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Gene: CTLA4 (cytotoxic T-lymphocyte associated protein 4) Homo sapiens
Symbol: CTLA4
Name: cytotoxic T-lymphocyte associated protein 4
Description: Involved in several processes, including B cell receptor signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Localizes to several cellular components, including clathrin-coated endocytic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Implicated in several diseases, including autoimmune hypersensitivity disease (multiple); carcinoma (multiple); hematologic cancer (multiple); kidney disease (multiple); and type 1 diabetes mellitus (multiple). Biomarker of several diseases, including Sjogren's syndrome; atopic dermatitis; hepatocellular carcinoma; lung disease (multiple); and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS5; CD; CD152; cd152 antigen; CD152 isoform; celiac disease 3; CELIAC3; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; ICOS; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Mus musculus (house mouse) : Ctla4 (cytotoxic T-lymphocyte-associated protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctla4 (cytotoxic T-lymphocyte-associated protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctla4 (cytotoxic T-lymphocyte associated protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Canis lupus familiaris (dog) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctla4 (cytotoxic T-lymphocyte associated protein 4)
Sus scrofa (pig) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Chlorocebus sabaeus (African green monkey) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Heterocephalus glaber (naked mole-rat) : Ctla4 (cytotoxic T-lymphocyte associated protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2203,867,771 - 203,873,965 (+)EnsemblGRCh38hg38GRCh38
GRCh382203,867,771 - 203,873,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372204,732,511 - 204,738,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,440,754 - 204,446,928 (+)NCBINCBI36hg18NCBI36
Build 342204,558,016 - 204,564,189NCBI
Celera2198,487,330 - 198,493,462 (+)NCBI
Cytogenetic Map2q33.2NCBI
HuRef2196,579,809 - 196,585,939 (+)NCBIHuRef
CHM1_12204,739,066 - 204,745,196 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CTLA4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737465
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.