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Gene: NQO1 (NAD(P)H quinone dehydrogenase 1) Homo sapiens
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Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Description: Exhibits identical protein binding activity. Involved in cell redox homeostasis and response to oxidative stress. Localizes to the cytosol. Implicated in several diseases, including asthma; hematologic cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Biomarker of breast cancer; chronic obstructive pulmonary disease; and pulmonary emphysema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: azoreductase; DHQU; DIA4; diaphorase (NADH/NADPH) (cytochrome b-5 reductase); diaphorase-4; dioxin-inducible 1; DT-diaphorase; DTD; menadione reductase; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; NMOR1; NMORI; phylloquinone reductase; QR1; quinone reductase 1
Orthologs:
Mus musculus (house mouse) : Nqo1 (NAD(P)H dehydrogenase, quinone 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nqo1 (NAD(P)H quinone dehydrogenase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nqo1 (NAD(P)H quinone dehydrogenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NQO1 (NAD(P)H quinone dehydrogenase 1)
Canis lupus familiaris (dog) : NQO1 (NAD(P)H quinone dehydrogenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nqo1 (NAD(P)H quinone dehydrogenase 1)
Sus scrofa (pig) : NQO1 (NAD(P)H quinone dehydrogenase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,709,401 - 69,726,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,743,304 - 69,760,849 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,300,805 - 68,318,034 (-)NCBINCBI36hg18NCBI36
Build 341668,300,809 - 68,317,893NCBI
Celera1654,257,766 - 54,274,991 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,621,397 - 55,638,606 (-)NCBIHuRef
CHM1_11671,151,192 - 71,168,455 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations