RGD Reference Report - The role of kinin B1 in the plasma extravasation of carrageenin-induced pleurisy. - Rat Genome Database

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The role of kinin B1 in the plasma extravasation of carrageenin-induced pleurisy.

Authors: Hayashi, I  Amano, H  Ishihara, K  Kumagai, Y  Yoshimura, H  Majima, MC 
Citation: Hayashi I, etal., Life Sci. 2002 Jan 11;70(8):937-49.
RGD ID: 5129218
Pubmed: PMID:11853231   (View Abstract at PubMed)

The role of des-Arg9-bradykinin (des-Arg9-BK) and kinin B1 receptor in the plasma extravasation of rat carrageenin-induced pleurisy was investigated employing B1 receptor agonist and antagonists and kininogen-deficient rats. Expression of the B1 receptor mRNA in pleura was induced from 3 to 5 h after the injection of carrageenin into the pleural cavity of Sprague-Dawley rats. Exogenous injection of des-Arg9-BK into the pleural cavity provoked a significant increase in plasma extravasation in 5 h carrageenin-induced pleurisy, but not in 20 min kaolin-induced pleurisy. The level of immunoreactive des-Arg9-BK in the exudate of 5 h carrageenin-induced pleurisy was higher than that of bradykinin (BK). Administration of the B1 receptor antagonists, des-Arg9-[Leu8]-BK or des-Arg9-D-Arg-[Hyp3, Thi5, D-Tic7,Oic8]-BK significantly reduced the exudation rate. However, intrapleural administration of des-Arg9-BK to plasma kininogen-deficient. Brown Norway-Katholiek rats did not result in a further increase in the plasma extravasation. In conclusion, endogenously generated des-Arg9-BK could contribute to the plasma extravasation in carrageenin-induced pleurisy via mediation of the inducible B1 receptor.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pleurisy  ISOBdkrb1 (Rattus norvegicus)5129218; 5129218 RGD 
pleurisy  IMP 5129218 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdkrb1  (bradykinin receptor B1)

Genes (Mus musculus)
Bdkrb1  (bradykinin receptor, beta 1)

Genes (Homo sapiens)
BDKRB1  (bradykinin receptor B1)


Additional Information