BDKRB1 (bradykinin receptor B1) - Rat Genome Database

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Gene: BDKRB1 (bradykinin receptor B1) Homo sapiens
Analyze
Symbol: BDKRB1
Name: bradykinin receptor B1
RGD ID: 730874
HGNC Page HGNC:1029
Description: Enables bradykinin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cyclooxygenase pathway; and smooth muscle relaxation of the bladder outlet. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Biomarker of end stage renal disease; glomerulonephritis; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B1 bradykinin receptor; B1BKR; B1R; BDKRB2; BK-1 receptor; BKB1R; BKR1; BRADYB1; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,256,210 - 96,264,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,722,547 - 96,731,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,792,312 - 95,800,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,792,311 - 95,800,851NCBI
Celera1476,778,278 - 76,786,817 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,907,652 - 76,916,201 (+)NCBIHuRef
CHM1_11496,661,476 - 96,670,026 (+)NCBICHM1_1
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
BDKRB1HumanDiabetes Complications  ISORGD:7313587241550 RGD 
BDKRB1Humandiabetic angiopathy  ISORGD:6204017241570 RGD 
BDKRB1Humandiabetic neuropathy  ISORGD:6204015129222 RGD 
BDKRB1Humandiabetic retinopathy treatmentISORGD:6204012313334associated with Diabetes Mellitus, ExperimentalRGD 
BDKRB1HumanEdema severityISORGD:620401628496 RGD 
BDKRB1Humanend stage renal disease resistanceIAGP 7241560DNA: SNP: G-699-->CRGD 
BDKRB1Humanend stage renal disease  IEP 7241582 RGD 
BDKRB1Humanend stage renal disease no_associationIAGP 7241561DNA: SNP: G(-699)CRGD 
BDKRB1Humanepilepsy  ISORGD:620401704381 RGD 
BDKRB1HumanExperimental Arthritis  ISORGD:6204011625760 RGD 
BDKRB1HumanExperimental Diabetes Mellitus  ISORGD:620401704380 RGD 
BDKRB1HumanExperimental Diabetes Mellitus  ISORGD:7313587241569 RGD 
BDKRB1HumanExperimental Diabetes Mellitus  ISORGD:620401704379mRNA:increased expression:heartRGD 
BDKRB1HumanFibrosis  ISORGD:6204019068941 RGDPMID:15253105|REF_RGD_ID:1625759
BDKRB1Humanfocal segmental glomerulosclerosis  ISORGD:7313587175321 RGD 
BDKRB1Humanglomerulonephritis  IEP 7241551 RGD 
BDKRB1HumanHyperalgesia  ISORGD:6204011579989 RGD 
BDKRB1HumanHyperalgesia  ISORGD:7313587241581 RGD 
BDKRB1Humanhypertension  ISORGD:6204015129214 RGD 
BDKRB1Humanhypertension  IAGP 1625732DNA:polymorphisms:CDS:in American-Caucasians,T allele of SNP8, C allele of SNP12, T allele of SNP13RGD 
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Original Reference(s)
BDKRB1Humanacute myeloid leukemia  IAGPRGD:103986638554872ClinVar Annotator: match by term: Acute myeloid leukemiaClinVar 
BDKRB1Humanessential thrombocythemia  IAGPRGD:103986638554872ClinVar Annotator: match by term: Thrombocythemia 1ClinVar 
BDKRB1Humanmyelofibrosis  IAGPRGD:103986638554872ClinVar Annotator: match by term: Primary myelofibrosisClinVar 
Object Symbol
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Original Reference(s)
BDKRB1HumanExperimental Diabetes Mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21430409
BDKRB1HumanHyperalgesia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17989505|PMID:19300402|PMID:19815945
BDKRB1HumanInflammation  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20152050
BDKRB1HumanPain  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20152050
BDKRB1HumanSplenomegaly  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20096676
BDKRB1Humantemporal lobe epilepsy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15196965
BDKRB1HumanVascular System Injuries  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16982965

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Original Reference(s)
BDKRB1Human(+)-pilocarpine decreases response to substanceISORGD:7313586480464BDKRB1 protein mutant form results in decreased susceptibility to PilocarpineCTDPMID:15196965
BDKRB1Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BDKRB1 mRNACTDPMID:22079256
BDKRB1Human1-naphthyl isothiocyanate increases expressionISORGD:62040164804641-Naphthylisothiocyanate results in increased expression of BDKRB1 mRNACTDPMID:30723492
BDKRB1Human15-acetyldeoxynivalenol increases expressionEXP 648046415-acetyldeoxynivalenol results in increased expression of BDKRB1 mRNACTDPMID:23792671
BDKRB1Human17beta-estradiol affects expressionISORGD:7313586480464Estradiol affects the expression of BDKRB1 mRNACTDPMID:15598610
BDKRB1Human17beta-estradiol multiple interactionsEXP 6480464[Progesterone co-treated with Estradiol] results in decreased expression of BDKRB1 mRNACTDPMID:17404688
BDKRB1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of BDKRB1 mRNACTDPMID:22298810
BDKRB1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:6204016480464Tetrachlorodibenzodioxin results in increased expression of BDKRB1 mRNACTDPMID:33387578
BDKRB1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:6204016480464Tetrachlorodibenzodioxin affects the expression of BDKRB1 mRNACTDPMID:22298810
BDKRB1Human3',5'-cyclic GMP multiple interactionsISORGD:6204016480464[bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] inhibits the reaction [Valsartan results in more ...CTDPMID:16982965
BDKRB1Human3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...CTDPMID:28628672
BDKRB1Human4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...CTDPMID:28628672
BDKRB1Human8-Br-cAMP increases expressionEXP 64804648-Bromo Cyclic Adenosine Monophosphate results in increased expression of BDKRB1 mRNACTDPMID:20147733
BDKRB1Human[des-Arg(9)]-bradykinin increases expressionISORGD:7313586480464bradykinin, des-Arg(9)- results in increased expression of BDKRB1 proteinCTDPMID:16039549
BDKRB1Human[des-Arg(9)]-bradykinin multiple interactionsISORGD:7313586480464lipopolysaccharide A promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; Thalidomide more ...CTDPMID:16039549
BDKRB1HumanAc-Ser-Asp-Lys-Pro-OH multiple interactionsISORGD:7313586480464[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatideCTDPMID:20096676
BDKRB1HumanAc-Ser-Asp-Lys-Pro-OH affects abundanceISORGD:7313586480464BDKRB1 protein affects the abundance of goralatideCTDPMID:20096676
BDKRB1Humanaldehydo-D-glucose increases expressionISORGD:6204016480464Glucose results in increased expression of BDKRB1 proteinCTDPMID:29165388
BDKRB1Humanaldehydo-D-glucose multiple interactionsISORGD:6204016480464argan oil inhibits the reaction [Glucose results in increased expression of BDKRB1 protein]; Corn Oil more ...CTDPMID:29165388
BDKRB1Humanall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of BDKRB1 mRNACTDPMID:23830798

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Biological Process
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Original Reference(s)
BDKRB1Humancell migration  ISORGD:6204019068941 RGDPMID:20411591|REF_RGD_ID:5129223
BDKRB1Humancell migration involved_inIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humancyclooxygenase pathway involved_inISORGD:140910389068941 PMID:23846981AgBasePMID:23846981
BDKRB1HumanG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276|InterPro:IPR000496|InterPro:IPR001186150520179 InterProGO_REF:0000002
BDKRB1HumanG protein-coupled receptor signaling pathway involved_inIBAFB:FBgn0025631|MGI:1346086|MGI:2441843|MGI:87966|PANTHER:PTN001200905|RGD:2070|RGD:2071|RGD:621645|UniProtKB:P30556|UniProtKB:P35414|UniProtKB:P48039|UniProtKB:P49685|ZFIN:ZDB-GENE-030131-4347150520179 GO_CentralGO_REF:0000033
BDKRB1HumanG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-0297150520179 UniProtGO_REF:0000043
BDKRB1Humaninflammatory response involved_inIEAInterPro:IPR001186150520179 InterProGO_REF:0000002
BDKRB1Humannegative regulation of blood pressure  ISORGD:6204019068941 RGDPMID:15253105|PMID:16507603|REF_RGD_ID:1625747|REF_RGD_ID:1625759
BDKRB1Humannegative regulation of blood pressure involved_inIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humannegative regulation of cell growth  ISORGD:6204019068941cardiomyocytesRGDPMID:16497153|REF_RGD_ID:1625749
BDKRB1Humannegative regulation of cell growth involved_inIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humannegative regulation of protein phosphorylation  ISORGD:6204019068941inhibition increases phosphorylation of ERK, p38, JNK and Thr495 of eNOS in SHR-SP ratsRGDPMID:16497153|REF_RGD_ID:1625749
BDKRB1Humanpositive regulation of cytosolic calcium ion concentration involved_inTAS 150520179 PMID:8063797PINCPMID:8063797
BDKRB1Humanpositive regulation of leukocyte migration  ISORGD:6204019068941 RGDPMID:12522068|REF_RGD_ID:704380
BDKRB1Humanpositive regulation of leukocyte migration involved_inIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humanpositive regulation of release of sequestered calcium ion into cytosol involved_inIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humanpositive regulation of release of sequestered calcium ion into cytosol NOTISORGD:6204019068941in nociceptive dorsal root ganglion neuronsRGDPMID:15319421|REF_RGD_ID:1625754
BDKRB1Humanpositive regulation of release of sequestered calcium ion into cytosol  ISORGD:6204019068941in urinary bladder urotheliumRGDPMID:15576455|REF_RGD_ID:1625040
BDKRB1Humanresponse to lipopolysaccharide  ISORGD:6204019068941 RGDPMID:19561153|REF_RGD_ID:5129225
BDKRB1Humanresponse to lipopolysaccharide involved_inIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
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Cellular Component

  
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Original Reference(s)
BDKRB1Humanendoplasmic reticulum located_inTAS 150520179 PMID:9930991PINCPMID:9930991
BDKRB1Humanmembrane located_inIEAInterPro:IPR000276|InterPro:IPR000496|InterPro:IPR001186|InterPro:IPR017452150520179 InterProGO_REF:0000002
BDKRB1Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
BDKRB1Humanplasma membrane is_active_inIBAMGI:87964|PANTHER:PTN000659605|RGD:2070|RGD:621645|UniProtKB:P30411|UniProtKB:P30556|UniProtKB:P35414|UniProtKB:P49685|ZFIN:ZDB-GENE-141216-12150520179 GO_CentralGO_REF:0000033
BDKRB1Humanplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044
BDKRB1Humanplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
BDKRB1Humanplasma membrane located_inTAS 150520179 PMID:8063797, PMID:9930991ReactomePMID:8063797|PMID:9930991|Reactome:R-HSA-374331|Reactome:R-HSA-379048|Reactome:R-HSA-380073|Reactome:R-HSA-749448|Reactome:R-HSA-749452|Reactome:R-HSA-749454|Reactome:R-HSA-749456

Molecular Function
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Original Reference(s)
BDKRB1Humanbradykinin receptor activity enablesIBAPANTHER:PTN002796037|RGD:2201|RGD:620401|UniProtKB:P30411|UniProtKB:P46663|ZFIN:ZDB-GENE-030814-1150520179 GO_CentralGO_REF:0000033
BDKRB1Humanbradykinin receptor activity enablesIDA 150520179 PMID:10422787, PMID:1314587UniProtPMID:10422787|PMID:1314587
BDKRB1Humanbradykinin receptor activity enablesIEAInterPro:IPR000496|InterPro:IPR001186150520179 InterProGO_REF:0000002
BDKRB1Humanbradykinin receptor activity enablesIEAUniProtKB:P97583|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humanbradykinin receptor activity  ISORGD:6204019068941 RGDPMID:12025968|REF_RGD_ID:727669
BDKRB1HumanG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-0297150520179 UniProtGO_REF:0000043
BDKRB1HumanG protein-coupled receptor activity enablesIEAInterPro:IPR000276150520179 InterProGO_REF:0000002
BDKRB1HumanG protein-coupled receptor activity enablesIEAARBA:ARBA00029151150520179 UniProtGO_REF:0000117
BDKRB1Humanpeptide binding  ISOPubChem_Substance:6825219068941 RGDPMID:10422787|REF_RGD_ID:1625744
BDKRB1Humanpeptide binding enablesIEAUniProtKB:P97583|UniProtKB:Q61125|ensembl:ENSMUSP00000045335|ensembl:ENSRNOP00000005953150520179 EnsemblGO_REF:0000107
BDKRB1Humanprotein binding enablesIPIUniProtKB:P01042-PRO_0000006687150520179 PMID:23597562IntActPMID:23597562
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
BDKRB1Humancoagulation cascade pathway   IEA 6907045 KEGGhsa:04610
BDKRB1Humancomplement system pathway  IEA 6907045 KEGGhsa:04610
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Original Reference(s)
BDKRB1HumanAcute myeloid leukemia  IAGPRGD:103986638554872ClinVar Annotator: match by term: Acute myelogenous leukemiaClinVar 

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#
Reference Title
Reference Citation
1. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
2. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Abe KC, etal., Regul Pept. 2007 Feb 1;138(2-3):56-8. Epub 2006 Dec 20.
3. Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure. Bachvarov DR, etal., J Am Soc Nephrol. 1998 Apr;9(4):598-604.
4. Antidiabetic efficacy of bradykinin antagonist R-954 on glucose tolerance test in diabetic type 1 mice. Catanzaro OL, etal., Neuropeptides. 2010 Apr;44(2):187-9. doi: 10.1016/j.npep.2009.12.010. Epub 2010 Jan 21.
5. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. Chopra B, etal., J Physiol. 2005 Feb 1;562(Pt 3):859-71. Epub 2004 Dec 2.
6. Up-regulation of functional kinin B1 receptors in allergic airway inflammation. Christiansen SC, etal., J Immunol. 2002 Aug 15;169(4):2054-60.
7. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. Cui J, etal., J Hypertens. 2005 Jan;23(1):55-62.
8. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
9. The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Dias JP, etal., Br J Pharmacol. 2007 Sep;152(2):280-7. Epub 2007 Jul 9.
10. Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis. Emblom-Callahan MC, etal., Genomics. 2010 Sep;96(3):134-45. Epub 2010 May 6.
11. Regulation and function of spinal and peripheral neuronal B1 bradykinin receptors in inflammatory mechanical hyperalgesia. Fox A, etal., Pain. 2003 Aug;104(3):683-91.
12. Kinin B1 receptor antagonists inhibit diabetes-induced hyperalgesia in mice. Gabra BH and Sirois P, Neuropeptides. 2003 Feb;37(1):36-44.
13. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
14. The role of kinin B1 in the plasma extravasation of carrageenin-induced pleurisy. Hayashi I, etal., Life Sci. 2002 Jan 11;70(8):937-49.
15. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
16. Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. Klein J, etal., FASEB J. 2009 Jan;23(1):134-42. doi: 10.1096/fj.08-115600. Epub 2008 Sep 22.
17. Blockade of the kinin B1 receptor ameloriates glomerulonephritis. Klein J, etal., J Am Soc Nephrol. 2010 Jul;21(7):1157-64. doi: 10.1681/ASN.2009090887. Epub 2010 May 6.
18. G(-699)/C polymorphism in the bradykinin-1 receptor gene in patients with renal failure. Knigge H, etal., Nephrol Dial Transplant. 2000 May;15(5):586-8.
19. Effects of a selective bradykinin B1 receptor antagonist on increased plasma extravasation in streptozotocin-induced diabetic rats: distinct vasculopathic profile of major key organs. Lawson SR, etal., Eur J Pharmacol. 2005 May 2;514(1):69-78. Epub 2005 Apr 21.
20. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
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PMID:1314587   PMID:7495867   PMID:8063797   PMID:8651911   PMID:8660997   PMID:8808279   PMID:8995263   PMID:9930991   PMID:10188626   PMID:10329474   PMID:10422787   PMID:11025765  
PMID:11710536   PMID:11880373   PMID:12025967   PMID:12063092   PMID:12130679   PMID:12450400   PMID:12477932   PMID:12481150   PMID:14499231   PMID:15033977   PMID:15489334   PMID:15492119  
PMID:15520046   PMID:15634338   PMID:15681300   PMID:15705059   PMID:15805101   PMID:15837330   PMID:15840906   PMID:15883268   PMID:16644486   PMID:16712791   PMID:16754659   PMID:17110500  
PMID:17128974   PMID:17303584   PMID:17327486   PMID:17328065   PMID:17878384   PMID:18039523   PMID:18039525   PMID:18187413   PMID:18240029   PMID:18467203   PMID:18577758   PMID:18577888  
PMID:18938142   PMID:19038786   PMID:19082699   PMID:19086053   PMID:19120546   PMID:19184415   PMID:19404481   PMID:19546528   PMID:19641039   PMID:19661485   PMID:19725054   PMID:19796797  
PMID:19885862   PMID:19913121   PMID:20152050   PMID:20189583   PMID:20628086   PMID:21052031   PMID:21147512   PMID:21216565   PMID:21454694   PMID:21871009   PMID:21873635   PMID:21986309  
PMID:22088753   PMID:22092568   PMID:22468084   PMID:22706224   PMID:22971439   PMID:23201435   PMID:23224295   PMID:23351078   PMID:23428345   PMID:23597562   PMID:23934212   PMID:24108126  
PMID:24304135   PMID:24401952   PMID:24475248   PMID:24686079   PMID:24728914   PMID:25289859   PMID:25503118   PMID:28099911   PMID:28298427   PMID:28935640   PMID:28990089   PMID:29034546  
PMID:29334504   PMID:30132865   PMID:30366000   PMID:30862715   PMID:31017477   PMID:31218444   PMID:32087235   PMID:32338605   PMID:33284471   PMID:36142237   PMID:37703419   PMID:37818853  



BDKRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,256,210 - 96,264,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,722,547 - 96,731,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,792,312 - 95,800,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,792,311 - 95,800,851NCBI
Celera1476,778,278 - 76,786,817 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,907,652 - 76,916,201 (+)NCBIHuRef
CHM1_11496,661,476 - 96,670,026 (+)NCBICHM1_1
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBIT2T-CHM13v2.0
Bdkrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,570,350 - 105,571,770 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,569,344 - 105,571,687 (+)EnsemblGRCm39 Ensembl
GRCm3812105,604,091 - 105,605,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,603,085 - 105,605,428 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,842,301 - 106,843,638 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612106,005,141 - 106,006,478 (+)NCBIMGSCv36mm8
Celera12106,838,703 - 106,840,040 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.81NCBI
Bdkrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,275,631 - 130,284,968 (+)NCBIGRCr8
mRatBN7.26124,510,827 - 124,514,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,510,870 - 124,513,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,632,115 - 124,634,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,927,381 - 124,929,797 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,288,772 - 124,291,188 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,437,423 - 129,441,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,438,158 - 129,440,574 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,631,450 - 138,633,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,760,129 - 129,762,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,763,875 - 129,766,292 (+)NCBI
Celera6122,077,962 - 122,080,378 (+)NCBICelera
RH 3.4 Map6821.1RGD
Cytogenetic Map6q32NCBI
Bdkrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,500,633 - 16,501,691 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,500,219 - 16,505,394 (-)NCBIChiLan1.0ChiLan1.0
BDKRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,412,576 - 97,424,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,629,081 - 96,641,330 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,885,923 - 76,894,456 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,208,312 - 96,221,049 (+)NCBIpanpan1.1PanPan1.1panPan2
BDKRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,017,655 - 65,028,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,541,610 - 64,542,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,289,047 - 65,301,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,297,113 - 65,298,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,970,187 - 64,971,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0865,031,504 - 65,032,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,355,171 - 65,356,223 (+)NCBIUU_Cfam_GSD_1.0
Bdkrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,515,392 - 9,516,560 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936604551,774 - 567,014 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDKRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,491,350 - 117,492,410 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,491,350 - 117,492,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,701,695 - 124,749,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDKRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,136,464 - 74,146,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,145,531 - 74,146,592 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,287,030 - 61,297,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdkrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,548,356 - 8,549,414 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,545,707 - 8,549,846 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in BDKRB1
37 total Variants

1 to 10 of 71 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q32.13-32.2(chr14:95787358-96453757)x3 copy number gain See cases [RCV000052089] Chr14:95787358..96453757 [GRCh38]
Chr14:96253695..96920094 [GRCh37]
Chr14:95323448..95989847 [NCBI36]
Chr14:14q32.13-32.2
uncertain significance
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
NM_000710.3(BDKRB1):c.1022C>T (p.Ser341Phe) single nucleotide variant Malignant melanoma [RCV000070678] Chr14:96264704 [GRCh38]
Chr14:96731041 [GRCh37]
Chr14:95800794 [NCBI36]
Chr14:14q32.2
not provided
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
1 to 10 of 71 rows

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:391
Interacting mature miRNAs:419
Transcripts:ENST00000216629, ENST00000553356, ENST00000557122
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

RH17999  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371496,730,837 - 96,730,997UniSTSGRCh37
Build 361495,800,590 - 95,800,750RGDNCBI36
Celera1476,786,554 - 76,786,714RGD
Cytogenetic Map14q32.1-q32.2UniSTS
HuRef1476,915,938 - 76,916,098UniSTS
GeneMap99-GB4 RH Map14261.84UniSTS
BDKRB1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371496,731,007 - 96,731,078UniSTSGRCh37
Build 361495,800,760 - 95,800,831RGDNCBI36
Celera1476,786,724 - 76,786,795RGD
HuRef1476,916,108 - 76,916,179UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1203 2405 2533 2027 4572 1629 2195 4 552 875 394 2173 5726 5180 30 3445 813 1659 1531 169


1 to 23 of 23 rows
RefSeq Transcripts NM_000710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001386007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF032889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF117819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX646477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY275464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB130642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ950627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ950628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U30271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W49512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENST00000216629   ⟹   ENSP00000216629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,256,210 - 96,264,763 (+)Ensembl
Ensembl Acc Id: ENST00000553356   ⟹   ENSP00000452064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,256,210 - 96,268,967 (+)Ensembl
Ensembl Acc Id: ENST00000557122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,264,826 - 96,268,455 (+)Ensembl
Ensembl Acc Id: ENST00000611804   ⟹   ENSP00000479276
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,263,670 - 96,264,754 (+)Ensembl
RefSeq Acc Id: NM_000710   ⟹   NP_000701
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,256,210 - 96,264,763 (+)NCBI
GRCh371496,721,641 - 96,735,304 (+)NCBI
Build 361495,792,312 - 95,800,853 (+)NCBI Archive
HuRef1476,907,652 - 76,916,201 (+)NCBI
CHM1_11496,661,476 - 96,670,026 (+)NCBI
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001386007   ⟹   NP_001372936
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,256,210 - 96,264,763 (+)NCBI
T2T-CHM13v2.01490,487,459 - 90,496,013 (+)NCBI
Sequence:
RefSeq Acc Id: NP_000701   ⟸   NM_000710
- UniProtKB: Q546S7 (UniProtKB/Swiss-Prot),   A8K7F5 (UniProtKB/Swiss-Prot),   Q8N0Y8 (UniProtKB/Swiss-Prot),   P46663 (UniProtKB/Swiss-Prot),   A0A075E6Y0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000216629   ⟸   ENST00000216629
Ensembl Acc Id: ENSP00000479276   ⟸   ENST00000611804
Ensembl Acc Id: ENSP00000452064   ⟸   ENST00000553356
RefSeq Acc Id: NP_001372936   ⟸   NM_001386007
- UniProtKB: Q546S7 (UniProtKB/Swiss-Prot),   P46663 (UniProtKB/Swiss-Prot),   A8K7F5 (UniProtKB/Swiss-Prot),   Q8N0Y8 (UniProtKB/Swiss-Prot),   A0A075E6Y0 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-P46663-F1-model_v2 AlphaFold P46663 1-353 view protein structure

RGD ID:7228587
Promoter ID:EPDNEW_H20039
Type:initiation region
Name:BDKRB1_1
Description:bradykinin receptor B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20031  EPDNEW_H20040  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,256,210 - 96,256,270EPDNEW
RGD ID:7228589
Promoter ID:EPDNEW_H20040
Type:initiation region
Name:BDKRB1_3
Description:bradykinin receptor B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20031  EPDNEW_H20039  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,262,564 - 96,262,624EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
COSMIC BDKRB1 COSMIC
Ensembl Genes ENSG00000100739 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000216629 ENTREZGENE
  ENST00000216629.11 UniProtKB/Swiss-Prot
  ENST00000611804 ENTREZGENE
  ENST00000611804.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000100739 GTEx
HGNC ID HGNC:1029 ENTREZGENE
Human Proteome Map BDKRB1 Human Proteome Map
InterPro Brdyknn_1_rcpt UniProtKB/Swiss-Prot
  Brdyknn_rcpt UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report hsa:623 UniProtKB/Swiss-Prot
NCBI Gene 623 ENTREZGENE
OMIM 600337 OMIM
PANTHER B2 BRADYKININ RECEPTOR UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA79 PharmGKB
PRINTS BRADYKININR UniProtKB/Swiss-Prot
  BRADYKINNB1R UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A075E6Y0 ENTREZGENE, UniProtKB/TrEMBL
  A8K7F5 ENTREZGENE
  BKRB1_HUMAN UniProtKB/Swiss-Prot
  G3V4Y2_HUMAN UniProtKB/TrEMBL
  P46663 ENTREZGENE
  Q546S7 ENTREZGENE
  Q8N0Y8 ENTREZGENE
UniProt Secondary A8K7F5 UniProtKB/Swiss-Prot
  Q546S7 UniProtKB/Swiss-Prot
  Q8N0Y8 UniProtKB/Swiss-Prot
1 to 37 of 37 rows