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Gene: CBR1 (carbonyl reductase 1) Homo sapiens
Symbol: CBR1
Name: carbonyl reductase 1
RGD ID: 737546
Description: Exhibits carbonyl reductase (NADPH) activity and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in several processes, including drug metabolic process; epithelial cell differentiation; and vitamin K metabolic process. Localizes to extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; carbonyl reductase (NADPH) 1; carbonyl reductase [NADPH] 1; CBR; hCBR1; NADPH-dependent carbonyl reductase 1; PG-9-KR; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; SDR21C1; short chain dehydrogenase/reductase family 21C member 1; short chain dehydrogenase/reductase family 21C, member 1
Mus musculus (house mouse) : Cbr1 (carbonyl reductase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cbr1 (carbonyl reductase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbr1 (carbonyl reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CBR1 (carbonyl reductase 1)
Canis lupus familiaris (dog) : LOC610164 (carbonyl reductase [NADPH] 1)
Sus scrofa (pig) : CBR1 (carbonyl reductase 1)
Chlorocebus sabaeus (African green monkey) : CBR1 (carbonyl reductase 1)
more info ...
Related Pseudogenes: AC009248.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2136,069,941 - 36,073,166 (+)EnsemblGRCh38hg38GRCh38
GRCh382136,070,024 - 36,073,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372137,442,285 - 37,445,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,364,155 - 36,367,332 (+)NCBINCBI36hg18NCBI36
Build 342136,364,154 - 36,367,332NCBI
Celera2122,641,173 - 22,644,350 (+)NCBI
Cytogenetic Map21q22.12NCBI
HuRef2122,920,731 - 22,923,910 (+)NCBIHuRef
CHM1_12137,004,016 - 37,007,269 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CBR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737546
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.