1-naphthol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1-naphthol	go back to main search page
Accession:	CHEBI:10319	browse the term
Definition:	A naphthol carrying a hydroxy group at position 1.
Synonyms:	exact_synonym:	naphthalen-1-ol
	related_synonym:	1-hydroxynaphthalene; 1-naphthalenol; Formula=C10H8O; InChI=1S/C10H8O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11H; InChIKey=KJCVRFUGPWSIIH-UHFFFAOYSA-N; SMILES=Oc1cccc2ccccc12; alpha-hydroxynaphthalene; alpha-naphthol
	xref:	Beilstein:1817321; CAS:90-15-3; Gmelin:69192; HMDB:HMDB0012138; KEGG:C11714
	xref_mesh:	MESH:C029350
	xref:	MetaCyc:NAPHTHOL; PDBeChem:1NP; PMID:16721410; PMID:18966375; PMID:22740618; Reaxys:1817321; Wikipedia:1-Naphthol

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Genes (176)

1-naphthol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[1-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

androgen receptor

multiple interactions

1-naphthol inhibits the reaction [Metribolone binds to AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases abundance

CYP1A1 protein results in increased abundance of 1-naphthol

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases abundance
affects binding
decreases activity

CYP1A2 protein results in increased abundance of 1-naphthol
1-naphthol binds to CYP1A2 protein
1-naphthol results in decreased activity of CYP1A2 protein

PMID:15916432 PMID:16243959 PMID:32278787

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases abundance
multiple interactions

CYP1B1 protein results in increased abundance of 1-naphthol
[1-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA

PMID:16243959 PMID:27837168

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases abundance
multiple interactions

CYP2A13 protein results in increased abundance of 1-naphthol
[CYP2A13 protein results in increased oxidation of naphthalene] which results in increased abundance of 1-naphthol

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases abundance

CYP2B6 protein results in increased abundance of 1-naphthol

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases abundance

CYP2C19 protein results in increased abundance of 1-naphthol

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases abundance

CYP2C8 protein results in increased abundance of 1-naphthol

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases abundance

CYP2D6 protein results in increased abundance of 1-naphthol

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases abundance

CYP2E1 protein results in increased abundance of 1-naphthol

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases abundance

CYP3A4 protein results in increased abundance of 1-naphthol

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases abundance

CYP3A5 protein results in increased abundance of 1-naphthol

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

estrogen receptor 2

affects binding
multiple interactions

ESR2 protein binds to 1-naphthol
1-naphthol inhibits the reaction [ESR2 protein binds to Estradiol]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

jagged canonical Notch ligand 1

decreases expression

1-naphthol results in decreased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

nuclear receptor subfamily 1, group I, member 2

increases activity

1-naphthol results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity

1-naphthol results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor interacting protein 1

increases expression

1-naphthol results in increased expression of NRIP1 mRNA

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

peroxisome proliferator activated receptor alpha

increases activity

1-naphthol results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

sulfotransferase family 1A member 1

increases sulfation

SULT1A1 protein results in increased sulfation of 1-naphthol

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

thyroid hormone receptor beta

multiple interactions

1-naphthol binds to and results in decreased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

transient receptor potential cation channel, subfamily A, member 1

increases activity

1-naphthol analog results in increased activity of TRPA1 protein

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily V, member 3

increases activity

1-naphthol analog results in increased activity of TRPV3 protein

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

G

UDP glucuronosyltransferase family 1 member A6

increases metabolic processing
multiple interactions
increases glucuronidation
affects metabolic processing

UGT1A6 protein results in increased metabolism of 1-naphthol
beta-Naphthoflavone promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; Indomethacin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]
Methylcholanthrene promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; Paraquat promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]
UGT1A6 gene polymorphism affects the metabolism of 1-naphthol; UGT1A6 protein affects the metabolism of 1-naphthol

PMID:7646562 PMID:9429234 PMID:12153725 PMID:12756209 PMID:15336321 More...

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of 1-naphthol; UGT1A8 protein results in increased glucuronidation of 1-naphthol

PMID:15502008 PMID:22846377

NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 1-naphthol

PMID:15044611 PMID:18816295

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A1

increases glucuronidation

UGT2A1 protein results in increased glucuronidation of 1-naphthol

NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases glucuronidation

UGT2B1 protein results in increased glucuronidation of 1-naphthol

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of 1-naphthol

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

carbaryl

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]
[Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein

PMID:4859365 PMID:7713347 PMID:14644616 PMID:16256972 PMID:19934164 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

alanine--glyoxylate aminotransferase

decreases activity

Carbaryl results in decreased activity of AGXT protein

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

aryl hydrocarbon receptor

multiple interactions

AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein]

PMID:9169082 PMID:9853009 PMID:17553063

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

increases hydrolysis
multiple interactions

ALB protein results in increased hydrolysis of Carbaryl
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

androgen receptor

affects binding

Carbaryl binds to AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

butyrylcholinesterase

decreases activity
multiple interactions

Carbaryl results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein

PMID:20708061 PMID:22649187

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

Bcl2-like 11

decreases expression

Carbaryl results in decreased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

brain-derived neurotrophic factor

decreases secretion

Carbaryl results in decreased secretion of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

caspase 3

increases expression

Carbaryl results in increased expression of CASP3

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CCAAT/enhancer binding protein alpha

decreases expression

Carbaryl results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
increases expression
multiple interactions

Carbaryl results in increased activity of CYP1A1 protein
Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]

PMID:9169082 PMID:9858662 PMID:11226373

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases activity

Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]
Carbaryl results in increased expression of CYP1A2 protein
Carbaryl results in decreased activity of CYP1A2 protein

PMID:9858662 PMID:16790556

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases activity
increases expression

Carbaryl results in increased activity of CYP2B6 protein
Carbaryl results in increased expression of CYP2B6 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Carbaryl results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

Carbaryl results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

increases expression

Carbaryl results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Carbaryl results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Carbaryl results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression

Carbaryl results in increased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

E2F transcription factor 5

decreases expression

Carbaryl results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

ectodermal-neural cortex 1

decreases expression

Carbaryl results in decreased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

estrogen receptor 1

multiple interactions

Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

PMID:9126867 PMID:16626760

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
decreases expression

Carbaryl binds to and results in decreased activity of ESR2 protein
Carbaryl results in decreased expression of ESR2 mRNA

PMID:16626760 PMID:27829164

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression

Carbaryl results in increased expression of FOS mRNA
Carbaryl results in decreased expression of FOS mRNA

PMID:11226373 PMID:27829164

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

decreases expression

Carbaryl results in decreased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

follicle stimulating hormone subunit beta

multiple interactions

Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphate dehydrogenase

increases activity
multiple interactions

Carbaryl results in increased activity of G6PD protein
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, beta

decreases expression

Carbaryl results in decreased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

glutamate cysteine ligase, modifier subunit

increases expression

Carbaryl results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione peroxidase 5

increases expression

Carbaryl results in increased expression of GPX5 mRNA

NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression

Carbaryl results in increased expression of GRIN2B protein

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

Carbaryl results in increased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

heme oxygenase 1

increases expression

Carbaryl results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

increases expression

Carbaryl results in increased expression of HSPA5 mRNA

PMID:11226373 PMID:27829164

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

decreases expression

Carbaryl results in decreased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

interferon beta 1

multiple interactions

Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]

PMID:15907790 PMID:18177342

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interleukin 2

decreases response to substance

Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

kynurenine aminotransferase 1

decreases activity

Carbaryl results in decreased activity of KYAT1 protein

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

microtubule-associated protein 2

multiple interactions

Carbaryl promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

melanocyte inducing transcription factor

decreases expression

Carbaryl results in decreased expression of MITF mRNA

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

melatonin receptor 1A

affects binding
multiple interactions

Carbaryl binds to MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]

NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919

G

melatonin receptor 1B

affects binding
multiple interactions

Carbaryl binds to MTNR1B protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]

NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737

G

neurofilament heavy chain

increases phosphorylation

Carbaryl results in increased phosphorylation of NEFH protein

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nuclear factor kappa B subunit 1

multiple interactions

Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]

PMID:15907790 PMID:17015962

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group I, member 2

increases expression
increases activity

Carbaryl results in increased expression of NR1I2 mRNA
Carbaryl results in increased activity of NR1I2 protein

PMID:22310298 PMID:27665777

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity

Carbaryl results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

orthodenticle homeobox 2

multiple interactions

Carbaryl inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

paired box 6

multiple interactions

Carbaryl inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

pyridoxal kinase

decreases activity

Carbaryl results in decreased activity of PDXK protein

NCBI chr20:10,210,276...10,232,314
Ensembl chr20:10,210,289...10,232,110

G

progesterone receptor

multiple interactions

Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

patatin-like phospholipase domain containing 6

decreases activity

Carbaryl results in decreased activity of PNPLA6 protein

NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734

G

POU class 5 homeobox 1

multiple interactions

Carbaryl promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA]

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

increases activity

Carbaryl results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression

Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
Carbaryl results in decreased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

tryptophan 2,3-dioxygenase

decreases activity

Carbaryl results in decreased activity of TDO2 protein

PMID:2119399 PMID:2547861

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

G

transforming growth factor, beta 2

increases expression

Carbaryl results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

thyroid hormone receptor beta

multiple interactions
affects binding

Carbaryl binds to and results in decreased activity of THRB protein
Carbaryl binds to THRB protein

PMID:18584933 PMID:28973306

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

thyroid peroxidase

increases activity

Carbaryl results in increased activity of TPO protein

NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199

G

Wnt family member 6

decreases expression

Carbaryl results in decreased expression of WNT6 mRNA

NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523

G

X-box binding protein 1

increases expression

Carbaryl results in increased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

propranolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aralkylamine N-acetyltransferase

multiple interactions

Propranolol inhibits the reaction [Parathion results in increased expression of AANAT protein]

NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

Propranolol results in increased expression of ABCB1 mRNA
Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]

PMID:15276086 PMID:16671962

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

adenosine deaminase

multiple interactions

Propranolol promotes the reaction [ADA protein results in decreased susceptibility to Norepinephrine]

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adrenomedullin

decreases response to substance

Propranolol results in decreased susceptibility to ADM protein

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adrenoceptor beta 1

multiple interactions
affects response to substance
affects binding
increases activity
increases expression

Propranolol binds to and results in decreased activity of ADRB1 protein; Propranolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Propranolol
Propranolol binds to ADRB1 protein
[Propranolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Propranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Propranolol binds to and results in decreased activity of ADRB1 protein; Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; Propranolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Propranolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]
Propranolol results in increased activity of ADRB1 protein
Propranolol results in increased expression of ADRB1 mRNA

PMID:2462161 PMID:6141285 PMID:9593075 PMID:10372227 PMID:10952688 More...

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

decreases expression
multiple interactions
affects binding
increases expression

Propranolol results in decreased expression of ADRB2 mRNA
Propranolol binds to and results in decreased activity of ADRB2 protein; Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
Propranolol binds to ADRB2 protein
Propranolol results in increased expression of ADRB2 mRNA
[Propranolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Propranolol co-treated with ADRB2 protein] results in increased expression of GNAS protein; [Propranolol co-treated with ADRB2 protein] results in increased expression of GRK2 protein; Propranolol binds to and results in decreased activity of ADRB2 protein; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]; Propranolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]; Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]

PMID:2169833 PMID:2462161 PMID:2897299 PMID:6141285 PMID:9593075 More...

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions
affects response to substance

Propranolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]
ADRB3 affects the susceptibility to Propranolol

PMID:11159692 PMID:14730417

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

angiotensinogen

multiple interactions
decreases expression

Propranolol inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]
Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; Propranolol inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]
Propranolol results in decreased expression of AGT protein

PMID:14627 PMID:1653766 PMID:7104148 PMID:7843740 PMID:12606818

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

Propranolol results in decreased phosphorylation of AKT1 protein
ANGPT2 protein inhibits the reaction [Propranolol results in decreased phosphorylation of AKT1 protein]

PMID:30130526 PMID:31838054

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

arachidonate 5-lipoxygenase

multiple interactions

1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]; Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

amylase 2a3

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]

NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532

G

angiopoietin 2

decreases expression
multiple interactions

Propranolol results in decreased expression of ANGPT2 mRNA; Propranolol results in decreased expression of ANGPT2 protein
ANGPT2 protein inhibits the reaction [Propranolol results in decreased expression of BCL2 protein]; ANGPT2 protein inhibits the reaction [Propranolol results in decreased expression of MKI67 protein]; ANGPT2 protein inhibits the reaction [Propranolol results in decreased phosphorylation of AKT1 protein]; ANGPT2 protein inhibits the reaction [Propranolol results in increased expression of BAX protein]

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

ADP-ribosylation factor 6

affects localization

Propranolol affects the localization of ARF6 protein

NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114

G

arrestin, beta 2

multiple interactions

Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

Propranolol inhibits the reaction [Terbutaline results in increased expression of ATP1A1 mRNA]

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions
increases expression

Propranolol results in decreased expression of BAX mRNA
Propranolol inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]
Fat Emulsions, Intravenous inhibits the reaction [Propranolol results in increased expression of BAX protein]
ANGPT2 protein inhibits the reaction [Propranolol results in increased expression of BAX protein]

PMID:11218852 PMID:31838054 PMID:35738838 PMID:36707890

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
multiple interactions
decreases expression

Propranolol results in increased expression of BCL2 mRNA
Propranolol inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]
Propranolol results in decreased expression of BCL2 protein
ANGPT2 protein inhibits the reaction [Propranolol results in decreased expression of BCL2 protein]

PMID:11218852 PMID:31838054 PMID:36707890

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B2

multiple interactions

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

calcitonin-related polypeptide alpha

multiple interactions
affects activity

Propranolol promotes the reaction [CALCA protein affects the susceptibility to Norepinephrine]
Propranolol affects the activity of CALCA protein

PMID:7906887 PMID:8058111 PMID:10075105 PMID:18055875

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 3

increases cleavage
multiple interactions
increases activity
decreases expression

Propranolol results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Propranolol results in increased cleavage of CASP3 protein]; Fat Emulsions, Intravenous inhibits the reaction [Propranolol results in increased cleavage of CASP3 protein]
Propranolol results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Propranolol results in increased activity of CASP3 protein]
Propranolol results in decreased expression of CASP3 mRNA

PMID:11218852 PMID:19106745 PMID:22700542 PMID:35738838

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity

Propranolol results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases cleavage
multiple interactions

Propranolol results in increased cleavage of CASP9 protein
Fat Emulsions, Intravenous inhibits the reaction [Propranolol results in increased cleavage of CASP9 protein]

PMID:19106745 PMID:35738838

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 3

multiple interactions

Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]]
Propranolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Propranolol promotes the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]

PMID:9863660 PMID:12538206

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

collagen type II alpha 1 chain

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

cAMP responsive element binding protein 1

multiple interactions

Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

multiple interactions

Propranolol affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]; Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]; Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein]

PMID:3497798 PMID:12039681

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

Propranolol results in increased expression of CYP1A1 protein
Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]]
Propranolol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]

PMID:15618653 PMID:15627480 PMID:15710352

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
increases expression
multiple interactions

CYP1A2 protein affects the metabolism of Propranolol
Propranolol results in increased expression of CYP1A2 protein
Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]]

PMID:15286053 PMID:15618653 PMID:15710352

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

Propranolol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases oxidation
affects metabolic processing

CYP2C19 protein results in increased oxidation of Propranolol
CYP2C19 protein affects the metabolism of Propranolol

PMID:15286053 PMID:19853591

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Propranolol inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
increases oxidation
affects metabolic processing

CYP2D6 protein results in increased metabolism of Propranolol
CYP2D6 protein results in increased oxidation of Propranolol
CYP2D6 protein affects the metabolism of Propranolol

PMID:12464242 PMID:15286053 PMID:19853591 PMID:21184751

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases oxidation

CYP3A4 protein results in increased oxidation of Propranolol

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

delta like canonical Notch ligand 4

decreases expression
multiple interactions

Propranolol results in decreased expression of DLL4 protein
DLL4 protein inhibits the reaction [Propranolol results in decreased expression of MMP2 protein]; DLL4 protein inhibits the reaction [Propranolol results in decreased expression of MMP9 protein]

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

epidermal growth factor receptor

multiple interactions

Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ETS transcription factor ELK1

multiple interactions

[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein]

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

Fas cell surface death receptor

decreases expression

Propranolol results in decreased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibroblast growth factor 1

increases expression

Propranolol results in increased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

flavin containing dimethylaniline monoxygenase 2

increases oxidation

FMO2 protein results in increased oxidation of Propranolol

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

fibronectin 1

multiple interactions

[Norepinephrine co-treated with Propranolol] results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Propranolol inhibits the reaction [3-(N-phenylamino)-1,2-propanediol 1,2-dioleoyl ester analog results in increased expression of FOS mRNA]; Propranolol inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of FOS]

PMID:7905536 PMID:9748542 PMID:15501433

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamate decarboxylase 1

multiple interactions

Propranolol inhibits the reaction [Amphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

gap junction protein, alpha 1

affects localization

Propranolol affects the localization of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glycerol kinase

decreases activity

Propranolol results in decreased activity of GK protein

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

GNAS complex locus

increases expression
multiple interactions

Propranolol results in increased expression of GNAS mRNA
[Propranolol co-treated with ADRB2 protein] results in increased expression of GNAS protein

PMID:10455254 PMID:20668454

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein-coupled receptor kinase 2

multiple interactions
increases expression
decreases expression

[Propranolol co-treated with ADRB2 protein] results in increased expression of GRK2 protein
Propranolol results in increased expression of GRK2 protein
Propranolol results in decreased expression of GRK2 protein

PMID:9788834 PMID:10455254

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

glycogen synthase kinase 3 beta

decreases phosphorylation

Propranolol results in decreased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heme oxygenase 1

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in increased expression of HMOX1 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]

PMID:19483313 PMID:24929186

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hippocalcin

affects localization

Propranolol affects the localization of HPCA protein

NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841

G

5-hydroxytryptamine receptor 1B

affects binding

Propranolol binds to HTR1B protein

NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549

G

interleukin 10

increases expression

Propranolol results in increased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions
decreases secretion

Propranolol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Propranolol results in decreased secretion of IL1B protein

PMID:11854442 PMID:16386803

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Propranolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Propranolol inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; Propranolol inhibits the reaction [Ozone results in increased expression of IL6 protein]

PMID:12619890 PMID:29247675

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions
decreases expression

Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein]
Propranolol results in decreased expression of INS protein

PMID:3019152 PMID:6018752

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

potassium voltage-gated channel subfamily E regulatory subunit 2

multiple interactions

Propranolol results in decreased activity of [KCNH2 protein binds to KCNE2 protein]

NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Propranolol results in decreased activity of [KCNH2 protein binds to KCNE2 protein]; Propranolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein]
Propranolol results in decreased activity of KCNH2 protein

PMID:15679475 PMID:16314852

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 2

affects response to substance

KCNJ2 gene affects the susceptibility to Propranolol

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

potassium inwardly-rectifying channel, subfamily J, member 3

increases expression

Propranolol results in increased expression of KCNJ3 mRNA

NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124

G

potassium voltage-gated channel subfamily Q member 1

affects response to substance

KCNQ1 gene affects the susceptibility to Propranolol

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

G

leptin

multiple interactions
increases expression

Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein]
Propranolol results in increased expression of LEP protein

PMID:11022189 PMID:24250662

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

increases expression

Propranolol results in increased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

lipoprotein lipase

multiple interactions

Propranolol inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

mitogen activated protein kinase 1

multiple interactions

[Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK1 protein]

PMID:11093795 PMID:11880281 PMID:17925438 PMID:18448488 PMID:19903766 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK3 protein]

PMID:11093795 PMID:11880281 PMID:17925438 PMID:18448488 PMID:19903766 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

microRNA 34a

multiple interactions

Propranolol inhibits the reaction [Arsenic Trioxide results in increased expression of MIR34A mRNA]

NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103

G

marker of proliferation Ki-67

decreases expression
multiple interactions

Propranolol results in decreased expression of MKI67 protein
ANGPT2 protein inhibits the reaction [Propranolol results in decreased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 2

decreases expression
multiple interactions
decreases secretion

Propranolol results in decreased expression of MMP2; Propranolol results in decreased expression of MMP2 mRNA; Propranolol results in decreased expression of MMP2 protein
DLL4 protein inhibits the reaction [Propranolol results in decreased expression of MMP2 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Propranolol results in decreased secretion of MMP2 protein

PMID:20424515 PMID:21042766 PMID:24929186 PMID:30130526

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions
decreases secretion

Propranolol results in decreased expression of MMP9; Propranolol results in decreased expression of MMP9 mRNA; Propranolol results in decreased expression of MMP9 protein
DLL4 protein inhibits the reaction [Propranolol results in decreased expression of MMP9 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]
Propranolol results in decreased secretion of MMP9 protein

PMID:16574429 PMID:20424515 PMID:21042766 PMID:24929186 PMID:30130526

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myosin heavy chain 7

multiple interactions
increases expression

Propranolol promotes the reaction [Norepinephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
Propranolol results in increased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

neurofilament heavy chain

affects expression

Propranolol affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nerve growth factor

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in increased expression of NGF mRNA]

PMID:2174743 PMID:2853697

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 3

affects expression

Propranolol affects the expression of NOS3

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

decreases expression

Propranolol results in decreased expression of NOTCH1 protein

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

natriuretic peptide A

multiple interactions
affects activity
increases expression

Propranolol inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Propranolol affects the activity of NPPA protein modified form
Propranolol results in increased expression of NPPA mRNA

PMID:1363893 PMID:10997724 PMID:17592507

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

affects activity

Propranolol affects the activity of NPPB protein modified form

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Propranolol results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

ornithine decarboxylase 1

increases activity
multiple interactions

Propranolol results in increased activity of ODC1 protein
Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of ODC1 protein]

PMID:2286747 PMID:6284819 PMID:10353628

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

orosomucoid 1

affects binding

propranolol affects binding to Orm1 protein in rat serum

RGD

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

proenkephalin

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

phospholamban

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein]

NCBI chr20:32,629,537...32,639,559

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]; Propranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]
Propranolol results in decreased expression of PPARGC1A mRNA

PMID:16513826 PMID:17446185

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase C, alpha

decreases expression

Propranolol results in decreased expression of PRKCA protein

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, delta

decreases expression

Propranolol results in decreased expression of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

Propranolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of PTGS2 protein]; Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein]; Propranolol promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; Propranolol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Propranolol promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Propranolol results in decreased expression of PTGS2; Propranolol results in decreased expression of PTGS2 mRNA; Propranolol results in decreased expression of PTGS2 protein

PMID:11854442 PMID:12872987 PMID:15210717 PMID:18805435 PMID:20424515 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 5

multiple interactions

Propranolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]

NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882

G

renin

multiple interactions
decreases activity
decreases expression

Propranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]; Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]; Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]
Propranolol results in decreased activity of REN protein
Propranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]; Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]; Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein]
Propranolol results in decreased expression of REN protein

PMID:145319 PMID:200433 PMID:637424 PMID:653302 PMID:791319 More...

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ribosomal protein S6 kinase B1

increases phosphorylation
multiple interactions

Propranolol results in increased phosphorylation of RPS6KB1 protein
Sirolimus inhibits the reaction [Propranolol results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

sodium channel epithelial 1 subunit alpha

multiple interactions

Propranolol inhibits the reaction [Terbutaline results in increased expression of SCNN1A mRNA]

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

serpin family F member 1

increases expression

propranolol increases expression of Serpinf1 protein in mononuclear phagocytes

RGD

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

sirtuin 1

multiple interactions

Propranolol inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 mRNA]; Propranolol inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 22 member 1

multiple interactions

Propranolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Propranolol inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Propranolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions

Propranolol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 4

multiple interactions

Propranolol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

multiple interactions

Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 47 member 1

multiple interactions

Propranolol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Propranolol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 8 member A1

multiple interactions

Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

signal transducer and activator of transcription 3

multiple interactions

Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]

PMID:18448488 PMID:20106947

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

steroid sulfatase

multiple interactions

Propranolol inhibits the reaction [Tretinoin results in increased activity of STS protein]

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

TEK receptor tyrosine kinase

decreases expression

Propranolol results in decreased expression of TEK mRNA; Propranolol results in decreased expression of TEK protein

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

Thy-1 cell surface antigen

multiple interactions

Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1]; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of THY1]; Propranolol inhibits the reaction [Norepinephrine results in decreased expression of THY1]

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

tumor necrosis factor

multiple interactions
increases expression

Propranolol inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Propranolol inhibits the reaction [Ozone results in increased expression of TNF mRNA]; Propranolol inhibits the reaction [Ozone results in increased expression of TNF protein]; Propranolol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Propranolol results in increased expression of TNF protein

PMID:11752888 PMID:15081246 PMID:29247675

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glycosyltransferase 2 family, polypeptide B

increases glucuronidation

UGT2B protein results in increased glucuronidation of Propranolol

NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776

G

vascular endothelial growth factor A

decreases expression
multiple interactions

Propranolol results in decreased expression of VEGFA mRNA; Propranolol results in decreased expression of VEGFA protein
Propranolol inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]

PMID:10788502 PMID:20424515 PMID:30130526

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

propranolol hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

decreases binding

propranolol hydrochloride decreases binding to the beta2-adrenergic receptor

RGD

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
biological role	19785
aetiopathogenetic role	19163
genotoxin	17675
1-naphthol	176
1-naphthyl N-acetyl-beta-D-glucosaminide	0
1-naphthyl beta-D-glucoside	0
1-naphthyl tetradecanoate	0
1-naphthyloxyacetic acid	0
carbaryl +	65
propranolol +	106
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
main group molecular entity	19759
s-block molecular entity	19628
hydrogen molecular entity	19614
hydrides	19087
organic hydride	18656
organic fundamental parent	18656
hydrocarbon	18396
cyclic hydrocarbon	17214
arene	17209
polycyclic arene	17023
ortho-fused polycyclic arene	9816
ortho-fused bicyclic arene	2428
naphthalene	2372
naphthol	197
1-naphthol	176
1-naphthyl N-acetyl-beta-D-glucosaminide	0
1-naphthyl beta-D-glucoside	0
1-naphthyl tetradecanoate	0
1-naphthyloxyacetic acid	0
carbaryl +	65
propranolol +	106

paths to the root