IL1RN (interleukin 1 receptor antagonist) - Rat Genome Database

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Gene: IL1RN (interleukin 1 receptor antagonist) Homo sapiens
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Symbol: IL1RN
Name: interleukin 1 receptor antagonist
RGD ID: 1344540
HGNC Page HGNC
Description: Enables cytokine receptor binding activity. Involved in several processes, including acute-phase response; negative regulation of heterotypic cell-cell adhesion; and negative regulation of interleukin-1-mediated signaling pathway. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); chronic kidney disease (multiple); glomerulonephritis (multiple); lung disease (multiple); and obesity (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1 inhibitor; IL1F3; IL1RA; IL1RN (IL1F3); interleukin-1 receptor antagonist protein; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); IRAP; MGC10430; MVCD4; type II interleukin-1 receptor antagonist
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,099,360 - 113,134,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,099,315 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh372113,875,548 - 113,891,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abscess  (IDA)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (EXP,IMP)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (IDA)
adult respiratory distress syndrome  (IEP,ISO)
allergic conjunctivitis  (IDA)
alopecia areata  (IAGP)
Anorexia  (EXP,ISO)
anterior uveitis  (IMP)
anthracosis  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
Arsenic Poisoning  (EXP)
asthma  (EXP,IAGP,IEP,IMP)
Atrophy  (EXP)
autistic disorder  (EXP)
autoimmune thrombocytopenic purpura  (IAGP)
autosomal dominant polycystic kidney disease  (IEP)
B-Cell Chronic Lymphocytic Leukemia  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (IEP)
Brain Injuries  (EXP)
brain ischemia  (EXP)
Bronchial Hyperreactivity  (EXP,IDA)
bronchiolitis  (IEP)
bronchiolitis obliterans  (IEP)
Bronchopulmonary Dysplasia  (IAGP,IEP)
bronchus carcinoma  (IEP)
Cachexia  (ISO)
calcium oxalate nephrolithiasis  (IAGP)
cardiovascular system disease  (EXP)
Carotid Artery Injuries  (IMP)
Cerebral Hemorrhage  (IMP,ISO)
cerebrovascular disease  (EXP)
chronic kidney disease  (IAGP,IEP)
chronic myeloid leukemia  (IEP)
chronic obstructive pulmonary disease  (IAGP,IEP)
Chronic Rhinosinusitis  (IAGP)
Chronic Uveitis  (IEP)
cicatricial pemphigoid  (IEP)
Colonic Neoplasms  (EXP)
common cold  (IDA,IEP)
Corneal Graft Rejection  (IMP)
corneal neovascularization  (IDA,ISO)
COVID-19  (HEP)
crescentic glomerulonephritis  (IDA)
Cryopyrin-Associated Periodic Syndromes  (IDA)
cystic fibrosis  (IEP)
dacryocystitis  (IDA)
Deficiency of Interleukin-1 Receptor Antagonist  (IAGP)
diabetic angiopathy  (IAGP)
Diabetic Nephropathies  (IAGP)
diarrhea  (EXP)
Drug Hypersensitivity Syndrome  (IAGP)
Drug-Induced Agranulocytosis  (IEP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
dry eye syndrome  (IEP)
encephalitis  (ISO)
end stage renal disease  (IAGP,IEP)
endometriosis  (IAGP)
Endotoxemia  (IDA,ISO)
Endotoxin-Induced Uveitis  (ISO)
exanthem  (EXP)
Experimental Arthritis  (IDA,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (IDA)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IMP,ISO)
Extravasation of Diagnostic and Therapeutic Materials  (EXP)
Eye Manifestations  (IEP)
Febrile Seizures  (IDA)
Fever  (EXP,ISO)
fibromyalgia  (IEP)
Fibrosis  (EXP)
glomerulonephritis  (IDA,ISO)
gout  (EXP)
Graft vs Host Disease  (IDA)
Graves Ophthalmopathy  (IAGP,IEP)
hairy cell leukemia  (IEP)
hemolytic-uremic syndrome  (IDA,IEP)
Henoch-Schoenlein purpura  (IAGP)
hepatocellular carcinoma  (EXP)
herpes simplex virus keratitis  (IDA)
Human Influenza  (IDA,IEP)
Hyperalgesia  (EXP,IDA,ISO)
hyperglycemia  (IEP)
hypertension  (IAGP,ISO)
idiopathic pulmonary fibrosis  (IAGP)
IgA glomerulonephritis  (IAGP,IDA,IEP,ISO)
Inflammation  (EXP,ISO)
inflammatory bowel disease  (IMP)
interstitial lung disease  (IEP)
juvenile rheumatoid arthritis  (EXP)
keratoconus  (IAGP)
kidney disease  (EXP)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (EXP,IDA)
Leukocytosis  (IDA)
Lichen Sclerosus et Atrophicus  (IAGP)
listeriosis  (IDA)
Liver Reperfusion Injury  (IDA,ISO)
lung non-small cell carcinoma  (IAGP)
lupus nephritis  (IEP)
Mammary Neoplasms, Experimental  (IDA)
Meibomian Gland Dysfunction  (IEP)
melanoma  (IDA)
mental depression  (IDA)
middle cerebral artery infarction  (IMP)
morbid obesity  (IEP)
Muckle-Wells syndrome  (IDA)
mucositis  (EXP)
multiple myeloma  (IAGP)
Multiple Organ Failure  (IDA,IEP)
multiple sclerosis  (EXP)
myocardial infarction  (EXP)
Myocardial Reperfusion Injury  (IDA)
myositis  (EXP,IEP)
Necrosis  (EXP)
Neoplasm Invasiveness  (EXP)
nephrotic syndrome  (IAGP)
non-alcoholic fatty liver disease  (IEP)
obesity  (IEP,ISO)
Oligoanuria  (IEP)
osteoporosis  (IDA)
Pain  (EXP)
periodontitis  (IAGP,IEP)
pleural disease  (IEP)
pleural tuberculosis  (IAGP)
pleurisy  (IDA)
pneumonia  (HEP,IAGP,IDA,ISO)
Postoperative Cognitive Dysfunction  (IDA)
pre-eclampsia  (IEP)
Proctocolitis  (IEP)
Prostatic Neoplasms  (EXP)
prostatitis  (ISO)
proteinuria  (EXP,IAGP)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (IEP)
pulmonary eosinophilia  (IEP)
pulmonary fibrosis  (EXP,IAGP,IEP)
pulmonary hypertension  (IDA)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IDA,IEP)
pyelonephritis  (IEP)
renal cell carcinoma  (IDA)
respiratory allergy  (ISO)
rheumatoid arthritis  (EXP,IDA,ISO)
rhinitis  (IAGP,IEP)
Schnitzler syndrome  (EXP,IDA)
sciatic neuropathy  (IDA)
Sclerosis  (EXP)
Sepsis  (IAGP,IDA,IEP,ISO)
Serositis  (IAGP)
silicosis  (IAGP,ISO)
Sjogren's syndrome  (IAGP,IEP)
skin disease  (EXP)
Spinal Cord Injuries  (IEP,ISO)
status epilepticus  (EXP)
stomach cancer  (IAGP)
Stomach Neoplasms  (EXP)
Stroke  (EXP,IDA)
Subarachnoid Hemorrhage  (IDA)
systemic lupus erythematosus  (IAGP,IEP)
Tobacco Use Disorder  (IDA)
toxic shock syndrome  (IAGP,IMP)
transient cerebral ischemia  (IDA,ISO)
Transplant Rejection  (IDA)
type 1 diabetes mellitus  (IDA,IEP)
type 2 diabetes mellitus  (IAGP)
ulcerative colitis  (IAGP)
ureteral obstruction  (IDA,ISO)
urinary bladder cancer  (IAGP)
Urinary Calculi  (IAGP)
Uveitis, Chronic Anterior  (IAGP)
vascular disease  (IDA)
Venous Thrombosis  (IAGP)
Ventilator-Induced Lung Injury  (ISO)
Viral Bronchiolitis  (IAGP)
viral pneumonia  (HEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dichloroaniline  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
acetamide  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinyl palmitate  (EXP)
alpha-naphthoflavone  (EXP)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
antimonite  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
astressin  (ISO)
azathioprine  (EXP)
beclomethasone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
celastrol  (EXP)
ceric oxide  (ISO)
cholesterol  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
gedunin  (EXP)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
glycidol  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
hydroquinone  (EXP)
ibuprofen  (EXP,ISO)
indometacin  (EXP)
ionomycin  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lenalidomide  (ISO)
lipopolysaccharide  (EXP,ISO)
malonaldehyde  (EXP)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methacholine chloride  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
methyltestosterone  (EXP)
Mofezolac (TN)  (EXP)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctanoic acid  (ISO)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
potassium dichromate  (ISO)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rotenone  (ISO)
scopolamine  (ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
urethane  (EXP)
wortmannin  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal renal morphology  (IAGP)
Abnormality of bladder morphology  (IAGP)
Abnormality of the immune system  (IAGP)
Abnormality of the skin  (IAGP)
Abnormality of the urinary system  (IAGP)
Abnormality of urine homeostasis  (IAGP)
Abscess  (IAGP)
Acquired abnormal hair pattern  (IAGP)
Albuminuria  (IAGP)
Alopecia universalis  (IAGP)
Antinuclear antibody positivity  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Autosomal recessive inheritance  (IAGP)
Broad ribs  (IAGP)
Decreased glomerular filtration rate  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated circulating creatinine concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Endometriosis  (IAGP)
Epidermal acanthosis  (IAGP)
Failure to thrive in infancy  (IAGP)
Fetal distress  (IAGP)
Flaring of rib cage  (IAGP)
Fused cervical vertebrae  (IAGP)
Generalized edema  (IAGP)
Heavy proteinuria  (IAGP)
Hematuria  (IAGP)
Hepatomegaly  (IAGP)
Hypercholesterolemia  (IAGP)
Hyperglycemia  (IAGP)
Hyperkeratosis  (IAGP)
Hypoalbuminemia  (IAGP)
Increased inflammatory response  (IAGP)
Increased level of L-fucose in urine  (IAGP)
Inflammation of the large intestine  (IAGP)
Joint swelling  (IAGP)
Motor delay  (IAGP)
Multiple myeloma  (IAGP)
Neonatal onset  (IAGP)
Neutrophilia  (IAGP)
Osteolysis  (IAGP)
Osteomyelitis  (IAGP)
Osteopenia  (IAGP)
Periodontitis  (IAGP)
Periostitis  (IAGP)
Proteinuria  (IAGP)
Pulmonary fibrosis  (IAGP)
Pustule  (IAGP)
Respiratory distress  (IAGP)
Skin rash  (IAGP)
Small for gestational age  (IAGP)
Somatic mutation  (IAGP)
Splenomegaly  (IAGP)
Stomach cancer  (IAGP)
Stomatitis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans. null
2. Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma. Abazis-Stamboulieh D, etal., Leuk Lymphoma. 2007 Nov;48(11):2196-203.
3. Association of low-grade inflammation with nephropathy in type 2 diabetic patients: role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines. Abrahamian H, etal., Exp Clin Endocrinol Diabetes. 2007 Jan;115(1):38-41.
4. Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians. Achyut BR, etal., Clin Chim Acta. 2007 Feb;377(1-2):163-9. Epub 2006 Oct 27.
5. Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy. Ahirwar DK, etal., Biomarkers. 2009 Jun;14(4):213-8.
6. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Aki K, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F870-82. Epub 2010 Jan 13.
7. Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. Amin A, etal., J Pathol. 2012 Jun;227(2):165-74. doi: 10.1002/path.3960. Epub 2012 Feb 17.
8. Interleukin 1 receptor antagonist gene polymorphism is associated with severe renal involvement and renal sequelae in Henoch-Schonlein purpura. Amoli MM, etal., J Rheumatol. 2002 Jul;29(7):1404-7.
9. Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. Antin JH, etal., Blood. 1994 Aug 15;84(4):1342-8.
10. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Arnalich F, etal., Clin Exp Immunol. 2002 Feb;127(2):331-6.
11. Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporin A. Ayer LM, etal., Inflammation. 2000 Oct;24(5):447-61.
12. Regulation of proinflammatory cytokines in seasonal allergic rhinitis. Bachert C, etal., Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):375-9.
13. Multiplex immunoassay analysis of cytokines in idiopathic inflammatory myopathy. Baird GS and Montine TJ, Arch Pathol Lab Med. 2008 Feb;132(2):232-8. doi: 10.1043/1543-2165(2008)132[232:MIAOCI]2.0.CO;2.
14. Correlation of serum levels of interleukin-1 family members with disease activity and response to treatment in hairy cell leukemia. Barak V, etal., Eur Cytokine Netw. 1998 Mar;9(1):33-9.
15. Comparison of cytokine gene polymorphism in drug-induced maculopapular eruption, urticaria and drug reaction with eosinophilia and systemic symptoms (DRESS). Barbaud A, etal., J Eur Acad Dermatol Venereol. 2014 Apr;28(4):491-9. doi: 10.1111/jdv.12130. Epub 2013 Mar 6.
16. Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. Barrientos RM, etal., J Neurosci. 2012 Oct 17;32(42):14641-8. doi: 10.1523/JNEUROSCI.2173-12.2012.
17. Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids. Bartalena L, etal., Clin Endocrinol (Oxf). 2000 May;52(5):647-51.
18. Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. Belperio JA, etal., Transplantation. 2002 Feb 27;73(4):591-9.
19. Blood serum interleukin-1 receptor antagonist in pars planitis and ocular Behcet disease. Benezra D, etal., Am J Ophthalmol. 1997 May;123(5):593-8.
20. Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster. Bensen JT, etal., Genomics. 2003 Aug;82(2):194-217.
21. Altered levels of the soluble IL-1, IL-4 and TNF receptors, as well as the IL-1 receptor antagonist, in intermittent allergic rhinitis. Benson M, etal., Int Arch Allergy Immunol. 2004 Jul;134(3):227-32. Epub 2004 Jun 1.
22. Host adaptive immunity deficiency in severe pandemic influenza. Bermejo-Martin JF, etal., Crit Care. 2010 Sep 14;14(5):R167.
23. Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. Betz AL, etal., J Cereb Blood Flow Metab. 1995 Jul;15(4):547-51.
24. Association of interleukin-1Ra gene polymorphism in patients with bladder cancer: case control study from North India. Bid HK, etal., Urology. 2006 May;67(5):1099-104.
25. Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein. Biswas PS, etal., J Leukoc Biol. 2004 Oct;76(4):868-75. Epub 2004 Jul 16.
26. Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Blakemore AI, etal., Hum Genet. 1996 Mar;97(3):369-74.
27. Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis. Blankenberg FG, etal., J Nucl Med. 2011 Oct;52(10):1630-7. Epub 2011 Sep 2.
28. Acute bacterial inflammation of the mouse prostate. Boehm BJ, etal., Prostate. 2012 Feb;72(3):307-17. doi: 10.1002/pros.21433. Epub 2011 Jun 16.
29. Analysis of IL1 gene polymorphisms and transcript levels in periodontal and chronic kidney disease. Braosi AP, etal., Cytokine. 2012 Oct;60(1):76-82. Epub 2012 Jul 13.
30. Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease. Brugos B, etal., Hum Immunol. 2010 Sep;71(9):874-7. Epub 2010 Jun 9.
31. Interleukin 1 receptor antagonist (IL1RA) in acute leukaemia: IL1RA is both secreted spontaneously by myelogenous leukaemia blasts and is a part of the acute phase reaction in patients with chemotherapy-induced leucopenia. Bruserud O, etal., Eur J Haematol. 1996 Jul;57(1):87-95.
32. Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans. Buckham TA, etal., Am J Nephrol. 2010;32(2):103-8. Epub 2010 Jun 16.
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PMID:21054807   PMID:21086908   PMID:21111725   PMID:21174170   PMID:21182747   PMID:21235388   PMID:21241861   PMID:21243433   PMID:21248262   PMID:21265111   PMID:21278303   PMID:21357189  
PMID:21394384   PMID:21455057   PMID:21523343   PMID:21558284   PMID:21575667   PMID:21591983   PMID:21621860   PMID:21655939   PMID:21671260   PMID:21768915   PMID:21848462   PMID:21873635  
PMID:21968104   PMID:21980458   PMID:22032624   PMID:22035161   PMID:22059992   PMID:22127713   PMID:22205395   PMID:22267087   PMID:22285242   PMID:22286731   PMID:22312160   PMID:22322675  
PMID:22327782   PMID:22370044   PMID:22431772   PMID:22455686   PMID:22498095   PMID:22537067   PMID:22744645   PMID:22753384   PMID:22829643   PMID:22882407   PMID:22909148   PMID:22939635  
PMID:22948742   PMID:23009887   PMID:23013217   PMID:23028694   PMID:23049596   PMID:23049925   PMID:23053980   PMID:23122308   PMID:23168096   PMID:23192617   PMID:23195019   PMID:23212299  
PMID:23251650   PMID:23251661   PMID:23308180   PMID:23323013   PMID:23363559   PMID:23376485   PMID:23388595   PMID:23406623   PMID:23449693   PMID:23472661   PMID:23499887   PMID:23554905  
PMID:23562526   PMID:23577098   PMID:23584371   PMID:23592003   PMID:23602199   PMID:23602982   PMID:23609451   PMID:23633206   PMID:23743874   PMID:23749763   PMID:23765978   PMID:23800434  
PMID:23818854   PMID:23823136   PMID:23849770   PMID:23953530   PMID:23954849   PMID:23969696   PMID:23991111   PMID:23999825   PMID:24014495   PMID:24055697   PMID:24162774   PMID:24182552  
PMID:24233813   PMID:24274595   PMID:24322806   PMID:24446526   PMID:24446657   PMID:24465880   PMID:24490166   PMID:24504887   PMID:24534280   PMID:24557417   PMID:24563688   PMID:24588341  
PMID:24592969   PMID:24603878   PMID:24611340   PMID:24680088   PMID:24771848   PMID:24819208   PMID:24840811   PMID:24850227   PMID:24905619   PMID:24918527   PMID:24933945   PMID:24952603  
PMID:24969107   PMID:24998848   PMID:25073651   PMID:25080789   PMID:25089931   PMID:25124963   PMID:25174605   PMID:25201247   PMID:25207923   PMID:25223242   PMID:25286391   PMID:25292060  
PMID:25331947   PMID:25422100   PMID:25461401   PMID:25466956   PMID:25500257   PMID:25530139   PMID:25542762   PMID:25616863   PMID:25726324   PMID:25738940   PMID:25821855   PMID:25826984  
PMID:26003199   PMID:26046681   PMID:26097611   PMID:26101331   PMID:26158606   PMID:26186194   PMID:26269955   PMID:26279136   PMID:26316104   PMID:26330006   PMID:26445016   PMID:26449434  
PMID:26474296   PMID:26487586   PMID:26500244   PMID:26502861   PMID:26521731   PMID:26555681   PMID:26610735   PMID:26612588   PMID:26646252   PMID:26654556   PMID:26813462   PMID:26831858  
PMID:26861613   PMID:26972847   PMID:26994310   PMID:27031441   PMID:27061312   PMID:27105431   PMID:27116880   PMID:27138824   PMID:27340011   PMID:27400406   PMID:27432980   PMID:27436278  
PMID:27538648   PMID:27717726   PMID:27769857   PMID:28083609   PMID:28110439   PMID:28129679   PMID:28252571   PMID:28293435   PMID:28296777   PMID:28342152   PMID:28370589   PMID:28383060  
PMID:28384207   PMID:28405733   PMID:28428221   PMID:28514442   PMID:28593919   PMID:28612927   PMID:28682145   PMID:28972805   PMID:29023524   PMID:29047186   PMID:29117667   PMID:29169428  
PMID:29226727   PMID:29235261   PMID:29281611   PMID:29339698   PMID:29395365   PMID:29425823   PMID:29454070   PMID:29620037   PMID:29718011   PMID:29802240   PMID:29943912   PMID:29949333  
PMID:29968322   PMID:30075593   PMID:30095747   PMID:30360750   PMID:30375100   PMID:30382562   PMID:30523673   PMID:30593746   PMID:30779222   PMID:30969811   PMID:30978442   PMID:30995661  
PMID:31002437   PMID:31059114   PMID:31102307   PMID:31125901   PMID:31294845   PMID:31299415   PMID:31357078   PMID:31444012   PMID:31550242   PMID:31554783   PMID:31650822   PMID:31693463  
PMID:31698971   PMID:31846791   PMID:31852669   PMID:31854275   PMID:31953354   PMID:32020215   PMID:32148206   PMID:32170523   PMID:32185578   PMID:32204425   PMID:32282310   PMID:32319224  
PMID:32470060   PMID:32526258   PMID:32657162   PMID:32739831   PMID:32790111   PMID:32881904   PMID:33128925   PMID:33238942   PMID:33464542   PMID:33466672   PMID:33480001   PMID:33961781  
PMID:34002010   PMID:34070905   PMID:34363079   PMID:34732716   PMID:34741549   PMID:34897107   PMID:34990893   PMID:35066451   PMID:35272075  


Genomics

Comparative Map Data
IL1RN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,099,360 - 113,134,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,099,315 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh372113,875,548 - 113,891,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
Il1rn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,226,872 - 24,241,503 (+)NCBIGRCm39mm39
GRCm39 Ensembl224,226,865 - 24,241,506 (+)Ensembl
GRCm38224,336,860 - 24,351,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,336,853 - 24,351,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,192,380 - 24,207,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv36224,158,869 - 24,173,490 (+)NCBImm8
Celera224,056,294 - 24,070,923 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.36NCBI
Il1rn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.237,111,567 - 7,127,451 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl37,111,550 - 7,127,445 (+)Ensembl
Rnor_6.031,449,778 - 1,468,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,452,644 - 1,468,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,445,598 - 1,461,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,607,800 - 2,613,216 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.132,607,803 - 2,611,842 (+)NCBI
Celera31,959,290 - 1,964,693 (+)NCBICelera
Cytogenetic Map3p13NCBI
Il1rn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,144,810 - 1,159,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,145,022 - 1,159,413 (-)NCBIChiLan1.0ChiLan1.0
LOC100991079
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A114,061,182 - 114,077,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,061,182 - 114,078,839 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A88,991,646 - 89,008,013 (-)NCBIMhudiblu_PPA_v0panPan3
IL1RN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,236,690 - 37,250,424 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,212,751 - 37,249,329 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,014,575 - 37,019,617 (+)NCBI
ROS_Cfam_1.01738,014,380 - 38,028,164 (+)NCBI
ROS_Cfam_1.0 Ensembl1738,014,324 - 38,027,492 (+)Ensembl
UMICH_Zoey_3.11737,157,832 - 37,162,873 (+)NCBI
UNSW_CanFamBas_1.01737,214,332 - 37,219,374 (+)NCBI
UU_Cfam_GSD_1.01737,426,795 - 37,431,843 (+)NCBI
Il1rn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,552,650 - 82,571,860 (+)NCBI
SpeTri2.0NW_0049367831,447,158 - 1,466,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RN
(Sus scrofa - pig)
No map positions available.
IL1RN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,136,667 - 16,152,451 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,146,333 - 16,151,326 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660803,528,175 - 3,543,946 (-)NCBIVero_WHO_p1.0
Il1rn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,210,476 - 13,225,890 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474913,210,365 - 13,224,471 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH17495  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,890,540 - 113,890,674UniSTSGRCh37
Build 362113,607,011 - 113,607,145RGDNCBI36
Celera2107,275,138 - 107,275,272RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,344,844 - 106,344,978UniSTS
GeneMap99-GB4 RH Map2411.03UniSTS
NCBI RH Map2844.2UniSTS
GDB:182560  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,887,202 - 113,888,680UniSTSGRCh37
Build 362113,603,673 - 113,605,151RGDNCBI36
Celera2107,271,886 - 107,273,278RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,341,678 - 106,342,984UniSTS
GDB:204180  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,888,072 - 113,888,483UniSTSGRCh37
Build 362113,604,543 - 113,604,954RGDNCBI36
Celera2107,272,756 - 107,273,081RGD
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map2q14.2UniSTS
HuRef2106,342,548 - 106,342,787UniSTS
HuRef5151,816,575 - 151,817,980UniSTS
IL1RN_3322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,890,235 - 113,891,019UniSTSGRCh37
Build 362113,606,706 - 113,607,490RGDNCBI36
Celera2107,274,833 - 107,275,617RGD
HuRef2106,344,539 - 106,345,323UniSTS
D2S2718  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,890,569 - 113,890,917UniSTSGRCh37
Build 362113,607,040 - 113,607,388RGDNCBI36
Celera2107,275,167 - 107,275,515RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,344,873 - 106,345,221UniSTS
Stanford-G3 RH Map24796.0UniSTS
NCBI RH Map2847.2UniSTS
GeneMap99-G3 RH Map25709.0UniSTS
RH70911  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,875,703 - 113,875,864UniSTSGRCh37
Build 362113,592,174 - 113,592,335RGDNCBI36
Celera2107,260,392 - 107,260,553RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,330,183 - 106,330,344UniSTS
GeneMap99-GB4 RH Map2412.71UniSTS
NCBI RH Map2844.2UniSTS
WI-13878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,891,434 - 113,891,561UniSTSGRCh37
Build 362113,607,905 - 113,608,032RGDNCBI36
Celera2107,276,032 - 107,276,159RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,345,738 - 106,345,865UniSTS
GeneMap99-GB4 RH Map2411.14UniSTS
Whitehead-RH Map2594.1UniSTS
NCBI RH Map2844.2UniSTS
RH11709  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,891,299 - 113,891,501UniSTSGRCh37
Build 362113,607,770 - 113,607,972RGDNCBI36
Celera2107,275,897 - 107,276,099RGD
Cytogenetic Map2q14.2UniSTS
HuRef2106,345,603 - 106,345,805UniSTS
GeneMap99-GB4 RH Map2411.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3377
Count of miRNA genes:822
Interacting mature miRNAs:938
Transcripts:ENST00000259206, ENST00000354115, ENST00000361779, ENST00000409052, ENST00000409930, ENST00000463073, ENST00000465812, ENST00000472292, ENST00000486167
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 2 1 3 22 1 3 1 37 19
Medium 328 788 427 420 972 391 1496 72 41 46 433 406 41 258 723
Low 1613 1430 1125 159 481 57 1510 815 1087 243 779 1048 107 1 887 1005 5
Below cutoff 474 755 158 14 326 7 1114 1252 2464 107 176 55 7 59 1050 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011511121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A49726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A50144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC024704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF043143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF057168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF387734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF387735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ005835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM260202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY196903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI766516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA667440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI656437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M97748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U65590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000259206   ⟹   ENSP00000259206
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,897 - 113,134,016 (+)Ensembl
RefSeq Acc Id: ENST00000354115   ⟹   ENSP00000329072
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,897 - 113,134,016 (+)Ensembl
RefSeq Acc Id: ENST00000361779   ⟹   ENSP00000354816
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,893 - 113,134,016 (+)Ensembl
RefSeq Acc Id: ENST00000409052   ⟹   ENSP00000387210
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,099,360 - 113,134,013 (+)Ensembl
RefSeq Acc Id: ENST00000409930   ⟹   ENSP00000387173
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,598 - 113,134,014 (+)Ensembl
RefSeq Acc Id: ENST00000463073
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,099,487 - 113,115,690 (+)Ensembl
RefSeq Acc Id: ENST00000465812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,099,315 - 113,120,080 (+)Ensembl
RefSeq Acc Id: ENST00000472292
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,576 - 113,129,982 (+)Ensembl
RefSeq Acc Id: ENST00000486167
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,981 - 113,130,121 (+)Ensembl
RefSeq Acc Id: ENST00000696879   ⟹   ENSP00000512947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,483 - 113,133,536 (+)Ensembl
RefSeq Acc Id: ENST00000696880   ⟹   ENSP00000512948
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,695 - 113,134,014 (+)Ensembl
RefSeq Acc Id: ENST00000696881   ⟹   ENSP00000512949
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,117,941 - 113,133,001 (+)Ensembl
RefSeq Acc Id: ENST00000696882   ⟹   ENSP00000512950
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,127,613 - 113,133,428 (+)Ensembl
RefSeq Acc Id: ENST00000696883
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,130,895 - 113,132,937 (+)Ensembl
RefSeq Acc Id: NM_000577   ⟹   NP_000568
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,591,941 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,879,899 - 113,896,017 (+)NCBI
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001318914   ⟹   NP_001305843
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
CHM1_12113,879,899 - 113,896,017 (+)NCBI
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379360   ⟹   NP_001366289
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,127,489 - 113,134,014 (+)NCBI
T2T-CHM13v2.02113,554,069 - 113,560,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173841   ⟹   NP_776213
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,591,941 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,879,899 - 113,896,017 (+)NCBI
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173842   ⟹   NP_776214
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,127,598 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,601,609 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,889,562 - 113,896,017 (+)NCBI
T2T-CHM13v2.02113,554,178 - 113,560,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173843   ⟹   NP_776215
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,117,971 - 113,134,014 (+)NCBI
GRCh372113,868,693 - 113,891,593 (+)NCBI
Build 362113,591,941 - 113,608,064 (+)NCBI Archive
HuRef2106,329,950 - 106,345,897 (+)ENTREZGENE
CHM1_12113,879,899 - 113,896,017 (+)NCBI
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011511121   ⟹   XP_011509423
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,099,360 - 113,134,014 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047444184   ⟹   XP_047300140
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,099,360 - 113,134,014 (+)NCBI
RefSeq Acc Id: XM_047444185   ⟹   XP_047300141
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,099,360 - 113,134,014 (+)NCBI
RefSeq Acc Id: XM_047444186   ⟹   XP_047300142
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,099,360 - 113,134,014 (+)NCBI
Protein Sequences
Protein RefSeqs NP_000568 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305843 (Get FASTA)   NCBI Sequence Viewer  
  NP_001366289 (Get FASTA)   NCBI Sequence Viewer  
  NP_776213 (Get FASTA)   NCBI Sequence Viewer  
  NP_776214 (Get FASTA)   NCBI Sequence Viewer  
  NP_776215 (Get FASTA)   NCBI Sequence Viewer  
  XP_011509423 (Get FASTA)   NCBI Sequence Viewer  
  XP_047300140 (Get FASTA)   NCBI Sequence Viewer  
  XP_047300141 (Get FASTA)   NCBI Sequence Viewer  
  XP_047300142 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA59138 (Get FASTA)   NCBI Sequence Viewer  
  AAB41943 (Get FASTA)   NCBI Sequence Viewer  
  AAB92268 (Get FASTA)   NCBI Sequence Viewer  
  AAB92269 (Get FASTA)   NCBI Sequence Viewer  
  AAB92270 (Get FASTA)   NCBI Sequence Viewer  
  AAC13499 (Get FASTA)   NCBI Sequence Viewer  
  AAC39672 (Get FASTA)   NCBI Sequence Viewer  
  AAH09745 (Get FASTA)   NCBI Sequence Viewer  
  AAN87150 (Get FASTA)   NCBI Sequence Viewer  
  AAX93278 (Get FASTA)   NCBI Sequence Viewer  
  BAF83587 (Get FASTA)   NCBI Sequence Viewer  
  BAF83615 (Get FASTA)   NCBI Sequence Viewer  
  CAA03191 (Get FASTA)   NCBI Sequence Viewer  
  CAA03210 (Get FASTA)   NCBI Sequence Viewer  
  CAA06730 (Get FASTA)   NCBI Sequence Viewer  
  CAA36262 (Get FASTA)   NCBI Sequence Viewer  
  CAA37386 (Get FASTA)   NCBI Sequence Viewer  
  CAA45832 (Get FASTA)   NCBI Sequence Viewer  
  CAA59087 (Get FASTA)   NCBI Sequence Viewer  
  CAD29879 (Get FASTA)   NCBI Sequence Viewer  
  CAJ91094 (Get FASTA)   NCBI Sequence Viewer  
  CBY45189 (Get FASTA)   NCBI Sequence Viewer  
  EAW73621 (Get FASTA)   NCBI Sequence Viewer  
  EAW73622 (Get FASTA)   NCBI Sequence Viewer  
  EAW73623 (Get FASTA)   NCBI Sequence Viewer  
  EAW73624 (Get FASTA)   NCBI Sequence Viewer  
  EAW73625 (Get FASTA)   NCBI Sequence Viewer  
  P18510 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_776213   ⟸   NM_173841
- Peptide Label: isoform 2
- UniProtKB: P18510 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_776215   ⟸   NM_173843
- Peptide Label: isoform 4
- UniProtKB: P18510 (UniProtKB/Swiss-Prot),   A0A024R528 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000568   ⟸   NM_000577
- Peptide Label: isoform 3
- UniProtKB: P18510 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_776214   ⟸   NM_173842
- Peptide Label: isoform 1 precursor
- UniProtKB: P18510 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011509423   ⟸   XM_011511121
- Peptide Label: isoform X1
- UniProtKB: P18510 (UniProtKB/Swiss-Prot),   A0A024R528 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305843   ⟸   NM_001318914
- Peptide Label: isoform 4
- UniProtKB: P18510 (UniProtKB/Swiss-Prot),   A0A024R528 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001366289   ⟸   NM_001379360
- Peptide Label: isoform 4
RefSeq Acc Id: ENSP00000354816   ⟸   ENST00000361779
RefSeq Acc Id: ENSP00000259206   ⟸   ENST00000259206
RefSeq Acc Id: ENSP00000329072   ⟸   ENST00000354115
RefSeq Acc Id: ENSP00000387173   ⟸   ENST00000409930
RefSeq Acc Id: ENSP00000387210   ⟸   ENST00000409052
RefSeq Acc Id: ENSP00000512950   ⟸   ENST00000696882
RefSeq Acc Id: ENSP00000512949   ⟸   ENST00000696881
RefSeq Acc Id: ENSP00000512947   ⟸   ENST00000696879
RefSeq Acc Id: ENSP00000512948   ⟸   ENST00000696880
RefSeq Acc Id: XP_047300140   ⟸   XM_047444184
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047300141   ⟸   XM_047444185
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047300142   ⟸   XM_047444186
- Peptide Label: isoform X1

Protein Structures