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Gene: CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1) Homo sapiens
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Symbol: CASTOR1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Description: Exhibits arginine binding activity and identical protein binding activity. Involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Localizes to cytosol. Colocalizes with GATOR2 complex; PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cellular arginine sensor for mTORC1 protein 1; GATS protein like 3; GATS protein-like 3; GATS-like protein 3; GATSL3
Orthologs:
Mus musculus (house mouse) : Castor1 (cytosolic arginine sensor for mTORC1 subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Castor1 (cytosolic arginine sensor for mTORC1 subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Castor1 (cytosolic arginine sensor for mTORC1 subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)
Canis lupus familiaris (dog) : CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Castor1 (cytosolic arginine sensor for mTORC1 subunit 1)
Sus scrofa (pig) : CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)
Chlorocebus sabaeus (African green monkey) : CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)
Heterocephalus glaber (naked mole-rat) : Castor1 (cytosolic arginine sensor for mTORC1 subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,285,117 - 30,289,627 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2230,285,117 - 30,289,622 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,285,117 - 30,289,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,681,106 - 30,685,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,011,107 - 29,015,502 (-)NCBINCBI36hg18NCBI36
Celera2214,480,787 - 14,485,320 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,642,884 - 13,647,417 (-)NCBIHuRef
CHM1_12230,640,242 - 30,644,751 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on CASTOR1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2306475
Created: 2009-04-17
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.