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Gene: NR4A2 (nuclear receptor subfamily 4 group A member 2) Homo sapiens
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Symbol: NR4A2
Name: nuclear receptor subfamily 4 group A member 2
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; and transcription, DNA-templated. Localizes to nuclear speck. Implicated in Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HZF-3; immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B/nur77 beta-type transcription factor homolog; NOT; nuclear receptor related 1; nuclear receptor subfamily 4, group A, member 2; nur related protein-1, human homolog of; NURR1; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; RNR1; T-cell nuclear receptor NOT; TINUR; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor
Orthologs:
Mus musculus (house mouse) : Nr4a2 (nuclear receptor subfamily 4, group A, member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr4a2 (nuclear receptor subfamily 4, group A, member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr4a2 (nuclear receptor subfamily 4 group A member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR4A2 (nuclear receptor subfamily 4 group A member 2)
Canis lupus familiaris (dog) : NR4A2 (nuclear receptor subfamily 4 group A member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr4a2 (nuclear receptor subfamily 4 group A member 2)
Sus scrofa (pig) : NR4A2 (nuclear receptor subfamily 4 group A member 2)
Chlorocebus sabaeus (African green monkey) : NR4A2 (nuclear receptor subfamily 4 group A member 2)
Heterocephalus glaber (naked mole-rat) : Nr4a2 (nuclear receptor subfamily 4 group A member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2156,324,437 - 156,342,348 (-)EnsemblGRCh38hg38GRCh38
GRCh382156,324,432 - 156,332,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372157,180,944 - 157,189,287 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362156,889,195 - 156,897,446 (-)NCBINCBI36hg18NCBI36
Build 342157,006,458 - 157,014,708NCBI
Celera2150,794,299 - 150,802,639 (-)NCBI
Cytogenetic Map2q24.1NCBI
HuRef2149,066,205 - 149,074,545 (-)NCBIHuRef
CHM1_12157,187,025 - 157,195,368 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NR4A2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732028
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.