Gene: NTS (neurotensin) Homo sapiens
Analyze
Symbol:
NTS
Name:
neurotensin
Description:
Predicted to have neuropeptide hormone activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to localize to the axon terminus.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
neurotensin/neuromedin N; NMN-125; NN; NT; NT/N; NTS1; pro-neurotensin/neuromedin
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Nts (neurotensin) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Nts (neurotensin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Nts (neurotensin) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
NTS (neurotensin) NCBI
Ortholog
Canis lupus familiaris (dog):
NTS (neurotensin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nts (neurotensin) NCBI
Ortholog
Sus scrofa (pig):
NTS (neurotensin) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Nts (neurotensin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Nts (neurotensin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
nts (neurotensin)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, ZFIN)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 12 85,874,295 - 85,882,992 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 12 86,268,073 - 86,276,770 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 12 84,792,206 - 84,800,898 (+) NCBI NCBI36 hg18 NCBI36 Build 34 12 84,770,542 - 84,779,231 NCBI Celera 12 85,930,823 - 85,939,559 (+) NCBI Cytogenetic Map 12 q21.31 NCBI HuRef 12 83,324,584 - 83,333,603 (+) NCBI HuRef CHM1_1 12 86,233,027 - 86,241,361 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
breast ductal carcinoma IAGP RGD:11039575 8554872 ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar
Imported Annotations - CTD
Bradycardia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:2326505 Catalepsy EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:20882060 Hyperkinesis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:3748325 , PMID:6682440 Muscle Rigidity EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:8036282
(S)-amphetamine increases expression ISO RGD:1319093 6480464 Dextroamphetamine results in increased expression of NTS mRNA CTD PMID:11120399 (S)-colchicine increases expression ISO RGD:621612 6480464 Colchicine results in increased expression of NTS mRNA CTD PMID:1850078 17beta-estradiol increases expression ISO RGD:621612 6480464 Estradiol results in increased expression of NTS mRNA CTD PMID:20068009 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of NTS mRNA CTD PMID:21795739 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA, Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA] CTD PMID:20823114 , PMID:21795739 17beta-hydroxy-5alpha-androstan-3-one affects expression EXP 6480464 Dihydrotestosterone affects the expression of NTS mRNA CTD PMID:17094431 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:621612 6480464 Tetrachlorodibenzodioxin affects the expression of NTS mRNA CTD PMID:15977195 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:1319093 6480464 NTS protein promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VWF protein] CTD PMID:25307345 3,4-methylenedioxymethamphetamine increases expression ISO RGD:621612 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of NTS mRNA CTD PMID:15661373 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases activity ISO RGD:621612 6480464 bisindolylmaleimide I results in increased activity of NTS protein CTD PMID:18313772 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases activity EXP 6480464 bisindolylmaleimide I results in increased activity of NTS protein CTD PMID:18313772 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions EXP 6480464 bisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates] more ... CTD PMID:18313772 5-azacytidine decreases expression EXP 6480464 Azacitidine results in decreased expression of NTS mRNA CTD PMID:20823114 5-fluorouracil affects response to substance EXP 6480464 NTS protein affects the susceptibility to Fluorouracil CTD PMID:16217747 6-propyl-2-thiouracil increases expression ISO RGD:621612 6480464 Propylthiouracil results in increased expression of NTS mRNA CTD PMID:24780913 , PMID:25825206 8-(3-chlorostyryl)caffeine multiple interactions ISO RGD:621612 6480464 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 aflatoxin B1 increases expression ISO RGD:1319093 6480464 Aflatoxin B1 results in increased expression of NTS mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of NTS mRNA CTD PMID:21641981 aldehydo-D-glucose increases transport ISO RGD:621612 6480464 NTS protein results in increased transport of Glucose CTD PMID:11208724 aldrin increases expression ISO RGD:1319093 6480464 Aldrin results in increased expression of NTS mRNA CTD PMID:18579281 alpha-hexylcinnamaldehyde affects expression ISO RGD:1319093 6480464 hexyl cinnamic aldehyde affects the expression of NTS mRNA CTD PMID:22302311 ammonium chloride affects expression ISO RGD:621612 6480464 Ammonium Chloride affects the expression of NTS mRNA CTD PMID:16483693 amphetamine increases expression ISO RGD:1319093 6480464 Amphetamine results in increased expression of NTS mRNA CTD PMID:14698760 arsenite(3-) decreases expression ISO RGD:1319093 6480464 arsenite results in decreased expression of NTS mRNA CTD PMID:18929588 arsenite(3-) multiple interactions ISO RGD:1319093 6480464 TRP53 protein affects the reaction [arsenite results in decreased expression of NTS mRNA] CTD PMID:18929588 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of NTS mRNA CTD PMID:26705709 benzo[a]pyrene increases expression ISO RGD:621612 6480464 Benzo(a)pyrene results in increased expression of NTS mRNA CTD PMID:21839799 benzo[a]pyrene increases expression ISO RGD:1319093 6480464 Benzo(a)pyrene results in increased expression of NTS mRNA CTD PMID:19770486 , PMID:23735875 bicalutamide decreases response to substance EXP 6480464 NTS protein results in decreased susceptibility to bicalutamide CTD PMID:17044078 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of NTS mRNA CTD PMID:31163220 bisphenol A decreases expression ISO RGD:621612 6480464 bisphenol A results in decreased expression of NTS mRNA CTD PMID:25181051 bucladesine multiple interactions EXP 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA CTD PMID:20823114 chelerythrine increases activity EXP 6480464 chelerythrine results in increased activity of NTS protein CTD PMID:18313772 chlorpyrifos increases expression ISO RGD:621612 6480464 Chlorpyrifos results in increased expression of NTS mRNA CTD PMID:20682304 chromium atom increases transport ISO RGD:621612 6480464 NTS protein results in increased transport of Chromium CTD PMID:11208724 clozapine increases expression ISO RGD:621612 6480464 Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 cocaine increases expression ISO RGD:1319093 6480464 Cocaine results in increased expression of NTS mRNA CTD PMID:11120399 cocaine increases expression ISO RGD:621612 6480464 Cocaine results in increased expression of NTS mRNA CTD PMID:27899881 cocaine multiple interactions ISO RGD:621612 6480464 NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid] CTD PMID:18252810 cocaine multiple interactions ISO RGD:1319093 6480464 DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA] CTD PMID:11120399 copper atom multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NTS mRNA CTD PMID:20971185 copper(0) multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NTS mRNA CTD PMID:20971185 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of NTS mRNA CTD PMID:20106945 D-glucose increases transport ISO RGD:621612 6480464 NTS protein results in increased transport of Glucose CTD PMID:11208724 D-mannitol increases transport ISO RGD:621612 6480464 NTS protein results in increased transport of Mannitol CTD PMID:11208724 dehydroepiandrosterone affects expression EXP 6480464 Dehydroepiandrosterone affects the expression of NTS mRNA CTD PMID:17094431 dexloxiglumide multiple interactions EXP 6480464 dexloxiglumide inhibits the reaction [osteum results in increased secretion of NTS protein] CTD PMID:18303078 dextran sulfate multiple interactions ISO RGD:1319093 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NTS mRNA CTD PMID:29950665 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of NTS mRNA CTD PMID:26705709 diazinon increases expression ISO RGD:621612 6480464 Diazinon results in increased expression of NTS mRNA CTD PMID:20682304 diazinon decreases expression ISO RGD:621612 6480464 Diazinon results in decreased expression of NTS mRNA CTD PMID:29108742 dieldrin increases expression ISO RGD:621612 6480464 Dieldrin results in increased expression of NTS mRNA CTD PMID:20682304 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of NTS mRNA CTD PMID:24236059 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 emamectin benzoate affects activity EXP 6480464 emamectin benzoate affects the activity of NTS protein CTD PMID:23611293 ethanol increases response to substance ISO RGD:621612 6480464 NTS protein results in increased susceptibility to Ethanol CTD PMID:11602683 fragrance increases expression EXP 6480464 Perfume results in increased expression of NTS mRNA CTD PMID:24768652 gamma-aminobutyric acid multiple interactions ISO RGD:621612 6480464 NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid] CTD PMID:18252810 gamma-aminobutyric acid increases secretion ISO RGD:621612 6480464 NTS protein results in increased secretion of gamma-Aminobutyric Acid CTD PMID:18252810 glucose increases transport ISO RGD:621612 6480464 NTS protein results in increased transport of Glucose CTD PMID:11208724 Goe 6976 increases activity EXP 6480464 Go 6976 results in increased activity of NTS protein CTD PMID:18313772 Goe 6976 multiple interactions EXP 6480464 Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] more ... CTD PMID:18313772 haloperidol multiple interactions ISO RGD:1319093 6480464 SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:14698760 haloperidol increases expression ISO RGD:1319093 6480464 Haloperidol results in increased expression of NTS mRNA CTD PMID:11120399 more ... haloperidol increases expression ISO RGD:621612 6480464 Haloperidol results in increased expression of NTS mRNA, Haloperidol results in increased expression of NTS protein CTD PMID:10199625 more ... haloperidol multiple interactions ISO RGD:621612 6480464 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA], Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934 medroxyprogesterone acetate multiple interactions EXP 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA CTD PMID:20823114 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of NTS mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA CTD PMID:27188386 methamphetamine increases expression ISO RGD:621612 6480464 Methamphetamine results in increased expression of NTS mRNA CTD PMID:19564919 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of NTS mRNA CTD PMID:28001369 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:621612 6480464 Ethylnitrosourea results in increased mutagenesis of NTS gene CTD PMID:16495775 nickel atom increases expression ISO RGD:621612 6480464 Nickel results in increased expression of NTS mRNA CTD PMID:20682304 okadaic acid decreases activity EXP 6480464 Okadaic Acid results in decreased activity of NTS protein CTD PMID:18313772 okadaic acid multiple interactions EXP 6480464 Okadaic Acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] CTD PMID:18313772 orlistat multiple interactions EXP 6480464 orlistat inhibits the reaction [Fats results in increased secretion of NTS protein], orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 paracetamol affects expression ISO RGD:1319093 6480464 Acetaminophen affects the expression of NTS mRNA CTD PMID:17562736 phenylephrine decreases response to substance ISO RGD:621612 6480464 NTS protein results in decreased susceptibility to Phenylephrine CTD PMID:2326505 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate decreases activity EXP 6480464 Tetradecanoylphorbol Acetate results in decreased activity of NTS protein CTD PMID:18313772 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] more ... CTD PMID:18313772 phosphoramidon multiple interactions EXP 6480464 phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934 phthalaldehyde affects expression ISO RGD:1319093 6480464 o-Phthalaldehyde affects the expression of NTS mRNA CTD PMID:22302311 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTS mRNA CTD PMID:19710929 progesterone multiple interactions EXP 6480464 Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA] CTD PMID:21795739 quercetin increases activity EXP 6480464 Quercetin results in increased activity of NTS protein CTD PMID:18313772 reserpine increases expression ISO RGD:621612 6480464 Reserpine results in increased expression of NTS mRNA CTD PMID:1850078 Ro 31-8220 increases activity EXP 6480464 Ro 31-8220 results in increased activity of NTS protein CTD PMID:18313772 Ro 31-8220 multiple interactions EXP 6480464 Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein] CTD PMID:18313772 rotenone decreases expression ISO RGD:621612 6480464 Rotenone results in decreased expression of NTS mRNA CTD PMID:19013527 rottlerin multiple interactions EXP 6480464 rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates] more ... CTD PMID:15177934 , PMID:18313772 rottlerin increases activity EXP 6480464 rottlerin results in increased activity of NTS protein CTD PMID:18313772 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide analog results in decreased expression of NTS mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1319093 6480464 Silicon Dioxide results in increased expression of NTS mRNA CTD PMID:23221170 sodium arsenate increases expression ISO RGD:1319093 6480464 sodium arsenate results in increased expression of NTS mRNA CTD PMID:30953684 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of NTS mRNA CTD PMID:29301061 Sodium oleate multiple interactions EXP 6480464 dexloxiglumide inhibits the reaction [osteum results in increased secretion of NTS protein] CTD PMID:18303078 Sodium oleate increases secretion EXP 6480464 osteum results in increased secretion of NTS protein CTD PMID:18303078 staurosporine multiple interactions EXP 6480464 Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934 , PMID:18313772 staurosporine increases activity EXP 6480464 Staurosporine results in increased activity of NTS protein CTD PMID:18313772 sucrose decreases activity EXP 6480464 Sucrose results in decreased activity of NTS protein CTD PMID:18313772 sucrose multiple interactions EXP 6480464 Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein], Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] CTD PMID:18313772 theophylline multiple interactions ISO RGD:621612 6480464 Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 titanium dioxide multiple interactions ISO RGD:1319093 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NTS mRNA CTD PMID:29950665 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of NTS mRNA CTD PMID:24935251 trimellitic anhydride increases expression ISO RGD:1319093 6480464 trimellitic anhydride results in increased expression of NTS mRNA CTD PMID:19042947 trimellitic anhydride affects expression ISO RGD:1319093 6480464 trimellitic anhydride affects the expression of NTS mRNA CTD PMID:22302311 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [NTS protein results in increased expression of CXCL8 mRNA] more ... CTD PMID:15177934 , PMID:15247267 U-73122 multiple interactions EXP 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:15177934 valproic acid affects expression ISO RGD:1319093 6480464 Valproic Acid affects the expression of NTS mRNA CTD PMID:17292431 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA CTD PMID:27188386 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of NTS mRNA CTD PMID:19101580 more ... wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:15177934
Gene-Chemical Interaction Annotations
