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Gene: BCL2L1 (BCL2 like 1) Homo sapiens
Symbol: BCL2L1
Name: BCL2 like 1
Description: Exhibits BH3 domain binding activity; identical protein binding activity; and protein kinase binding activity. Involved in several processes, including mitochondrion organization; negative regulation of apoptotic process; and negative regulation of protein localization to plasma membrane. Localizes to Bcl-2 family protein complex; centrosome; and mitochondrial outer membrane. Predicted to colocalize with clathrin-coated pit and synaptic vesicle membrane. Implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Biomarker of several diseases, including chronic obstructive pulmonary disease; colorectal adenocarcinoma; hematologic cancer (multiple); urinary system cancer (multiple); and uterine disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulator Bcl-X; bcl-2-like protein 1; Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; bcl2-L-1; BCL2-like 1; BCL2L; BCLX; BCLXL; BCLXS; DKFZp781P2092; PPP1R52; protein phosphatase 1, regulatory subunit 52
Mus musculus (house mouse) : Bcl2l1 (BCL2-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bcl2l1 (Bcl2-like 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcl2l1 (BCL2 like 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BCL2L1 (BCL2 like 1)
Canis lupus familiaris (dog) : BCL2L1 (BCL2 like 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcl2l1 (BCL2 like 1)
Sus scrofa (pig) : BCL2L1 (BCL2 like 1)
Chlorocebus sabaeus (African green monkey) : BCL2L1 (BCL2 like 1)
Heterocephalus glaber (naked mole-rat) : Bcl2l1 (BCL2 like 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2031,664,452 - 31,723,989 (-)EnsemblGRCh38hg38GRCh38
GRCh382031,664,452 - 31,723,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,252,261 - 30,311,752 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,715,922 - 29,774,317 (-)NCBINCBI36hg18NCBI36
Build 342029,715,923 - 29,774,317NCBI
Celera2027,008,611 - 27,067,007 (-)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,040,965 - 27,099,720 (-)NCBIHuRef
CHM1_12030,156,165 - 30,215,683 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences