IL1RN (interleukin 1 receptor antagonist) - Rat Genome Database

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Gene: IL1RN (interleukin 1 receptor antagonist) Homo sapiens
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Symbol: IL1RN
Name: interleukin 1 receptor antagonist
RGD ID: 1344540
HGNC Page HGNC
Description: Exhibits cytokine receptor binding activity. Involved in several processes, including acute-phase response; negative regulation of heterotypic cell-cell adhesion; and negative regulation of interleukin-1-mediated signaling pathway. Localizes to extracellular space. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); chronic kidney disease (multiple); lung disease (multiple); myositis (multiple); and obesity (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1 inhibitor; IL1F3; IL1RA; IL1RN (IL1F3); interleukin-1 receptor antagonist protein; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); IRAP; MGC10430; MVCD4; type II interleukin-1 receptor antagonist
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2113,107,214 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh382113,099,365 - 113,134,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,875,548 - 113,891,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abscess  (IDA)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (EXP,IMP)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (IDA)
adult respiratory distress syndrome  (IEP,ISO)
allergic conjunctivitis  (IDA)
alopecia areata  (IAGP)
Anorexia  (EXP,ISO)
anterior uveitis  (IMP)
anthracosis  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
Arsenic Poisoning  (EXP)
asthma  (EXP,IAGP,IEP,IMP)
Atrophy  (EXP)
autistic disorder  (EXP)
autoimmune thrombocytopenic purpura  (IAGP)
autosomal dominant polycystic kidney disease  (IEP)
B-Cell Chronic Lymphocytic Leukemia  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (IEP)
Brain Injuries  (EXP)
brain ischemia  (EXP)
Bronchial Hyperreactivity  (EXP,IDA)
bronchiolitis  (IEP)
bronchiolitis obliterans  (IEP)
Bronchopulmonary Dysplasia  (IAGP,IEP)
bronchus carcinoma  (IEP)
Cachexia  (ISO)
calcium oxalate nephrolithiasis  (IAGP)
cardiovascular system disease  (EXP)
Carotid Artery Injuries  (IMP)
Cerebral Hemorrhage  (IMP,ISO)
cerebrovascular disease  (EXP)
chronic kidney disease  (IAGP,IEP)
chronic myeloid leukemia  (IEP)
chronic obstructive pulmonary disease  (IAGP,IEP)
Chronic Rhinosinusitis  (IAGP)
Chronic Uveitis  (IEP)
cicatricial pemphigoid  (IEP)
Colonic Neoplasms  (EXP)
common cold  (IDA,IEP)
Corneal Graft Rejection  (IMP)
corneal neovascularization  (IDA,ISO)
COVID-19  (HEP)
crescentic glomerulonephritis  (IDA)
Cryopyrin-Associated Periodic Syndromes  (IDA)
cystic fibrosis  (IEP)
dacryocystitis  (IDA)
Deficiency of Interleukin-1 Receptor Antagonist  (IAGP)
diabetic angiopathy  (IAGP)
Diabetic Nephropathies  (IAGP)
diarrhea  (EXP)
Drug Hypersensitivity Syndrome  (IAGP)
Drug-Induced Agranulocytosis  (IEP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
dry eye syndrome  (IEP)
encephalitis  (ISO)
end stage renal disease  (IAGP,IEP)
Endotoxemia  (IDA,ISO)
Endotoxin-Induced Uveitis  (ISO)
exanthem  (EXP)
Experimental Arthritis  (IDA,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (IDA)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IMP,ISO)
Extravasation of Diagnostic and Therapeutic Materials  (EXP)
Eye Manifestations  (IEP)
Febrile Seizures  (IDA)
Fever  (EXP,ISO)
fibromyalgia  (IEP)
Fibrosis  (EXP)
glomerulonephritis  (IDA,ISO)
gout  (EXP)
Graft vs Host Disease  (IDA)
Graves Ophthalmopathy  (IAGP,IEP)
hairy cell leukemia  (IEP)
hemolytic-uremic syndrome  (IDA,IEP)
Henoch-Schoenlein purpura  (IAGP)
hepatocellular carcinoma  (EXP)
hereditary diffuse gastric cancer  (IAGP)
herpes simplex virus keratitis  (IDA)
Human Influenza  (IDA,IEP)
Hyperalgesia  (EXP,IDA,ISO)
hyperglycemia  (IEP)
hypertension  (IAGP,ISO)
idiopathic pulmonary fibrosis  (IAGP)
IgA glomerulonephritis  (IAGP,IDA,IEP,ISO)
Inflammation  (EXP,ISO)
inflammatory bowel disease  (IMP)
interstitial lung disease  (IEP)
juvenile rheumatoid arthritis  (EXP)
keratoconus  (IAGP)
kidney disease  (EXP)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (EXP,IDA)
Leukocytosis  (IDA)
Lichen Sclerosus et Atrophicus  (IAGP)
listeriosis  (IDA)
Liver Reperfusion Injury  (IDA,ISO)
lung non-small cell carcinoma  (IAGP)
lupus nephritis  (IEP)
Mammary Neoplasms, Experimental  (IDA)
Meibomian Gland Dysfunction  (IEP)
melanoma  (IDA)
mental depression  (IDA)
middle cerebral artery infarction  (IMP)
morbid obesity  (IEP)
Muckle-Wells syndrome  (IDA)
mucositis  (EXP)
multiple myeloma  (IAGP)
Multiple Organ Failure  (IDA,IEP)
multiple sclerosis  (EXP)
myocardial infarction  (EXP)
Myocardial Reperfusion Injury  (IDA)
myositis  (EXP,IEP)
Necrosis  (EXP)
Neoplasm Invasiveness  (EXP)
nephrotic syndrome  (IAGP)
non-alcoholic fatty liver disease  (IEP)
obesity  (IEP,ISO)
Oligoanuria  (IEP)
osteoporosis  (IDA)
Pain  (EXP)
periodontitis  (IAGP,IEP)
pleural disease  (IEP)
pleural tuberculosis  (IAGP)
pleurisy  (IDA)
pneumonia  (HEP,IAGP,IDA,ISO)
Postoperative Cognitive Dysfunction  (IDA)
pre-eclampsia  (IEP)
Proctocolitis  (IEP)
Prostatic Neoplasms  (EXP)
prostatitis  (ISO)
proteinuria  (EXP,IAGP)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (IEP)
pulmonary eosinophilia  (IEP)
pulmonary fibrosis  (EXP,IAGP,IEP)
pulmonary hypertension  (IDA)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IDA,IEP)
pyelonephritis  (IEP)
renal cell carcinoma  (IDA)
respiratory allergy  (ISO)
rheumatoid arthritis  (EXP,IDA,ISO)
rhinitis  (IAGP,IEP)
Schnitzler syndrome  (EXP,IDA)
sciatic neuropathy  (IDA)
Sclerosis  (EXP)
Sepsis  (IAGP,IDA,IEP,ISO)
Serositis  (IAGP)
silicosis  (IAGP,ISO)
Sjogren's syndrome  (IAGP,IEP)
skin disease  (EXP)
Spinal Cord Injuries  (IEP,ISO)
status epilepticus  (EXP)
Stomach Neoplasms  (EXP)
Stroke  (EXP,IDA)
Subarachnoid Hemorrhage  (IDA)
systemic lupus erythematosus  (IAGP,IEP)
Tobacco Use Disorder  (IDA)
toxic shock syndrome  (IAGP,IMP)
transient cerebral ischemia  (IDA,ISO)
Transplant Rejection  (IDA)
type 1 diabetes mellitus  (IDA,IEP)
type 2 diabetes mellitus  (IAGP)
ulcerative colitis  (IAGP)
ureteral obstruction  (IDA,ISO)
urinary bladder cancer  (IAGP)
Urinary Calculi  (IAGP)
Uveitis, Chronic Anterior  (IAGP)
vascular disease  (IDA)
Venous Thrombosis  (IAGP)
Ventilator-Induced Lung Injury  (ISO)
Viral Bronchiolitis  (IAGP)
viral pneumonia  (HEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dichloroaniline  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
acetamide  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinyl palmitate  (EXP)
alpha-naphthoflavone  (EXP)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
azathioprine  (EXP)
beclomethasone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
celastrol  (EXP)
ceric oxide  (ISO)
cholesterol  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dioxygen  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
gedunin  (EXP)
Genipin  (ISO)
genistein  (ISO)
glafenine  (ISO)
glucose  (ISO)
glycidol  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
ibuprofen  (EXP,ISO)
indometacin  (EXP)
ionomycin  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lenalidomide  (ISO)
lipopolysaccharide  (EXP,ISO)
malonaldehyde  (EXP)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methacholine chloride  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
methyltestosterone  (EXP)
Mofezolac (TN)  (EXP)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
paricalcitol  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctanoic acid  (ISO)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
potassium dichromate  (ISO)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rotenone  (ISO)
scopolamine  (ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
urethane  (EXP)
wortmannin  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal renal morphology  (IAGP)
Abnormality of bladder morphology  (IAGP)
Abnormality of the immune system  (IAGP)
Abnormality of the skin  (IAGP)
Abnormality of the urinary system  (IAGP)
Abnormality of urine homeostasis  (IAGP)
Abscess  (IAGP)
Acquired abnormal hair pattern  (IAGP)
Albuminuria  (IAGP)
Alopecia universalis  (IAGP)
Antinuclear antibody positivity  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Broad ribs  (IAGP)
Chronic atrophic gastritis  (IAGP)
Cleft palate  (IAGP)
Cleft upper lip  (IAGP)
Decreased glomerular filtration rate  (IAGP)
Elevated C-reactive protein level  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Elevated serum creatinine  (IAGP)
Epidermal acanthosis  (IAGP)
Failure to thrive in infancy  (IAGP)
Fetal distress  (IAGP)
Flaring of rib cage  (IAGP)
Fused cervical vertebrae  (IAGP)
Generalized edema  (IAGP)
Heavy proteinuria  (IAGP)
Hematuria  (IAGP)
Hepatomegaly  (IAGP)
Hypercholesterolemia  (IAGP)
Hyperglycemia  (IAGP)
Hyperkeratosis  (IAGP)
Hypoalbuminemia  (IAGP)
Increased inflammatory response  (IAGP)
Inflammation of the large intestine  (IAGP)
Joint swelling  (IAGP)
Motor delay  (IAGP)
Multiple myeloma  (IAGP)
Neonatal onset  (IAGP)
Neutrophilia  (IAGP)
Osteolysis  (IAGP)
Osteomyelitis  (IAGP)
Osteopenia  (IAGP)
Periodontitis  (IAGP)
Periostitis  (IAGP)
Proteinuria  (IAGP)
Pulmonary fibrosis  (IAGP)
Pustule  (IAGP)
Respiratory distress  (IAGP)
Skin rash  (IAGP)
Small for gestational age  (IAGP)
Splenomegaly  (IAGP)
Stomach cancer  (IAGP)
Stomatitis  (IAGP)
References

References - curated
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PMID:17074546   PMID:17083033   PMID:17096351   PMID:17113632   PMID:17114844   PMID:17115419   PMID:17174563   PMID:17177339   PMID:17182583   PMID:17207379   PMID:17222831   PMID:17235630  
PMID:17256873   PMID:17257312   PMID:17290743   PMID:17292896   PMID:17295877   PMID:17309751   PMID:17314118   PMID:17324969   PMID:17327408   PMID:17332449   PMID:17335371   PMID:17348243  
PMID:17351514   PMID:17359523   PMID:17373677   PMID:17380888   PMID:17388919   PMID:17391700   PMID:17443229   PMID:17444587   PMID:17444864   PMID:17446060   PMID:17448214   PMID:17453104  
PMID:17454884   PMID:17459217   PMID:17482260   PMID:17483707   PMID:17532232   PMID:17548705   PMID:17572155   PMID:17584583   PMID:17592300   PMID:17593860   PMID:17607501   PMID:17607547  
PMID:17610660   PMID:17611547   PMID:17611673   PMID:17618436   PMID:17627763   PMID:17640324   PMID:17645476   PMID:17656565   PMID:17703412   PMID:17716546   PMID:17760842   PMID:17846855  
PMID:17847930   PMID:17867984   PMID:17899305   PMID:17900737   PMID:17903994   PMID:17907045   PMID:17914732   PMID:17948066   PMID:17959519   PMID:17963170   PMID:17964974   PMID:17993728  
PMID:18008080   PMID:18029348   PMID:18038187   PMID:18047563   PMID:18052703   PMID:18052726   PMID:18063673   PMID:18069935   PMID:18086767   PMID:18165865   PMID:18180150   PMID:18239554  
PMID:18243027   PMID:18271063   PMID:18272394   PMID:18278133   PMID:18288276   PMID:18288454   PMID:18299273   PMID:18321309   PMID:18322311   PMID:18329282   PMID:18332090   PMID:18333945  
PMID:18336824   PMID:18354254   PMID:18361937   PMID:18385937   PMID:18386294   PMID:18389618   PMID:18396210   PMID:18416755   PMID:18423886   PMID:18451331   PMID:18455629   PMID:18464913  
PMID:18468936   PMID:18471873   PMID:18484169   PMID:18484691   PMID:18494930   PMID:18496214   PMID:18545091   PMID:18551993   PMID:18565646   PMID:18572364   PMID:18581280   PMID:18583979  
PMID:18589098   PMID:18597398   PMID:18624935   PMID:18632425   PMID:18633131   PMID:18665932   PMID:18666137   PMID:18676680   PMID:18688110   PMID:18702109   PMID:18703194   PMID:18715339  
PMID:18723088   PMID:18728809   PMID:18754838   PMID:18761558   PMID:18771989   PMID:18773331   PMID:18779738   PMID:18782283   PMID:18805892   PMID:18807132   PMID:18808736   PMID:18810365  
PMID:18814951   PMID:18815552   PMID:18818748   PMID:18821666   PMID:18832862   PMID:18853133   PMID:18940468   PMID:18942754   PMID:18987561   PMID:19004046   PMID:19009622   PMID:19012493  
PMID:19013788   PMID:19019335   PMID:19026124   PMID:19026700   PMID:19030199   PMID:19031173   PMID:19046297   PMID:19053923   PMID:19056867   PMID:19058789   PMID:19066720   PMID:19073760  
PMID:19074885   PMID:19076825   PMID:19086955   PMID:19102413   PMID:19111743   PMID:19117745   PMID:19125864   PMID:19127455   PMID:19129082   PMID:19132772   PMID:19134476   PMID:19135625  
PMID:19141860   PMID:19142372   PMID:19151976   PMID:19170196   PMID:19191798   PMID:19203086   PMID:19247692   PMID:19258032   PMID:19267917   PMID:19269948   PMID:19272615   PMID:19290009  
PMID:19290417   PMID:19295440   PMID:19322919   PMID:19332120   PMID:19334424   PMID:19336370   PMID:19336475   PMID:19338208   PMID:19347053   PMID:19375283   PMID:19399323   PMID:19408823  
PMID:19418669   PMID:19419456   PMID:19427781   PMID:19431193   PMID:19453261   PMID:19470040   PMID:19494218   PMID:19495883   PMID:19497711   PMID:19505916   PMID:19505919   PMID:19506726  
PMID:19527514   PMID:19544559   PMID:19544973   PMID:19550417   PMID:19573080   PMID:19574724   PMID:19594368   PMID:19603010   PMID:19607807   PMID:19618316   PMID:19625176   PMID:19638314  
PMID:19643686   PMID:19644155   PMID:19664671   PMID:19683555   PMID:19684156   PMID:19692168   PMID:19701653   PMID:19706048   PMID:19711225   PMID:19729601   PMID:19733643   PMID:19733878  
PMID:19764937   PMID:19773279   PMID:19804405   PMID:19811432   PMID:19811433   PMID:19811434   PMID:19818512   PMID:19820020   PMID:19822419   PMID:19822442   PMID:19839644   PMID:19844779  
PMID:19850242   PMID:19860911   PMID:19876593   PMID:19889076   PMID:19892918   PMID:19904560   PMID:19909950   PMID:19913121   PMID:19925477   PMID:19930406   PMID:19934104   PMID:19948975  
PMID:20002810   PMID:20005085   PMID:20012999   PMID:20032313   PMID:20034444   PMID:20056442   PMID:20070880   PMID:20080142   PMID:20087638   PMID:20092400   PMID:20113413   PMID:20131253  
PMID:20140262   PMID:20141484   PMID:20169140   PMID:20175886   PMID:20178882   PMID:20185814   PMID:20188863   PMID:20192980   PMID:20193596   PMID:20196868   PMID:20200422   PMID:20207250  
PMID:20213229   PMID:20213597   PMID:20237151   PMID:20237496   PMID:20301318   PMID:20305143   PMID:20334849   PMID:20335539   PMID:20347268   PMID:20353565   PMID:20364673   PMID:20378664  
PMID:20379614   PMID:20399384   PMID:20400062   PMID:20412719   PMID:20427258   PMID:20450372   PMID:20452482   PMID:20453000   PMID:20463618   PMID:20467172   PMID:20472930   PMID:20482626  
PMID:20484876   PMID:20485444   PMID:20486195   PMID:20495422   PMID:20503287   PMID:20536609   PMID:20564140   PMID:20568250   PMID:20581747   PMID:20592454   PMID:20595916   PMID:20603050  
PMID:20621920   PMID:20628086   PMID:20630038   PMID:20631624   PMID:20650788   PMID:20654748   PMID:20673868   PMID:20709104   PMID:20734064   PMID:20800651   PMID:20802378   PMID:20837746  
PMID:20839488   PMID:20863445   PMID:20880168   PMID:20880945   PMID:20934174   PMID:20940514   PMID:20942594   PMID:20975573   PMID:21035110   PMID:21037510   PMID:21044950   PMID:21048327  
PMID:21049406   PMID:21054807   PMID:21086908   PMID:21111725   PMID:21174170   PMID:21182747   PMID:21235388   PMID:21241861   PMID:21243433   PMID:21248262   PMID:21265111   PMID:21278303  
PMID:21357189   PMID:21394384   PMID:21455057   PMID:21523343   PMID:21558284   PMID:21575667   PMID:21591983   PMID:21621860   PMID:21655939   PMID:21671260   PMID:21768915   PMID:21848462  
PMID:21873635   PMID:21968104   PMID:21980458   PMID:22032624   PMID:22035161   PMID:22059992   PMID:22127713   PMID:22205395   PMID:22267087   PMID:22285242   PMID:22286731   PMID:22312160  
PMID:22322675   PMID:22327782   PMID:22370044   PMID:22431772   PMID:22455686   PMID:22498095   PMID:22537067   PMID:22744645   PMID:22753384   PMID:22829643   PMID:22882407   PMID:22909148  
PMID:22939635   PMID:22948742   PMID:23009887   PMID:23013217   PMID:23028694   PMID:23049596   PMID:23049925   PMID:23053980   PMID:23122308   PMID:23168096   PMID:23192617   PMID:23195019  
PMID:23212299   PMID:23251650   PMID:23251661   PMID:23308180   PMID:23323013   PMID:23363559   PMID:23376485   PMID:23388595   PMID:23406623   PMID:23449693   PMID:23472661   PMID:23499887  
PMID:23554905   PMID:23562526   PMID:23577098   PMID:23584371   PMID:23592003   PMID:23602199   PMID:23602982   PMID:23609451   PMID:23633206   PMID:23743874   PMID:23749763   PMID:23765978  
PMID:23800434   PMID:23818854   PMID:23823136   PMID:23849770   PMID:23953530   PMID:23954849   PMID:23969696   PMID:23991111   PMID:23999825   PMID:24014495   PMID:24055697   PMID:24162774  
PMID:24182552   PMID:24233813   PMID:24274595   PMID:24322806   PMID:24446526   PMID:24446657   PMID:24465880   PMID:24490166   PMID:24504887   PMID:24534280   PMID:24557417   PMID:24563688  
PMID:24588341   PMID:24592969   PMID:24603878   PMID:24611340   PMID:24680088   PMID:24771848   PMID:24819208   PMID:24840811   PMID:24850227   PMID:24905619   PMID:24918527   PMID:24933945  
PMID:24952603   PMID:24969107   PMID:24998848   PMID:25073651   PMID:25080789   PMID:25089931   PMID:25124963   PMID:25174605   PMID:25201247   PMID:25207923   PMID:25223242   PMID:25286391  
PMID:25292060   PMID:25331947   PMID:25422100   PMID:25461401   PMID:25466956   PMID:25500257   PMID:25530139   PMID:25542762   PMID:25616863   PMID:25726324   PMID:25738940   PMID:25821855  
PMID:25826984   PMID:26003199   PMID:26046681   PMID:26097611   PMID:26101331   PMID:26158606   PMID:26186194   PMID:26269955   PMID:26279136   PMID:26316104   PMID:26330006   PMID:26445016  
PMID:26449434   PMID:26474296   PMID:26487586   PMID:26500244   PMID:26502861   PMID:26521731   PMID:26555681   PMID:26610735   PMID:26612588   PMID:26646252   PMID:26654556   PMID:26813462  
PMID:26831858   PMID:26861613   PMID:26972847   PMID:26994310   PMID:27031441   PMID:27061312   PMID:27105431   PMID:27116880   PMID:27138824   PMID:27340011   PMID:27400406   PMID:27432980  
PMID:27436278   PMID:27538648   PMID:27717726   PMID:27769857   PMID:28083609   PMID:28110439   PMID:28129679   PMID:28252571   PMID:28293435   PMID:28296777   PMID:28342152   PMID:28370589  
PMID:28383060   PMID:28384207   PMID:28405733   PMID:28428221   PMID:28514442   PMID:28593919   PMID:28612927   PMID:28682145   PMID:28972805   PMID:29023524   PMID:29047186   PMID:29117667  
PMID:29169428   PMID:29226727   PMID:29235261   PMID:29281611   PMID:29339698   PMID:29395365   PMID:29425823   PMID:29454070   PMID:29620037   PMID:29718011   PMID:29802240   PMID:29943912  
PMID:29949333   PMID:29968322   PMID:30075593   PMID:30095747   PMID:30360750   PMID:30375100   PMID:30382562   PMID:30523673   PMID:30593746   PMID:30779222   PMID:30969811   PMID:30978442  
PMID:30995661   PMID:31002437   PMID:31059114   PMID:31102307   PMID:31125901   PMID:31294845   PMID:31299415   PMID:31357078   PMID:31444012   PMID:31550242   PMID:31554783   PMID:31650822  
PMID:31693463   PMID:31698971   PMID:31846791   PMID:31852669   PMID:31854275   PMID:31953354   PMID:32020215   PMID:32204425   PMID:32470060   PMID:32790111   PMID:32881904  


Genomics

Comparative Map Data
IL1RN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2113,107,214 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh382113,099,365 - 113,134,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,875,548 - 113,891,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
Il1rn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,226,872 - 24,241,503 (+)NCBIGRCm39mm39
GRCm39 Ensembl224,226,865 - 24,241,506 (+)Ensembl
GRCm38224,336,860 - 24,351,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,336,853 - 24,351,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,192,380 - 24,207,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv36224,158,869 - 24,173,490 (+)NCBImm8
Celera224,056,294 - 24,070,923 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.36NCBI
Il1rn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.237,111,567 - 7,127,451 (+)NCBI
Rnor_6.0 Ensembl31,452,644 - 1,468,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.031,449,778 - 1,468,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.031,445,598 - 1,461,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,607,800 - 2,613,216 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.132,607,803 - 2,611,842 (+)NCBI
Celera31,959,290 - 1,964,693 (+)NCBICelera
Cytogenetic Map3p13NCBI
Il1rn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,144,810 - 1,159,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,145,022 - 1,159,413 (-)NCBIChiLan1.0ChiLan1.0
LOC100991079
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A114,061,182 - 114,077,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,061,182 - 114,078,839 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A88,991,646 - 89,008,013 (-)NCBIMhudiblu_PPA_v0panPan3
IL1RN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,236,690 - 37,250,424 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,212,751 - 37,249,329 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,014,575 - 37,019,617 (+)NCBI
ROS_Cfam_1.01738,014,380 - 38,028,164 (+)NCBI
UMICH_Zoey_3.11737,157,832 - 37,162,873 (+)NCBI
UNSW_CanFamBas_1.01737,214,332 - 37,219,374 (+)NCBI
UU_Cfam_GSD_1.01737,426,795 - 37,431,843 (+)NCBI
Il1rn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,552,650 - 82,571,860 (+)NCBI
SpeTri2.0NW_0049367831,447,158 - 1,466,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RN
(Sus scrofa - pig)
No map positions available.
IL1RN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,136,667 - 16,152,451 (+)NCBI
ChlSab1.1 Ensembl1416,146,333 - 16,151,326 (+)Ensembl
Il1rn
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474913,210,365 - 13,224,471 (+)NCBI

Position Markers
RH17495  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,890,540 - 113,890,674UniSTSGRCh37
Build 362113,607,011 - 113,607,145RGDNCBI36
Celera2107,275,138 - 107,275,272RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,344,844 - 106,344,978UniSTS
GeneMap99-GB4 RH Map2411.03UniSTS
NCBI RH Map2844.2UniSTS
GDB:182560  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,887,202 - 113,888,680UniSTSGRCh37
Build 362113,603,673 - 113,605,151RGDNCBI36
Celera2107,271,886 - 107,273,278RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,341,678 - 106,342,984UniSTS
GDB:204180  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,888,072 - 113,888,483UniSTSGRCh37
Build 362113,604,543 - 113,604,954RGDNCBI36
Celera2107,272,756 - 107,273,081RGD
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map2q14.2UniSTS
HuRef2106,342,548 - 106,342,787UniSTS
HuRef5151,816,575 - 151,817,980UniSTS
IL1RN_3322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,890,235 - 113,891,019UniSTSGRCh37
Build 362113,606,706 - 113,607,490RGDNCBI36
Celera2107,274,833 - 107,275,617RGD
HuRef2106,344,539 - 106,345,323UniSTS
D2S2718  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,890,569 - 113,890,917UniSTSGRCh37
Build 362113,607,040 - 113,607,388RGDNCBI36
Celera2107,275,167 - 107,275,515RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,344,873 - 106,345,221UniSTS
Stanford-G3 RH Map24796.0UniSTS
NCBI RH Map2847.2UniSTS
GeneMap99-G3 RH Map25709.0UniSTS
RH70911  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,875,703 - 113,875,864UniSTSGRCh37
Build 362113,592,174 - 113,592,335RGDNCBI36
Celera2107,260,392 - 107,260,553RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,330,183 - 106,330,344UniSTS
GeneMap99-GB4 RH Map2412.71UniSTS
NCBI RH Map2844.2UniSTS
WI-13878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,891,434 - 113,891,561UniSTSGRCh37
Build 362113,607,905 - 113,608,032RGDNCBI36
Celera2107,276,032 - 107,276,159RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,345,738 - 106,345,865UniSTS
GeneMap99-GB4 RH Map2411.14UniSTS
Whitehead-RH Map2594.1UniSTS
NCBI RH Map2844.2UniSTS
RH11709  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,891,299 - 113,891,501UniSTSGRCh37
Build 362113,607,770 - 113,607,972RGDNCBI36
Celera2107,275,897 - 107,276,099RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,345,603 - 106,345,805UniSTS
GeneMap99-GB4 RH Map2411.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3377
Count of miRNA genes:822
Interacting mature miRNAs:938
Transcripts:ENST00000259206, ENST00000354115, ENST00000361779, ENST00000409052, ENST00000409930, ENST00000463073, ENST00000465812, ENST00000472292, ENST00000486167
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 2 1 3 22 1 3 1 37 19
Medium 328 788 427 420 972 391 1496 72 41 46 433 406 41 258 723
Low 1613 1430 1125 159 481 57 1510 815 1087 243 779 1048 107 1 887 1005 5
Below cutoff 474 755 158 14 326 7 1114 1252 2464 107 176 55 7 59 1050 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011511121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A49726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A50144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC024704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF043143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF057168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF387734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF387735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ005835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM260202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY196903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI766516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA667440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI656437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M97748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U65590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000259206   ⟹   ENSP00000259206
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,897 - 113,134,016 (+)Ensembl
RefSeq Acc Id: ENST00000354115   ⟹   ENSP00000329072
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,897 - 113,134,016 (+)Ensembl
RefSeq Acc Id: ENST00000361779   ⟹   ENSP00000354816
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,893 - 113,134,016 (+)Ensembl
RefSeq Acc Id: ENST00000409052   ⟹   ENSP00000387210
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,111,116 - 113,134,013 (+)Ensembl
RefSeq Acc Id: ENST00000409930   ⟹   ENSP00000387173
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,561 - 113,133,121 (+)Ensembl
RefSeq Acc Id: ENST00000463073
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,111,116 - 113,115,690 (+)Ensembl
RefSeq Acc Id: ENST00000465812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,107,214 - 113,117,665 (+)Ensembl
RefSeq Acc Id: ENST00000472292
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,576 - 113,129,982 (+)Ensembl
RefSeq Acc Id: ENST00000486167
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,981 - 113,130,121 (+)Ensembl
RefSeq Acc Id: NM_000577   ⟹   NP_000568
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,591,941 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,879,899 - 113,896,017 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001318914   ⟹   NP_001305843
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
CHM1_12113,879,899 - 113,896,017 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379360   ⟹   NP_001366289
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,127,489 - 113,134,014 (+)NCBI
RefSeq Acc Id: NM_173841   ⟹   NP_776213
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,591,941 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,879,899 - 113,896,017 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173842   ⟹   NP_776214
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,127,598 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,601,609 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,889,562 - 113,896,017 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173843   ⟹   NP_776215
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,591,941 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,879,899 - 113,896,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011511121   ⟹   XP_011509423
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,099,365 - 113,134,016 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000568 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305843 (Get FASTA)   NCBI Sequence Viewer  
  NP_001366289 (Get FASTA)   NCBI Sequence Viewer  
  NP_776213 (Get FASTA)   NCBI Sequence Viewer  
  NP_776214 (Get FASTA)   NCBI Sequence Viewer  
  NP_776215 (Get FASTA)   NCBI Sequence Viewer  
  XP_011509423 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA59138 (Get FASTA)   NCBI Sequence Viewer  
  AAB41943 (Get FASTA)   NCBI Sequence Viewer  
  AAB92268 (Get FASTA)   NCBI Sequence Viewer  
  AAB92269 (Get FASTA)   NCBI Sequence Viewer  
  AAB92270 (Get FASTA)   NCBI Sequence Viewer  
  AAC13499 (Get FASTA)   NCBI Sequence Viewer  
  AAC39672 (Get FASTA)   NCBI Sequence Viewer  
  AAH09745 (Get FASTA)   NCBI Sequence Viewer  
  AAN87150 (Get FASTA)   NCBI Sequence Viewer  
  AAX93278 (Get FASTA)   NCBI Sequence Viewer  
  BAF83587 (Get FASTA)   NCBI Sequence Viewer  
  BAF83615 (Get FASTA)   NCBI Sequence Viewer  
  CAA03191 (Get FASTA)   NCBI Sequence Viewer  
  CAA03210 (Get FASTA)   NCBI Sequence Viewer  
  CAA06730 (Get FASTA)   NCBI Sequence Viewer  
  CAA36262 (Get FASTA)   NCBI Sequence Viewer  
  CAA37386 (Get FASTA)   NCBI Sequence Viewer  
  CAA45832 (Get FASTA)   NCBI Sequence Viewer  
  CAA59087 (Get FASTA)   NCBI Sequence Viewer  
  CAD29879 (Get FASTA)   NCBI Sequence Viewer  
  CAJ91094 (Get FASTA)   NCBI Sequence Viewer  
  CBY45189 (Get FASTA)   NCBI Sequence Viewer  
  EAW73621 (Get FASTA)   NCBI Sequence Viewer  
  EAW73622 (Get FASTA)   NCBI Sequence Viewer  
  EAW73623 (Get FASTA)   NCBI Sequence Viewer  
  EAW73624 (Get FASTA)   NCBI Sequence Viewer  
  EAW73625 (Get FASTA)   NCBI Sequence Viewer  
  P18510 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_776213   ⟸   NM_173841
- Peptide Label: isoform 2
- UniProtKB: P18510 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_776215   ⟸   NM_173843
- Peptide Label: isoform 4
- UniProtKB: P18510 (UniProtKB/Swiss-Prot),   A0A024R528 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000568   ⟸   NM_000577
- Peptide Label: isoform 3
- UniProtKB: P18510 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_776214   ⟸   NM_173842
- Peptide Label: isoform 1 precursor
- UniProtKB: P18510 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011509423   ⟸   XM_011511121
- Peptide Label: isoform X1
- UniProtKB: P18510 (UniProtKB/Swiss-Prot),   A0A024R528 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305843   ⟸   NM_001318914
- Peptide Label: isoform 4
- UniProtKB: P18510 (UniProtKB/Swiss-Prot),   A0A024R528 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001366289   ⟸   NM_001379360
- Peptide Label: isoform 4
RefSeq Acc Id: ENSP00000354816   ⟸   ENST00000361779
RefSeq Acc Id: ENSP00000259206   ⟸   ENST00000259206
RefSeq Acc Id: ENSP00000329072   ⟸   ENST00000354115
RefSeq Acc Id: ENSP00000387173   ⟸   ENST00000409930
RefSeq Acc Id: ENSP00000387210   ⟸   ENST00000409052

Promoters
RGD ID:6861390
Promoter ID:EPDNEW_H3860
Type:initiation region
Name:IL1RN_3
Description:interleukin 1 receptor antagonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3859  EPDNEW_H3861  EPDNEW_H3862  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,866 - 113,117,926EPDNEW
RGD ID:6861392
Promoter ID:EPDNEW_H3861
Type:initiation region
Name:IL1RN_2
Description:interleukin 1 receptor antagonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3859  EPDNEW_H3860  EPDNEW_H3862  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,118,031EPDNEW
RGD ID:6861394
Promoter ID:EPDNEW_H3862
Type:initiation region
Name:IL1RN_1
Description:interleukin 1 receptor antagonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3859  EPDNEW_H3860  EPDNEW_H3861  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,127,598 - 113,127,658EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
IL1RN, IVS2, 86-BP DUP duplication Gastric cancer susceptibility after h. pylori infection [RCV000015787]|Microvascular complications of diabetes 4 [RCV000015788] Chr2:2q14.2 pathogenic|risk factor
IL1RN, 2-BP DEL, 156CA deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000015791] Chr2:2q14.2 pathogenic
IL1RN, 175-KB DEL deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000015792] Chr2:2q14.2 pathogenic
NM_173842.3(IL1RN):c.229G>T (p.Glu77Ter) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000015789]|not provided [RCV000084165] Chr2:113131068 [GRCh38]
Chr2:113888645 [GRCh37]
Chr2:2q14.1
pathogenic|not provided
NM_173842.3(IL1RN):c.160C>T (p.Gln54Ter) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000015790]|not provided [RCV000084164] Chr2:113129619 [GRCh38]
Chr2:113887196 [GRCh37]
Chr2:2q14.1
pathogenic|not provided
NM_173841.2(IL1RN):c.442T>G (p.Phe148Val) single nucleotide variant Malignant melanoma [RCV000060302] Chr2:113132770 [GRCh38]
Chr2:113890347 [GRCh37]
Chr2:113606818 [NCBI36]
Chr2:2q14.1
not provided
NM_173842.3(IL1RN):c.156_157del (p.Asn52fs) deletion not provided [RCV000084163] Chr2:113129614..113129615 [GRCh38]
Chr2:113887191..113887192 [GRCh37]
Chr2:2q14.1
not provided
NM_173842.1(IL1RN):c.-64_1696del deletion not provided [RCV000162093] Chr2:113127561..113134033 [GRCh38]
Chr2:113885138..113891610 [GRCh37]
Chr2:2q14.1
not provided
GRCh38/hg38 2q14.1(chr2:112924872-113105404)x1 copy number loss See cases [RCV000053808] Chr2:112924872..113105404 [GRCh38]
Chr2:113682449..113862981 [GRCh37]
Chr2:113398920..113579452 [NCBI36]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*1039C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000260421] Chr2:113133910 [GRCh38]
Chr2:113891487 [GRCh37]
Chr2:2q14.1
likely benign|uncertain significance
NM_173842.3(IL1RN):c.459C>T (p.Asp153=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000386219] Chr2:113132796 [GRCh38]
Chr2:113890373 [GRCh37]
Chr2:2q14.1
benign|likely benign
NM_173842.3(IL1RN):c.171T>C (p.Ala57=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000389038]|not specified [RCV000455594] Chr2:113129630 [GRCh38]
Chr2:113887207 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.-31A>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000264084] Chr2:113117988 [GRCh38]
Chr2:113875565 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.327+12C>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000275837] Chr2:113131169 [GRCh38]
Chr2:113888746 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.529G>A (p.Glu177Lys) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000282452] Chr2:113132866 [GRCh38]
Chr2:113890443 [GRCh37]
Chr2:2q14.1
likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_173841.3(IL1RN):c.73+8A>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000364652]|not specified [RCV000455023] Chr2:113120136 [GRCh38]
Chr2:113877713 [GRCh37]
Chr2:2q14.1
benign
NM_173842.3(IL1RN):c.390T>C (p.Ser130=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000330957]|not specified [RCV000454505] Chr2:113132727 [GRCh38]
Chr2:113890304 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.125+5G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000325166] Chr2:113127745 [GRCh38]
Chr2:113885322 [GRCh37]
Chr2:2q14.1
benign|likely benign
GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1 copy number loss See cases [RCV000240053] Chr2:106423310..115054828 [GRCh37]
Chr2:2q12.2-14.1
pathogenic
NM_173841.2(IL1RN):c.*138C>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000279064] Chr2:113133009 [GRCh38]
Chr2:113890586 [GRCh37]
Chr2:2q14.1
benign
NM_173842.3(IL1RN):c.69G>A (p.Thr23=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000269844]|not provided [RCV000658875] Chr2:113127693 [GRCh38]
Chr2:113885270 [GRCh37]
Chr2:2q14.1
benign|likely benign|conflicting interpretations of pathogenicity|uncertain significance
GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1 copy number loss See cases [RCV000240485] Chr2:109798247..125658380 [GRCh37]
Chr2:2q12.3-14.3
pathogenic
NM_000577.5(IL1RN):c.*691del deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000275491] Chr2:113133553 [GRCh38]
Chr2:113891130 [GRCh37]
Chr2:2q14.1
uncertain significance
GRCh37/hg19 2q12.3-14.1(chr2:109556627-117570152)x1 copy number loss See cases [RCV000240490] Chr2:109556627..117570152 [GRCh37]
Chr2:2q12.3-14.1
pathogenic
NM_173842.3(IL1RN):c.370G>A (p.Ala124Thr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000550180] Chr2:113132707 [GRCh38]
Chr2:113890284 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.*130C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000373524] Chr2:113133001 [GRCh38]
Chr2:113890578 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*601C>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000315277] Chr2:113133472 [GRCh38]
Chr2:113891049 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*964G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000355397] Chr2:113133835 [GRCh38]
Chr2:113891412 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.-87G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000402395] Chr2:113117932 [GRCh38]
Chr2:113875509 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.-83G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000304296] Chr2:113117936 [GRCh38]
Chr2:113875513 [GRCh37]
Chr2:2q14.1
likely benign|uncertain significance
NM_173841.2(IL1RN):c.*119C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000318920] Chr2:113132990 [GRCh38]
Chr2:113890567 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*958C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000319231] Chr2:113133829 [GRCh38]
Chr2:113891406 [GRCh37]
Chr2:2q14.1
benign|uncertain significance
NM_173841.2(IL1RN):c.-71A>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000359043] Chr2:113117948 [GRCh38]
Chr2:113875525 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*310T>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000340072] Chr2:113133181 [GRCh38]
Chr2:113890758 [GRCh37]
Chr2:2q14.1
likely benign
NM_173841.2(IL1RN):c.*162C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000343482] Chr2:113133033 [GRCh38]
Chr2:113890610 [GRCh37]
Chr2:2q14.1
benign|likely benign
NM_173841.2(IL1RN):c.*382C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000364326] Chr2:113133253 [GRCh38]
Chr2:113890830 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.3(IL1RN):c.-12G>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000309920]|not specified [RCV000454566] Chr2:113118007 [GRCh38]
Chr2:113875584 [GRCh37]
Chr2:2q14.1
benign
NM_000577.5(IL1RN):c.*644del deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000370119] Chr2:113133515 [GRCh38]
Chr2:113891092 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*311G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000394829] Chr2:113133182 [GRCh38]
Chr2:113890759 [GRCh37]
Chr2:2q14.1
benign|likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_173841.2(IL1RN):c.*1049A>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000379765] Chr2:113133920 [GRCh38]
Chr2:113891497 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_000577.5(IL1RN):c.*490del deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000398420] Chr2:113133351 [GRCh38]
Chr2:113890928 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*1040G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000315607] Chr2:113133911 [GRCh38]
Chr2:113891488 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*245G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000284512] Chr2:113133116 [GRCh38]
Chr2:113890693 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*1145A>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000285357] Chr2:113134016 [GRCh38]
Chr2:113891593 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*369T>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000309586] Chr2:113133240 [GRCh38]
Chr2:113890817 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.*165C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000394827] Chr2:113133036 [GRCh38]
Chr2:113890613 [GRCh37]
Chr2:2q14.1
uncertain significance
GRCh37/hg19 2q13(chr2:113735617-113891118)x1 copy number loss See cases [RCV000448884] Chr2:113735617..113891118 [GRCh37]
Chr2:2q13
benign
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_173842.3(IL1RN):c.79C>T (p.Pro27Ser) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000646721] Chr2:113127703 [GRCh38]
Chr2:113885280 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.245T>A (p.Phe82Tyr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000646722] Chr2:113131084 [GRCh38]
Chr2:113888661 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.237T>C (p.His79=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000646723] Chr2:113131076 [GRCh38]
Chr2:113888653 [GRCh37]
Chr2:2q14.1
benign
NM_173842.3(IL1RN):c.465C>T (p.Pro155=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000646724] Chr2:113132802 [GRCh38]
Chr2:113890379 [GRCh37]
Chr2:2q14.1
benign
NM_173841.2(IL1RN):c.214+242C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000646725] Chr2:113129906 [GRCh38]
Chr2:113887483 [GRCh37]
Chr2:2q14.1
benign
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
NM_173842.3(IL1RN):c.62C>G (p.Ser21Ter) single nucleotide variant not provided [RCV000512716] Chr2:113127686 [GRCh38]
Chr2:113885263 [GRCh37]
Chr2:2q14.1
likely pathogenic
NM_173842.3(IL1RN):c.23G>A (p.Arg8His) single nucleotide variant not provided [RCV000513390] Chr2:113127647 [GRCh38]
Chr2:113885224 [GRCh37]
Chr2:2q14.1
likely benign
NM_173842.3(IL1RN):c.374T>G (p.Phe125Cys) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000686492] Chr2:113132711 [GRCh38]
Chr2:113890288 [GRCh37]
Chr2:2q14.1
uncertain significance
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
NM_173841.2(IL1RN):c.74-2A>G single nucleotide variant Idiopathic Pulmonary Fibrosis [RCV000677223]|Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000779276] Chr2:113127687 [GRCh38]
Chr2:113885264 [GRCh37]
Chr2:2q14.1
uncertain significance
GRCh37/hg19 2q13(chr2:113698135-114064263)x1 copy number loss not provided [RCV000682066] Chr2:113698135..114064263 [GRCh37]
Chr2:2q13
uncertain significance
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
NM_173842.3(IL1RN):c.450G>A (p.Met150Ile) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000694345] Chr2:113132787 [GRCh38]
Chr2:113890364 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_000577.5(IL1RN):c.10+2055G>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000687661] Chr2:113120083 [GRCh38]
Chr2:113877660 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_000577.5(IL1RN):c.10+2085A>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000693420] Chr2:113120113 [GRCh38]
Chr2:113877690 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.272G>T (p.Cys91Phe) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000705510]|not provided [RCV000997195] Chr2:113131111 [GRCh38]
Chr2:113888688 [GRCh37]
Chr2:2q14.1
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_173842.3(IL1RN):c.339G>A (p.Leu113=) single nucleotide variant not provided [RCV000981805] Chr2:113132676 [GRCh38]
Chr2:113890253 [GRCh37]
Chr2:2q14.1
likely benign
NM_173841.2(IL1RN):c.126-9C>T single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000929590] Chr2:113129567 [GRCh38]
Chr2:113887144 [GRCh37]
Chr2:2q14.1
likely benign|conflicting interpretations of pathogenicity
NM_173842.3(IL1RN):c.489C>T (p.Asp163=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000926784] Chr2:113132826 [GRCh38]
Chr2:113890403 [GRCh37]
Chr2:2q14.1
likely benign
NM_173842.3(IL1RN):c.418G>A (p.Ala140Thr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001041483] Chr2:113132755 [GRCh38]
Chr2:113890332 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.466G>A (p.Val156Ile) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001041752] Chr2:113132803 [GRCh38]
Chr2:113890380 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.495C>T (p.Gly165=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000930942] Chr2:113132832 [GRCh38]
Chr2:113890409 [GRCh37]
Chr2:2q14.1
likely benign
NM_173842.3(IL1RN):c.192T>C (p.Asn64=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000980969] Chr2:113129651 [GRCh38]
Chr2:113887228 [GRCh37]
Chr2:2q14.1
likely benign
NM_173842.3(IL1RN):c.486T>C (p.Pro162=) single nucleotide variant not provided [RCV000977088] Chr2:113132823 [GRCh38]
Chr2:113890400 [GRCh37]
Chr2:2q14.1
likely benign
NM_173842.3(IL1RN):c.213_227del (p.Asp72_Ile76del) deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000818103] Chr2:113131050..113131064 [GRCh38]
Chr2:113888627..113888641 [GRCh37]
Chr2:2q14.1
likely pathogenic|uncertain significance
NM_173842.3(IL1RN):c.109G>T (p.Ala37Ser) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000813494] Chr2:113127733 [GRCh38]
Chr2:113885310 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.185G>A (p.Gly62Glu) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000817668] Chr2:113129644 [GRCh38]
Chr2:113887221 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.166G>A (p.Val56Ile) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001132305] Chr2:113129625 [GRCh38]
Chr2:113887202 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.*290T>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001134695] Chr2:113133161 [GRCh38]
Chr2:113890738 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.205+8G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001132306] Chr2:113129672 [GRCh38]
Chr2:113887249 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.2(IL1RN):c.44G>A (p.Gly15Glu) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000811873] Chr2:113120099 [GRCh38]
Chr2:113877676 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.426C>T (p.Pro142=) single nucleotide variant not provided [RCV000936632] Chr2:113132763 [GRCh38]
Chr2:113890340 [GRCh37]
Chr2:2q14.1
likely benign
GRCh37/hg19 2q13(chr2:113717386-113892774)x1 copy number loss not provided [RCV000847007] Chr2:113717386..113892774 [GRCh37]
Chr2:2q13
pathogenic
NM_173842.3(IL1RN):c.305G>C (p.Arg102Thr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001238669] Chr2:113131144 [GRCh38]
Chr2:113888721 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.220G>A (p.Val74Ile) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001231377] Chr2:113131059 [GRCh38]
Chr2:113888636 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.446C>T (p.Ala149Val) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001226366] Chr2:113132783 [GRCh38]
Chr2:113890360 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173841.3(IL1RN):c.4G>A (p.Ala2Thr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001226116] Chr2:113118022 [GRCh38]
Chr2:113875599 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.*75C>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001133237] Chr2:113132946 [GRCh38]
Chr2:113890523 [GRCh37]
Chr2:2q14.1
uncertain significance
NC_000002.12:g.(?_113116893)_(113135016_?)del deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001032678] Chr2:113874470..113892593 [GRCh37]
Chr2:2q13
pathogenic
NM_173842.3(IL1RN):c.414T>C (p.Ser138=) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV000910623] Chr2:113132751 [GRCh38]
Chr2:113890328 [GRCh37]
Chr2:2q14.1
likely benign|conflicting interpretations of pathogenicity
NC_000002.12:g.113134027T>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001132403] Chr2:113134027 [GRCh38]
Chr2:113891604 [GRCh37]
Chr2:2q14.1
likely benign
NM_173842.3(IL1RN):c.*350C>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001129689] Chr2:113133221 [GRCh38]
Chr2:113890798 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.*537G>A single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001129690] Chr2:113133408 [GRCh38]
Chr2:113890985 [GRCh37]
Chr2:2q14.1
benign
NM_173842.3(IL1RN):c.496G>A (p.Val166Ile) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001214883] Chr2:113132833 [GRCh38]
Chr2:113890410 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.169G>T (p.Ala57Ser) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001220016] Chr2:113129628 [GRCh38]
Chr2:113887205 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.*303C>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001134696] Chr2:113133174 [GRCh38]
Chr2:113890751 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.68C>T (p.Thr23Met) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001027789] Chr2:113127692 [GRCh38]
Chr2:113885269 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.*1070T>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001132402] Chr2:113133941 [GRCh38]
Chr2:113891518 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.*605T>C single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001129691] Chr2:113133476 [GRCh38]
Chr2:113891053 [GRCh37]
Chr2:2q14.1
uncertain significance
GRCh37/hg19 2q13(chr2:113853399-114095549)x1 copy number loss not provided [RCV001259646] Chr2:113853399..114095549 [GRCh37]
Chr2:2q13
pathogenic
NM_173841.3(IL1RN):c.26A>T (p.Glu9Val) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001306761] Chr2:113120081 [GRCh38]
Chr2:113877658 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.449T>C (p.Met150Thr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001298499] Chr2:113132786 [GRCh38]
Chr2:113890363 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.526G>A (p.Asp176Asn) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001301841] Chr2:113132863 [GRCh38]
Chr2:113890440 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.318+3A>G single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001301399] Chr2:113131160 [GRCh38]
Chr2:113888737 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.212T>C (p.Ile71Thr) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001314665] Chr2:113131051 [GRCh38]
Chr2:113888628 [GRCh37]
Chr2:2q14.1
uncertain significance
NC_000002.11:g.(?_113877623)_(113877725_?)del deletion Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001348882] Chr2:113877623..113877725 [GRCh37]
Chr2:2q13
uncertain significance
NM_173842.3(IL1RN):c.331dup (p.Thr111fs) duplication Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001343321] Chr2:113132667..113132668 [GRCh38]
Chr2:113890244..113890245 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.267G>C (p.Lys89Asn) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001303678] Chr2:113131106 [GRCh38]
Chr2:113888683 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.197A>G (p.Asn66Ser) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001294372] Chr2:113129656 [GRCh38]
Chr2:113887233 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.298G>A (p.Glu100Lys) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001324731] Chr2:113131137 [GRCh38]
Chr2:113888714 [GRCh37]
Chr2:2q14.1
uncertain significance
NM_173842.3(IL1RN):c.388A>G (p.Ser130Gly) single nucleotide variant Osteomyelitis, sterile multifocal, with periostitis and pustulosis [RCV001340372] Chr2:113132725 [GRCh38]
Chr2:113890302 [GRCh37]
Chr2:2q14.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6000 AgrOrtholog
COSMIC IL1RN COSMIC
Ensembl Genes ENSG00000136689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000259206 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000329072 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000354816 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387173 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387210 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000259206 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000354115 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000361779 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409052 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409930 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000136689 GTEx
HGNC ID HGNC:6000 ENTREZGENE
Human Proteome Map IL1RN Human Proteome Map
InterPro IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1RA/IL-36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1RA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3557 UniProtKB/Swiss-Prot
NCBI Gene 3557 ENTREZGENE
OMIM 137215 OMIM
  147679 OMIM
  612628 OMIM
  612852 OMIM
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29816 PharmGKB
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN1X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R528 ENTREZGENE, UniProtKB/TrEMBL
  IL1RA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K4G1 UniProtKB/Swiss-Prot
  Q14628 UniProtKB/Swiss-Prot
  Q53SC2 UniProtKB/Swiss-Prot
  Q7RTZ4 UniProtKB/Swiss-Prot
  Q96GD6 UniProtKB/Swiss-Prot
  Q9UPC0 UniProtKB/Swiss-Prot