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Gene: GPX1 (glutathione peroxidase 1) Homo sapiens
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Symbol: GPX1
Name: glutathione peroxidase 1
Description: Exhibits SH3 domain binding activity and glutathione peroxidase activity. Involved in several processes, including UV protection; cell redox homeostasis; and negative regulation of apoptotic process. Localizes to the mitochondrion. Colocalizes with the Lewy body. Implicated in several diseases, including cardiovascular system disease (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); pseudoxanthoma elasticum; and sickle cell anemia. Biomarker of Huntington's disease; artery disease (multiple); diabetic angiopathy; inflammatory bowel disease (multiple); and nephrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cellular glutathione peroxidase; GPx-1; GPXD; GSHPx-1; GSHPX1; MGC14399; MGC88245
Orthologs:
Mus musculus (house mouse) : Gpx1 (glutathione peroxidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpx1 (glutathione peroxidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx1 (glutathione peroxidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX1 (glutathione peroxidase 1)
Canis lupus familiaris (dog) : GPX1 (glutathione peroxidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx1 (glutathione peroxidase 1)
Sus scrofa (pig) : GPX1 (glutathione peroxidase 1)
more info ...
Related Pseudogenes: GPX1P1   GPX1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,357,171 - 49,358,600 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,394,609 - 49,395,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,369,613 - 49,370,795 (-)NCBINCBI36hg18NCBI36
Build 34349,369,614 - 49,370,795NCBI
Celera349,359,484 - 49,360,663 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,454,091 - 49,455,270 (-)NCBIHuRef
CHM1_1349,347,422 - 49,348,601 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GPX1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737005
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.