3-phenylprop-2-enal - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	3-phenylprop-2-enal	go back to main search page
Accession:	CHEBI:142921	browse the term
Definition:	A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Synonyms:	related_synonym:	3-phenylacrylaldehyde; 3-phenylpropenal; Formula=C9H8O; InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H; InChIKey=KJPRLNWUNMBNBZ-UHFFFAOYSA-N; SMILES=C=1C=CC=CC1C(=C(C=O)[H])[H]; cinnamaldehyde
	xref:	CAS:104-55-2
	xref_mesh:	MESH:C012843

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Genes (315)

3-phenylprop-2-enal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 3

increases expression

cinnamaldehyde results in increased expression of ABCC3 mRNA

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

abhydrolase domain containing 12B

increases expression

cinnamaldehyde results in increased expression of ABHD12B mRNA

NCBI chr14:50,872,053...50,904,970
Ensembl chr14:50,872,053...50,904,970

G

actin alpha 2, smooth muscle

multiple interactions

cinnamaldehyde inhibits the reaction [Glucose results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

actin beta

increases metabolic processing

cinnamaldehyde results in increased metabolism of ACTB protein

NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902

G

ADAM metallopeptidase domain 23

increases expression

cinnamaldehyde results in increased expression of ADAM23 mRNA

NCBI chr 2:206,443,532...206,621,127
Ensembl chr 2:206,443,532...206,621,127

G

adenosine kinase

increases expression

cinnamaldehyde results in increased expression of ADK mRNA

NCBI chr10:74,151,221...74,709,290
Ensembl chr10:74,151,202...74,709,963

G

adrenomedullin

increases expression

cinnamaldehyde results in increased expression of ADM mRNA

NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397

G

advanced glycosylation end-product specific receptor

multiple interactions

cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein]

NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322

G

aldo-keto reductase family 1 member B10

increases expression

cinnamaldehyde results in increased expression of AKR1B10 mRNA

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C1

increases expression

cinnamaldehyde results in increased expression of AKR1C1 mRNA

NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283

G

aldo-keto reductase family 1 member C2

increases activity
increases expression
multiple interactions

cinnamaldehyde results in increased activity of AKR1C2 promoter
cinnamaldehyde results in increased expression of AKR1C2 mRNA
NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of AKR1C2 mRNA]

PMID:21195160 PMID:25724174 PMID:26244607

NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

cinnamaldehyde results in increased phosphorylation of AKT1 protein
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]

PMID:20467561 PMID:21469739

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

albumin

increases metabolic processing

cinnamaldehyde results in increased metabolism of ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

alsin Rho guanine nucleotide exchange factor ALS2

increases expression

cinnamaldehyde results in increased expression of ALS2 mRNA

NCBI chr 2:201,700,267...201,780,933
Ensembl chr 2:201,700,267...201,782,112

G

adenosine monophosphate deaminase 3

increases expression

cinnamaldehyde results in increased expression of AMPD3 mRNA

NCBI chr11:10,450,388...10,507,579
Ensembl chr11:10,308,313...10,507,579

G

Rho GTPase activating protein 23

increases expression

cinnamaldehyde results in increased expression of ARHGAP23 mRNA

NCBI chr17:38,419,275...38,512,385
Ensembl chr17:38,419,280...38,512,385

G

activating transcription factor 3

increases expression

cinnamaldehyde results in increased expression of ATF3 mRNA

PMID:23999411 PMID:27965148

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

ATPase phospholipid transporting 11A

increases expression

cinnamaldehyde results in increased expression of ATP11A mRNA

NCBI chr13:112,690,038...112,887,168
Ensembl chr13:112,690,038...112,887,168

G

beta-2-microglobulin

decreases expression

cinnamaldehyde results in decreased expression of B2M mRNA

NCBI chr15:44,711,517...44,718,145
Ensembl chr15:44,711,358...44,718,851

G

BTB domain and CNC homolog 1

multiple interactions

BACH1 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]

NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

cinnamaldehyde results in increased expression of BAX protein
cinnamaldehyde inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]
Vitamin E inhibits the reaction [cinnamaldehyde results in increased expression of BAX protein]

PMID:15566391 PMID:15964311 PMID:32628957

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

B cell receptor associated protein 29

increases expression

cinnamaldehyde results in increased expression of BCAP29 mRNA

NCBI chr 7:107,580,007...107,623,317
Ensembl chr 7:107,580,246...107,629,170

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

cinnamaldehyde analog results in decreased expression of BCL2 protein; cinnamaldehyde results in decreased expression of BCL2 protein
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BCL2 protein]

PMID:15566391 PMID:15964311 PMID:17510524 PMID:32628957

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BH3 interacting domain death agonist

increases cleavage

cinnamaldehyde results in increased cleavage of BID protein

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 2

multiple interactions
decreases expression

Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BIRC2 protein]

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

multiple interactions
decreases expression

Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BIRC3 protein]

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

caspase 1

increases expression

cinnamaldehyde results in increased expression of CASP1 mRNA

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

increases cleavage
increases expression
multiple interactions
increases activity

cinnamaldehyde results in increased cleavage of CASP3 protein
cinnamaldehyde analog results in increased expression of CASP3 protein
Vitamin E inhibits the reaction [cinnamaldehyde results in increased activity of CASP3 protein]
cinnamaldehyde analog results in increased activity of CASP3 protein; cinnamaldehyde results in increased activity of CASP3 protein

PMID:15566391 PMID:16343908 PMID:17510524 PMID:19000754

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity

cinnamaldehyde results in increased activity of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

decreases expression

cinnamaldehyde results in decreased expression of CASP9 mRNA

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

increases expression
multiple interactions
decreases activity

cinnamaldehyde results in increased expression of CAT mRNA
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of CAT mRNA]
cinnamaldehyde inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
cinnamaldehyde results in decreased activity of CAT protein

PMID:17076691 PMID:23959918 PMID:28219650

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

coiled-coil domain containing 34

increases expression

cinnamaldehyde results in increased expression of CCDC34 mRNA

NCBI chr11:27,338,512...27,363,215
Ensembl chr11:27,330,827...27,363,234

G

C-C motif chemokine ligand 20

affects expression
increases expression

cinnamaldehyde affects the expression of CCL20 mRNA
cinnamaldehyde results in increased expression of CCL20 mRNA

PMID:28219650 PMID:30806763

NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564

G

C-C motif chemokine ligand 22

decreases expression

cinnamaldehyde results in decreased expression of CCL22 mRNA

NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189

G

C-C motif chemokine ligand 3

multiple interactions
affects expression
increases secretion

NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CCL3 mRNA]
cinnamaldehyde affects the expression of CCL3 mRNA
cinnamaldehyde results in increased secretion of CCL3 protein

PMID:23624239 PMID:28219650

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

G

C-C motif chemokine ligand 4

affects expression
increases secretion

cinnamaldehyde affects the expression of CCL4 mRNA
cinnamaldehyde results in increased secretion of CCL4 protein

PMID:28219650 PMID:30806763

NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621

G

C-C motif chemokine ligand 5

decreases expression
increases secretion

cinnamaldehyde results in decreased expression of CCL5 mRNA
cinnamaldehyde results in increased secretion of CCL5 protein

PMID:20488241 PMID:28219650

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

cellular communication network factor 2

decreases expression

cinnamaldehyde results in decreased expression of CCN2 mRNA

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cyclin D1

multiple interactions

cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of CCND1 protein]

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

CD274 molecule

increases expression

cinnamaldehyde results in increased expression of CD274 protein

PMID:20488241 PMID:23624239

NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566

G

CD80 molecule

increases expression

cinnamaldehyde results in increased expression of CD80 mRNA

NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614

G

CD83 molecule

decreases expression
increases expression

cinnamaldehyde results in decreased expression of CD83 mRNA
cinnamaldehyde results in increased expression of CD83 mRNA

PMID:27196738 PMID:28219650

NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918

G

CD86 molecule

decreases expression
increases expression

cinnamaldehyde results in decreased expression of CD86 mRNA
cinnamaldehyde results in increased expression of CD86 protein
cinnamaldehyde results in increased expression of CD86 mRNA; cinnamaldehyde results in increased expression of CD86 protein

PMID:11244134 PMID:19524605 PMID:19665512 PMID:20488241 PMID:23624239 More...

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

cell division cycle 25B

decreases activity

cinnamaldehyde analog results in decreased activity of CDC25B protein

NCBI chr20:3,786,951...3,806,115
Ensembl chr20:3,786,772...3,806,121

G

cyclin dependent kinase inhibitor 1A

increases expression

cinnamaldehyde results in increased expression of CDKN1A mRNA; cinnamaldehyde results in increased expression of CDKN1A protein

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

CCAAT enhancer binding protein alpha

decreases expression

cinnamaldehyde results in decreased expression of CEBPA mRNA

NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534

G

carboxylesterase 1

increases expression

cinnamaldehyde results in increased expression of CES1 mRNA

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

G

component of inhibitor of nuclear factor kappa B kinase complex

decreases phosphorylation

cinnamaldehyde results in decreased phosphorylation of CHUK protein

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

C-type lectin domain family 4 member A

decreases expression

cinnamaldehyde results in decreased expression of CLEC4A protein

NCBI chr12:8,102,907...8,138,607
Ensembl chr12:8,123,617...8,138,607

G

CDC like kinase 2

decreases expression

cinnamaldehyde results in decreased expression of CLK2 mRNA

NCBI chr 1:155,262,868...155,273,504
Ensembl chr 1:155,262,868...155,278,491

G

CCR4-NOT transcription complex subunit 2

decreases expression

cinnamaldehyde results in decreased expression of CNOT2 mRNA

NCBI chr12:70,243,018...70,354,993
Ensembl chr12:70,243,002...70,354,993

G

collagen type VII alpha 1 chain

increases expression

cinnamaldehyde results in increased expression of COL7A1 mRNA

NCBI chr 3:48,564,073...48,595,329
Ensembl chr 3:48,564,073...48,595,329

G

cAMP responsive element binding protein 1

decreases expression

cinnamaldehyde results in decreased expression of CREB1 mRNA

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

cAMP responsive element modulator

increases expression

cinnamaldehyde results in increased expression of CREM mRNA

NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958

G

cysteine rich transmembrane BMP regulator 1

increases expression

cinnamaldehyde results in increased expression of CRIM1 mRNA

NCBI chr 2:36,355,778...36,551,135
Ensembl chr 2:36,355,778...36,551,135

G

CRK like proto-oncogene, adaptor protein

decreases phosphorylation

cinnamaldehyde results in decreased phosphorylation of CRKL protein

NCBI chr22:20,917,407...20,953,747
Ensembl chr22:20,917,407...20,953,747

G

C-X-C motif chemokine ligand 1

increases expression
multiple interactions
affects expression

cinnamaldehyde results in increased expression of CXCL1 mRNA
NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL1 mRNA]
cinnamaldehyde affects the expression of CXCL1 mRNA

PMID:28219650 PMID:30806763

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 10

increases expression
multiple interactions

cinnamaldehyde results in increased expression of CXCL10 mRNA
NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL10 mRNA]

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 14

increases expression

cinnamaldehyde results in increased expression of CXCL14 mRNA

NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279

G

C-X-C motif chemokine ligand 8

increases secretion
multiple interactions
increases expression

cinnamaldehyde results in increased secretion of CXCL8 protein
Betamethasone inhibits the reaction [cinnamaldehyde results in increased expression of CXCL8 mRNA]; cinnamaldehyde results in increased expression of and results in increased secretion of CXCL8 protein; SB 203580 affects the reaction [cinnamaldehyde results in increased secretion of CXCL8 protein]; Tacrolimus inhibits the reaction [cinnamaldehyde results in increased expression of CXCL8 mRNA]
cinnamaldehyde results in increased expression of CXCL8 mRNA; cinnamaldehyde results in increased expression of CXCL8 protein

PMID:18494145 PMID:19524605 PMID:19878716 PMID:20090409 PMID:20713136 More...

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

C-X-C motif chemokine receptor 1

increases expression

cinnamaldehyde results in increased expression of CXCR1 mRNA

NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962

G

C-X-C motif chemokine receptor 4

decreases expression

cinnamaldehyde results in decreased expression of CXCR4 mRNA

NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177

G

cytochrome c, somatic

affects localization
multiple interactions

cinnamaldehyde affects the localization of CYCS protein
Vitamin E inhibits the reaction [cinnamaldehyde affects the localization of CYCS protein]

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

increases expression

cinnamaldehyde results in increased expression of CYP1A1 mRNA

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 2 subfamily A member 6

decreases activity
multiple interactions

cinnamaldehyde results in decreased activity of CYP2A6 protein
[[cinnamaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [cinnamaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin

NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447

G

cytochrome P450 family 7 subfamily A member 1

increases expression

cinnamaldehyde results in increased expression of CYP7A1 mRNA

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

DNA damage inducible transcript 3

increases expression

cinnamaldehyde results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DNA damage inducible transcript 4

decreases expression

cinnamaldehyde results in decreased expression of DDIT4 mRNA

NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036

G

diablo IAP-binding mitochondrial protein

affects localization
multiple interactions

cinnamaldehyde affects the localization of DIABLO protein
Vitamin E inhibits the reaction [cinnamaldehyde affects the localization of DIABLO protein]

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

dematin actin binding protein

increases expression

cinnamaldehyde results in increased expression of DMTN mRNA

NCBI chr 8:22,048,931...22,082,525
Ensembl chr 8:22,048,995...22,082,527

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

cinnamaldehyde results in increased expression of DNAJB4 mRNA

PMID:23999411 PMID:27965148

NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964

G

DNA methyltransferase 3 beta

decreases expression

cinnamaldehyde results in decreased expression of DNMT3B mRNA

NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359

G

dual specificity phosphatase 1

increases expression

cinnamaldehyde results in increased expression of DUSP1 mRNA

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

G

dual specificity phosphatase 6

decreases expression

cinnamaldehyde results in decreased expression of DUSP6 mRNA

NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501

G

dynein light chain roadblock-type 1

increases expression

cinnamaldehyde results in increased expression of DYNLRB1 mRNA

NCBI chr20:34,515,602...34,540,958
Ensembl chr20:34,516,395...34,540,958

G

ELL associated factor 2

decreases expression

cinnamaldehyde results in decreased expression of EAF2 mRNA

NCBI chr 3:121,835,209...121,886,526
Ensembl chr 3:121,835,183...121,886,526

G

early growth response 1

increases expression

cinnamaldehyde results in increased expression of EGR1 mRNA

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

eukaryotic translation initiation factor 3 subunit A

increases metabolic processing

cinnamaldehyde results in increased metabolism of EIF3A protein

NCBI chr10:119,033,670...119,080,817
Ensembl chr10:119,033,670...119,080,817

G

endothelial PAS domain protein 1

increases expression

cinnamaldehyde results in increased expression of EPAS1 mRNA

NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697

G

F2R like trypsin receptor 1

multiple interactions

edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]

NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315

G

fatty acid binding protein 4

increases expression

cinnamaldehyde results in increased expression of FABP4 mRNA

NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236

G

Fas cell surface death receptor

multiple interactions
decreases expression

dorsomorphin inhibits the reaction [cinnamaldehyde results in decreased expression of FAS mRNA]

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fc gamma receptor IIb

increases expression

cinnamaldehyde results in increased expression of FCGR2B mRNA

NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654

G

Fc gamma receptor IIc (gene/pseudogene)

increases expression

cinnamaldehyde results in increased expression of FCGR2C mRNA

NCBI chr 1:161,581,339...161,601,220
Ensembl chr 1:161,581,339...161,605,662

G

fibroblast growth factor receptor 2

decreases expression

cinnamaldehyde results in decreased expression of FGFR2 mRNA

NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458

G

flavin containing dimethylaniline monoxygenase 5

increases expression

cinnamaldehyde results in increased expression of FMO5 mRNA

NCBI chr 1:147,184,305...147,227,284
Ensembl chr 1:147,175,351...147,243,050

G

fibronectin 1

multiple interactions

cinnamaldehyde inhibits the reaction [Glucose results in increased expression of FN1 protein]

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

cinnamaldehyde analog results in decreased expression of FOS protein

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

ferritin heavy chain 1

increases expression

cinnamaldehyde results in increased expression of FTH1 mRNA

PMID:19524605 PMID:24211530

NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634

G

ferritin light chain

increases expression

cinnamaldehyde results in increased expression of FTL mRNA

NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879

G

frizzled class receptor 2

increases expression

cinnamaldehyde results in increased expression of FZD2 mRNA

NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262

G

glucose-6-phosphate dehydrogenase

increases expression

cinnamaldehyde results in increased expression of G6PD mRNA

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

glutamate-cysteine ligase catalytic subunit

increases expression
multiple interactions

cinnamaldehyde results in increased expression of GCLC mRNA; cinnamaldehyde results in increased expression of GCLC protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 mRNA affects the reaction [cinnamaldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]

PMID:17178418 PMID:20351055 PMID:21469739 PMID:30806763

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

multiple interactions
increases expression

[cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA
cinnamaldehyde results in increased expression of GCLM mRNA

PMID:17178418 PMID:20351055 PMID:23999411 PMID:24211530 PMID:27965148 More...

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glutaredoxin

increases expression
increases activity
multiple interactions

cinnamaldehyde results in increased expression of GLRX mRNA
cinnamaldehyde results in increased activity of GLRX protein
[Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein

NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726

G

G protein-coupled receptor 21

increases expression

cinnamaldehyde results in increased expression of GPR21 mRNA

NCBI chr 9:123,033,667...123,049,103
Ensembl chr 9:123,033,667...123,035,665

G

glutathione peroxidase 1

affects expression
multiple interactions

cinnamaldehyde affects the expression of GPX1 mRNA
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX1 mRNA]

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 2

multiple interactions
affects expression
increases expression

NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX2 mRNA]
cinnamaldehyde affects the expression of GPX2 mRNA

PMID:19000754 PMID:28219650

NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746

G

glutathione peroxidase 5

affects expression
multiple interactions

cinnamaldehyde affects the expression of GPX5 mRNA
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX5 mRNA]

NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955

G

glutathione peroxidase 6

multiple interactions
affects expression

NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX6 mRNA]
cinnamaldehyde affects the expression of GPX6 mRNA

NCBI chr 6:28,503,296...28,515,793
Ensembl chr 6:28,503,296...28,528,215

G

glutathione peroxidase 7

decreases expression

cinnamaldehyde results in decreased expression of GPX7 mRNA

NCBI chr 1:52,602,371...52,609,051
Ensembl chr 1:52,602,371...52,609,051

G

glycogen synthase kinase 3 beta

decreases expression

cinnamaldehyde results in decreased expression of GSK3B mRNA

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

glutathione-disulfide reductase

multiple interactions
increases expression

NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GSR mRNA]

PMID:19000754 PMID:28219650

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione S-transferase mu 1

increases expression

cinnamaldehyde results in increased expression of GSTM1 mRNA

NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039

G

glutathione S-transferase pi 1

multiple interactions

cinnamaldehyde binds to and results in decreased activity of GSTP1 protein

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

glutathione S-transferase theta 1

affects expression

cinnamaldehyde affects the expression of GSTT1 mRNA

G

H4 clustered histone 1

increases metabolic processing

cinnamaldehyde results in increased metabolism of H4C1 protein

NCBI chr 6:26,021,649...26,022,050
Ensembl chr 6:26,021,649...26,022,050

G

hemoglobin subunit beta

increases metabolic processing

cinnamaldehyde results in increased metabolism of HBB protein

NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395

G

homeostatic iron regulator

increases expression

cinnamaldehyde results in increased expression of HFE mRNA

NCBI chr 6:26,087,429...26,098,343
Ensembl chr 6:26,087,226...26,098,343

G

high mobility group box 1

decreases expression

cinnamaldehyde results in decreased expression of HMGB1 mRNA

NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597

G

heme oxygenase 1

increases expression
multiple interactions

cinnamaldehyde results in increased expression of HMOX1 mRNA
cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]; BACH1 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]
cinnamaldehyde analog results in increased expression of HMOX1 mRNA; cinnamaldehyde analog results in increased expression of HMOX1 protein; cinnamaldehyde results in increased expression of HMOX1 mRNA; cinnamaldehyde results in increased expression of HMOX1 protein

PMID:17178418 PMID:18304597 PMID:18482591 PMID:19000754 PMID:19033392 More...

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heterogeneous nuclear ribonucleoprotein K

increases metabolic processing

cinnamaldehyde results in increased metabolism of HNRNPK protein

NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,631

G

hypoxanthine phosphoribosyltransferase 1

decreases mutagenesis

cinnamaldehyde results in decreased mutagenesis of HPRT1 gene

NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513

G

heat shock protein 90 alpha family class A member 1

increases metabolic processing

cinnamaldehyde results in increased metabolism of HSP90AA1 protein

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

heat shock protein family A (Hsp70) member 1B

increases expression

cinnamaldehyde results in increased expression of HSPA1B mRNA

NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254

G

heat shock protein family A (Hsp70) member 6

increases expression

cinnamaldehyde results in increased expression of HSPA6 mRNA

NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894

G

heat shock protein family A (Hsp70) member 8

increases metabolic processing

cinnamaldehyde results in increased metabolism of HSPA8 protein

NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230

G

heat shock protein family H (Hsp110) member 1

increases expression

cinnamaldehyde results in increased expression of HSPH1 mRNA

NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388

G

HIV-1 Tat interactive protein 2

increases expression

cinnamaldehyde results in increased expression of HTATIP2 mRNA

NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,782

G

HtrA serine peptidase 2

affects localization
multiple interactions

cinnamaldehyde affects the localization of HTRA2 protein
Vitamin E inhibits the reaction [cinnamaldehyde affects the localization of HTRA2 protein]

NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,596...74,533,350

G

intercellular adhesion molecule 1

increases expression
multiple interactions

cinnamaldehyde results in increased expression of ICAM1 mRNA; cinnamaldehyde results in increased expression of ICAM1 protein
cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
[cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:20351055 PMID:30806763 PMID:33522063

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interferon alpha inducible protein 27

decreases expression

cinnamaldehyde results in decreased expression of IFI27 mRNA

NCBI chr14:94,105,894...94,116,690
Ensembl chr14:94,104,836...94,116,695

G

interferon induced protein 44 like

decreases expression

cinnamaldehyde results in decreased expression of IFI44L mRNA

NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145

G

interferon beta 1

multiple interactions

cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]

NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942

G

interferon gamma

increases expression
affects expression

cinnamaldehyde results in increased expression of IFNG protein
cinnamaldehyde affects the expression of IFNG mRNA

PMID:11244134 PMID:28219650

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases phosphorylation

cinnamaldehyde results in decreased phosphorylation of IKBKB protein

NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460

G

interleukin 10

affects expression

cinnamaldehyde affects the expression of IL10 mRNA

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 12A

affects expression
multiple interactions

cinnamaldehyde affects the expression of IL12A mRNA
NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL12A mRNA]

NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019

G

interleukin 12B

decreases expression

cinnamaldehyde results in decreased expression of IL12B mRNA

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 16

increases secretion
multiple interactions

cinnamaldehyde results in increased secretion of IL16 protein
cinnamaldehyde results in increased expression of and results in increased secretion of IL16 protein

PMID:23624239 PMID:30806763

NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058

G

interleukin 18

increases expression

cinnamaldehyde results in increased expression of IL18 mRNA; cinnamaldehyde results in increased expression of IL18 protein

PMID:23063874 PMID:30806763

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 alpha

increases expression

cinnamaldehyde results in increased expression of IL1A mRNA

PMID:25290854 PMID:28219650 PMID:30806763 PMID:33715048

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

multiple interactions
increases expression

cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]
cinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of IL1B protein]
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL1B mRNA]

PMID:16624280 PMID:19524605 PMID:20467561 PMID:21807015 PMID:28219650 More...

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of IL6 protein]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]

PMID:17868967 PMID:32628957 PMID:33522063

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 7 receptor

increases expression

cinnamaldehyde results in increased expression of IL7R mRNA

NCBI chr 5:35,856,891...35,879,603
Ensembl chr 5:35,852,695...35,879,603

G

insulin induced gene 1

decreases expression

cinnamaldehyde results in decreased expression of INSIG1 mRNA

NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235

G

interferon regulatory factor 3

multiple interactions

cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]

NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875

G

integrin subunit alpha 11

increases expression

cinnamaldehyde results in increased expression of ITGA11 mRNA

NCBI chr15:68,296,532...68,432,163
Ensembl chr15:68,296,532...68,432,163

G

Janus kinase 1

multiple interactions

cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of JAK1 protein]

NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754

G

Janus kinase 2

multiple interactions

cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein]

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

cinnamaldehyde analog results in decreased expression of JUN protein

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

cinnamaldehyde results in decreased expression of JUND mRNA

NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622

G

kelch like ECH associated protein 1

affects expression
increases expression

cinnamaldehyde affects the expression of KEAP1 mRNA
cinnamaldehyde results in increased expression of KEAP1 protein

PMID:19033392 PMID:28219650

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

LHFPL tetraspan subfamily member 6

increases expression

cinnamaldehyde results in increased expression of LHFPL6 mRNA

NCBI chr13:39,342,892...39,603,193
Ensembl chr13:39,209,116...39,603,528

G

LIM and cysteine rich domains 1

decreases expression

cinnamaldehyde results in decreased expression of LMCD1 mRNA

NCBI chr 3:8,501,823...8,574,668
Ensembl chr 3:8,501,807...8,574,668

G

lamin A/C

increases metabolic processing

cinnamaldehyde results in increased metabolism of LMNA protein

NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,572...156,140,081

G

lipoprotein lipase

decreases expression

cinnamaldehyde results in decreased expression of LPL mRNA

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

LDL receptor related protein 12

increases expression

cinnamaldehyde results in increased expression of LRP12 mRNA

NCBI chr 8:104,489,236...104,589,258
Ensembl chr 8:104,489,231...104,589,258

G

lymphotoxin alpha

increases expression

cinnamaldehyde results in increased expression of LTA mRNA

NCBI chr 6:31,560,610...31,574,324
Ensembl chr 6:31,572,054...31,574,324

G

MAGI family member, X-linked

increases expression

cinnamaldehyde results in increased expression of MAGIX mRNA

NCBI chr X:49,162,665...49,168,774
Ensembl chr X:49,162,564...49,168,774

G

mitogen-activated protein kinase kinase 2

decreases expression

cinnamaldehyde results in decreased expression of MAP2K2 mRNA

NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122

G

mitogen-activated protein kinase kinase kinase 14

decreases phosphorylation

cinnamaldehyde results in decreased phosphorylation of MAP3K14 protein

NCBI chr17:45,263,119...45,317,020
Ensembl chr17:45,263,119...45,317,029

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation

cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein
cinnamaldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
cinnamaldehyde results in decreased phosphorylation of MAPK1 protein

PMID:15964311 PMID:17486422 PMID:17868967 PMID:20060012

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

decreases phosphorylation
multiple interactions

cinnamaldehyde results in decreased phosphorylation of MAPK14 protein
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK14 protein; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]

PMID:15964311 PMID:17486422

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

decreases phosphorylation
multiple interactions

cinnamaldehyde results in decreased phosphorylation of MAPK3 protein
cinnamaldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein

PMID:15964311 PMID:17486422 PMID:17868967 PMID:20060012

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

cinnamaldehyde results in increased phosphorylation of MAPK8 protein
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK8 protein; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK8 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK8 protein]
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]

PMID:15964311 PMID:17868967 PMID:21469739

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK9 protein]

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

MAPK activated protein kinase 5

increases expression

cinnamaldehyde results in increased expression of MAPKAPK5 mRNA

NCBI chr12:111,842,228...111,902,222
Ensembl chr12:111,842,013...111,902,222

G

microtubule affinity regulating kinase 4

decreases expression

cinnamaldehyde results in decreased expression of MARK4 mRNA

NCBI chr19:45,251,271...45,305,284
Ensembl chr19:45,079,288...45,305,284

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

cinnamaldehyde results in decreased expression of MCL1 protein

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

MDM2 proto-oncogene

increases expression

cinnamaldehyde results in increased expression of MDM2 mRNA

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

macrophage migration inhibitory factor

increases expression

cinnamaldehyde results in increased expression of MIF mRNA

NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227

G

matrix metallopeptidase 2

multiple interactions

cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 3

increases expression

cinnamaldehyde results in increased expression of MMP3 mRNA

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

myeloperoxidase

multiple interactions
increases activity

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]
cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:21466812 PMID:33522063

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

MX dynamin like GTPase 1

decreases expression

cinnamaldehyde results in decreased expression of MX1 mRNA

NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071

G

MYC proto-oncogene, bHLH transcription factor

increases expression
decreases expression

cinnamaldehyde results in increased expression of MYC mRNA
cinnamaldehyde results in decreased expression of MYC protein

PMID:21729535 PMID:24211530

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

MYD88 innate immune signal transduction adaptor

multiple interactions

cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA]

NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024

G

NBPF member 10

increases expression

cinnamaldehyde results in increased expression of NBPF10 mRNA

NCBI chr 1:146,064,699...146,144,804
Ensembl chr 1:146,064,711...146,229,000

G

neutrophil cytosolic factor 1

increases expression

cinnamaldehyde results in increased expression of NCF1 mRNA

NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315

G

NFE2 like bZIP transcription factor 2

affects localization
increases activity
multiple interactions
affects response to substance
affects expression
increases expression

cinnamaldehyde affects the localization of NFE2L2 protein
cinnamaldehyde results in increased activity of NFE2L2 protein
cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CCL3 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL1 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL10 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL12A mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL1B mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of CAT mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX1 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX2 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX5 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX6 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GSR mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of NOS2 mRNA]
NFE2L2 affects the susceptibility to cinnamaldehyde
[cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; cinnamaldehyde results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 mRNA affects the reaction [cinnamaldehyde results in increased expression of GCLC protein]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of AKR1C2 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]
cinnamaldehyde affects the expression of NFE2L2 protein
cinnamaldehyde analog results in increased expression of NFE2L2 protein; cinnamaldehyde results in increased expression of NFE2L2 protein

PMID:18304597 PMID:18482591 PMID:19033392 PMID:20351055 PMID:21469739 More...

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

decreases expression

cinnamaldehyde results in decreased expression of NFKB1 mRNA
cinnamaldehyde results in decreased expression of NFKB1 protein

PMID:17486422 PMID:20385217 PMID:28219650

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions

cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

ninein like

increases expression

cinnamaldehyde results in increased expression of NINL mRNA

NCBI chr20:25,452,697...25,585,531
Ensembl chr20:25,451,594...25,585,531

G

nitric oxide synthase 2

affects expression
decreases expression
multiple interactions

cinnamaldehyde affects the expression of NOS2 mRNA
cinnamaldehyde results in decreased expression of NOS2 protein
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of NOS2 mRNA]

PMID:17486422 PMID:20467561 PMID:28219650

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch receptor 3

increases expression

cinnamaldehyde results in increased expression of NOTCH3 mRNA

NCBI chr19:15,159,038...15,200,995
Ensembl chr19:15,159,038...15,200,995

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression

cinnamaldehyde results in increased activity of NQO1 protein
cinnamaldehyde analog results in increased expression of NQO1 mRNA; cinnamaldehyde results in increased expression of NQO1 mRNA

PMID:18482591 PMID:19033392 PMID:19524605 PMID:24211530 PMID:28219650 More...

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear respiratory factor 1

decreases expression

cinnamaldehyde results in decreased expression of NRF1 mRNA

NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082

G

pannexin 2

increases expression

cinnamaldehyde results in increased expression of PANX2 mRNA

NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295

G

poly(ADP-ribose) polymerase 1

increases cleavage

cinnamaldehyde analog results in increased cleavage of PARP1 protein

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

cinnamaldehyde inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA]

NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121

G

phosphodiesterase 3B

increases expression

cinnamaldehyde results in increased expression of PDE3B mRNA

NCBI chr11:14,643,804...14,872,044
NCBI chr11:14,887,823...14,899,321
Ensembl chr11:14,643,804...14,872,044

G

pyruvate dehydrogenase kinase 1

multiple interactions

cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of PDK1 protein]

NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669

G

pleckstrin homology like domain family A member 2

increases expression

cinnamaldehyde results in increased expression of PHLDA2 mRNA

NCBI chr11:2,928,273...2,929,420
Ensembl chr11:2,928,273...2,929,420

G

pirin

increases expression

cinnamaldehyde results in increased expression of PIR mRNA

NCBI chr X:15,384,799...15,493,333
Ensembl chr X:15,384,799...15,493,564

G

pyruvate kinase L/R

multiple interactions

cinnamaldehyde inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA]

NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438

G

pyruvate kinase M1/2

increases metabolic processing

cinnamaldehyde results in increased metabolism of PKM protein

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

plasminogen activator, urokinase

multiple interactions

cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of PLAU protein]

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

cinnamaldehyde results in increased expression of PMAIP1 mRNA

NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305

G

cytochrome p450 oxidoreductase

increases expression

cinnamaldehyde results in increased expression of POR mRNA

NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855

G

peroxisome proliferator activated receptor gamma

decreases expression

cinnamaldehyde results in decreased expression of PPARG mRNA

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

pro-platelet basic protein

increases expression
multiple interactions

cinnamaldehyde results in increased expression of PPBP mRNA
cinnamaldehyde results in increased expression of and results in increased secretion of PPBP protein

NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190

G

PPFIA binding protein 1

increases expression

cinnamaldehyde results in increased expression of PPFIBP1 mRNA

NCBI chr12:27,524,206...27,695,564
Ensembl chr12:27,523,431...27,695,564

G

protein phosphatase 1 regulatory subunit 10

decreases expression

cinnamaldehyde results in decreased expression of PPP1R10 mRNA

NCBI chr 6:30,600,413...30,617,243
Ensembl chr 6:30,600,413...30,618,612

G

PR/SET domain 5

increases expression

cinnamaldehyde results in increased expression of PRDM5 mRNA

NCBI chr 4:120,684,291...120,922,726
Ensembl chr 4:120,684,919...120,922,870

G

prostaglandin reductase 1

multiple interactions

[PTGR1 protein co-treated with NADP] affects the reduction of cinnamaldehyde

NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

cinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]
cinnamaldehyde results in increased expression of PTGS2 mRNA
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
cinnamaldehyde results in decreased expression of PTGS2 protein

PMID:16624280 PMID:17486422 PMID:17920563 PMID:21807015 PMID:30806763

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

Rac family small GTPase 1

decreases expression

cinnamaldehyde results in decreased expression of RAC1 protein

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

retinol binding protein 4

multiple interactions

cinnamaldehyde inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein]

NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases glutathionylation
decreases expression

[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [cinnamaldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [cinnamaldehyde results in increased abundance of Hydrogen Peroxide] which results in increased glutathionylation of RELA protein; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]; Dithiothreitol inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of RELA protein]
cinnamaldehyde results in decreased expression of RELA protein

PMID:17486422 PMID:20351055 PMID:32628957

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

reticulon 4 receptor like 1

decreases expression

cinnamaldehyde results in decreased expression of RTN4RL1 mRNA

NCBI chr17:1,934,677...2,025,334
Ensembl chr17:1,934,677...2,025,334

G

SEL1L family member 3

increases expression

cinnamaldehyde results in increased expression of SEL1L3 mRNA

NCBI chr 4:25,713,964...25,863,566
Ensembl chr 4:25,747,433...25,863,760

G

serpin family B member 3

increases expression

cinnamaldehyde results in increased expression of SERPINB3 mRNA

NCBI chr18:63,655,197...63,661,893
Ensembl chr18:63,655,197...63,661,893

G

serpin family E member 1

increases expression

cinnamaldehyde results in increased expression of SERPINE1 mRNA

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

sarcoglycan delta

increases expression

cinnamaldehyde results in increased expression of SGCD mRNA

NCBI chr 5:155,727,832...156,767,788
Ensembl chr 5:155,870,344...156,767,788

G

solute carrier family 14 member 1 (Kidd blood group)

increases expression

cinnamaldehyde results in increased expression of SLC14A1 mRNA

NCBI chr18:45,724,181...45,752,520
Ensembl chr18:45,687,025...45,752,520

G

solute carrier family 1 member 2

increases expression

cinnamaldehyde results in increased expression of SLC1A2 mRNA

NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063

G

solute carrier family 26 member 7

increases expression

cinnamaldehyde results in increased expression of SLC26A7 mRNA

NCBI chr 8:91,209,496...91,398,155
Ensembl chr 8:91,209,494...91,398,155

G

solute carrier family 2 member 1

multiple interactions
increases activity

[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein; Cysteine inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]; Mercaptoethanol inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]
cinnamaldehyde results in increased activity of SLC2A1 protein

NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893

G

solute carrier family 2 member 13

increases expression

cinnamaldehyde results in increased expression of SLC2A13 mRNA

NCBI chr12:39,755,025...40,106,081
Ensembl chr12:39,755,025...40,106,089

G

solute carrier family 2 member 4

multiple interactions

cinnamaldehyde inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; cinnamaldehyde inhibits the reaction [Streptozocin affects the localization of SLC2A4 protein]

PMID:19080170 PMID:20363216

NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257

G

solute carrier family 35 member D2

decreases expression

cinnamaldehyde results in decreased expression of SLC35D2 mRNA

NCBI chr 9:96,313,444...96,383,711
Ensembl chr 9:96,313,444...96,383,711

G

solute carrier family 7 member 11

increases expression

cinnamaldehyde results in increased expression of SLC7A11 mRNA

PMID:17178418 PMID:24211530 PMID:30806763

NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349

G

solute carrier family 8 member A1

increases expression

cinnamaldehyde results in increased expression of SLC8A1 mRNA

NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053

G

SMAD family member 2

increases expression

cinnamaldehyde results in increased expression of SMAD2 mRNA

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

synuclein alpha

multiple interactions

cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]

NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315

G

sorting nexin 24

increases expression

cinnamaldehyde results in increased expression of SNX24 mRNA

NCBI chr 5:122,845,613...123,029,318
Ensembl chr 5:122,843,439...123,029,354

G

suppressor of cytokine signaling 3

multiple interactions

cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein]

NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077

G

superoxide dismutase 2

decreases expression

cinnamaldehyde results in decreased expression of SOD2 mRNA

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

sequestosome 1

increases expression

cinnamaldehyde results in increased expression of SQSTM1 mRNA

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

dorsomorphin inhibits the reaction [cinnamaldehyde results in decreased expression of SREBF1 mRNA]

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

serine and arginine rich splicing factor 11

increases expression

cinnamaldehyde results in increased expression of SRSF11 mRNA

NCBI chr 1:70,205,696...70,253,052
Ensembl chr 1:70,205,682...70,253,052

G

sulfiredoxin 1

increases expression

cinnamaldehyde results in increased expression of SRXN1 mRNA

NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200

G

signal transducer and activator of transcription 3

multiple interactions

cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of STAT3 protein modified form]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]

PMID:32628957 PMID:33522063

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

staufen double-stranded RNA binding protein 2

increases expression

cinnamaldehyde results in increased expression of STAU2 mRNA

NCBI chr 8:73,420,369...73,747,480
Ensembl chr 8:73,420,369...73,747,708

G

serine/threonine kinase 24

decreases expression

cinnamaldehyde results in decreased expression of STK24 mRNA

NCBI chr13:98,445,185...98,577,107
Ensembl chr13:98,445,185...98,577,940

G

SUFU negative regulator of hedgehog signaling

increases expression

cinnamaldehyde results in increased expression of SUFU mRNA

NCBI chr10:102,502,819...102,633,535
Ensembl chr10:102,503,972...102,633,535

G

spectrin repeat containing nuclear envelope protein 2

decreases expression

cinnamaldehyde results in decreased expression of SYNE2 mRNA

NCBI chr14:63,761,596...64,226,449
Ensembl chr14:63,761,899...64,226,433

G

thromboxane A2 receptor

multiple interactions

cinnamaldehyde binds to and results in decreased activity of TBXA2R protein

NCBI chr19:3,594,507...3,606,875
Ensembl chr19:3,594,507...3,606,875

G

transforming growth factor beta 1

multiple interactions
increases expression

cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of PLAU protein]
cinnamaldehyde results in increased expression of TGFB1 mRNA

PMID:11244134 PMID:28258635

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 1 induced transcript 1

decreases expression

cinnamaldehyde results in decreased expression of TGFB1I1 mRNA

NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960

G

tyrosine hydroxylase

multiple interactions

cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

threonine synthase like 2

increases expression

cinnamaldehyde results in increased expression of THNSL2 mRNA

NCBI chr 2:88,170,346...88,186,627
Ensembl chr 2:88,170,295...88,186,636

G

toll like receptor 3

multiple interactions

cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]

NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073

G

toll like receptor 4

increases expression
multiple interactions

cinnamaldehyde results in increased expression of TLR4 mRNA
cinnamaldehyde inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]

PMID:17920563 PMID:18306459 PMID:19524605

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions
increases expression

cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; cinnamaldehyde inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of TNF protein]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
[cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]; cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
cinnamaldehyde results in increased expression of TNF mRNA

PMID:17868967 PMID:20351055 PMID:20385217 PMID:20467561 PMID:21807015 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 21

increases expression

cinnamaldehyde results in increased expression of TNFRSF21 mRNA

NCBI chr 6:47,231,532...47,309,905
Ensembl chr 6:47,231,532...47,309,905

G

troponin T2, cardiac type

decreases expression

cinnamaldehyde results in decreased expression of TNNT2 mRNA

NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764

G

tumor protein p53

decreases expression

cinnamaldehyde results in decreased expression of TP53 mRNA

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

TNF receptor associated factor 6

multiple interactions

cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA]

NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272

G

tripartite motif containing 16

increases expression

cinnamaldehyde results in increased expression of TRIM16 mRNA

PMID:17178418 PMID:19524605

NCBI chr17:15,627,966...15,684,311
Ensembl chr17:15,627,960...15,684,311

G

tripartite motif containing 16 like (pseudogene)

increases expression

cinnamaldehyde results in increased expression of TRIM16L mRNA

NCBI chr17:18,697,998...18,736,112
Ensembl chr17:18,722,237...18,735,460
Ensembl chr17:18,722,237...18,735,460

G

transient receptor potential cation channel subfamily A member 1

increases activity
affects response to substance
increases response to substance
multiple interactions

cinnamaldehyde results in increased activity of TRPA1 protein
TRPA1 mRNA affects the susceptibility to cinnamaldehyde
TRPA1 protein results in increased susceptibility to cinnamaldehyde
TRPA1 affects the susceptibility to cinnamaldehyde
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; cinnamaldehyde binds to and results in increased activity of TRPA1 protein; isopentenyl pyrophosphate inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; [cinnamaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased uptake of Calcium]

PMID:15046718 PMID:17571167 PMID:17991581 PMID:19507004 PMID:20442136 More...

NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584

G

transient receptor potential cation channel subfamily V member 1

increases expression

cinnamaldehyde results in increased expression of TRPV1 mRNA

NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411

G

titin

decreases expression

cinnamaldehyde results in decreased expression of TTN mRNA

NCBI chr 2:178,525,989...178,807,423
Ensembl chr 2:178,525,989...178,830,802

G

thioredoxin reductase 1

increases expression

cinnamaldehyde results in increased expression of TXNRD1 mRNA; cinnamaldehyde results in increased expression of TXNRD1 protein

PMID:18304597 PMID:19000754 PMID:24211530 PMID:30806763

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thioredoxin reductase 2

decreases expression

cinnamaldehyde results in decreased expression of TXNRD2 mRNA

NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820

G

ubiquitin conjugating enzyme E2 D1

increases expression

cinnamaldehyde results in increased expression of UBE2D1 mRNA

NCBI chr10:58,335,006...58,370,748
Ensembl chr10:58,334,979...58,370,751

G

UDP-glucose pyrophosphorylase 2

increases expression

cinnamaldehyde results in increased expression of UGP2 mRNA

NCBI chr 2:63,840,969...63,891,560
Ensembl chr 2:63,840,952...63,891,562

G

uracil DNA glycosylase

decreases expression

cinnamaldehyde results in decreased expression of UNG mRNA

NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725

G

xanthine dehydrogenase

multiple interactions

cinnamaldehyde inhibits the reaction [Testosterone results in increased activity of XDH protein modified form]

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

G

X-linked inhibitor of apoptosis

decreases expression
multiple interactions

cinnamaldehyde results in decreased expression of XIAP protein
Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of XIAP protein]

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

zinc finger DHHC-type palmitoyltransferase 21

increases expression

cinnamaldehyde results in increased expression of ZDHHC21 mRNA

NCBI chr 9:14,588,797...14,693,432
Ensembl chr 9:14,611,071...14,693,432

G

zinc finger protein 442

increases expression

cinnamaldehyde results in increased expression of ZNF442 mRNA

NCBI chr19:12,345,944...12,373,779
Ensembl chr19:12,345,944...12,365,905

G

zinc finger protein 506

increases expression

cinnamaldehyde results in increased expression of ZNF506 mRNA

NCBI chr19:19,792,711...19,821,750
Ensembl chr19:19,785,839...19,821,751

G

zinc finger protein 639

increases expression

cinnamaldehyde results in increased expression of ZNF639 mRNA

NCBI chr 3:179,322,876...179,338,583
Ensembl chr 3:179,323,031...179,338,583

alpha-hexylcinnamaldehyde

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activation induced cytidine deaminase

affects expression

hexyl cinnamic aldehyde affects the expression of AICDA mRNA

NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242

G

aldo-keto reductase family 1 member B

increases expression

hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

aldo-keto reductase family 1 member B10

increases expression

hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C1

increases expression

hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA

NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283

G

aldo-keto reductase family 1 member C3

increases expression
affects expression

hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA
hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA

PMID:20566472 PMID:22302311

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

activating transcription factor 3

increases expression

hexyl cinnamic aldehyde results in increased expression of ATF3 mRNA

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

catalase

increases expression

hexyl cinnamic aldehyde results in increased expression of CAT mRNA

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

increases secretion

hexyl cinnamic aldehyde results in increased secretion of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 4

increases expression

hexyl cinnamic aldehyde results in increased expression of CCL4 protein

NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621

G

cyclin A2

affects expression

hexyl cinnamic aldehyde affects the expression of CCNA2 mRNA

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

affects expression

hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin E2

affects expression

hexyl cinnamic aldehyde affects the expression of CCNE2 mRNA

NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678

G

C-C motif chemokine receptor 4

affects expression

hexyl cinnamic aldehyde affects the expression of CCR4 mRNA

NCBI chr 3:32,951,644...32,956,349
Ensembl chr 3:32,951,644...32,956,349

G

C-C motif chemokine receptor 7

decreases expression

hexyl cinnamic aldehyde results in decreased expression of CCR7 protein

NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472

G

CD160 molecule

affects expression

hexyl cinnamic aldehyde affects the expression of CD160 mRNA

NCBI chr 1:145,719,499...145,739,288
Ensembl chr 1:145,719,471...145,739,288

G

CD207 molecule

affects expression

hexyl cinnamic aldehyde affects the expression of CD207 mRNA

NCBI chr 2:70,824,130...70,835,816
Ensembl chr 2:70,830,211...70,835,816

G

CD5 molecule like

affects expression

hexyl cinnamic aldehyde affects the expression of CD5L mRNA

NCBI chr 1:157,827,068...157,841,808
Ensembl chr 1:157,830,911...157,898,256

G

CD80 molecule

multiple interactions
increases expression

[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
hexyl cinnamic aldehyde results in increased expression of CD80 protein

NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614

G

CD83 molecule

affects expression

hexyl cinnamic aldehyde affects the expression of CD83 mRNA

NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918

G

CD86 molecule

multiple interactions
increases expression

[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein]

PMID:31958493 PMID:37326882

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

cell division cycle 20

affects expression

hexyl cinnamic aldehyde affects the expression of CDC20 mRNA

NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203

G

cell division cycle 25C

affects expression

hexyl cinnamic aldehyde affects the expression of CDC25C mRNA

NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355

G

cyclin dependent kinase 1

affects expression

hexyl cinnamic aldehyde affects the expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cytoplasmic polyadenylated homeobox like 2

affects expression

hexyl cinnamic aldehyde affects the expression of CPHX1 mRNA

NCBI chr16:75,660,227...75,677,009
Ensembl chr16:75,660,227...75,677,009
Ensembl chr16:75,660,227...75,677,009

G

cytotoxic T-lymphocyte associated protein 4

affects expression

hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA

NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965

G

C-X-C motif chemokine ligand 1

increases expression

hexyl cinnamic aldehyde results in increased expression of CXCL1 mRNA

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 14

decreases expression

hexyl cinnamic aldehyde results in decreased expression of CXCL14 protein

NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279

G

C-X-C motif chemokine ligand 2

increases expression
decreases expression

hexyl cinnamic aldehyde results in increased expression of CXCL2 mRNA; hexyl cinnamic aldehyde results in increased expression of CXCL2 protein
hexyl cinnamic aldehyde results in decreased expression of CXCL2 protein

PMID:23178550 PMID:28826779

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

C-X-C motif chemokine ligand 8

increases expression
increases secretion

hexyl cinnamic aldehyde results in increased expression of CXCL8 mRNA
hexyl cinnamic aldehyde results in increased secretion of CXCL8 protein

PMID:27965148 PMID:31958493

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

iodothyronine deiodinase 2

decreases activity

hexyl cinnamic aldehyde results in decreased activity of DIO2 protein

NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757

G

iodothyronine deiodinase 3

decreases activity

hexyl cinnamic aldehyde results in decreased activity of DIO3 protein

NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452

G

E2F transcription factor 1

affects expression

hexyl cinnamic aldehyde affects the expression of E2F1 mRNA

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

G

fatty acid binding protein 7

affects expression

hexyl cinnamic aldehyde affects the expression of FABP7 mRNA

NCBI chr 6:122,749,201...122,784,074
Ensembl chr 6:122,779,716...122,784,074

G

ferrochelatase

increases expression

hexyl cinnamic aldehyde results in increased expression of FECH mRNA

NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732

G

ferritin light chain

increases expression

hexyl cinnamic aldehyde results in increased expression of FTL mRNA

NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879

G

FXYD domain containing ion transport regulator 4

affects expression

hexyl cinnamic aldehyde affects the expression of FXYD4 mRNA

NCBI chr10:43,371,636...43,376,335
Ensembl chr10:43,371,636...43,376,335

G

glucose-6-phosphate dehydrogenase

increases expression

hexyl cinnamic aldehyde results in increased expression of G6PD mRNA

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

glutamate-cysteine ligase catalytic subunit

increases expression

hexyl cinnamic aldehyde results in increased expression of GCLC mRNA

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

increases expression

hexyl cinnamic aldehyde results in increased expression of GCLM mRNA

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glutathione peroxidase 3

increases expression

hexyl cinnamic aldehyde results in increased expression of GPX3 mRNA

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

glutathione-disulfide reductase

increases expression

hexyl cinnamic aldehyde results in increased expression of GSR mRNA

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

granzyme B

affects expression

hexyl cinnamic aldehyde affects the expression of GZMB mRNA

NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267

G

heme oxygenase 1

increases expression

hexyl cinnamic aldehyde results in increased expression of HMOX1 mRNA

PMID:20566472 PMID:26244607

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

interferon gamma

increases secretion

hexyl cinnamic aldehyde results in increased secretion of IFNG protein

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 12B

affects expression

hexyl cinnamic aldehyde affects the expression of IL12B mRNA

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 17A

increases expression

hexyl cinnamic aldehyde results in increased expression of IL17A mRNA; hexyl cinnamic aldehyde results in increased expression of IL17A protein

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 1 alpha

increases expression

hexyl cinnamic aldehyde results in increased expression of IL1A protein

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 2

increases secretion
increases expression

hexyl cinnamic aldehyde results in increased secretion of IL2 protein
hexyl cinnamic aldehyde results in increased expression of IL2 protein

PMID:22245253 PMID:22381623

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 21

affects expression

hexyl cinnamic aldehyde affects the expression of IL21 mRNA

NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066

G

interleukin 2 receptor subunit alpha

affects expression

hexyl cinnamic aldehyde affects the expression of IL2RA mRNA

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 4

affects expression
multiple interactions

hexyl cinnamic aldehyde affects the expression of IL4 mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein

PMID:22302311 PMID:31958493

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 4 receptor

increases expression

hexyl cinnamic aldehyde results in increased expression of IL4RA protein

NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778

G

interleukin 6

increases secretion

hexyl cinnamic aldehyde results in increased secretion of IL6 protein

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit alpha V

affects expression

hexyl cinnamic aldehyde affects the expression of ITGAV mRNA

NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901

G

MAF bZIP transcription factor F

increases expression

hexyl cinnamic aldehyde results in increased expression of MAFF mRNA

NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507

G

MAF bZIP transcription factor G

increases expression

hexyl cinnamic aldehyde results in increased expression of MAFG mRNA

NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735

G

MAF bZIP transcription factor K

increases expression

hexyl cinnamic aldehyde results in increased expression of MAFK mRNA

NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043

G

malic enzyme 1

increases expression

hexyl cinnamic aldehyde results in increased expression of ME1 mRNA

NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051

G

microsomal glutathione S-transferase 1

increases expression

hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA

NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259

G

microRNA 146a

multiple interactions
increases expression

PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA]

NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450

G

microRNA 27a

decreases expression

hexyl cinnamic aldehyde results in decreased expression of MIR27A mRNA

NCBI chr19:13,836,440...13,836,517
Ensembl chr19:13,836,440...13,836,517

G

marker of proliferation Ki-67

affects expression

hexyl cinnamic aldehyde affects the expression of MKI67 mRNA

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

matrix metallopeptidase 10

affects expression

hexyl cinnamic aldehyde affects the expression of MMP10 mRNA

NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628

G

metallothionein 1X

increases expression

hexyl cinnamic aldehyde results in increased expression of MT1X mRNA

NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196

G

NAD(P)H quinone dehydrogenase 1

increases expression

hexyl cinnamic aldehyde results in increased expression of NQO1 mRNA

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

neurotensin

affects expression

hexyl cinnamic aldehyde affects the expression of NTS mRNA

NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992

G

phosphogluconate dehydrogenase

increases expression

hexyl cinnamic aldehyde results in increased expression of PGD mRNA

NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511

G

protein kinase C beta

multiple interactions

PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein]; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA]

NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611

G

prostaglandin reductase 1

increases expression

hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA

NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893

G

superoxide dismutase 1

increases expression

hexyl cinnamic aldehyde results in increased expression of SOD1 mRNA

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

increases expression

hexyl cinnamic aldehyde results in increased expression of SOD2 mRNA

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

superoxide dismutase 3

increases expression

hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA

NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842

G

sulfiredoxin 1

increases expression

hexyl cinnamic aldehyde results in increased expression of SRXN1 mRNA

NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200

G

thrombospondin 1

affects expression

hexyl cinnamic aldehyde affects the expression of THBS1 mRNA

NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466

G

thrombospondin 4

affects expression

hexyl cinnamic aldehyde affects the expression of THBS4 mRNA

NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287

G

tumor necrosis factor

increases expression
multiple interactions

hexyl cinnamic aldehyde results in increased expression of TNF mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein

PMID:28826779 PMID:31958493

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

transient receptor potential cation channel subfamily M member 6

affects expression

hexyl cinnamic aldehyde affects the expression of TRPM6 mRNA

NCBI chr 9:74,722,495...74,887,921
Ensembl chr 9:74,722,495...74,888,094

G

thioredoxin 2

increases expression

hexyl cinnamic aldehyde results in increased expression of TXN2 mRNA

NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640

G

thioredoxin reductase 1

increases expression

hexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thioredoxin reductase 2

increases expression

hexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA

NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820

G

UDP glucuronosyltransferase family 1 member A6

increases expression

hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA

NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300

G

vascular endothelial growth factor A

increases expression

hexyl cinnamic aldehyde results in increased expression of VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

coniferyl aldehyde

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

coniferaldehyde results in increased expression of ABCC2 mRNA

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

increases expression

coniferaldehyde results in increased expression of ABCC3 mRNA

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

aldo-keto reductase family 1 member C1

increases expression
multiple interactions

coniferaldehyde results in increased expression of AKR1C1 mRNA; coniferaldehyde results in increased expression of AKR1C1 protein
NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]

NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283

G

aldo-keto reductase family 1 member C2

increases expression

coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein

NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031

G

aldo-keto reductase family 1 member C3

increases expression

coniferaldehyde results in increased expression of AKR1C3 mRNA

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

glutamate-cysteine ligase catalytic subunit

increases expression

coniferaldehyde results in increased expression of GCLC mRNA

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

increases expression

coniferaldehyde results in increased expression of GCLM mRNA

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glutathione-disulfide reductase

increases expression

coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

heme oxygenase 1

multiple interactions
increases expression

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

interferon gamma

multiple interactions

coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

Janus kinase 2

multiple interactions

coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

mitogen-activated protein kinase 14

multiple interactions

MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

MAPK activated protein kinase 2

multiple interactions

MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]

NCBI chr 1:206,684,905...206,734,281
Ensembl chr 1:206,684,905...206,734,281

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression
multiple interactions

coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nitric oxide synthase 2

multiple interactions

coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

NAD(P)H quinone dehydrogenase 1

increases expression

coniferaldehyde results in increased expression of NQO1 protein

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

protein kinase N3

multiple interactions

PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]

NCBI chr 9:128,702,503...128,720,916
Ensembl chr 9:128,702,503...128,720,916

G

signal transducer and activator of transcription 1

multiple interactions

coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]

NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960

G

tumor necrosis factor

multiple interactions

coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

transient receptor potential cation channel subfamily A member 1

increases activity

coniferaldehyde results in increased activity of TRPA1 protein

NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584

G

thioredoxin reductase 1

increases expression

coniferaldehyde results in increased expression of TXNRD1 mRNA

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26040
chemical entity	26019
atom	26015
nonmetal atom	25503
carbon atom	25395
organic molecular entity	25395
olefinic compound	18216
enal	3169
cinnamaldehydes	317
3-phenylprop-2-enal	315
(E)-cinnamaldehyde +	94
(Z)-3-phenyl-2-propenal	0
Path 2
Term	Annotations
CHEBI ontology	26040
subatomic particle	26015
composite particle	26015
hadron	26015
baryon	26015
nucleon	26015
atomic nucleus	26015
atom	26015
main group element atom	25840
p-block element atom	25840
carbon group element atom	25437
carbon atom	25395
organic molecular entity	25395
heteroorganic entity	24770
organochalcogen compound	24383
organooxygen compound	24060
carbon oxoacid	22761
carboxylic acid	22741
carboacyl group	20058
univalent carboacyl group	20058
formyl group	9970
aldehyde	9970
alpha,beta-unsaturated aldehyde	3169
enal	3169
cinnamaldehydes	317
3-phenylprop-2-enal	315
(E)-cinnamaldehyde +	94
(Z)-3-phenyl-2-propenal	0

paths to the root