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Gene: CEBPA (CCAAT enhancer binding protein alpha) Homo sapiens
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Symbol: CEBPA
Name: CCAAT enhancer binding protein alpha
Description: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c/EBP alpha; C/EBP-alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein alpha; ccaat/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; CEBP
Orthologs:
Mus musculus (house mouse) : Cebpa (CCAAT/enhancer binding protein (C/EBP), alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cebpa (CCAAT/enhancer binding protein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cebpa (CCAAT enhancer binding protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : CEBPA (CCAAT enhancer binding protein alpha)
Canis lupus familiaris (dog) : CEBPA (CCAAT enhancer binding protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cebpa (CCAAT enhancer binding protein alpha)
Sus scrofa (pig) : CEBPA (CCAAT enhancer binding protein alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381933,299,934 - 33,302,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371933,790,840 - 33,793,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361938,482,776 - 38,485,160 (-)NCBINCBI36hg18NCBI36
Build 341938,482,775 - 38,485,160NCBI
Celera1930,484,405 - 30,486,995 (-)NCBI
Cytogenetic Map19q13.11NCBI
HuRef1930,291,676 - 30,294,205 (-)NCBIHuRef
CHM1_11933,791,795 - 33,794,425 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CEBPA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69121
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.