Gene: ARHGDIA (Rho GDP dissociation inhibitor alpha) Homo sapiens
Analyze
Symbol:
ARHGDIA
Name:
Rho GDP dissociation inhibitor alpha
Description:
Predicted to have Rac GTPase binding activity and Rho GDP-dissociation inhibitor activity. Involved in regulation of Rho protein signal transduction and regulation of actin cytoskeleton reorganization. Localizes to the extracellular exosome. Implicated in nephrotic syndrome type 8.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
epididymis secretory sperm binding protein Li 47e; GDIA1; GDP-dissociation inhibitor, aplysia RAS-related 1; HEL-S-47e; MGC117248; NPHS8; rho GDI 1; Rho GDP dissociation inhibitor (GDI) alpha; rho GDP-dissociation inhibitor 1; rho-GDI alpha; RHOGDI; RHOGDI-1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Arhgdia (Rho GDP dissociation inhibitor (GDI) alpha) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Arhgdia (Rho GDP dissociation inhibitor alpha) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Arhgdia (Rho GDP dissociation inhibitor alpha) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
ARHGDIA (Rho GDP dissociation inhibitor alpha) NCBI
Ortholog
Canis lupus familiaris (dog):
ARHGDIA (Rho GDP dissociation inhibitor alpha) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Arhgdia (Rho GDP dissociation inhibitor alpha) NCBI
Ortholog
Sus scrofa (pig):
ARHGDIA (Rho GDP dissociation inhibitor alpha) HGNC
Ensembl, NCBI, OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Arhgdia (Rho GDP dissociation inhibitor alpha)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Arhgdia (Rho GDP dissociation inhibitor (GDI) alpha)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
arhgdia (Rho GDP dissociation inhibitor (GDI) alpha)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
RDI1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
RhoGDI
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
rhi-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 17 81,867,719 - 81,871,337 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 17 79,825,595 - 79,829,282 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 17 77,418,886 - 77,422,527 (-) NCBI NCBI36 hg18 NCBI36 Build 34 17 77,418,886 - 77,422,527 NCBI Celera 17 76,429,063 - 76,432,256 (-) NCBI Cytogenetic Map 17 q25.3 NCBI HuRef 17 75,227,385 - 75,230,633 (-) NCBI HuRef CHM1_1 17 79,911,831 - 79,915,499 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
nephrotic syndrome type 1 IAGP RGD:13592718 8554872 ClinVar Annotator: match by term: NEPHROTIC SYNDROME, CONGENITAL ClinVar PMID:25741868 nephrotic syndrome type 8 IAGP RGD:8696331 8554872 ClinVar Annotator: match by term: Nephrotic syndrome, type 8 ClinVar PMID:23867502 nephrotic syndrome type 8 IAGP RGD:8696332 8554872 ClinVar Annotator: match by term: Nephrotic syndrome, type 8 ClinVar
Imported Annotations - CTD
Breast Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20562527 human immunodeficiency virus infectious disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15308739 Keloid EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20128793 Neoplasm Metastasis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20562527 Imported Annotations - MGI
nephrotic syndrome ISS RGD:1552296 13592920 OMIM:256300 more ... MouseDO Imported Annotations - OMIM
nephrotic syndrome type 8 IAGP 7240710 OMIM
(S)-naringenin increases expression EXP 6480464 naringenin results in increased expression of ARHGDIA mRNA, naringenin results in increased expression of ARHGDIA protein CTD PMID:27838343 (Z)-3-butylidenephthalide increases expression EXP 6480464 butylidenephthalide results in increased expression of ARHGDIA protein CTD PMID:23770345 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 , PMID:15757668 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1552296 6480464 Tetrachlorodibenzodioxin results in decreased expression of ARHGDIA mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552296 6480464 Tetrachlorodibenzodioxin affects the expression of ARHGDIA mRNA CTD PMID:24680724 2,4-dinitrotoluene affects expression ISO RGD:1359547 6480464 2, 4-dinitrotoluene affects the expression of ARHGDIA mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1359547 6480464 2, 6-dinitrotoluene affects the expression of ARHGDIA mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression EXP 6480464 4-hydroxy-2-nonenal results in decreased expression of ARHGDIA mRNA CTD PMID:12419474 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of ARHGDIA mRNA CTD PMID:23724009 ampicillin increases expression EXP 6480464 Ampicillin results in increased expression of ARHGDIA mRNA CTD PMID:21632981 arachidonic acid increases expression EXP 6480464 Arachidonic Acid results in increased expression of ARHGDIA mRNA CTD PMID:16704987 bathocuproine disulfonic acid multiple interactions EXP 6480464 [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ARHGDIA mRNA CTD PMID:15477007 beauvericin decreases expression EXP 6480464 beauvericin results in decreased expression of ARHGDIA mRNA CTD PMID:29203277 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of ARHGDIA mRNA CTD PMID:20106945 benzo[a]pyrene multiple interactions EXP 6480464 Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of ARHGDIA protein] CTD PMID:22138271 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of ARHGDIA protein CTD PMID:22138271 benzo[a]pyrene multiple interactions ISO RGD:1552296 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to ARHGDIA promoter] CTD PMID:19654925 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of ARHGDIA mRNA CTD PMID:31163220 bisphenol A increases expression ISO RGD:1359547 6480464 bisphenol A results in increased expression of ARHGDIA mRNA CTD PMID:25181051 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ARHGDIA mRNA CTD PMID:30903817 bortezomib decreases expression EXP 6480464 Bortezomib results in decreased expression of ARHGDIA mRNA CTD PMID:20977926 busulfan multiple interactions EXP 6480464 ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] CTD PMID:17264767 busulfan affects response to substance EXP 6480464 ARHGDIA mRNA affects the susceptibility to Busulfan CTD PMID:17264767 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of ARHGDIA mRNA, Cadmium results in increased expression of ARHGDIA protein CTD PMID:16440303 , PMID:24376830 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of ARHGDIA mRNA, Cadmium Chloride results in decreased expression of ARHGDIA protein CTD PMID:12760830 , PMID:26220685 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of ARHGDIA protein CTD PMID:16440303 , PMID:24527689 choline multiple interactions ISO RGD:1552296 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGDIA mRNA CTD PMID:20938992 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of ARHGDIA mRNA CTD PMID:27392435 , PMID:27594783 cisplatin multiple interactions EXP 6480464 Cisplatin promotes the reaction [jinfukang results in decreased expression of ARHGDIA mRNA], jinfukang promotes the reaction [Cisplatin results in decreased expression of ARHGDIA mRNA] CTD PMID:27392435 copper atom decreases expression ISO RGD:1552296 6480464 Copper results in decreased expression of ARHGDIA protein CTD PMID:23882024 copper(0) decreases expression ISO RGD:1552296 6480464 Copper results in decreased expression of ARHGDIA protein CTD PMID:23882024 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ARHGDIA mRNA CTD PMID:19167446 CU-O LINKAGE decreases expression ISO RGD:1552296 6480464 cupric oxide analog results in decreased expression of ARHGDIA protein CTD PMID:23882024 daidzein decreases expression EXP 6480464 daidzein results in decreased expression of ARHGDIA mRNA CTD PMID:15757668 desferrioxamine B decreases expression EXP 6480464 Deferoxamine results in decreased expression of ARHGDIA protein CTD PMID:19515424 desferrioxamine B multiple interactions EXP 6480464 ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] CTD PMID:19515424 dibutyl phthalate increases expression ISO RGD:1359547 6480464 Dibutyl Phthalate results in increased expression of ARHGDIA mRNA CTD PMID:21266533 dicrotophos increases expression EXP 6480464 dicrotophos results in increased expression of ARHGDIA mRNA CTD PMID:28302478 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of ARHGDIA mRNA CTD PMID:15766595 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 doxorubicin multiple interactions EXP 6480464 ARHGDIA mRNA affects the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:17264767 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of ARHGDIA mRNA CTD PMID:29803840 doxorubicin affects response to substance EXP 6480464 ARHGDIA mRNA affects the susceptibility to Doxorubicin CTD PMID:17264767 elemental selenium increases expression EXP 6480464 Selenium results in increased expression of ARHGDIA mRNA CTD PMID:19244175 endosulfan increases expression ISO RGD:1359547 6480464 Endosulfan results in increased expression of ARHGDIA mRNA CTD PMID:29391264 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ARHGDIA mRNA CTD PMID:19167446 estriol decreases expression EXP 6480464 Estriol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 estrone decreases expression EXP 6480464 Estrone results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 ethanol increases expression ISO RGD:1552296 6480464 Ethanol results in increased expression of ARHGDIA mRNA CTD PMID:19167417 ethanol affects splicing ISO RGD:1552296 6480464 Ethanol affects the splicing of ARHGDIA mRNA CTD PMID:30319688 ethanol decreases expression ISO RGD:1359547 6480464 Ethanol results in decreased expression of ARHGDIA protein CTD PMID:23702218 ethyl methanesulfonate decreases expression EXP 6480464 Ethyl Methanesulfonate results in decreased expression of ARHGDIA mRNA CTD PMID:23649840 ferric ammonium citrate multiple interactions EXP 6480464 ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] CTD PMID:19515424 fipronil decreases expression ISO RGD:1359547 6480464 fipronil results in decreased expression of ARHGDIA mRNA CTD PMID:23962444 flutamide increases expression ISO RGD:1359547 6480464 Flutamide results in increased expression of ARHGDIA mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1552296 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGDIA mRNA CTD PMID:20938992 fumonisin B1 increases expression ISO RGD:1552296 6480464 fumonisin B1 results in increased expression of ARHGDIA mRNA CTD PMID:16221962 genistein decreases expression EXP 6480464 Genistein results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 , PMID:15757668 glycitein decreases expression EXP 6480464 glycitein results in decreased expression of ARHGDIA mRNA CTD PMID:15757668 heparin increases expression ISO RGD:1359547 6480464 Heparin results in increased expression of ARHGDIA protein CTD PMID:17488504 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of ARHGDIA mRNA CTD PMID:12419474 hydroquinone affects expression EXP 6480464 hydroquinone affects the expression of ARHGDIA protein CTD PMID:17181942 L-ascorbic acid increases expression ISO RGD:1552296 6480464 Ascorbic Acid results in increased expression of ARHGDIA mRNA CTD PMID:22139585 L-methionine multiple interactions EXP 6480464 Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of ARHGDIA protein] CTD PMID:22138271 L-methionine multiple interactions ISO RGD:1552296 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGDIA mRNA CTD PMID:20938992 lead(0) decreases expression EXP 6480464 Lead results in decreased expression of ARHGDIA mRNA CTD PMID:19921347 lead(2+) decreases expression EXP 6480464 Lead results in decreased expression of ARHGDIA mRNA CTD PMID:19921347 lovastatin increases expression ISO RGD:1552296 6480464 Lovastatin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 manganese atom decreases expression EXP 6480464 Manganese results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 manganese(0) decreases expression EXP 6480464 Manganese results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 methamphetamine increases expression ISO RGD:1359547 6480464 Methamphetamine results in increased expression of ARHGDIA protein CTD PMID:19826936 methotrexate affects response to substance EXP 6480464 ARHGDIA protein affects the susceptibility to Methotrexate CTD PMID:16217747 nickel atom increases expression EXP 6480464 Nickel results in increased expression of ARHGDIA mRNA CTD PMID:24768652 , PMID:25583101 Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of ARHGDIA mRNA CTD PMID:17762391 paclitaxel multiple interactions EXP 6480464 ARHGDIA mRNA affects the reaction [Paclitaxel results in increased activity of CASP3 protein] CTD PMID:17264767 paclitaxel affects response to substance EXP 6480464 ARHGDIA mRNA affects the susceptibility to Paclitaxel CTD PMID:17264767 paracetamol affects expression ISO RGD:1552296 6480464 Acetaminophen affects the expression of ARHGDIA mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of ARHGDIA mRNA CTD PMID:29067470 paracetamol increases expression ISO RGD:1552296 6480464 Acetaminophen results in increased expression of ARHGDIA mRNA CTD PMID:29246445 paracetamol multiple interactions ISO RGD:1552296 6480464 PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of ARHGDIA mRNA] CTD PMID:29246445 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of ARHGDIA mRNA CTD PMID:22230336 paraoxon increases expression EXP 6480464 Paraoxon results in increased expression of ARHGDIA protein CTD PMID:20931991 pentachlorophenol increases expression ISO RGD:1552296 6480464 Pentachlorophenol results in increased expression of ARHGDIA mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1552296 6480464 perfluorooctane sulfonic acid results in decreased expression of ARHGDIA protein CTD PMID:26178269 phenobarbital multiple interactions ISO RGD:1552296 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARHGDIA mRNA] CTD PMID:19482888 phenobarbital increases expression ISO RGD:1552296 6480464 Phenobarbital results in increased expression of ARHGDIA mRNA CTD PMID:19482888 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of ARHGDIA mRNA CTD PMID:18070364 pyrogallol increases expression ISO RGD:1552296 6480464 Pyrogallol results in increased expression of ARHGDIA mRNA CTD PMID:20362636 pyrrolidine dithiocarbamate decreases expression EXP 6480464 pyrrolidine dithiocarbamic acid results in decreased expression of ARHGDIA mRNA CTD PMID:15477007 pyrrolidine dithiocarbamate multiple interactions EXP 6480464 [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ARHGDIA mRNA CTD PMID:15477007 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of ARHGDIA mRNA CTD PMID:25667456 selenium atom increases expression EXP 6480464 Selenium results in increased expression of ARHGDIA mRNA CTD PMID:19244175 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of ARHGDIA mRNA CTD PMID:28595984 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of ARHGDIA mRNA CTD PMID:12760830 sodium dichromate decreases expression ISO RGD:1359547 6480464 sodium bichromate results in decreased expression of ARHGDIA mRNA, sodium bichromate results in decreased expression of ARHGDIA protein CTD PMID:21437922 Soman increases expression ISO RGD:1359547 6480464 Soman results in increased expression of ARHGDIA mRNA CTD PMID:19281266 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of ARHGDIA mRNA CTD PMID:12419474 thalidomide increases expression ISO RGD:1552296 6480464 Thalidomide results in increased expression of ARHGDIA mRNA CTD PMID:26217789 triacsin C increases expression EXP 6480464 triacsin C results in increased expression of ARHGDIA mRNA CTD PMID:16704987 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of ARHGDIA mRNA CTD PMID:29453283 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of ARHGDIA mRNA CTD PMID:23179753 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of ARHGDIA mRNA CTD PMID:25979313 vitamin E increases expression EXP 6480464 Vitamin E results in increased expression of ARHGDIA mRNA CTD PMID:19244175 warfarin increases expression ISO RGD:1552296 6480464 Warfarin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 WIN 55212-2 decreases expression ISO RGD:1552296 6480464 Win 55212-2 results in decreased expression of ARHGDIA mRNA CTD PMID:12237329 zoledronic acid decreases expression EXP 6480464 zoledronic acid results in decreased expression of ARHGDIA protein CTD PMID:28871336
Biological Process cellular response to mechanical stimulus IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 cellular response to organic cyclic compound IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 cellular response to redox state IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 negative regulation of apoptotic process TAS 2290271 (PMID:16130169) UniProtKB PMID:16130169 negative regulation of axonogenesis TAS 2290271 Reactome Reactome:R-HSA-193634 negative regulation of cell adhesion TAS 2290271 (PMID:8262133) PINC PMID:8262133 negative regulation of cell migration IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 positive regulation of axonogenesis TAS 2290271 Reactome Reactome:R-HSA-209563 positive regulation of GTPase activity IEA GO:0005096 2290271 GOC GO_REF:0000108 regulation of actin cytoskeleton reorganization IMP 2290271 (PMID:8262133) UniProtKB PMID:8262133 regulation of catalytic activity IEA GO:0005094 2290271 GOC GO_REF:0000108 regulation of cell shape IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 regulation of protein localization IEA UniProtKB:Q99PT1 , ensembl:ENSMUSP000000637142290271 Ensembl GO_REF:0000107 regulation of Rho protein signal transduction IMP 2290271 (PMID:8262133) UniProtKB PMID:8262133 regulation of small GTPase mediated signal transduction TAS 2290271 Reactome Reactome:R-HSA-194840 Rho protein signal transduction IBA MGI:MGI:2178103 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 Rho protein signal transduction IEA UniProtKB:Q99PT1 , ensembl:ENSMUSP000000637142290271 Ensembl GO_REF:0000107 semaphorin-plexin signaling pathway IEA UniProtKB:Q99PT1 , ensembl:ENSMUSP000000637142290271 Ensembl GO_REF:0000107 semaphorin-plexin signaling pathway ISS UniProtKB:Q99PT1 2290271 UniProtKB GO_REF:0000024 Cellular Component cytoplasm IEA InterPro:IPR000406 2290271 InterPro GO_REF:0000002 cytoskeleton TAS 2290271 (PMID:16130169) UniProtKB PMID:16130169 cytosol TAS 2290271 Reactome Reactome:R-HSA-193646 more ... cytosol IBA PANTHER:PTN000104723 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 cytosol IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 extracellular exosome HDA 2290271 (PMID:19056867), (PMID:20458337), (PMID:23533145) UniProtKB PMID:19056867 more ... extracellular space IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 immunological synapse IEA UniProtKB:Q99PT1 , ensembl:ENSMUSP000000637142290271 Ensembl GO_REF:0000107 membrane IBA MGI:MGI:108430 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 nucleus IEA UniProtKB:Q99PT1 , ensembl:ENSMUSP000000637142290271 Ensembl GO_REF:0000107 synapse IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 Molecular Function fatty acid binding IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 GTPase activator activity IEA UniProtKB-KW:KW-0343 2290271 UniProtKB GO_REF:0000037 Hsp90 protein binding IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 protein binding IPI UniProtKB:Q9BSI4 2290271 (PMID:21044950) IntAct PMID:21044950 protein binding IPI UniProtKB:Q9NS68 2290271 (PMID:30337686) IntAct PMID:30337686 protein binding IPI UniProtKB:Q63ZY3 2290271 (PMID:25961457) UniProt PMID:25961457 protein binding IPI UniProtKB:P61586 2290271 (PMID:10489445), (PMID:20711218), (PMID:25416956) IntAct PMID:10489445 more ... protein binding IPI UniProtKB:P63000 2290271 (PMID:11513578), (PMID:17245428), (PMID:21900206), (PMID:22157745), (PMID:27173435) IntAct PMID:11513578 more ... protein kinase binding IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107 Rac GTPase binding IBA PANTHER:PTN000104723 , UniProtKB:P52566 2290271 (PMID:21873635) GO_Central PMID:21873635 Rho GDP-dissociation inhibitor activity IEA InterPro:IPR000406 2290271 InterPro GO_REF:0000002 Rho GDP-dissociation inhibitor activity IBA MGI:MGI:2178103 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 Rho GDP-dissociation inhibitor activity IEA UniProtKB:Q99PT1 , ensembl:ENSMUSP000000637142290271 Ensembl GO_REF:0000107 Rho GTPase binding IEA UniProtKB:Q5XI73 , ensembl:ENSRNOP000000518402290271 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
