GLRX (glutaredoxin) - Rat Genome Database

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Gene: GLRX (glutaredoxin) Homo sapiens
Analyze
Symbol: GLRX
Name: glutaredoxin
RGD ID: 736383
HGNC Page HGNC
Description: Enables glutathione disulfide oxidoreductase activity and protein N-terminus binding activity. Involved in positive regulation of membrane potential and positive regulation of sodium ion transmembrane transporter activity. Located in extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ43648; glutaredoxin (thioltransferase); glutaredoxin 1 (thioltransferase); glutaredoxin-1; GRX; GRX1; MGC117407; thioltransferase; thioltransferase-1; TTase-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: GLRXP1   GLRXP2   GLRXP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl595,751,319 - 95,822,726 (-)EnsemblGRCh38hg38GRCh38
GRCh38595,813,849 - 95,822,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37595,149,553 - 95,158,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36595,175,431 - 95,184,137 (-)NCBINCBI36hg18NCBI36
Build 34595,175,430 - 95,184,137NCBI
Celera591,028,293 - 91,037,329 (-)NCBI
Cytogenetic Map5q15NCBI
HuRef590,339,863 - 90,348,899 (-)NCBIHuRef
CHM1_1594,582,332 - 94,591,368 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimonite  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (ISO)
aristolochic acid  (EXP)
arsenite(3-)  (EXP)
asbestos  (EXP)
azathioprine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
butan-1-ol  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
chloropicrin  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (EXP)
Deguelin  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
gemcitabine  (EXP)
glucose  (EXP)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
indole-3-methanol  (ISO)
isobutanol  (EXP)
ivermectin  (EXP)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (EXP)
menadione  (EXP)
mercury dichloride  (EXP)
methylene blue  (ISO)
methylmercury chloride  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PD 0325901  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
picoxystrobin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
propiconazole  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
rotenone  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
succimer  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tebufenpyrad  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrahydropalmatine  (EXP)
thifluzamide  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vorinostat  (EXP)

References

Additional References at PubMed
PMID:7851394   PMID:7961993   PMID:8018729   PMID:8019414   PMID:8549805   PMID:8645179   PMID:8838810   PMID:9325327   PMID:9332366   PMID:9417094   PMID:9677297   PMID:9860827  
PMID:10037490   PMID:10350489   PMID:10508218   PMID:10737800   PMID:11024467   PMID:11146114   PMID:11222536   PMID:11274078   PMID:11297543   PMID:11832487   PMID:12029072   PMID:12244106  
PMID:12477932   PMID:12556467   PMID:12723971   PMID:12892645   PMID:14702039   PMID:15184054   PMID:15297967   PMID:15342556   PMID:15489334   PMID:15637068   PMID:16311508   PMID:16884690  
PMID:16893901   PMID:17064412   PMID:17185628   PMID:17272816   PMID:17601350   PMID:18309294   PMID:18560520   PMID:18570454   PMID:18682255   PMID:18977241   PMID:19038358   PMID:19199708  
PMID:19265039   PMID:19542013   PMID:19578876   PMID:19896490   PMID:20566629   PMID:20877624   PMID:21078302   PMID:21323311   PMID:21454804   PMID:21900206   PMID:21988832   PMID:22634633  
PMID:22977247   PMID:23370801   PMID:23376485   PMID:24062305   PMID:24270206   PMID:24482236   PMID:24522867   PMID:24816595   PMID:25788646   PMID:25963833   PMID:26186194   PMID:26210445  
PMID:26344197   PMID:26601956   PMID:27162359   PMID:27224303   PMID:27744453   PMID:28062360   PMID:28162284   PMID:28514442   PMID:28843170   PMID:28963348   PMID:29117863   PMID:29183158  
PMID:29356545   PMID:29656893   PMID:30253414   PMID:30367780   PMID:30639960   PMID:30661098   PMID:31470122   PMID:31594818   PMID:31813265   PMID:32296183   PMID:32457219   PMID:32481517  
PMID:32513696   PMID:32892658   PMID:32948023   PMID:33329553  


Genomics

Comparative Map Data
GLRX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl595,751,319 - 95,822,726 (-)EnsemblGRCh38hg38GRCh38
GRCh38595,813,849 - 95,822,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37595,149,553 - 95,158,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36595,175,431 - 95,184,137 (-)NCBINCBI36hg18NCBI36
Build 34595,175,430 - 95,184,137NCBI
Celera591,028,293 - 91,037,329 (-)NCBI
Cytogenetic Map5q15NCBI
HuRef590,339,863 - 90,348,899 (-)NCBIHuRef
CHM1_1594,582,332 - 94,591,368 (-)NCBICHM1_1
Glrx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391375,988,004 - 75,998,270 (+)NCBIGRCm39mm39
GRCm39 Ensembl1375,987,987 - 75,998,273 (+)Ensembl
GRCm381375,839,885 - 75,850,151 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1375,839,868 - 75,850,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv371375,977,334 - 75,987,599 (+)NCBIGRCm37mm9NCBIm37
MGSCv361376,305,914 - 76,316,151 (+)NCBImm8
Celera1378,161,342 - 78,171,745 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.95NCBI
Glrx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.225,341,873 - 5,351,686 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl25,341,885 - 5,351,680 (+)Ensembl
Rnor_6.022,606,032 - 2,615,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl22,605,996 - 2,615,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,604,479 - 2,614,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.422,888,605 - 2,899,216 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.122,908,046 - 2,918,657 (+)NCBI
Celera21,812,028 - 1,821,780 (+)NCBICelera
Cytogenetic Map2q11NCBI
Glrx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541816,747,776 - 16,752,858 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541816,747,709 - 16,754,718 (+)NCBIChiLan1.0ChiLan1.0
GLRX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1519,671,833 - 19,680,685 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl519,671,965 - 19,680,685 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0519,526,210 - 19,535,237 (+)NCBIMhudiblu_PPA_v0panPan3
GLRX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1313,795,609 - 13,804,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl313,795,817 - 13,803,895 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha315,134,941 - 15,144,033 (+)NCBI
ROS_Cfam_1.0313,675,696 - 13,684,691 (+)NCBI
UMICH_Zoey_3.1313,638,543 - 13,647,633 (+)NCBI
UNSW_CanFamBas_1.0313,635,534 - 13,644,630 (+)NCBI
UU_Cfam_GSD_1.0313,835,410 - 13,844,529 (+)NCBI
Glrx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213169,350,320 - 169,358,900 (+)NCBI
SpeTri2.0NW_0049365237,535,650 - 7,544,339 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12102,425,580 - 102,437,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22106,309,433 - 106,321,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLRX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1489,687,354 - 89,696,236 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl489,685,984 - 89,696,231 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604938,333,100 - 38,342,156 (-)NCBIVero_WHO_p1.0
Glrx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474314,443,394 - 14,451,561 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
G60224  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37595,149,612 - 95,149,896UniSTSGRCh37
Build 36595,175,368 - 95,175,652RGDNCBI36
Celera591,028,352 - 91,028,636RGD
Cytogenetic Map5q14UniSTS
HuRef590,339,922 - 90,340,206UniSTS
WIAF-1594  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37595,149,602 - 95,149,733UniSTSGRCh37
Build 36595,175,358 - 95,175,489RGDNCBI36
Celera591,028,342 - 91,028,473RGD
Cytogenetic Map5q14UniSTS
HuRef590,339,912 - 90,340,043UniSTS
GeneMap99-GB4 RH Map5414.92UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1504
Count of miRNA genes:808
Interacting mature miRNAs:927
Transcripts:ENST00000237858, ENST00000379979, ENST00000505427, ENST00000507412, ENST00000507605, ENST00000508780, ENST00000512469
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1225 2396 1185 549 1655 403 2976 1405 1658 338 445 1062 150 1098 2019 4 2
Low 1211 595 540 75 287 62 1380 790 2076 80 1014 548 25 1 106 769 2
Below cutoff 3 1 9 1 1 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001118890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA485178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF069668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF162769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW128930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW792936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE738446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG547098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP196332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU949348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX106369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ026062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB890896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB890976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB892720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB892800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB903199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB903279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC931648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC931728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC939706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC939786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC948305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC948385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC950129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC950209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC952777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC952857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC960608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC960688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X76648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000237858   ⟹   ENSP00000237858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,813,849 - 95,822,726 (-)Ensembl
RefSeq Acc Id: ENST00000379979   ⟹   ENSP00000369314
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,813,971 - 95,822,714 (-)Ensembl
RefSeq Acc Id: ENST00000505427   ⟹   ENSP00000427353
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,814,563 - 95,822,722 (-)Ensembl
RefSeq Acc Id: ENST00000507412
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,813,979 - 95,819,502 (-)Ensembl
RefSeq Acc Id: ENST00000507605
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,781,336 - 95,822,291 (-)Ensembl
RefSeq Acc Id: ENST00000508780   ⟹   ENSP00000422708
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,751,319 - 95,822,726 (-)Ensembl
RefSeq Acc Id: ENST00000512469   ⟹   ENSP00000424636
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl595,816,410 - 95,822,711 (-)Ensembl
RefSeq Acc Id: NM_001118890   ⟹   NP_001112362
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38595,813,849 - 95,822,726 (-)NCBI
GRCh37595,149,553 - 95,158,577 (-)ENTREZGENE
HuRef590,339,863 - 90,348,899 (-)ENTREZGENE
CHM1_1594,582,332 - 94,591,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243658   ⟹   NP_001230587
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38595,813,849 - 95,822,726 (-)NCBI
GRCh37595,149,553 - 95,158,577 (-)NCBI
HuRef590,339,863 - 90,348,899 (-)NCBI
CHM1_1594,582,332 - 94,591,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243659   ⟹   NP_001230588
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38595,813,849 - 95,822,726 (-)NCBI
GRCh37595,149,553 - 95,158,577 (-)NCBI
HuRef590,339,863 - 90,348,899 (-)NCBI
CHM1_1594,582,332 - 94,591,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002064   ⟹   NP_002055
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38595,813,849 - 95,822,726 (-)NCBI
GRCh37595,149,553 - 95,158,577 (-)ENTREZGENE
Build 36595,175,431 - 95,184,137 (-)NCBI Archive
HuRef590,339,863 - 90,348,899 (-)ENTREZGENE
CHM1_1594,582,332 - 94,591,368 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001112362 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230587 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230588 (Get FASTA)   NCBI Sequence Viewer  
  NP_002055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC35798 (Get FASTA)   NCBI Sequence Viewer  
  AAC98318 (Get FASTA)   NCBI Sequence Viewer  
  AAD43353 (Get FASTA)   NCBI Sequence Viewer  
  AAH05304 (Get FASTA)   NCBI Sequence Viewer  
  AAH10965 (Get FASTA)   NCBI Sequence Viewer  
  AAP35335 (Get FASTA)   NCBI Sequence Viewer  
  AAY29058 (Get FASTA)   NCBI Sequence Viewer  
  BAA04769 (Get FASTA)   NCBI Sequence Viewer  
  BAG34809 (Get FASTA)   NCBI Sequence Viewer  
  CAA54094 (Get FASTA)   NCBI Sequence Viewer  
  CAG29308 (Get FASTA)   NCBI Sequence Viewer  
  CAG46962 (Get FASTA)   NCBI Sequence Viewer  
  CBF61363 (Get FASTA)   NCBI Sequence Viewer  
  CBF61403 (Get FASTA)   NCBI Sequence Viewer  
  CBF61772 (Get FASTA)   NCBI Sequence Viewer  
  CBF61812 (Get FASTA)   NCBI Sequence Viewer  
  CBF64857 (Get FASTA)   NCBI Sequence Viewer  
  CBF64897 (Get FASTA)   NCBI Sequence Viewer  
  CBF65421 (Get FASTA)   NCBI Sequence Viewer  
  CBF65461 (Get FASTA)   NCBI Sequence Viewer  
  CBF69710 (Get FASTA)   NCBI Sequence Viewer  
  CBF69794 (Get FASTA)   NCBI Sequence Viewer  
  CBF71563 (Get FASTA)   NCBI Sequence Viewer  
  CBF71645 (Get FASTA)   NCBI Sequence Viewer  
  CBF72880 (Get FASTA)   NCBI Sequence Viewer  
  CBF72962 (Get FASTA)   NCBI Sequence Viewer  
  CBF74203 (Get FASTA)   NCBI Sequence Viewer  
  CBF74290 (Get FASTA)   NCBI Sequence Viewer  
  CBF82256 (Get FASTA)   NCBI Sequence Viewer  
  CBF82341 (Get FASTA)   NCBI Sequence Viewer  
  CBU86391 (Get FASTA)   NCBI Sequence Viewer  
  CBU86431 (Get FASTA)   NCBI Sequence Viewer  
  CBU86648 (Get FASTA)   NCBI Sequence Viewer  
  CBU86688 (Get FASTA)   NCBI Sequence Viewer  
  CBU89728 (Get FASTA)   NCBI Sequence Viewer  
  CBU89768 (Get FASTA)   NCBI Sequence Viewer  
  CBU90292 (Get FASTA)   NCBI Sequence Viewer  
  CBU90332 (Get FASTA)   NCBI Sequence Viewer  
  CBU94391 (Get FASTA)   NCBI Sequence Viewer  
  CBU94431 (Get FASTA)   NCBI Sequence Viewer  
  CBU95270 (Get FASTA)   NCBI Sequence Viewer  
  CBU95310 (Get FASTA)   NCBI Sequence Viewer  
  CBU95899 (Get FASTA)   NCBI Sequence Viewer  
  CBU95939 (Get FASTA)   NCBI Sequence Viewer  
  CBU96548 (Get FASTA)   NCBI Sequence Viewer  
  CBU96588 (Get FASTA)   NCBI Sequence Viewer  
  CBV00296 (Get FASTA)   NCBI Sequence Viewer  
  CBV00336 (Get FASTA)   NCBI Sequence Viewer  
  EAW96056 (Get FASTA)   NCBI Sequence Viewer  
  EAW96057 (Get FASTA)   NCBI Sequence Viewer  
  P35754 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001112362   ⟸   NM_001118890
- UniProtKB: P35754 (UniProtKB/Swiss-Prot),   A0A024RAM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002055   ⟸   NM_002064
- UniProtKB: P35754 (UniProtKB/Swiss-Prot),   A0A024RAM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230587   ⟸   NM_001243658
- UniProtKB: P35754 (UniProtKB/Swiss-Prot),   A0A024RAM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230588   ⟸   NM_001243659
- UniProtKB: P35754 (UniProtKB/Swiss-Prot),   A0A024RAM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000427353   ⟸   ENST00000505427
RefSeq Acc Id: ENSP00000422708   ⟸   ENST00000508780
RefSeq Acc Id: ENSP00000369314   ⟸   ENST00000379979
RefSeq Acc Id: ENSP00000424636   ⟸   ENST00000512469
RefSeq Acc Id: ENSP00000237858   ⟸   ENST00000237858
Protein Domains
Glutaredoxin

Promoters
RGD ID:6803222
Promoter ID:HG_KWN:50694
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002064,   OTTHUMT00000241653
Position:
Human AssemblyChrPosition (strand)Source
Build 36595,184,071 - 95,185,242 (-)MPROMDB
RGD ID:6852860
Promoter ID:EP74247
Type:multiple initiation site
Name:HS_GLRX
Description:Glutaredoxin (thioltransferase).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36595,184,186 - 95,184,246EPD
RGD ID:6870122
Promoter ID:EPDNEW_H8226
Type:initiation region
Name:GLRX_1
Description:glutaredoxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8227  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38595,822,726 - 95,822,786EPDNEW
RGD ID:6870124
Promoter ID:EPDNEW_H8227
Type:initiation region
Name:GLRX_2
Description:glutaredoxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8226  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38595,822,946 - 95,823,006EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q14.3-21.1(chr5:87376883-101524443)x1 copy number loss See cases [RCV000050945] Chr5:87376883..101524443 [GRCh38]
Chr5:86672700..100860147 [GRCh37]
Chr5:86708456..100888046 [NCBI36]
Chr5:5q14.3-21.1
pathogenic
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1
pathogenic
GRCh38/hg38 5q15(chr5:93405010-97716265)x3 copy number gain See cases [RCV000053285] Chr5:93405010..97716265 [GRCh38]
Chr5:92740716..97051969 [GRCh37]
Chr5:92766472..97077725 [NCBI36]
Chr5:5q15
uncertain significance
GRCh38/hg38 5q14.3-21.2(chr5:89081352-104687248)x1 copy number loss See cases [RCV000053516] Chr5:89081352..104687248 [GRCh38]
Chr5:88377169..104022949 [GRCh37]
Chr5:88412925..104050848 [NCBI36]
Chr5:5q14.3-21.2
pathogenic
GRCh38/hg38 5q14.3-15(chr5:91386552-98365880)x1 copy number loss See cases [RCV000053519] Chr5:91386552..98365880 [GRCh38]
Chr5:90682369..97701584 [GRCh37]
Chr5:90718125..97729488 [NCBI36]
Chr5:5q14.3-15
pathogenic
GRCh38/hg38 5q14.3-21.1(chr5:85966055-101335711)x1 copy number loss See cases [RCV000135748] Chr5:85966055..101335711 [GRCh38]
Chr5:85261873..100671415 [GRCh37]
Chr5:85297629..100699314 [NCBI36]
Chr5:5q14.3-21.1
pathogenic
GRCh38/hg38 5q15(chr5:94902711-95930059)x3 copy number gain See cases [RCV000139042] Chr5:94902711..95930059 [GRCh38]
Chr5:94238416..95265763 [GRCh37]
Chr5:94264172..95291519 [NCBI36]
Chr5:5q15
likely benign
GRCh38/hg38 5q14.3-23.3(chr5:90374606-128076423)x1 copy number loss See cases [RCV000139893] Chr5:90374606..128076423 [GRCh38]
Chr5:89670423..127412115 [GRCh37]
Chr5:89706179..127440014 [NCBI36]
Chr5:5q14.3-23.3
pathogenic
GRCh38/hg38 5q14.3-22.1(chr5:84603580-111435081)x1 copy number loss See cases [RCV000139656] Chr5:84603580..111435081 [GRCh38]
Chr5:83899398..110770779 [GRCh37]
Chr5:83935154..110798678 [NCBI36]
Chr5:5q14.3-22.1
pathogenic
GRCh38/hg38 5q14.3-23.1(chr5:92899734-119614119)x1 copy number loss See cases [RCV000141252] Chr5:92899734..119614119 [GRCh38]
Chr5:92235441..118949814 [GRCh37]
Chr5:92261197..118977713 [NCBI36]
Chr5:5q14.3-23.1
pathogenic
GRCh38/hg38 5q15-22.2(chr5:93193104-113287795)x1 copy number loss See cases [RCV000143249] Chr5:93193104..113287795 [GRCh38]
Chr5:92528810..112623492 [GRCh37]
Chr5:92554566..112651391 [NCBI36]
Chr5:5q15-22.2
pathogenic
GRCh38/hg38 5q14.3-31.1(chr5:91411708-131319563)x1 copy number loss See cases [RCV000143746] Chr5:91411708..131319563 [GRCh38]
Chr5:90707525..130655256 [GRCh37]
Chr5:90743281..130683155 [NCBI36]
Chr5:5q14.3-31.1
pathogenic
GRCh37/hg19 5q15(chr5:94319893-95158593)x3 copy number gain See cases [RCV000240498] Chr5:94319893..95158593 [GRCh37]
Chr5:5q15
uncertain significance
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q15-21.2(chr5:95049966-103537589)x1 copy number loss See cases [RCV000510548] Chr5:95049966..103537589 [GRCh37]
Chr5:5q15-21.2
likely pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5q15(chr5:95028385-95581195)x3 copy number gain See cases [RCV000511716] Chr5:95028385..95581195 [GRCh37]
Chr5:5q15
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q15(chr5:94881523-95294150)x3 copy number gain not provided [RCV000682582] Chr5:94881523..95294150 [GRCh37]
Chr5:5q15
uncertain significance
GRCh37/hg19 5q14.3-21.3(chr5:91504101-104858348)x1 copy number loss not provided [RCV000682580] Chr5:91504101..104858348 [GRCh37]
Chr5:5q14.3-21.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh37/hg19 5q14.3-23.3(chr5:89949118-129317455)x3 copy number gain not provided [RCV000849289] Chr5:89949118..129317455 [GRCh37]
Chr5:5q14.3-23.3
pathogenic
GRCh37/hg19 5q13.2-15(chr5:72790061-97478870)x3 copy number gain not provided [RCV001005683] Chr5:72790061..97478870 [GRCh37]
Chr5:5q13.2-15
pathogenic
GRCh37/hg19 5q15(chr5:94715085-95251238)x3 copy number gain not provided [RCV001005703] Chr5:94715085..95251238 [GRCh37]
Chr5:5q15
uncertain significance
GRCh37/hg19 5q14.3-21.3(chr5:87792844-109221844)x3 copy number gain See cases [RCV001007415] Chr5:87792844..109221844 [GRCh37]
Chr5:5q14.3-21.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4330 AgrOrtholog
COSMIC GLRX COSMIC
Ensembl Genes ENSG00000173221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000237858 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000369314 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000422708 UniProtKB/Swiss-Prot
  ENSP00000424636 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427353 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000237858 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000379979 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000505427 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000508780 UniProtKB/Swiss-Prot
  ENST00000512469 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000173221 GTEx
HGNC ID HGNC:4330 ENTREZGENE
Human Proteome Map GLRX Human Proteome Map
InterPro GLR_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_euk/vir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2745 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2745 ENTREZGENE
OMIM 600443 OMIM
Pfam Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28731 PharmGKB
PRINTS GLUTAREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTAREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs GRX_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAM2 ENTREZGENE, UniProtKB/TrEMBL
  GLRX1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2R4L2 UniProtKB/Swiss-Prot
  Q3KQS1 UniProtKB/Swiss-Prot
  Q6ICT1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 GLRX  glutaredoxin    glutaredoxin (thioltransferase)  Symbol and/or name change 5135510 APPROVED
2011-08-23 GLRX  glutaredoxin (thioltransferase)  GLRX  glutaredoxin (thioltransferase)  Symbol and/or name change 5135510 APPROVED