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Gene: CD274 (CD274 molecule) Homo sapiens
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Symbol: CD274
Name: CD274 molecule
Description: Involved in several processes, including negative regulation of cytokine production; positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process; and regulation of T cell activation. Localizes to endosome membrane; extracellular exosome; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B7 homolog 1; B7-H; B7H1; CD274 antigen; hPD-L1; MGC142294; MGC142296; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; programmed cell death 1 ligand 1; programmed death ligand 1
Orthologs:
Mus musculus (house mouse) : Cd274 (CD274 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd274 (CD274 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd274 (CD274 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD274 (CD274 molecule)
Canis lupus familiaris (dog) : CD274 (CD274 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd274 (CD274 molecule)
Sus scrofa (pig) : CD274 (CD274 molecule)
Chlorocebus sabaeus (African green monkey) : CD274 (CD274 molecule)
Heterocephalus glaber (naked mole-rat) : Cd274 (CD274 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl95,450,503 - 5,470,566 (+)EnsemblGRCh38hg38GRCh38
GRCh3895,450,503 - 5,470,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3795,450,503 - 5,470,567 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,440,559 - 5,458,477 (+)NCBINCBI36hg18NCBI36
Celera95,376,139 - 5,396,204 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef95,406,210 - 5,426,274 (+)NCBIHuRef
CHM1_195,450,664 - 5,470,759 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD274
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605684
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-05-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.