BDKRB1 (bradykinin receptor B1) - Rat Genome Database

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Gene: BDKRB1 (bradykinin receptor B1) Homo sapiens
Analyze
Symbol: BDKRB1
Name: bradykinin receptor B1
RGD ID: 730874
HGNC Page HGNC:1029
Description: Enables bradykinin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cyclooxygenase pathway; and smooth muscle relaxation of the bladder outlet. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Biomarker of end stage renal disease; glomerulonephritis; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B1 bradykinin receptor; B1BKR; B1R; BDKRB2; BK-1 receptor; BKB1R; BKR1; BRADYB1; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,256,210 - 96,264,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,722,547 - 96,731,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,792,312 - 95,800,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,792,311 - 95,800,851NCBI
Celera1476,778,278 - 76,786,817 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,907,652 - 76,916,201 (+)NCBIHuRef
CHM1_11496,661,476 - 96,670,026 (+)NCBICHM1_1
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
8-Br-cAMP  (EXP)
[des-Arg(9)]-bradykinin  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
AM-251  (EXP)
ammonium chloride  (ISO)
anandamide  (EXP)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP)
beclomethasone  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
ceruletide  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
corn oil  (ISO)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
DDE  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (EXP)
dextran sulfate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
goralatide  (ISO)
hydrochlorothiazide  (ISO)
indometacin  (EXP,ISO)
ketamine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
medroxyprogesterone acetate  (EXP)
meloxicam  (ISO)
Methanandamide  (EXP)
Mitotane  (ISO)
N-acetyl-L-cysteine  (ISO)
paracetamol  (ISO)
perindopril  (ISO)
phenobarbital  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
quercitrin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium atom  (EXP)
streptozocin  (ISO)
temozolomide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
valsartan  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
2. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Abe KC, etal., Regul Pept. 2007 Feb 1;138(2-3):56-8. Epub 2006 Dec 20.
3. Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure. Bachvarov DR, etal., J Am Soc Nephrol. 1998 Apr;9(4):598-604.
4. Antidiabetic efficacy of bradykinin antagonist R-954 on glucose tolerance test in diabetic type 1 mice. Catanzaro OL, etal., Neuropeptides. 2010 Apr;44(2):187-9. doi: 10.1016/j.npep.2009.12.010. Epub 2010 Jan 21.
5. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. Chopra B, etal., J Physiol. 2005 Feb 1;562(Pt 3):859-71. Epub 2004 Dec 2.
6. Up-regulation of functional kinin B1 receptors in allergic airway inflammation. Christiansen SC, etal., J Immunol. 2002 Aug 15;169(4):2054-60.
7. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. Cui J, etal., J Hypertens. 2005 Jan;23(1):55-62.
8. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
9. The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Dias JP, etal., Br J Pharmacol. 2007 Sep;152(2):280-7. Epub 2007 Jul 9.
10. Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis. Emblom-Callahan MC, etal., Genomics. 2010 Sep;96(3):134-45. Epub 2010 May 6.
11. Regulation and function of spinal and peripheral neuronal B1 bradykinin receptors in inflammatory mechanical hyperalgesia. Fox A, etal., Pain. 2003 Aug;104(3):683-91.
12. Kinin B1 receptor antagonists inhibit diabetes-induced hyperalgesia in mice. Gabra BH and Sirois P, Neuropeptides. 2003 Feb;37(1):36-44.
13. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
14. The role of kinin B1 in the plasma extravasation of carrageenin-induced pleurisy. Hayashi I, etal., Life Sci. 2002 Jan 11;70(8):937-49.
15. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
16. Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. Klein J, etal., FASEB J. 2009 Jan;23(1):134-42. doi: 10.1096/fj.08-115600. Epub 2008 Sep 22.
17. Blockade of the kinin B1 receptor ameloriates glomerulonephritis. Klein J, etal., J Am Soc Nephrol. 2010 Jul;21(7):1157-64. doi: 10.1681/ASN.2009090887. Epub 2010 May 6.
18. G(-699)/C polymorphism in the bradykinin-1 receptor gene in patients with renal failure. Knigge H, etal., Nephrol Dial Transplant. 2000 May;15(5):586-8.
19. Effects of a selective bradykinin B1 receptor antagonist on increased plasma extravasation in streptozotocin-induced diabetic rats: distinct vasculopathic profile of major key organs. Lawson SR, etal., Eur J Pharmacol. 2005 May 2;514(1):69-78. Epub 2005 Apr 21.
20. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
21. Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance. Lungu C, etal., Neuropeptides. 2007 Dec;41(6):375-87. Epub 2007 Nov 7.
22. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
23. Tissue kallikrein and kinins in renal disease. Naicker S, etal., Immunopharmacology. 1999 Oct 15;44(1-2):183-92.
24. Overexpression of Kinin B1 Receptors Induces Hypertensive Response to Des-Arg9-bradykinin and Susceptibility to Inflammation. Ni A, etal., J Biol Chem 2003 Jan 3;278(1):219-25.
25. Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy. Ongali B, etal., J Comp Neurol 2003 Jul 7;461(4):506-19.
26. Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis. Pereira RL, etal., Kidney Int. 2011 Jun;79(11):1217-27. doi: 10.1038/ki.2011.14. Epub 2011 Mar 16.
27. Role of kinin B1 and B2 receptors in a rat model of neuropathic pain. Petcu M, etal., Int Immunopharmacol. 2008 Feb;8(2):188-96. Epub 2007 Sep 29.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats. Qadri F, etal., Can J Physiol Pharmacol 2002 Apr;80(4):258-63.
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis. Sainz IM, etal., FASEB J. 2004 May;18(7):887-9. Epub 2004 Mar 4.
33. Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy. Spillmann F, etal., Int Immunopharmacol 2002 Dec;2(13-14):1823-32.
34. Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy. Talbot S, etal., J Neuroinflammation. 2010 Jun 29;7(1):36.
35. Up-regulation of kinin B1 receptor in the lung of streptozotocin-diabetic rat: autoradiographic and functional evidence. Vianna RM, etal., Br J Pharmacol 2003 Jan;138(1):13-22.
36. Bradykinin B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury. Wang PH, etal., PLoS One. 2008 Aug 25;3(8):e3050. doi: 10.1371/journal.pone.0003050.
Additional References at PubMed
PMID:1314587   PMID:7495867   PMID:8063797   PMID:8651911   PMID:8660997   PMID:8808279   PMID:8995263   PMID:9930991   PMID:10188626   PMID:10329474   PMID:10422787   PMID:11025765  
PMID:11710536   PMID:11880373   PMID:12025967   PMID:12063092   PMID:12130679   PMID:12450400   PMID:12477932   PMID:12481150   PMID:14499231   PMID:15033977   PMID:15489334   PMID:15492119  
PMID:15520046   PMID:15634338   PMID:15681300   PMID:15705059   PMID:15805101   PMID:15837330   PMID:15840906   PMID:15883268   PMID:16644486   PMID:16712791   PMID:16754659   PMID:17110500  
PMID:17128974   PMID:17303584   PMID:17327486   PMID:17328065   PMID:17878384   PMID:18039523   PMID:18039525   PMID:18187413   PMID:18240029   PMID:18467203   PMID:18577758   PMID:18577888  
PMID:18938142   PMID:19038786   PMID:19082699   PMID:19086053   PMID:19120546   PMID:19184415   PMID:19404481   PMID:19546528   PMID:19641039   PMID:19661485   PMID:19725054   PMID:19796797  
PMID:19885862   PMID:19913121   PMID:20152050   PMID:20189583   PMID:20628086   PMID:21052031   PMID:21147512   PMID:21216565   PMID:21454694   PMID:21871009   PMID:21873635   PMID:21986309  
PMID:22088753   PMID:22092568   PMID:22468084   PMID:22706224   PMID:22971439   PMID:23201435   PMID:23224295   PMID:23351078   PMID:23428345   PMID:23597562   PMID:23934212   PMID:24108126  
PMID:24304135   PMID:24401952   PMID:24475248   PMID:24686079   PMID:24728914   PMID:25289859   PMID:25503118   PMID:28099911   PMID:28298427   PMID:28935640   PMID:28990089   PMID:29034546  
PMID:29334504   PMID:30132865   PMID:30366000   PMID:30862715   PMID:31017477   PMID:31218444   PMID:32087235   PMID:32338605   PMID:33284471   PMID:36142237   PMID:37703419   PMID:37818853  


Genomics

Comparative Map Data
BDKRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,256,210 - 96,264,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,722,547 - 96,731,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,792,312 - 95,800,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,792,311 - 95,800,851NCBI
Celera1476,778,278 - 76,786,817 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,907,652 - 76,916,201 (+)NCBIHuRef
CHM1_11496,661,476 - 96,670,026 (+)NCBICHM1_1
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBIT2T-CHM13v2.0
Bdkrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,570,350 - 105,571,770 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,569,344 - 105,571,687 (+)EnsemblGRCm39 Ensembl
GRCm3812105,604,091 - 105,605,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,603,085 - 105,605,428 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,842,301 - 106,843,638 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612106,005,141 - 106,006,478 (+)NCBIMGSCv36mm8
Celera12106,838,703 - 106,840,040 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.81NCBI
Bdkrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,275,631 - 130,284,968 (+)NCBIGRCr8
mRatBN7.26124,510,827 - 124,514,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,510,870 - 124,513,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,632,115 - 124,634,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,927,381 - 124,929,797 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,288,772 - 124,291,188 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,437,423 - 129,441,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,438,158 - 129,440,574 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,631,450 - 138,633,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,760,129 - 129,762,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,763,875 - 129,766,292 (+)NCBI
Celera6122,077,962 - 122,080,378 (+)NCBICelera
RH 3.4 Map6821.1RGD
Cytogenetic Map6q32NCBI
Bdkrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,500,633 - 16,501,691 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,500,219 - 16,505,394 (-)NCBIChiLan1.0ChiLan1.0
BDKRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,412,576 - 97,424,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,629,081 - 96,641,330 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,885,923 - 76,894,456 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,208,312 - 96,221,049 (+)NCBIpanpan1.1PanPan1.1panPan2
BDKRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,017,655 - 65,028,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,541,610 - 64,542,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,289,047 - 65,301,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,297,113 - 65,298,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,970,187 - 64,971,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0865,031,504 - 65,032,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,355,171 - 65,356,223 (+)NCBIUU_Cfam_GSD_1.0
Bdkrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,515,392 - 9,516,560 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936604551,774 - 567,014 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDKRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,491,350 - 117,492,410 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,491,350 - 117,492,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,701,695 - 124,749,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDKRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,136,464 - 74,146,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,145,531 - 74,146,592 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,287,030 - 61,297,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdkrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,548,356 - 8,549,414 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,545,707 - 8,549,846 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BDKRB1
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.2(chr14:95787358-96453757)x3 copy number gain See cases [RCV000052089] Chr14:95787358..96453757 [GRCh38]
Chr14:96253695..96920094 [GRCh37]
Chr14:95323448..95989847 [NCBI36]
Chr14:14q32.13-32.2		 uncertain significance
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33		 pathogenic
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33		 pathogenic
GRCh37/hg19 14q31.2-32.2(chr14:84783137-96908198)x1 copy number loss not provided [RCV000683625] Chr14:84783137..96908198 [GRCh37]
Chr14:14q31.2-32.2		 pathogenic
GRCh37/hg19 14q32.2(chr14:96641506-97154180)x3 copy number gain not provided [RCV000683609] Chr14:96641506..97154180 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q31.2-32.2(chr14:84783523-96907490)x1 copy number loss Deletion syndrome [RCV001004048] Chr14:84783523..96907490 [GRCh37]
Chr14:14q31.2-32.2		 pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
NM_000710.3(BDKRB1):c.1022C>T (p.Ser341Phe) single nucleotide variant Malignant melanoma [RCV000070678] Chr14:96264704 [GRCh38]
Chr14:96731041 [GRCh37]
Chr14:95800794 [NCBI36]
Chr14:14q32.2		 not provided
NC_000014.9:g.95696766_96390792dup duplication Acute myeloid leukemia [RCV000190405]|Primary myelofibrosis [RCV000190404]|Thrombocythemia 1 [RCV000190403]|Thrombocythemia 1 [RCV000190406] Chr14:95696766..96390792 [GRCh38]
Chr14:96163103..96857129 [GRCh37]
Chr14:14q32.13-32.2		 likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_000710.4(BDKRB1):c.928G>C (p.Val310Leu) single nucleotide variant not provided [RCV000970479] Chr14:96264610 [GRCh38]
Chr14:96730947 [GRCh37]
Chr14:14q32.2		 likely benign
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q32.12-32.33(chr14:91969028-107285437)x3 copy number gain not provided [RCV000848687] Chr14:91969028..107285437 [GRCh37]
Chr14:14q32.12-32.33		 pathogenic
NM_000710.4(BDKRB1):c.248A>C (p.Asp83Ala) single nucleotide variant not specified [RCV004282034] Chr14:96263930 [GRCh38]
Chr14:96730267 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q31.2-32.33(chr14:84537502-107285437)x3 copy number gain not provided [RCV002472581] Chr14:84537502..107285437 [GRCh37]
Chr14:14q31.2-32.33		 pathogenic
GRCh37/hg19 14q32.2(chr14:96509822-96832238)x3 copy number gain not provided [RCV001006653] Chr14:96509822..96832238 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q32.13-32.31(chr14:95871795-102457523)x1 copy number loss not provided [RCV001827727] Chr14:95871795..102457523 [GRCh37]
Chr14:14q32.13-32.31		 pathogenic
NC_000014.8:g.(?_95080779)_(97347545_?)dup duplication not provided [RCV003113847] Chr14:95080779..97347545 [GRCh37]
Chr14:14q32.13-32.2		 uncertain significance
GRCh37/hg19 14q31.1-32.2(chr14:81593708-97059276)x3 copy number gain not provided [RCV002472541] Chr14:81593708..97059276 [GRCh37]
Chr14:14q31.1-32.2		 likely pathogenic
NM_000710.4(BDKRB1):c.475G>A (p.Val159Met) single nucleotide variant not specified [RCV004239465] Chr14:96264157 [GRCh38]
Chr14:96730494 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.661T>A (p.Phe221Ile) single nucleotide variant not specified [RCV004127789] Chr14:96264343 [GRCh38]
Chr14:96730680 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.1006G>C (p.Ala336Pro) single nucleotide variant not specified [RCV004186217] Chr14:96264688 [GRCh38]
Chr14:96731025 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.437G>A (p.Arg146Gln) single nucleotide variant not specified [RCV004146684] Chr14:96264119 [GRCh38]
Chr14:96730456 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.373A>G (p.Ile125Val) single nucleotide variant not specified [RCV004217702] Chr14:96264055 [GRCh38]
Chr14:96730392 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.427A>G (p.Met143Val) single nucleotide variant not specified [RCV004075754] Chr14:96264109 [GRCh38]
Chr14:96730446 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.535C>G (p.Gln179Glu) single nucleotide variant not specified [RCV004170522] Chr14:96264217 [GRCh38]
Chr14:96730554 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.845G>A (p.Arg282Gln) single nucleotide variant not specified [RCV004204574] Chr14:96264527 [GRCh38]
Chr14:96730864 [GRCh37]
Chr14:14q32.2		 likely benign
NM_000710.4(BDKRB1):c.212T>C (p.Val71Ala) single nucleotide variant not specified [RCV004211151] Chr14:96263894 [GRCh38]
Chr14:96730231 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.683C>T (p.Ser228Phe) single nucleotide variant not specified [RCV004107222] Chr14:96264365 [GRCh38]
Chr14:96730702 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.342C>G (p.Asn114Lys) single nucleotide variant not specified [RCV004205844] Chr14:96264024 [GRCh38]
Chr14:96730361 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.584A>G (p.His195Arg) single nucleotide variant not specified [RCV004193552] Chr14:96264266 [GRCh38]
Chr14:96730603 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.583C>A (p.His195Asn) single nucleotide variant not specified [RCV004089899] Chr14:96264265 [GRCh38]
Chr14:96730602 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.199C>T (p.Arg67Trp) single nucleotide variant not specified [RCV004084194] Chr14:96263881 [GRCh38]
Chr14:96730218 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.692C>T (p.Thr231Met) single nucleotide variant not specified [RCV004263302] Chr14:96264374 [GRCh38]
Chr14:96730711 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.787T>C (p.Trp263Arg) single nucleotide variant not specified [RCV004259712] Chr14:96264469 [GRCh38]
Chr14:96730806 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.412G>A (p.Val138Met) single nucleotide variant not specified [RCV004260486] Chr14:96264094 [GRCh38]
Chr14:96730431 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.85G>C (p.Ala29Pro) single nucleotide variant not specified [RCV004356703] Chr14:96263767 [GRCh38]
Chr14:96730104 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
NM_000710.4(BDKRB1):c.343G>A (p.Gly115Arg) single nucleotide variant not specified [RCV004428887] Chr14:96264025 [GRCh38]
Chr14:96730362 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.404G>A (p.Arg135His) single nucleotide variant not specified [RCV004600116] Chr14:96264086 [GRCh38]
Chr14:96730423 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.463C>T (p.Arg155Trp) single nucleotide variant not specified [RCV004600115] Chr14:96264145 [GRCh38]
Chr14:96730482 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.28C>T (p.Leu10Phe) single nucleotide variant not specified [RCV004600117] Chr14:96263710 [GRCh38]
Chr14:96730047 [GRCh37]
Chr14:14q32.2		 likely benign
NM_000710.4(BDKRB1):c.527G>A (p.Arg176Gln) single nucleotide variant not specified [RCV004607022] Chr14:96264209 [GRCh38]
Chr14:96730546 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.11C>A (p.Ser4Tyr) single nucleotide variant not specified [RCV004600119] Chr14:96263693 [GRCh38]
Chr14:96730030 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.53T>C (p.Leu18Pro) single nucleotide variant not specified [RCV004600120] Chr14:96263735 [GRCh38]
Chr14:96730072 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.196C>T (p.Arg66Trp) single nucleotide variant not specified [RCV004600118] Chr14:96263878 [GRCh38]
Chr14:96730215 [GRCh37]
Chr14:14q32.2		 uncertain significance
NC_000014.8:g.(?_90429459)_(97347545_?)dup duplication not provided [RCV003109490] Chr14:90429459..97347545 [GRCh37]
Chr14:14q32.11-32.2		 uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
NM_000710.4(BDKRB1):c.101A>T (p.Asp34Val) single nucleotide variant not specified [RCV004332292] Chr14:96263783 [GRCh38]
Chr14:96730120 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.570C>G (p.Ile190Met) single nucleotide variant not specified [RCV004346629] Chr14:96264252 [GRCh38]
Chr14:96730589 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_000710.4(BDKRB1):c.694C>T (p.Arg232Trp) single nucleotide variant not specified [RCV004345091] Chr14:96264376 [GRCh38]
Chr14:96730713 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q31.3-32.33(chr14:88580184-107285437)x3 copy number gain not provided [RCV003485051] Chr14:88580184..107285437 [GRCh37]
Chr14:14q31.3-32.33		 pathogenic
NM_000710.4(BDKRB1):c.908C>T (p.Thr303Ile) single nucleotide variant not specified [RCV004428890] Chr14:96264590 [GRCh38]
Chr14:96730927 [GRCh37]
Chr14:14q32.2		 likely benign
NM_000710.4(BDKRB1):c.451C>T (p.Arg151Trp) single nucleotide variant not specified [RCV004428888] Chr14:96264133 [GRCh38]
Chr14:96730470 [GRCh37]
Chr14:14q32.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:391
Interacting mature miRNAs:419
Transcripts:ENST00000216629, ENST00000553356, ENST00000557122
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH17999  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371496,730,837 - 96,730,997UniSTSGRCh37
Build 361495,800,590 - 95,800,750RGDNCBI36
Celera1476,786,554 - 76,786,714RGD
Cytogenetic Map14q32.1-q32.2UniSTS
HuRef1476,915,938 - 76,916,098UniSTS
GeneMap99-GB4 RH Map14261.84UniSTS
BDKRB1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371496,731,007 - 96,731,078UniSTSGRCh37
Build 361495,800,760 - 95,800,831RGDNCBI36
Celera1476,786,724 - 76,786,795RGD
HuRef1476,916,108 - 76,916,179UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1203 2405 2533 2027 4572 1629 2195 4 552 875 394 2173 5726 5180 30 3445 813 1659 1531 169

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001386007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF032889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF117819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX646477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY275464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB130642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ950627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ950628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U30271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W49512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000216629   ⟹   ENSP00000216629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,256,210 - 96,264,763 (+)Ensembl
Ensembl Acc Id: ENST00000553356   ⟹   ENSP00000452064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)Ensembl
Ensembl Acc Id: ENST00000557122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,264,826 - 96,268,455 (+)Ensembl
Ensembl Acc Id: ENST00000611804   ⟹   ENSP00000479276
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,263,670 - 96,264,754 (+)Ensembl
RefSeq Acc Id: NM_000710   ⟹   NP_000701
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,256,210 - 96,264,763 (+)NCBI
GRCh371496,721,641 - 96,735,304 (+)NCBI
Build 361495,792,312 - 95,800,853 (+)NCBI Archive
HuRef1476,907,652 - 76,916,201 (+)NCBI
CHM1_11496,661,476 - 96,670,026 (+)NCBI
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001386007   ⟹   NP_001372936
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,256,210 - 96,264,763 (+)NCBI
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBI
Sequence:
RefSeq Acc Id: NP_000701   ⟸   NM_000710
- UniProtKB: Q546S7 (UniProtKB/Swiss-Prot),   A8K7F5 (UniProtKB/Swiss-Prot),   Q8N0Y8 (UniProtKB/Swiss-Prot),   P46663 (UniProtKB/Swiss-Prot),   A0A075E6Y0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000216629   ⟸   ENST00000216629
Ensembl Acc Id: ENSP00000479276   ⟸   ENST00000611804
Ensembl Acc Id: ENSP00000452064   ⟸   ENST00000553356
RefSeq Acc Id: NP_001372936   ⟸   NM_001386007
- UniProtKB: Q546S7 (UniProtKB/Swiss-Prot),   P46663 (UniProtKB/Swiss-Prot),   A8K7F5 (UniProtKB/Swiss-Prot),   Q8N0Y8 (UniProtKB/Swiss-Prot),   A0A075E6Y0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46663-F1-model_v2 AlphaFold P46663 1-353 view protein structure

Promoters
RGD ID:7228587
Promoter ID:EPDNEW_H20039
Type:initiation region
Name:BDKRB1_1
Description:bradykinin receptor B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20031  EPDNEW_H20040  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,256,210 - 96,256,270EPDNEW
RGD ID:7228589
Promoter ID:EPDNEW_H20040
Type:initiation region
Name:BDKRB1_3
Description:bradykinin receptor B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20031  EPDNEW_H20039  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,262,564 - 96,262,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1029 AgrOrtholog
COSMIC BDKRB1 COSMIC
Ensembl Genes ENSG00000100739 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000216629 ENTREZGENE
  ENST00000216629.11 UniProtKB/Swiss-Prot
  ENST00000553356.1 UniProtKB/TrEMBL
  ENST00000611804 ENTREZGENE
  ENST00000611804.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000100739 GTEx
HGNC ID HGNC:1029 ENTREZGENE
Human Proteome Map BDKRB1 Human Proteome Map
InterPro Brdyknn_1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Brdyknn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:623 UniProtKB/Swiss-Prot
NCBI Gene 623 ENTREZGENE
OMIM 600337 OMIM
PANTHER B2 BRADYKININ RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA79 PharmGKB
PRINTS BRADYKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRADYKINNB1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A075E6Y0 ENTREZGENE, UniProtKB/TrEMBL
  A8K7F5 ENTREZGENE
  BKRB1_HUMAN UniProtKB/Swiss-Prot
  G3V4Y2_HUMAN UniProtKB/TrEMBL
  P46663 ENTREZGENE
  Q546S7 ENTREZGENE
  Q8N0Y8 ENTREZGENE
UniProt Secondary A8K7F5 UniProtKB/Swiss-Prot
  Q546S7 UniProtKB/Swiss-Prot
  Q8N0Y8 UniProtKB/Swiss-Prot