OR9K2 (olfactory receptor family 9 subfamily K member 2) - Rat Genome Database
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Gene: OR9K2 (olfactory receptor family 9 subfamily K member 2) Homo sapiens
Analyze
Symbol: OR9K2
Name: olfactory receptor family 9 subfamily K member 2
RGD ID: 1345121
HGNC Page HGNC
Description: Predicted to have odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to localize to plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: olfactory receptor 9K2; olfactory receptor OR12-2; olfactory receptor, family 9, subfamily K, member 2; OR12-2
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,126,406 - 55,132,750 (+)EnsemblGRCh38hg38GRCh38
GRCh381255,126,406 - 55,132,750 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371255,523,553 - 55,524,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,809,820 - 53,810,827 (+)NCBINCBI36hg18NCBI36
Build 341253,809,819 - 53,810,827NCBI
Celera1255,175,406 - 55,176,413 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1252,562,122 - 52,563,129 (+)NCBIHuRef
CHM1_11255,490,466 - 55,491,472 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:14983052   PMID:21873635   PMID:24152035  


Genomics

Comparative Map Data
OR9K2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,126,406 - 55,132,750 (+)EnsemblGRCh38hg38GRCh38
GRCh381255,126,406 - 55,132,750 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371255,523,553 - 55,524,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,809,820 - 53,810,827 (+)NCBINCBI36hg18NCBI36
Build 341253,809,819 - 53,810,827NCBI
Celera1255,175,406 - 55,176,413 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1252,562,122 - 52,563,129 (+)NCBIHuRef
CHM1_11255,490,466 - 55,491,472 (+)NCBICHM1_1
Olfr826
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910130,015,806 - 130,016,747 (-)NCBIGRCm39mm39
GRCm3810130,179,937 - 130,180,878 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10130,178,471 - 130,184,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710129,616,993 - 129,617,934 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610129,582,886 - 129,583,827 (-)NCBImm8
Celera10132,557,773 - 132,558,714 (-)NCBICelera
Cytogenetic Map10D3NCBI
Olr1070
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.079,484,971 - 9,485,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl79,484,971 - 9,485,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.079,659,372 - 9,660,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.478,316,801 - 8,317,760 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.178,316,800 - 8,317,760 (-)NCBI
Celera75,089,156 - 5,090,115 (-)NCBICelera
Cytogenetic Map7q11NCBI
OR9K2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl27305,109 - 305,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.127304,715 - 305,957 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC100512466
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1520,148,192 - 20,149,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2521,180,458 - 21,181,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:67
Interacting mature miRNAs:67
Transcripts:ENST00000305377
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 1 1 1 5 2 2 1 2 3
Below cutoff 183 323 135 21 127 17 458 174 273 19 153 137 4 122 311

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000305377   ⟹   ENSP00000307598
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,129,681 - 55,130,802 (+)Ensembl
RefSeq Acc Id: ENST00000641329   ⟹   ENSP00000493006
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,126,406 - 55,132,750 (+)Ensembl
RefSeq Acc Id: ENST00000641353
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,126,406 - 55,132,750 (+)Ensembl
RefSeq Acc Id: ENST00000641374   ⟹   ENSP00000493328
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,129,681 - 55,130,802 (+)Ensembl
RefSeq Acc Id: ENST00000641982
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,126,406 - 55,132,750 (+)Ensembl
RefSeq Acc Id: NM_001005243   ⟹   NP_001005243
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,126,406 - 55,132,750 (+)NCBI
GRCh371255,523,553 - 55,524,560 (+)RGD
Build 361253,809,820 - 53,810,827 (+)NCBI Archive
Celera1255,175,406 - 55,176,413 (+)RGD
HuRef1252,562,122 - 52,563,129 (+)RGD
CHM1_11255,490,466 - 55,491,472 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005243 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI36989 (Get FASTA)   NCBI Sequence Viewer  
  ALI87585 (Get FASTA)   NCBI Sequence Viewer  
  BAC06080 (Get FASTA)   NCBI Sequence Viewer  
  DAA04724 (Get FASTA)   NCBI Sequence Viewer  
  Q8NGE7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001005243   ⟸   NM_001005243
- Sequence:
RefSeq Acc Id: ENSP00000493006   ⟸   ENST00000641329
RefSeq Acc Id: ENSP00000493328   ⟸   ENST00000641374
RefSeq Acc Id: ENSP00000307598   ⟸   ENST00000305377
Protein Domains
G_PROTEIN_RECEP_F1_2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001005243.1(OR9K2):c.233C>T (p.Pro78Leu) single nucleotide variant Malignant melanoma [RCV000070087] Chr12:55130001 [GRCh38]
Chr12:55523785 [GRCh37]
Chr12:53810052 [NCBI36]
Chr12:12q13.2
not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q13.13-13.3(chr12:53420606-56202942)x3 copy number gain See cases [RCV000141435] Chr12:53420606..56202942 [GRCh38]
Chr12:53814390..56596726 [GRCh37]
Chr12:52100657..54882993 [NCBI36]
Chr12:12q13.13-13.3
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15339 AgrOrtholog
COSMIC OR9K2 COSMIC
Ensembl Genes ENSG00000170605 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000307598 UniProtKB/Swiss-Prot
  ENSP00000493006 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000493328 UniProtKB/TrEMBL
Ensembl Transcript ENST00000305377 UniProtKB/Swiss-Prot
  ENST00000641329 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000641374 UniProtKB/TrEMBL
GTEx ENSG00000170605 GTEx
HGNC ID HGNC:15339 ENTREZGENE
Human Proteome Map OR9K2 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:441639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 441639 ENTREZGENE
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32799 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.553827 ENTREZGENE
UniProt A0A126GW01_HUMAN UniProtKB/TrEMBL
  A0A286YF25_HUMAN UniProtKB/TrEMBL
  OR9K2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B9EH19 UniProtKB/Swiss-Prot
  Q6IFD6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR9K2  olfactory receptor family 9 subfamily K member 2    olfactory receptor, family 9, subfamily K, member 2  Symbol and/or name change 5135510 APPROVED
2011-09-01 OR9K2  olfactory receptor, family 9, subfamily K, member 2  OR9K2  olfactory receptor, family 9, subfamily K, member 2  Symbol and/or name change 5135510 APPROVED