RHOA (ras homolog family member A) - Rat Genome Database

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Gene: RHOA (ras homolog family member A) Homo sapiens
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Symbol: RHOA
Name: ras homolog family member A
RGD ID: 1347797
HGNC Page HGNC
Description: Enables GTP binding activity; GTPase activity; and myosin binding activity. Involved in several processes, including cell surface receptor signaling pathway; cytoskeleton organization; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of stress fiber assembly. Located in several cellular components, including apical junction complex; dendritic spine; and endosome. Is extrinsic component of cytoplasmic side of plasma membrane. Is active in glutamatergic synapse and postsynapse. Colocalizes with cleavage furrow. Implicated in breast carcinoma. Biomarker of breast cancer; colorectal cancer; multiple sclerosis; ovarian carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Aplysia ras-related homolog 12; ARH12; ARHA; EDFAOB; h12; oncogene RHO H12; ras homolog gene family, member A; rho cDNA clone 12; RHO12; RHOH12; small GTP binding protein RhoA; transforming protein RhoA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AL590635.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,388 - 49,402,293 (-)NCBICHM1_1
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (EXP)
Aicardi-Goutieres Syndrome 1  (IAGP)
alopecia  (EXP)
Animal Disease Models  (EXP)
asthma  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (IAGP)
Brain Injuries  (ISO)
breast cancer  (IEP)
breast carcinoma  (IMP)
Breast Neoplasms  (IAGP)
carcinoma  (EXP)
Cardiomegaly  (ISO)
Cocaine-Related Disorders  (EXP)
colorectal cancer  (IEP)
Colorectal Neoplasms  (IAGP)
congenital diaphragmatic hernia  (EXP)
Craniofacial Abnormalities  (EXP)
ectodermal dysplasia  (EXP)
ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES  (IAGP)
esophageal carcinoma  (IAGP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
fetal alcohol syndrome  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (IAGP)
genetic disease  (IAGP)
Germ Cell and Embryonal Neoplasms  (IEP)
glycine encephalopathy  (IAGP)
head and neck squamous cell carcinoma  (IAGP)
hypertension  (ISO)
Hypopigmentation  (EXP)
Immunoblastic Lymphadenopathy  (EXP)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (EXP)
lung adenocarcinoma  (IAGP)
Lymphatic Metastasis  (IEP)
membranous glomerulonephritis  (ISO)
multiple sclerosis  (IEP)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (IEP)
Neurocutaneous Syndromes  (EXP)
non-Hodgkin lymphoma  (IAGP)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
ovarian carcinoma  (IEP)
peripheral T-cell lymphoma  (EXP)
Pierson syndrome  (IAGP)
primary cutaneous T-cell non-Hodgkin lymphoma  (EXP)
proteinuria  (EXP)
pulmonary hypertension  (ISO)
Stomach Neoplasms  (EXP)
T-Cell Lymphoma  (EXP)
tooth disease  (EXP)
urinary bladder cancer  (EXP,IEP)
Urologic Neoplasms  (IEP)
withdrawal disorder  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (EXP,ISO)
(S)-(-)-perillyl alcohol  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroxy-TEMPO  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-(4-chlorophenylthio)-cGMP  (EXP)
9-cis-retinoic acid  (EXP)
acetylcholine  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP,ISO)
atropine  (EXP)
beclomethasone  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP)
beryllium sulfate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
brimonidine tartrate  (ISO)
bufalin  (EXP)
cadmium dichloride  (EXP,ISO)
calcidiol  (ISO)
Calpeptin  (ISO)
cannabidiol  (EXP)
carvone  (EXP)
casticin  (ISO)
celecoxib  (EXP)
cerivastatin  (EXP)
chloropicrin  (EXP)
chrysin  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cocaine  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cytochalasin D  (EXP)
D-glucose  (ISO)
deguelin  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
emodin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
everolimus  (EXP)
farnesol  (EXP,ISO)
farnesyl diphosphate  (EXP,ISO)
fasudil  (EXP,ISO)
finasteride  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flavonol  (EXP)
flubendazole  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
gallic acid  (EXP)
Ganoderic acid A  (ISO)
geranylgeraniol  (EXP,ISO)
glucose  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
GTP  (EXP,ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
indometacin  (EXP)
isotretinoin  (EXP)
ivermectin  (EXP)
kainic acid  (ISO)
kanamycin A  (ISO)
KT 5823  (EXP)
latrunculin B  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (ISO)
mebendazole  (EXP)
menadione  (EXP)
mercury dichloride  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
mevastatin  (EXP)
myrtenol  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
nonanoic acid  (ISO)
oroxylin A  (ISO)
ozone  (EXP)
p-cresol  (EXP)
p-menthan-3-ol  (EXP)
pamidronate  (EXP)
paracetamol  (ISO)
parathion  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perillic acid  (EXP)
perillyl alcohol  (EXP,ISO)
perillyl aldehyde  (EXP)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 12,13-dibutanoate  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
quercetin  (EXP)
quinpirole  (EXP)
raloxifene  (ISO)
ramipril  (ISO)
resveratrol  (EXP,ISO)
Risedronate sodium  (EXP,ISO)
Ro 31-8220  (ISO)
rotenone  (ISO)
sevoflurane  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
terbinafine  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
U-73122  (ISO)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
warfarin  (ISO)
Y-27632  (EXP)
zaragozic acid A  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO,TAS)
actin cytoskeleton reorganization  (IMP)
actin filament organization  (IBA)
alpha-beta T cell lineage commitment  (IEA)
androgen receptor signaling pathway  (IEA,ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IEA,ISO)
apical junction assembly  (IEA,IMP)
apolipoprotein A-I-mediated signaling pathway  (IMP)
beta selection  (IEA)
cell adhesion  (IEA,ISO)
cell differentiation  (IEA,ISO)
cell division  (IEA)
cell junction assembly  (IMP)
cell migration  (IBA,IDA,IMP)
cell morphogenesis  (IEA,ISO)
cell-matrix adhesion  (IEA,ISO)
cellular response to chemokine  (IMP)
cellular response to cytokine stimulus  (IMP)
cellular response to lipopolysaccharide  (IDA)
cerebral cortex cell migration  (IEA,ISO)
cleavage furrow formation  (IDA)
cortical cytoskeleton organization  (IBA)
cytoplasmic microtubule organization  (IMP)
cytoskeleton organization  (IEA,ISO)
embryonic cleavage  (ISO)
endothelial cell migration  (IGI)
endothelial tube lumen extension  (IGI)
establishment of epithelial cell apical/basal polarity  (IMP)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
establishment or maintenance of cell polarity  (IBA)
forebrain radial glial cell differentiation  (IEA,ISO)
GTP metabolic process  (IEA)
kidney development  (IEA,ISO)
meiotic spindle organization  (ISO)
mitotic cleavage furrow formation  (IMP)
mitotic spindle assembly  (IMP)
motor neuron apoptotic process  (IEA,ISO)
negative chemotaxis  (IMP)
negative regulation of cell death  (IEA,ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (IGI)
negative regulation of cell size  (IMP)
negative regulation of cell-substrate adhesion  (IEA,ISS)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IEA,ISO)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of neuron projection development  (IEA)
negative regulation of oxidative phosphorylation  (IEA)
negative regulation of reactive oxygen species biosynthetic process  (IEA)
negative regulation of vascular associated smooth muscle cell migration  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
neuron migration  (IEA,ISO)
neuron projection morphogenesis  (IEA,ISO)
odontogenesis  (IEA,ISO)
ossification involved in bone maturation  (IEA,ISS)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of alpha-beta T cell differentiation  (IEA)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
positive regulation of cytokinesis  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEP)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of lipase activity  (IDA,IMP)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of neuron differentiation  (IMP)
positive regulation of NIK/NF-kappaB signaling  (IMP,NAS)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of protein serine/threonine kinase activity  (IDA)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of stress fiber assembly  (IDA,IEA,IMP)
positive regulation of T cell migration  (IMP)
positive regulation of translation  (IEA,ISO)
positive regulation of vascular associated smooth muscle contraction  (IEA,ISO)
positive regulation of vasoconstriction  (IEA,ISO)
regulation of actin cytoskeleton organization  (IBA,IDA,IEA)
regulation of actin polymerization or depolymerization  (IEA,ISO)
regulation of calcium ion transport  (IEA,ISO)
regulation of cell migration  (IMP)
regulation of cell shape  (IBA)
regulation of dendrite development  (IEA,ISO)
regulation of focal adhesion assembly  (TAS)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of modification of postsynaptic actin cytoskeleton  (IMP)
regulation of modification of synaptic structure  (IEA)
regulation of neural precursor cell proliferation  (IEA,ISO)
regulation of neuron projection development  (IEA,ISO)
regulation of osteoblast proliferation  (IEA,ISS)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to amino acid  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to glucocorticoid  (IEA,ISO)
response to glucose  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to mechanical stimulus  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
Rho protein signal transduction  (IDA,IEA,IMP,ISO,TAS)
Roundabout signaling pathway  (IDA)
skeletal muscle satellite cell migration  (ISS)
skeletal muscle tissue development  (IEA,ISO)
small GTPase mediated signal transduction  (IEA)
spindle localization  (ISO)
stress fiber assembly  (IBA,IEA,IMP,ISO)
stress-activated protein kinase signaling cascade  (IEA,ISO)
substantia nigra development  (HEP)
substrate adhesion-dependent cell spreading  (IMP)
trabecula morphogenesis  (IEA,ISS)
Wnt signaling pathway, planar cell polarity pathway  (NAS)
wound healing, spreading of cells  (ISS)

Cellular Component

Molecular Function

References

References - curated
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2. Bellizzi A, etal., Int J Mol Med. 2008 Jul;22(1):25-31.
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6. Hilgers RH, etal., J Hypertens. 2007 Aug;25(8):1687-97.
7. Homma N, etal., J Cardiovasc Pharmacol. 2007 Dec;50(6):697-702.
8. Horiuchi A, etal., Lab Invest. 2003 Jun;83(6):861-70.
9. Joshi S, etal., Cell Mol Life Sci. 2006 Dec;63(23):2859-70.
10. Kamai T, etal., BJU Int 2003 Feb;91(3):234-8.
11. Kamai T, etal., BJU Int. 2002 Mar;89(4):449-53.
12. Kamai T, etal., Clin Cancer Res. 2003 Jul;9(7):2632-41.
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16. Phillips HM, etal., Circ Res. 2005 Feb 18;96(3):292-9. Epub 2005 Jan 6.
17. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
18. Pille JY, etal., Hum Gene Ther. 2006 Oct;17(10):1019-26.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. RGD automated import pipeline for gene-chemical interactions
22. Rihet S, etal., J Cancer Res Clin Oncol 2001 Dec;127(12):733-8.
23. Saka M, etal., Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1164-71.
24. Takami Y, etal., Dig Dis Sci. 2008 Feb;53(2):467-73. Epub 2007 Jun 28.
25. Trebicka J, etal., Hepatology. 2007 Jul;46(1):242-53.
26. Wang YH, etal., Ophthalmic Res. 2007;39(3):174-8. Epub 2007 May 25.
27. Zhang H, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F148-56. Epub 2007 Mar 20.
28. Zhang Z, etal., Acta Neuropathol. 2008 Mar;115(3):335-43. Epub 2007 Oct 11.
29. Zhang Z, etal., J Cell Mol Med. 2007 Jan-Feb;11(1):111-9.
30. Zhang Z, etal., Neuropathol Appl Neurobiol. 2008 Apr;34(2):231-40. Epub 2007 Nov 5.
31. Zhou Q, etal., Gut. 2006 Sep;55(9):1296-305. Epub 2006 Feb 21.
Additional References at PubMed
PMID:1328215   PMID:1556108   PMID:2407642   PMID:3822842   PMID:7835413   PMID:7989340   PMID:8039707   PMID:8125298   PMID:8491184   PMID:8543060   PMID:8571127   PMID:8617235  
PMID:8625410   PMID:8641286   PMID:8662891   PMID:8769096   PMID:8798490   PMID:8816443   PMID:8910519   PMID:9113980   PMID:9121475   PMID:9199174   PMID:9214622   PMID:9302995  
PMID:9354661   PMID:9407060   PMID:9446575   PMID:9490022   PMID:9535835   PMID:9535855   PMID:9545299   PMID:9548756   PMID:9565577   PMID:9582072   PMID:9605859   PMID:9614111  
PMID:9635436   PMID:9647788   PMID:9799233   PMID:9804788   PMID:9857026   PMID:10051605   PMID:10066731   PMID:10220378   PMID:10388627   PMID:10436159   PMID:10489445   PMID:10523675  
PMID:10526156   PMID:10595511   PMID:10619026   PMID:10713718   PMID:10748207   PMID:10854437   PMID:10896672   PMID:10940294   PMID:10947987   PMID:10948190   PMID:11067852   PMID:11085924  
PMID:11149925   PMID:11157984   PMID:11162552   PMID:11284700   PMID:11311142   PMID:11335720   PMID:11350930   PMID:11368848   PMID:11373293   PMID:11432776   PMID:11560922   PMID:11591790  
PMID:11672528   PMID:11689693   PMID:11696353   PMID:11741970   PMID:11751986   PMID:11779461   PMID:11786539   PMID:11788600   PMID:11818523   PMID:11822867   PMID:11830497   PMID:11830597  
PMID:11839748   PMID:11839765   PMID:11889037   PMID:11907271   PMID:11909943   PMID:11927263   PMID:11948427   PMID:11998687   PMID:12006984   PMID:12016230   PMID:12062101   PMID:12071848  
PMID:12093360   PMID:12115629   PMID:12119292   PMID:12154081   PMID:12169092   PMID:12221077   PMID:12221096   PMID:12244193   PMID:12397214   PMID:12401808   PMID:12423633   PMID:12432077  
PMID:12445208   PMID:12446789   PMID:12454018   PMID:12466390   PMID:12477932   PMID:12482610   PMID:12490434   PMID:12524425   PMID:12533515   PMID:12534282   PMID:12538863   PMID:12579323  
PMID:12584113   PMID:12593858   PMID:12654918   PMID:12692008   PMID:12692556   PMID:12719789   PMID:12748184   PMID:12761501   PMID:12766172   PMID:12773565   PMID:12777804   PMID:12805219  
PMID:12842009   PMID:12847276   PMID:12857875   PMID:12879077   PMID:12900402   PMID:12939257   PMID:12944407   PMID:12951563   PMID:12972426   PMID:12972601   PMID:14506264   PMID:14514689  
PMID:14530271   PMID:14581471   PMID:14605490   PMID:14612927   PMID:14644158   PMID:14657501   PMID:14660612   PMID:14749388   PMID:15003991   PMID:15009099   PMID:15016733   PMID:15023524  
PMID:15068789   PMID:15069594   PMID:15075243   PMID:15085137   PMID:15096506   PMID:15102021   PMID:15102857   PMID:15125835   PMID:15128850   PMID:15155793   PMID:15184877   PMID:15208091  
PMID:15210811   PMID:15298851   PMID:15308673   PMID:15322077   PMID:15331592   PMID:15364580   PMID:15448013   PMID:15467718   PMID:15475352   PMID:15475381   PMID:15489334   PMID:15530360  
PMID:15535843   PMID:15557193   PMID:15574779   PMID:15579505   PMID:15598682   PMID:15601624   PMID:15611088   PMID:15640525   PMID:15642170   PMID:15643515   PMID:15644318   PMID:15652748  
PMID:15659383   PMID:15668138   PMID:15670823   PMID:15710384   PMID:15755723   PMID:15761153   PMID:15766663   PMID:15793564   PMID:15793569   PMID:15809302   PMID:15817453   PMID:15834426  
PMID:15843433   PMID:15864301   PMID:15889147   PMID:15890975   PMID:15901767   PMID:15925904   PMID:15963982   PMID:16061799   PMID:16103226   PMID:16105876   PMID:16109481   PMID:16112081  
PMID:16118207   PMID:16188938   PMID:16189514   PMID:16215275   PMID:16247472   PMID:16257181   PMID:16308318   PMID:16352658   PMID:16394104   PMID:16397238   PMID:16402387   PMID:16424340  
PMID:16427251   PMID:16472676   PMID:16481321   PMID:16496227   PMID:16513651   PMID:16537448   PMID:16540523   PMID:16622418   PMID:16632465   PMID:16644720   PMID:16645187   PMID:16652149  
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PMID:18172303   PMID:18182571   PMID:18198190   PMID:18218625   PMID:18256687   PMID:18287089   PMID:18287519   PMID:18292502   PMID:18300342   PMID:18314880   PMID:18316594   PMID:18334926  
PMID:18356691   PMID:18407958   PMID:18426980   PMID:18434237   PMID:18445682   PMID:18458160   PMID:18477564   PMID:18495213   PMID:18509267   PMID:18509476   PMID:18524772   PMID:18541705  
PMID:18567581   PMID:18593598   PMID:18628484   PMID:18651974   PMID:18653556   PMID:18660502   PMID:18687805   PMID:18688040   PMID:18694745   PMID:18713748   PMID:18721871   PMID:18751372  
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PMID:18929667   PMID:18937283   PMID:18948190   PMID:18955552   PMID:18981818   PMID:18983771   PMID:18996344   PMID:18996642   PMID:19015318   PMID:19038009   PMID:19049388   PMID:19056867  
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PMID:20399237   PMID:20403997   PMID:20416077   PMID:20429915   PMID:20442409   PMID:20457808   PMID:20458337   PMID:20460433   PMID:20473500   PMID:20499158   PMID:20503409   PMID:20507639  
PMID:20547485   PMID:20553488   PMID:20554761   PMID:20558775   PMID:20591975   PMID:20628086   PMID:20628200   PMID:20655307   PMID:20660160   PMID:20682776   PMID:20696764   PMID:20709748  
PMID:20711218   PMID:20733052   PMID:20801873   PMID:20805359   PMID:20808760   PMID:20811643   PMID:20811682   PMID:20814828   PMID:20828398   PMID:20856855   PMID:20859068   PMID:20877624  
PMID:20886658   PMID:20937815   PMID:20945370   PMID:20971525   PMID:20974804   PMID:21029865   PMID:21071443   PMID:21079737   PMID:21087931   PMID:21112276   PMID:21129722   PMID:21130456  
PMID:21145500   PMID:21161732   PMID:21186079   PMID:21208644   PMID:21209619   PMID:21212278   PMID:21237226   PMID:21242305   PMID:21257924   PMID:21258369   PMID:21265091   PMID:21266463  
PMID:21273559   PMID:21277858   PMID:21281639   PMID:21303778   PMID:21351730   PMID:21390328   PMID:21402695   PMID:21423166   PMID:21423176   PMID:21439370   PMID:21451048   PMID:21454543  
PMID:21454546   PMID:21475975   PMID:21516116   PMID:21518791   PMID:21534245   PMID:21574962   PMID:21575498   PMID:21576392   PMID:21600098   PMID:21628952   PMID:21643014   PMID:21667311  
PMID:21698469   PMID:21708152   PMID:21739156   PMID:21750647   PMID:21756816   PMID:21757538   PMID:21779788   PMID:21816819   PMID:21858203   PMID:21873635   PMID:21878647   PMID:21898412  
PMID:21907186   PMID:21917148   PMID:21936715   PMID:21983114   PMID:21988832   PMID:22001926   PMID:22009749   PMID:22041269   PMID:22049212   PMID:22070920   PMID:22072711   PMID:22087025  
PMID:22092654   PMID:22114142   PMID:22120672   PMID:22161021   PMID:22197032   PMID:22226472   PMID:22226621   PMID:22228765   PMID:22241857   PMID:22242598   PMID:22251897   PMID:22275376  
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PMID:22750095   PMID:22774404   PMID:22820501   PMID:22842919   PMID:22847784   PMID:22854067   PMID:22891260   PMID:22893699   PMID:22907703   PMID:22926577   PMID:22939629   PMID:22949615  
PMID:22963825   PMID:22984590   PMID:22992742   PMID:23042265   PMID:23057787   PMID:23066013   PMID:23070684   PMID:23079622   PMID:23166513   PMID:23176180   PMID:23195957   PMID:23241886  
PMID:23243284   PMID:23255405   PMID:23283961   PMID:23295150   PMID:23307872   PMID:23322732   PMID:23324271   PMID:23333463   PMID:23352230   PMID:23361851   PMID:23376485   PMID:23405219  
PMID:23418489   PMID:23420497   PMID:23469924   PMID:23474751   PMID:23488932   PMID:23493395   PMID:23500462   PMID:23512987   PMID:23521319   PMID:23525486   PMID:23536606   PMID:23570668  
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PMID:23842948   PMID:23870313   PMID:23895422   PMID:23900609   PMID:23940119   PMID:24040310   PMID:24043311   PMID:24056963   PMID:24096540   PMID:24098519   PMID:24135036   PMID:24178298  
PMID:24200678   PMID:24220306   PMID:24225494   PMID:24240172   PMID:24241683   PMID:24276241   PMID:24280143   PMID:24287595   PMID:24297045   PMID:24316235   PMID:24318513   PMID:24324133  
PMID:24331979   PMID:24333506   PMID:24337944   PMID:24352656   PMID:24356540   PMID:24359561   PMID:24371121   PMID:24398689   PMID:24413734   PMID:24413737   PMID:24421399   PMID:24431302  
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PMID:26496610   PMID:26512756   PMID:26529257   PMID:26574607   PMID:26574844   PMID:26615410   PMID:26616858   PMID:26631033   PMID:26638075   PMID:26641092   PMID:26648547   PMID:26649141  
PMID:26719334   PMID:26741994   PMID:26751560   PMID:26752649   PMID:26774166   PMID:26825171   PMID:26829051   PMID:26830684   PMID:26852662   PMID:26892468   PMID:26900962   PMID:26928204  
PMID:26949251   PMID:26972000   PMID:26976596   PMID:27041563   PMID:27070728   PMID:27084452   PMID:27090015   PMID:27097314   PMID:27126939   PMID:27138333   PMID:27147504   PMID:27153759  
PMID:27175941   PMID:27195967   PMID:27216196   PMID:27229929   PMID:27250838   PMID:27279564   PMID:27288754   PMID:27311713   PMID:27333992   PMID:27342126   PMID:27369867   PMID:27378427  
PMID:27424208   PMID:27456030   PMID:27495873   PMID:27505894   PMID:27517626   PMID:27563375   PMID:27626171   PMID:27650961   PMID:27684187   PMID:27693615   PMID:27713154   PMID:27756879  
PMID:27775029   PMID:27795403   PMID:27802291   PMID:27806312   PMID:27807006   PMID:27812894   PMID:27863394   PMID:27909884   PMID:27913679   PMID:27917469   PMID:27923225   PMID:27927130  
PMID:27939884   PMID:28004812   PMID:28089989   PMID:28096473   PMID:28104444   PMID:28146427   PMID:28169289   PMID:28175289   PMID:28184030   PMID:28222172   PMID:28284839   PMID:28294307  
PMID:28329735   PMID:28411215   PMID:28499918   PMID:28508825   PMID:28509344   PMID:28514442   PMID:28522256   PMID:28536953   PMID:28558721   PMID:28608226   PMID:28608941   PMID:28624843  
PMID:28630045   PMID:28656284   PMID:28658604   PMID:28691928   PMID:28695771   PMID:28712859   PMID:28743511   PMID:28779705   PMID:28832024   PMID:28843271   PMID:28888686   PMID:28945625  
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PMID:30957191   PMID:31046837   PMID:31054987   PMID:31056743   PMID:31062076   PMID:31091453   PMID:31148579   PMID:31165762   PMID:31169331   PMID:31176746   PMID:31182584   PMID:31209254  
PMID:31220216   PMID:31324164   PMID:31339860   PMID:31394087   PMID:31406143   PMID:31431478   PMID:31432570   PMID:31451992   PMID:31467278   PMID:31485674   PMID:31527615   PMID:31536960  
PMID:31570889   PMID:31577094   PMID:31586073   PMID:31623230   PMID:31690619   PMID:31702382   PMID:31705019   PMID:31741433   PMID:31771969   PMID:31776046   PMID:31806702   PMID:31821646  
PMID:31828132   PMID:31870198   PMID:31871319   PMID:31907416   PMID:31964711   PMID:31973815   PMID:31976530   PMID:31980649   PMID:32000150   PMID:32037090   PMID:32107212   PMID:32165237  
PMID:32187555   PMID:32203420   PMID:32293133   PMID:32296183   PMID:32353859   PMID:32457342   PMID:32460013   PMID:32484856   PMID:32495879   PMID:32513696   PMID:32640259   PMID:32663194  
PMID:32672788   PMID:32705984   PMID:32709711   PMID:32719397   PMID:32725958   PMID:32751352   PMID:32754261   PMID:32808262   PMID:32814053   PMID:32839478   PMID:32841515   PMID:32877691  
PMID:32913203   PMID:32945366   PMID:32945485   PMID:32960451   PMID:33022573   PMID:33037251   PMID:33060197   PMID:33098508   PMID:33110215   PMID:33155211   PMID:33162807   PMID:33205415  
PMID:33277362   PMID:33379334   PMID:33406263   PMID:33441941   PMID:33453281   PMID:33482197   PMID:33497604   PMID:33502904   PMID:33545068   PMID:33670616   PMID:33687619   PMID:33824207  
PMID:33825439   PMID:33837725   PMID:33849798   PMID:33850145   PMID:33941959   PMID:33961781   PMID:33972524   PMID:34006635   PMID:34038160   PMID:34133714   PMID:34215617   PMID:34237247  
PMID:34275785   PMID:34285193   PMID:34321041   PMID:34465801   PMID:34532864   PMID:34551282   PMID:34638872   PMID:34709727   PMID:34813733   PMID:34826548   PMID:34830479   PMID:34893584  
PMID:34897929   PMID:34901393   PMID:34903051   PMID:34968454   PMID:35140242   PMID:35177391   PMID:35188451   PMID:35216178   PMID:35271311   PMID:35538035  


Genomics

Comparative Map Data
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,388 - 49,402,293 (-)NCBICHM1_1
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBImm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,991,926 - 109,025,746 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8108,991,954 - 109,025,746 (+)Ensembl
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0panPan3
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBI
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBI
ROS_Cfam_1.0 Ensembl2040,180,768 - 40,244,414 (+)Ensembl
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBI
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBI
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBI
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,239,560 - 64,285,154 (-)NCBI
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041156,205,022 - 156,258,776 (+)NCBIVero_WHO_p1.0
Rhoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D3S2384  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38349,380,651 - 49,380,774RGDGRCh38
GRCh37349,418,084 - 49,418,207UniSTSGRCh37
Celera349,382,948 - 49,383,065UniSTS
Cytogenetic Map3p21.3UniSTS
HuRef349,477,669 - 49,477,786UniSTS
Marshfield Genetic Map3 UniSTS
deCODE Assembly Map3 UniSTS
Whitehead-RH Map3 UniSTS
A004T30  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,396,588 - 49,396,834UniSTSGRCh37
Build 36349,371,592 - 49,371,838RGDNCBI36
Celera349,361,460 - 49,361,706RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,456,067 - 49,456,313UniSTS
GeneMap99-GB4 RH Map3158.62UniSTS
Whitehead-RH Map3195.2UniSTS
RH91501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,396,766 - 49,396,917UniSTSGRCh37
Build 36349,371,770 - 49,371,921RGDNCBI36
Celera349,361,638 - 49,361,789RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,456,245 - 49,456,396UniSTS
GeneMap99-GB4 RH Map3158.23UniSTS
G60181  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,397,205 - 49,397,486UniSTSGRCh37
Build 36349,372,209 - 49,372,490RGDNCBI36
Celera349,362,077 - 49,362,358RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,456,684 - 49,456,965UniSTS
TNG Radiation Hybrid Map330793.0UniSTS
D3S1330E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,397,032 - 49,397,140UniSTSGRCh37
Build 36349,372,036 - 49,372,144RGDNCBI36
Celera349,361,904 - 49,362,012RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,456,511 - 49,456,619UniSTS
GDB:181197  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,397,382 - 49,397,590UniSTSGRCh37
Build 36349,372,386 - 49,372,594RGDNCBI36
Celera349,362,254 - 49,362,462RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,456,861 - 49,457,069UniSTS
A004G04  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,425,598 - 49,425,702UniSTSGRCh37
Build 36349,400,602 - 49,400,706RGDNCBI36
Celera349,390,457 - 49,390,561RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,485,164 - 49,485,268UniSTS
GeneMap99-GB4 RH Map3158.23UniSTS
WI-18922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,396,678 - 49,396,825UniSTSGRCh37
Build 36349,371,682 - 49,371,829RGDNCBI36
Celera349,361,550 - 49,361,697RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,456,157 - 49,456,304UniSTS
GeneMap99-GB4 RH Map3158.23UniSTS
Whitehead-RH Map3195.2UniSTS
RH46190  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,426,321 - 49,426,441UniSTSGRCh37
Build 36349,401,325 - 49,401,445RGDNCBI36
Celera349,391,180 - 49,391,300RGD
Cytogenetic Map3p21.3UniSTS
HuRef349,485,887 - 49,486,007UniSTS
GeneMap99-GB4 RH Map3158.79UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR122hsa-miR-122-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19617899
MIR133A2hsa-miR-133aMirecordsexternal_infoNANA19644046
MIR375hsa-miR-375Mirtarbaseexternal_infoWestern blot;qRT-PCR;MicroarrayFunctional MTI20584986
MIR31hsa-miR-31-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19524507
MIR31hsa-miR-31-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22854067
MIR31hsa-miR-31-5pOncomiRDBexternal_infoNANA19524507
MIR31hsa-miR-31-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22854067
MIR31hsa-miR-31-3pOncomiRDBexternal_infoNANA22854067
MIR155hsa-miR-155-3pMirecordsexternal_info{unchanged}NA18794355
MIR185hsa-miR-185-5pOncomiRDBexternal_infoNANA21186079
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18794355
MIR185hsa-miR-185-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21186079

Predicted Target Of
Summary Value
Count of predictions:1728
Count of miRNA genes:807
Interacting mature miRNAs:937
Transcripts:ENST00000265538, ENST00000418115, ENST00000422781, ENST00000431929, ENST00000445425, ENST00000454011
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 15 417 4 1 217 1 360 5 18 6 77 34 11 327
Medium 2424 2574 1722 623 1734 464 3997 2192 3716 413 1383 1579 175 1 1193 2461 6 2
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_051308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA542841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC137114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI269293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW403464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF966305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ721697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU509012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS401488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB488811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EL952052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ900995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L09159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN607834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265538
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,411,945 - 49,412,998 (-)Ensembl
RefSeq Acc Id: ENST00000418115   ⟹   ENSP00000400175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,145 - 49,411,976 (-)Ensembl
RefSeq Acc Id: ENST00000422781   ⟹   ENSP00000413587
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,139 - 49,411,970 (-)Ensembl
RefSeq Acc Id: ENST00000431929
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,373,240 - 49,412,097 (-)Ensembl
RefSeq Acc Id: ENST00000445425   ⟹   ENSP00000408402
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,140 - 49,411,968 (-)Ensembl
RefSeq Acc Id: ENST00000454011   ⟹   ENSP00000394483
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,140 - 49,411,928 (-)Ensembl
RefSeq Acc Id: ENST00000676712   ⟹   ENSP00000504603
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,140 - 49,412,000 (-)Ensembl
RefSeq Acc Id: ENST00000677684   ⟹   ENSP00000504494
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,362,496 - 49,411,938 (-)Ensembl
RefSeq Acc Id: ENST00000678200   ⟹   ENSP00000504180
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,139 - 49,412,538 (-)Ensembl
RefSeq Acc Id: ENST00000678921   ⟹   ENSP00000503490
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,140 - 49,411,994 (-)Ensembl
RefSeq Acc Id: ENST00000679208   ⟹   ENSP00000503282
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,359,145 - 49,411,645 (-)Ensembl
RefSeq Acc Id: NM_001313941   ⟹   NP_001300870
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313943   ⟹   NP_001300872
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313944   ⟹   NP_001300873
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313945   ⟹   NP_001300874
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313946   ⟹   NP_001300875
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313947   ⟹   NP_001300876
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001664   ⟹   NP_001655
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,359,145 - 49,411,976 (-)NCBI
GRCh37349,396,569 - 49,449,526 (-)NCBI
Build 36349,371,582 - 49,424,530 (-)NCBI Archive
HuRef349,456,057 - 49,509,248 (-)ENTREZGENE
CHM1_1349,349,379 - 49,402,297 (-)NCBI
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001655   ⟸   NM_001664
- Peptide Label: isoform 1 precursor
- UniProtKB: P61586 (UniProtKB/Swiss-Prot),   Q9BVT0 (UniProtKB/TrEMBL),   A0A024R324 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300874   ⟸   NM_001313945
- Peptide Label: isoform 4
- Sequence:
RefSeq Acc Id: NP_001300873   ⟸   NM_001313944
- Peptide Label: isoform 3
- UniProtKB: B4DKN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300875   ⟸   NM_001313946
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_001300876   ⟸   NM_001313947
- Peptide Label: isoform 6
- UniProtKB: C9JRM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300872   ⟸   NM_001313943
- Peptide Label: isoform 2
- UniProtKB: C9JX21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300870   ⟸   NM_001313941
- Peptide Label: isoform 1 precursor
- UniProtKB: P61586 (UniProtKB/Swiss-Prot),   A0A024R324 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000394483   ⟸   ENST00000454011
RefSeq Acc Id: ENSP00000400175   ⟸   ENST00000418115
RefSeq Acc Id: ENSP00000408402   ⟸   ENST00000445425
RefSeq Acc Id: ENSP00000413587   ⟸   ENST00000422781
RefSeq Acc Id: ENSP00000504603   ⟸   ENST00000676712
RefSeq Acc Id: ENSP00000504494   ⟸   ENST00000677684
RefSeq Acc Id: ENSP00000504180   ⟸   ENST00000678200
RefSeq Acc Id: ENSP00000503490   ⟸   ENST00000678921
RefSeq Acc Id: ENSP00000503282   ⟸   ENST00000679208

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61586-F1-model_v2 AlphaFold P61586 1-193 view protein structure

Promoters
RGD ID:6801532
Promoter ID:HG_KWN:45031
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000346200
Position:
Human AssemblyChrPosition (strand)Source
Build 36349,374,871 - 49,375,371 (-)MPROMDB
RGD ID:6864402
Promoter ID:EPDNEW_H5366
Type:initiation region
Name:RHOA_1
Description:ras homolog family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,411,973 - 49,412,033EPDNEW
RGD ID:6801538
Promoter ID:HG_KWN:45033
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001664,   NM_022171,   OTTHUMT00000346157,   OTTHUMT00000346201,   OTTHUMT00000346202,   OTTHUMT00000346203,   OTTHUMT00000346204,   OTTHUMT00000346208,   OTTHUMT00000346209,   OTTHUMT00000346211,   OTTHUMT00000346212,   OTTHUMT00000346213,   UC010HKU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36349,423,671 - 49,424,797 (-)MPROMDB
RGD ID:6801531
Promoter ID:HG_KWN:45034
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000346205
Position:
Human AssemblyChrPosition (strand)Source
Build 36349,425,611 - 49,426,167 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001664.4(RHOA):c.208A>G (p.Arg70Gly) single nucleotide variant Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies [RCV001526566] Chr3:49368497 [GRCh38]
Chr3:49405930 [GRCh37]
Chr3:3p21.31
likely pathogenic
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh38/hg38 3p21.31(chr3:49171381-49474635)x3 copy number gain See cases [RCV000143511] Chr3:49171381..49474635 [GRCh38]
Chr3:49208814..49512068 [GRCh37]
Chr3:49183818..49487072 [NCBI36]
Chr3:3p21.31
uncertain significance
NM_001664.4(RHOA):c.196T>C (p.Tyr66His) single nucleotide variant Inborn genetic diseases [RCV000623047] Chr3:49368509 [GRCh38]
Chr3:49405942 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
Chr3:3p22.2-21.31
likely pathogenic
NM_001664.4(RHOA):c.13C>T (p.Arg5Trp) single nucleotide variant Breast neoplasm [RCV000430517]|Carcinoma of esophagus [RCV000420653]|Gastric adenocarcinoma [RCV000430318]|Neoplasm of the large intestine [RCV000441218]|Non-Hodgkin lymphoma [RCV000423113] Chr3:49375577 [GRCh38]
Chr3:49413010 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.125A>G (p.Tyr42Cys) single nucleotide variant Gastric adenocarcinoma [RCV000427520]|Non-Hodgkin lymphoma [RCV000438221]|Squamous cell carcinoma of the head and neck [RCV000420783] Chr3:49375465 [GRCh38]
Chr3:49412898 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.14G>T (p.Arg5Leu) single nucleotide variant Breast neoplasm [RCV000444013]|Carcinoma of esophagus [RCV000431457]|Gastric adenocarcinoma [RCV000443944]|Neoplasm of the large intestine [RCV000432532]|Non-Hodgkin lymphoma [RCV000425080] Chr3:49375576 [GRCh38]
Chr3:49413009 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.118G>C (p.Glu40Gln) single nucleotide variant Breast neoplasm [RCV000425677]|Gastric adenocarcinoma [RCV000436482]|Lung adenocarcinoma [RCV000425897]|Squamous cell carcinoma of the head and neck [RCV000443212] Chr3:49375472 [GRCh38]
Chr3:49412905 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.118G>A (p.Glu40Lys) single nucleotide variant Breast neoplasm [RCV000435238]|Gastric adenocarcinoma [RCV000428054]|Lung adenocarcinoma [RCV000418248]|Squamous cell carcinoma of the head and neck [RCV000435482] Chr3:49375472 [GRCh38]
Chr3:49412905 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.125A>T (p.Tyr42Phe) single nucleotide variant Gastric adenocarcinoma [RCV000418559]|Non-Hodgkin lymphoma [RCV000430340]|Squamous cell carcinoma of the head and neck [RCV000440615] Chr3:49375465 [GRCh38]
Chr3:49412898 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.14G>A (p.Arg5Gln) single nucleotide variant Breast neoplasm [RCV000421840]|Carcinoma of esophagus [RCV000432727]|Gastric adenocarcinoma [RCV000422905]|Neoplasm of the large intestine [RCV000444856]|Non-Hodgkin lymphoma [RCV000440078] Chr3:49375576 [GRCh38]
Chr3:49413009 [GRCh37]
Chr3:3p21.31
likely pathogenic
NM_001664.4(RHOA):c.125A>C (p.Tyr42Ser) single nucleotide variant Gastric adenocarcinoma [RCV000427521]|Non-Hodgkin lymphoma [RCV000419217]|Squamous cell carcinoma of the head and neck [RCV000436909] Chr3:49375465 [GRCh38]
Chr3:49412898 [GRCh37]
Chr3:3p21.31
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
NM_001664.4(RHOA):c.139G>A (p.Glu47Lys) single nucleotide variant Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies [RCV001526531]|Hemihypertrophy [RCV001526536]|neuro-ectodermal phenotype [RCV001095368]|not provided [RCV001539108] Chr3:49375451 [GRCh38]
Chr3:49412884 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001664.4(RHOA):c.211C>T (p.Pro71Ser) single nucleotide variant Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies [RCV002221594] Chr3:49368494 [GRCh38]
Chr3:49405927 [GRCh37]
Chr3:3p21.31
pathogenic
GRCh37/hg19 3p21.31(chr3:48346677-49630228)x1 copy number loss not provided [RCV001005432] Chr3:48346677..49630228 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001664.4(RHOA):c.27G>A (p.Val9=) single nucleotide variant not provided [RCV000893901] Chr3:49375563 [GRCh38]
Chr3:49412996 [GRCh37]
Chr3:3p21.31
benign
NM_001664.4(RHOA):c.181G>A (p.Ala61Thr) single nucleotide variant not provided [RCV001029738] Chr3:49368524 [GRCh38]
Chr3:49405957 [GRCh37]
Chr3:3p21.31
uncertain significance
NC_000003.12:g.(?_49121216)_(49533209_?)del deletion Autosomal recessive limb-girdle muscular dystrophy type 2P [RCV001033498]|Pierson syndrome [RCV001384888] Chr3:49158649..49570642 [GRCh37]
Chr3:3p21.31
pathogenic
GRCh37/hg19 3p21.31-21.2(chr3:48807193-51363558)x1 copy number loss not provided [RCV001259686] Chr3:48807193..51363558 [GRCh37]
Chr3:3p21.31-21.2
pathogenic
NC_000003.11:g.(?_48507870)_(50340407_?)del deletion Aicardi-Goutieres syndrome 1 [RCV001380369] Chr3:48507870..50340407 [GRCh37]
Chr3:3p21.31
pathogenic
GRCh37/hg19 3p21.31(chr3:49060512-49678685) copy number gain not specified [RCV002053349] Chr3:49060512..49678685 [GRCh37]
Chr3:3p21.31
uncertain significance
NC_000003.11:g.(?_49394821)_(49459947_?)dup duplication Non-ketotic hyperglycinemia [RCV002014133] Chr3:49394821..49459947 [GRCh37]
Chr3:3p21.31
uncertain significance

Additional Information