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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbaryl
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Accession:CHEBI:3390 term browser browse the term
Definition:A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.
Synonyms:exact_synonym: naphthalen-1-yl methylcarbamate
 related_synonym: 1-Naphthalenol, methylcarbamate;   1-Naphthalenyl methylcarbamate;   1-Naphthyl N-methylcarbamate;   1-naphthol N-methylcarbamate;   Carbaril;   Formula=C12H11NO2;   InChI=1S/C12H11NO2/c1-13-12(14)15-11-8-4-6-9-5-2-3-7-10(9)11/h2-8H,1H3,(H,13,14);   InChIKey=CVXBEEMKQHEXEN-UHFFFAOYSA-N;   N-Methyl-1-naphthyl carbamate;   N-Methyl-alpha-naphthylurethan;   SMILES=CNC(=O)Oc1cccc2ccccc12;   Sevin;   alpha-Naphthyl N-methylcarbamate
 xref: CAS:63-25-2;   Drug_Central:3066;   KEGG:C07491;   KEGG:D07613;   LINCS:LSM-37123
 xref_mesh: MESH:D012721
 xref: PMID:15092421;   PMID:15092693;   PMID:19025094;   PPDB:115;   Reaxys:1875862;   Wikipedia:Carbaryl


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carbaryl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]
[Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein
CTD PMID:4859365, PMID:7713347, PMID:14644616, PMID:16256972, PMID:19934164, PMID:21251949, PMID:23418109, PMID:23962483, PMID:25707986 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases activity EXP Carbaryl results in decreased activity of AGXT protein CTD PMID:2119399 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein] CTD PMID:9169082, PMID:9853009, PMID:17553063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
EXP
ISO
ALB protein results in increased hydrolysis of Carbaryl
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl]
CTD PMID:27665777 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor affects binding EXP Carbaryl binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP Carbaryl results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein
CTD PMID:20708061, PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO Carbaryl results in decreased expression of BCL2L11 mRNA CTD PMID:27829164 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Casp3 caspase 3 increases expression EXP Carbaryl results in increased expression of CASP3 CTD PMID:27296064 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Carbaryl results in decreased expression of CEBPA mRNA CTD PMID:27829164 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
increases expression
ISO
EXP
Carbaryl results in increased activity of CYP1A1 protein
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein
CTD PMID:9169082, PMID:9858662, PMID:11226373 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases expression
ISO
EXP
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]
Carbaryl results in decreased activity of CYP1A2 protein
Carbaryl results in increased expression of CYP1A2 protein
CTD PMID:9858662, PMID:16790556 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO Carbaryl results in increased activity of CYP2B6 protein
Carbaryl results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Carbaryl results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Carbaryl results in increased expression of DDIT3 mRNA CTD PMID:11226373 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Carbaryl results in increased expression of DNAJB4 mRNA CTD PMID:27829164 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Carbaryl results in increased expression of DNAJB9 mRNA CTD PMID:27829164 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Carbaryl results in increased expression of DNAJC3 mRNA CTD PMID:27829164 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Carbaryl results in decreased expression of E2F5 mRNA CTD PMID:27829164 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Carbaryl results in decreased expression of ENC1 mRNA CTD PMID:27829164 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867, PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Carbaryl binds to and results in decreased activity of ESR2 protein
Carbaryl results in decreased expression of ESR2 mRNA
CTD PMID:16626760, PMID:27829164 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Carbaryl results in increased expression of FOS mRNA
Carbaryl results in decreased expression of FOS mRNA
CTD PMID:11226373, PMID:27829164 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Carbaryl results in decreased expression of FOXO1 mRNA CTD PMID:27829164 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone] CTD PMID:16413094 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP Carbaryl results in increased activity of G6PD protein
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
CTD PMID:27214522 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Carbaryl results in decreased expression of GADD45B mRNA CTD PMID:27829164 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Carbaryl results in increased expression of GCLM mRNA CTD PMID:27829164 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Carbaryl results in increased expression of GPX5 mRNA CTD PMID:27829164 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Carbaryl results in increased expression of HERPUD1 mRNA CTD PMID:27829164 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbaryl results in increased expression of HMOX1 mRNA CTD PMID:27829164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Carbaryl results in increased expression of HSPA5 mRNA CTD PMID:11226373, PMID:27829164 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:15907790, PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Carbaryl results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Carbaryl results in decreased expression of MITF mRNA CTD PMID:27829164 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions
ISO Carbaryl binds to MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]
CTD PMID:28027439 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions
ISO Carbaryl binds to MTNR1B protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]
CTD PMID:28027439 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nefh neurofilament heavy increases phosphorylation ISO Carbaryl results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:15907790, PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity
ISO
EXP
Carbaryl results in increased expression of NR1I2 mRNA
Carbaryl results in increased activity of NR1I2 protein
CTD PMID:22310298, PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP Carbaryl results in increased activity of NR1I3 protein CTD PMID:27665777 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pdxk pyridoxal kinase decreases activity ISO Carbaryl results in decreased activity of PDXK protein CTD PMID:2547861 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity EXP Carbaryl results in decreased activity of PNPLA6 protein CTD PMID:7713347 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Carbaryl results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15907790 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
Carbaryl results in decreased expression of STAR mRNA
CTD PMID:16413094 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO
EXP
Carbaryl results in decreased activity of TDO2 protein CTD PMID:2119399, PMID:2547861 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Carbaryl results in increased expression of TGFB2 mRNA CTD PMID:27829164 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
ISO Carbaryl binds to and results in decreased activity of THRB protein
Carbaryl binds to THRB protein
CTD PMID:18584933, PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tpo thyroid peroxidase increases activity ISO Carbaryl results in increased activity of TPO protein CTD PMID:21809831 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Wnt6 Wnt family member 6 decreases expression ISO Carbaryl results in decreased expression of WNT6 mRNA CTD PMID:27829164 NCBI chr 9:82,033,543...82,047,172
Ensembl chr 9:82,033,543...82,047,166
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Carbaryl results in increased expression of XBP1 mRNA CTD PMID:27829164 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        agrochemical 14436
          carbaryl 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  cyclic hydrocarbon 17065
                                    arene 17061
                                      polycyclic arene 16882
                                        ortho-fused polycyclic arene 9643
                                          ortho-fused bicyclic arene 2395
                                            naphthalene 2342
                                              naphthol 187
                                                1-naphthol 165
                                                  carbaryl 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.