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Gene: GPX1 (glutathione peroxidase 1) Homo sapiens
Symbol: GPX1
Name: glutathione peroxidase 1
RGD ID: 737005
Description: Exhibits SH3 domain binding activity; glutathione peroxidase activity; and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in several processes, including UV protection; icosanoid metabolic process; and negative regulation of apoptotic process. Localizes to mitochondrion. Colocalizes with Lewy body. Implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and pseudoxanthoma elasticum. Biomarker of Huntington's disease; artery disease (multiple); diabetic angiopathy; inflammatory bowel disease (multiple); and nephrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cellular glutathione peroxidase; GPx-1; GPXD; GSHPx-1; GSHPX1; MGC14399; MGC88245; selenoprotein GPX1
Mus musculus (house mouse) : Gpx1 (glutathione peroxidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpx1 (glutathione peroxidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx1 (glutathione peroxidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX1 (glutathione peroxidase 1)
Canis lupus familiaris (dog) : GPX1 (glutathione peroxidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx1 (glutathione peroxidase 1)
Sus scrofa (pig) : GPX1 (glutathione peroxidase 1)
Chlorocebus sabaeus (African green monkey) : GPX1 (glutathione peroxidase 1)
Heterocephalus glaber (naked mole-rat) : Gpx1 (glutathione peroxidase 1)
more info ...
Related Pseudogenes: GPX1P1   GPX1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl349,357,176 - 49,358,358 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,357,176 - 49,358,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,394,609 - 49,395,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,369,613 - 49,370,795 (-)NCBINCBI36hg18NCBI36
Build 34349,369,614 - 49,370,795NCBI
Celera349,359,484 - 49,360,663 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,454,091 - 49,455,270 (-)NCBIHuRef
CHM1_1349,347,422 - 49,348,601 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPX1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737005
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.