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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:8499
Term: propranolol
Definition: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Chemical ID: MESH:D011433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects metabolic processingISORGD:7362176480464CTDCYP2D6 protein affects the metabolism of Propranolol

PMID:15286053
increases metabolic processingISORGD:7362176480464CTDCYP2D6 protein results in increased metabolism of Propranolol

PMID:12464242, PMID:21184751
increases oxidationISORGD:7362176480464CTDCYP2D6 protein results in increased oxidation of Propranolol

PMID:19853591
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.