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Gene: NFE2L2 (nuclear factor, erythroid 2 like 2) Homo sapiens
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Symbol: NFE2L2
Name: nuclear factor, erythroid 2 like 2
Description: Exhibits several functions, including DNA-binding transcription factor activity; RNA polymerase II activating transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell redox homeostasis; negative regulation of cell death; and proteasomal protein catabolic process. Localizes to several cellular components, including the Golgi apparatus; centrosome; and nucleoplasm. Implicated in Alzheimer's disease; cataract; and macular degeneration. Biomarker of amyotrophic lateral sclerosis; asthma; chronic obstructive pulmonary disease; and pulmonary emphysema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HEBP1; IMDDHH; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; NRF2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2
Orthologs:
Mus musculus (house mouse) : Nfe2l2 (nuclear factor, erythroid derived 2, like 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfe2l2 (nuclear factor, erythroid 2-like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Canis lupus familiaris (dog) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
Sus scrofa (pig) : NFE2L2 (nuclear factor, erythroid 2 like 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2177,227,595 - 177,392,697 (-)Ensembl
GRCh382177,230,303 - 177,265,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372178,095,031 - 178,129,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362177,803,282 - 177,837,663 (-)NCBINCBI36hg18NCBI36
Build 342177,920,542 - 177,954,924NCBI
Celera2171,697,459 - 171,732,295 (-)NCBI
Cytogenetic Map2q31.2NCBI
HuRef2169,966,324 - 170,001,125 (-)NCBIHuRef
CHM1_12178,100,863 - 178,135,685 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model