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Gene: FEN1 (flap structure-specific endonuclease 1) Homo sapiens
Symbol: FEN1
Name: flap structure-specific endonuclease 1
Description: Exhibits DNA binding activity and nuclease activity. Involved in DNA replication, removal of RNA primer; nucleic acid phosphodiester bond hydrolysis; and positive regulation of sister chromatid cohesion. Localizes to mitochondrion; nuclear lumen; and protein-containing complex. Colocalizes with nuclear chromosome, telomeric region. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNase IV; FEN-1; flap endonuclease 1; hFEN-1; maturation factor 1; maturation factor-1; MF1; RAD2
Mus musculus (house mouse) : Fen1 (flap structure specific endonuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fen1 (flap structure-specific endonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fen1 (flap structure-specific endonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FEN1 (flap structure-specific endonuclease 1)
Canis lupus familiaris (dog) : FEN1 (flap structure-specific endonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fen1 (flap structure-specific endonuclease 1)
Sus scrofa (pig) : FEN1 (flap structure-specific endonuclease 1)
Chlorocebus sabaeus (African green monkey) : FEN1 (flap structure-specific endonuclease 1)
Heterocephalus glaber (naked mole-rat) : Fen1 (flap structure-specific endonuclease 1)
more info ...
Related Pseudogenes: FEN1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1161,792,911 - 61,797,238 (+)EnsemblGRCh38hg38GRCh38
GRCh381161,792,911 - 61,797,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,560,109 - 61,564,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,316,726 - 61,321,286 (+)NCBINCBI36hg18NCBI36
Build 341161,316,725 - 61,321,284NCBI
Celera1158,895,562 - 58,900,122 (+)NCBI
Cytogenetic Map11q12.2NCBI
HuRef1157,888,343 - 57,892,951 (+)NCBIHuRef
CHM1_11161,443,324 - 61,447,931 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FEN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732679
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.