NQO1 (NAD(P)H quinone dehydrogenase 1) - Rat Genome Database
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Gene: NQO1 (NAD(P)H quinone dehydrogenase 1) Homo sapiens
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
RGD ID: 735868
Description: Exhibits identical protein binding activity. Involved in cell redox homeostasis and response to oxidative stress. Localizes to cytosol. Implicated in several diseases, including asthma; hematologic cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Biomarker of breast cancer; chronic obstructive pulmonary disease; and pulmonary emphysema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: azoreductase; DHQU; DIA4; diaphorase (NADH/NADPH) (cytochrome b-5 reductase); diaphorase-4; dioxin-inducible 1; DT-diaphorase; DTD; menadione reductase; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; NMOR1; NMORI; phylloquinone reductase; QR1; quinone reductase 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1669,706,996 - 69,726,668 (-)EnsemblGRCh38hg38GRCh38
GRCh381669,709,401 - 69,726,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,743,304 - 69,760,849 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,300,805 - 68,318,034 (-)NCBINCBI36hg18NCBI36
Build 341668,300,809 - 68,317,893NCBI
Celera1654,257,766 - 54,274,991 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,621,397 - 55,638,606 (-)NCBIHuRef
CHM1_11671,151,192 - 71,168,455 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (EXP,IAGP)
acute myeloid leukemia  (IAGP)
asthma  (EXP,IAGP,IDA)
Brain Injuries  (ISO)
breast cancer  (IAGP,IEP,ISO)
Breast Neoplasms  (EXP)
Carbon Tetrachloride Poisoning  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (EXP,ISO)
Chromosome 8, Trisomy  (IAGP)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (IAGP)
chronic obstructive pulmonary disease  (IAGP,IEP,ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (EXP)
contact dermatitis  (EXP)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (EXP)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (EXP)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (EXP)
Experimental Pancreatitis, Chronic  (ISO)
fatty liver disease  (ISO)
hemolytic-uremic syndrome  (EXP)
Hemorrhage  (EXP)
hyperglycemia  (EXP)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (EXP)
Kidney Reperfusion Injury  (ISO)
Lead Poisoning  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (IAGP)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
liver disease  (EXP)
lung cancer  (IAGP)
lung carcinoma  (IAGP)
lung disease  (IAGP)
Lung Injury  (ISO)
Lung Neoplasms  (IAGP)
lung non-small cell carcinoma  (EXP,IAGP)
Lung Reperfusion Injury  (ISO)
macular degeneration  (IAGP)
membranous glomerulonephritis  (ISO)
mental depression  (ISO)
Mercury Poisoning  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (EXP,IAGP)
myelodysplastic syndrome  (IAGP)
myeloid leukemia  (EXP)
myeloid neoplasm  (ISO)
neurodegenerative disease  (ISO)
non-alcoholic fatty liver disease  (EXP,ISO)
obesity  (EXP)
Occupational Diseases  (EXP)
Overactive Urinary Bladder  (ISO)
papilloma  (EXP)
Parkinson's disease  (EXP)
Poisoning  (IAGP)
Prostatic Neoplasms  (EXP)
prostatitis  (ISO)
pulmonary emphysema  (IEP)
renal fibrosis  (ISO)
small cell carcinoma  (IAGP)
Spinal Cord Injuries  (ISO)
spinocerebellar ataxia type 17  (EXP)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
toxic encephalopathy  (EXP)
transient cerebral ischemia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (EXP,ISO)
urinary system cancer  (IAGP)
visual epilepsy  (ISO)
warfarin sensitivity  (EXP)