRCh37]
Chr17:17q22
uncertain significance
NM_000250.2(MPO):c.2047G>C (p.Glu683Gln) single nucleotide variant not provided [RCV001355756] Chr17:58270847 [GRCh38]
Chr17:56348208 [GRCh37]
Chr17:17q22
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7218 AgrOrtholog
COSMIC MPO COSMIC
Ensembl Genes ENSG00000005381 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000225275 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000464668 UniProtKB/TrEMBL
Ensembl Transcript ENST00000225275 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000577220 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000005381 GTEx
HGNC ID HGNC:7218 ENTREZGENE
Human Proteome Map MPO Human Proteome Map
InterPro Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4353 UniProtKB/Swiss-Prot
NCBI Gene 4353 ENTREZGENE
OMIM 104300 OMIM
  254600 OMIM
  606989 OMIM
PANTHER PTHR11475:SF108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot
PharmGKB MPO RGD, PharmGKB
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot
PROSITE PEROXIDASE_1 UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt J3QSF7_HUMAN UniProtKB/TrEMBL
  P05164 ENTREZGENE, UniProtKB/Swiss-Prot
  Q16771_HUMAN UniProtKB/TrEMBL
UniProt Secondary A1L4B8 UniProtKB/Swiss-Prot
  Q14862 UniProtKB/Swiss-Prot
  Q4PJH5 UniProtKB/Swiss-Prot
  Q9UCL7 UniProtKB/Swiss-Prot