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Gene: SOD1 (superoxide dismutase 1) Homo sapiens
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Symbol: SOD1
Name: superoxide dismutase 1
Description: Exhibits several functions, including chaperone binding activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of cholesterol biosynthetic process; and positive regulation of superoxide anion generation. Localizes to several cellular components, including the dendrite cytoplasm; neuronal cell body; and peroxisome. Colocalizes with the plasma membrane. Implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including Behcet's disease; artery disease (multiple); cutaneous leishmaniasis; eye disease (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS; ALS1; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HEL-S-44; homodimer; hSod1; indophenoloxidase A; IPOA; SOD; SOD, soluble; STAHP; superoxide dismutase; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic
Orthologs:
Mus musculus (house mouse) : Sod1 (superoxide dismutase 1, soluble)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sod1 (superoxide dismutase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sod1 (superoxide dismutase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOD1 (superoxide dismutase 1)
Canis lupus familiaris (dog) : SOD1 (superoxide dismutase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sod1 (superoxide dismutase 1)
Sus scrofa (pig) : SOD1 (superoxide dismutase 1)
more info ...
Related Pseudogenes: SOD1P1   SOD1P2  
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Tg(SOD1*G93A)26Dwc   SD-Tg(SOD1*G93A)39   SD-Tg(SOD1*H46R)4   SD-Tg(SOD1*G93A)26DwcTac  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,659,622 - 31,668,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372133,031,935 - 33,041,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,953,806 - 31,963,115 (+)NCBINCBI36hg18NCBI36
Build 342131,953,805 - 31,963,112NCBI
Celera2118,215,252 - 18,224,561 (+)NCBI
Cytogenetic Map21q22.11ENTREZGENE
HuRef2118,441,963 - 18,451,272 (+)NCBIHuRef
CHM1_12132,593,921 - 32,603,230 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated