GSK3B (glycogen synthase kinase 3 beta) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: GSK3B (glycogen synthase kinase 3 beta) Homo sapiens
Analyze
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
RGD ID: 733891
HGNC Page HGNC
Description: Enables several functions, including NF-kappaB binding activity; enzyme binding activity; and protein kinase activity. Involved in several processes, including pallium development; protein phosphorylation; and regulation of neuron death. Acts upstream of or within several processes, including ER overload response; peptidyl-serine phosphorylation; and positive regulation of protein export from nucleus. Located in several cellular components, including centrosome; nucleoplasm; and plasma membrane. Part of beta-catenin destruction complex. Is active in glutamatergic synapse. Implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Biomarker of colorectal adenocarcinoma; degenerative disc disease; endometrial carcinoma; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3119,821,321 - 120,094,994 (-)EnsemblGRCh38hg38GRCh38
GRCh383119,821,321 - 120,095,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373119,540,168 - 119,813,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (EXP)
(-)-Arctigenin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-gambogic acid  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-lipoic acid  (ISO)
(R)-Salsolinol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (EXP)
2-methylcholine  (EXP)
2-nitrotoluene  (ISO)
20-hydroxyecdysone  (ISO)
26-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (EXP)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-aminonicotinamide  (EXP)
6-bromoindirubin-3'-oxime  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
[6]-Shogaol  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
AH23848  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alsterpaullone  (EXP)
amino acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (ISO)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
avobenzone  (EXP)
baicalein  (EXP)
BAPTA  (ISO)
Bardoxolone methyl  (EXP)
belinostat  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP,ISO)
betulin  (EXP)
betulinic acid  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (EXP)
brazilein  (EXP)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calyculin a  (ISO)
capsaicin  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP)
chaetoglobosin A  (ISO)
CHIR 99021  (EXP,ISO)
chitosan  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
cilostazol  (ISO)
Cinobufagin  (EXP)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
Cryptotanshinone  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (EXP)
DDT  (EXP)
Deguelin  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
desmopressin  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
Di-n-hexyl phthalate  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
Dictamnine  (EXP)
Didymin  (EXP)
dioxygen  (EXP,ISO)
disodium cromoglycate  (ISO)
disodium selenite  (EXP)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
enzacamene  (EXP)
erlotinib hydrochloride  (EXP)
Estragole  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
ethyl methanesulfonate  (EXP)
etoposide  (ISO)
eugenol  (EXP)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (EXP)
fipronil  (EXP)
fisetin  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
Fusaric acid  (ISO)
gefitinib  (EXP)
gemcitabine  (EXP)
geraniol  (ISO)
gingerol  (EXP,ISO)
ginsenoside Re  (ISO)
ginsenoside Rg2  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
GSK690693  (EXP)
haloperidol  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
IC-87114  (ISO)
icariside II  (EXP)
indirubin-3'-monoxime  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
kaempferol  (ISO)
kahweol  (EXP)
kainic acid  (ISO)
ketamine  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
L-serine  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
liraglutide  (EXP)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
lonafarnib  (EXP)
losartan  (ISO)
lovastatin  (EXP,ISO)
lupeol  (ISO)
LY294002  (EXP,ISO)
lysophosphatidylethanolamine  (EXP)
magnesium atom  (EXP)
Magnolol  (ISO)
malathion  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
memantine  (ISO)
menadione  (EXP)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
Mizoribine  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
monodansylcadaverine  (EXP)
morin  (ISO)
morphine  (ISO)
mycophenolic acid  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naloxone  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitrofurazone  (ISO)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
oleic acid  (EXP)
omethoate  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentetrazol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phloretin  (EXP)
phloroglucinol  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (EXP)
Plantamajoside  (ISO)
potassium atom  (ISO)
potassium chromate  (EXP)
procyanidin B2  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (EXP)
radon atom  (EXP)
radon(0)  (EXP)
raffinose  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
risperidone  (ISO)
Ro 31-8220  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubimaillin  (EXP)
ruthenium atom  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (EXP)
SB 203580  (EXP)
SB 415286  (EXP,ISO)
SB 431542  (EXP)
SB-239063  (ISO)
sclareol  (EXP)
selenium atom  (EXP)
serotonin  (EXP)
serpentine asbestos  (EXP)
sesquiterpene  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sorafenib  (EXP)
sphingosine 1-phosphate  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
syringic acid  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tadalafil  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP)
tanespimycin  (EXP)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurochenodeoxycholic acid  (ISO)
temozolomide  (EXP,ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thymoquinone  (EXP)
tideglusib  (EXP)
toluene 2,4-diisocyanate  (ISO)
topiramate  (ISO)
topotecan  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
vitamin K  (ISO)
warfarin  (ISO)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
XAV939  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (ISO)
axonogenesis  (ISO)
beta-catenin destruction complex disassembly  (TAS)
bone remodeling  (ISO)
canonical Wnt signaling pathway  (ISO)
carbohydrate metabolic process  (IEA)
cell growth involved in cardiac muscle cell development  (ISO)
cell migration  (ISO)
cellular response to amyloid-beta  (ISS)
cellular response to dopamine  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-3  (ISS)
cellular response to iron(II) ion  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
circadian rhythm  (ISS)
dopamine receptor signaling pathway  (NAS)
epithelial to mesenchymal transition  (IMP)
ER overload response  (IDA)
establishment of cell polarity  (ISO,ISS,TAS)
establishment or maintenance of cell polarity  (ISO)
excitatory postsynaptic potential  (NAS)
extrinsic apoptotic signaling pathway  (ISS)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISS)
fat cell differentiation  (ISO)
glycogen metabolic process  (IDA,IEA)
hepatic stellate cell activation  (ISO)
hepatocyte apoptotic process  (ISO)
hippocampus development  (IMP)
hypermethylation of CpG island  (ISO)
insulin receptor signaling pathway  (IBA)
intracellular signal transduction  (IDA,TAS)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
maintenance of cell polarity  (ISS,TAS)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of calcineurin-NFAT signaling cascade  (IMP)
negative regulation of canonical Wnt signaling pathway  (IBA,IC,ISS,TAS)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of dendrite development  (ISO)
negative regulation of dendrite morphogenesis  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO,TAS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IMP)
negative regulation of glycogen (starch) synthase activity  (TAS)
negative regulation of glycogen biosynthetic process  (TAS)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron death  (IDA)
negative regulation of neuron maturation  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of phosphoprotein phosphatase activity  (TAS)
negative regulation of protein acetylation  (ISS)
negative regulation of protein binding  (IDA)
negative regulation of protein localization to centrosome  (ISO)
negative regulation of protein localization to nucleus  (ISS)
negative regulation of protein-containing complex assembly  (IMP)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of synaptic assembly at neuromuscular junction  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of type B pancreatic cell development  (TAS)
neuron projection development  (IDA)
neuron projection organization  (ISS)
peptidyl-serine phosphorylation  (IDA)
peptidyl-threonine phosphorylation  (IDA)
phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (ISS)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (ISS)
positive regulation of GTPase activity  (IMP)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISS)
positive regulation of mitochondrion organization  (IMP)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (IDA)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of osteoclast proliferation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IC,IDA,IMP,ISO)
positive regulation of protein binding  (ISO,ISS)
positive regulation of protein catabolic process  (IC,ISO)
positive regulation of protein export from nucleus  (IDA)
positive regulation of protein localization to centrosome  (IMP)
positive regulation of protein-containing complex assembly  (IDA)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell differentiation  (ISO)
positive regulation of synaptic assembly at neuromuscular junction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein autophosphorylation  (IDA)
protein export from nucleus  (ISO)
protein localization to microtubule  (ISO)
protein phosphorylation  (IDA,IEA,IMP,ISO,TAS)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of axon extension  (ISO,ISS)
regulation of axonogenesis  (ISO,ISS)
regulation of cell growth  (ISO)
regulation of cellular response to heat  (TAS)
regulation of circadian rhythm  (ISS)
regulation of dendrite morphogenesis  (ISO,ISS)
regulation of gene expression by genetic imprinting  (ISO)
regulation of long-term synaptic potentiation  (ISS)
regulation of microtubule anchoring at centrosome  (IMP)
regulation of microtubule cytoskeleton organization  (IBA,ISS)
regulation of microtubule-based process  (IMP)
regulation of modification of postsynaptic structure  (ISO)
regulation of neuron projection development  (IBA,ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of synaptic vesicle exocytosis  (EXP,IDA,IMP)
response to activity  (ISO)
response to angiotensin  (ISO)
response to epinephrine  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to insulin-like growth factor stimulus  (ISO)
response to L-glutamate  (ISO)
response to lithium ion  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
rhythmic process  (IEA)
signal transduction  (IBA)
superior temporal gyrus development  (IMP)
viral protein processing  (TAS)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

References

References - curated
1. Aschenbach WG, etal., Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E152-8. Epub 2006 Feb 14.
2. Bertsch S, etal., Shock. 2011 Mar;35(3):266-74. doi: 10.1097/SHK.0b013e3181fd068c.
3. Bhat RV and Budd SL, Neurosignals 2002 Sep-Oct;11(5):251-61.
4. Cao Y, etal., Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):437-46. doi: 10.1093/abbs/gmw024.
5. Chen D, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Sep;35(9):1090-8.
6. Chen S, etal., Oncotarget. 2016 May 10;7(19):27538-51. doi: 10.18632/oncotarget.8485.
7. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
8. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
9. Diaz-Hernandez JI, etal., Neurobiol Aging. 2012 Aug;33(8):1816-28. doi: 10.1016/j.neurobiolaging.2011.09.040. Epub 2011 Nov 1.
10. Emamian ES, etal., Nat Genet 2004 Feb;36(2):131-7. Epub 2004 Jan 25.
11. Fang CH, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Oct;293(4):R1545-51. Epub 2007 Aug 8.
12. Fang NX, etal., Mol Biol Rep. 2010 Dec;37(8):3763-9. Epub 2010 Mar 10.
13. Forde JE and Dale TC, Cell Mol Life Sci. 2007 Aug;64(15):1930-44.
14. GOA_HUMAN data from the GO Consortium
15. Gong L, etal., J Neurochem. 2012 Dec;123(5):876-85. doi: 10.1111/jnc.12038. Epub 2012 Oct 25.
16. Grassilli E, etal., Clin Cancer Res. 2013 Jul 15;19(14):3820-31. doi: 10.1158/1078-0432.CCR-12-3289. Epub 2013 May 31.
17. Hoeflich KP, etal., Nature 2000 Jul 6;406(6791):86-90.
18. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
19. Hu Z, etal., Cardiovasc Diabetol. 2017 Apr 26;16(1):57. doi: 10.1186/s12933-017-0537-3.
20. Hurtado DE, etal., J Neurosci. 2012 May 23;32(21):7392-402. doi: 10.1523/JNEUROSCI.0889-12.2012.
21. Iwata A, etal., Hum Mol Genet. 2014 Feb 1;23(3):648-56. doi: 10.1093/hmg/ddt451. Epub 2013 Sep 18.
22. Javadov S, etal., J Mol Cell Cardiol. 2009 Jun;46(6):998-1007. doi: 10.1016/j.yjmcc.2008.12.023. Epub 2009 Jan 20.
23. Kan C, etal., J Surg Res. 2017 Aug;216:207-218. doi: 10.1016/j.jss.2017.04.012. Epub 2017 Apr 20.
24. KEGG
25. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
26. Kozlovsky N, etal., J Neural Transm 2004 Aug;111(8):1093-8. Epub 2004 Apr 27.
27. Lachman HM, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Apr 5;144(3):259-65.
28. Lee CY, etal., PLoS One. 2012;7(6):e38789. doi: 10.1371/journal.pone.0038789. Epub 2012 Jun 26.
29. Liu Y, etal., Diabetologia. 2010 Dec;53(12):2600-10. doi: 10.1007/s00125-010-1882-x. Epub 2010 Sep 7.
30. Liu Y, etal., Int J Biol Macromol. 2016 Aug;89:484-8. doi: 10.1016/j.ijbiomac.2016.05.015. Epub 2016 May 6.
31. Lucas JJ, etal., EMBO J 2001 Jan 15;20(1-2):27-39.
32. Ma J, etal., Sci Rep. 2016 Mar 30;6:23817. doi: 10.1038/srep23817.
33. Ma QH, etal., Mol Med Rep. 2018 Mar;17(3):4113-4119. doi: 10.3892/mmr.2017.8289. Epub 2017 Dec 18.
34. Mateo I, etal., Acta Neurol Scand. 2009 Aug;120(2):130-3. doi: 10.1111/j.1600-0404.2008.01128.x. Epub 2008 Dec 22.
35. Nadri C, etal., Brain Res Dev Brain Res. 2003 Mar 14;141(1-2):33-7.
36. Nishihara M, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H748-55. Epub 2006 Mar 24.
37. Park H, etal., Yonsei Med J. 2018 Aug;59(6):736-745. doi: 10.3349/ymj.2018.59.6.736.
38. Park HJ, etal., Hear Res. 2009 Nov;257(1-2):53-62. doi: 10.1016/j.heares.2009.08.001. Epub 2009 Aug 8.
39. Peineau S, etal., Neuron. 2007 Mar 1;53(5):703-17.
40. Pipeline to import KEGG annotations from KEGG into RGD
41. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. Prema A, etal., PLoS One. 2016 Nov 28;11(11):e0165955. doi: 10.1371/journal.pone.0165955. eCollection 2016.
43. Puangpraphant S, etal., Biofactors. 2013 Jul-Aug;39(4):430-40. doi: 10.1002/biof.1083. Epub 2013 Mar 29.
44. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. RGD automated import pipeline for gene-chemical interactions
46. Saini MK and Sanyal SN, Exp Mol Pathol. 2012 Aug;93(1):135-46. doi: 10.1016/j.yexmp.2012.04.019. Epub 2012 Apr 25.
47. Salim T, etal., Int J Cancer. 2013 Aug 15;133(4):807-15. doi: 10.1002/ijc.28074. Epub 2013 Mar 9.
48. Sunters A, etal., J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30.
49. Szczepankiewicz A, etal., Neuropsychobiology. 2006;53(1):51-6. Epub 2006 Jan 4.
50. Szymanska M, etal., Pharmacol Rep. 2009 Jul-Aug;61(4):612-20.
51. Takahashi-Yanaga F, etal., Biochem Pharmacol. 2014 Jun 1;89(3):340-8. doi: 10.1016/j.bcp.2014.03.006. Epub 2014 Mar 23.
52. Tang W, etal., Acta Biochim Biophys Sin (Shanghai). 2016 Jun;48(6):581-3. doi: 10.1093/abbs/gmw027. Epub 2016 Apr 28.
53. Tian M, etal., FEBS Lett. 2012 Oct 19;586(20):3737-45. doi: 10.1016/j.febslet.2012.09.004. Epub 2012 Sep 13.
54. van der Vaart A, etal., Neuropsychopharmacology. 2018 Sep 6. pii: 10.1038/s41386-018-0202-x. doi: 10.1038/s41386-018-0202-x.
55. Wang HL, etal., Clin Colorectal Cancer. 2011 Mar 1;10(1):30-6. doi: 10.3816/CCC.2011.n.004.
56. Wang X and Zhao L, Biochem Biophys Res Commun. 2016 Apr 29;473(2):428-34. doi: 10.1016/j.bbrc.2016.03.024. Epub 2016 Mar 10.
57. Wei X, etal., Zhonghua Bing Li Xue Za Zhi. 2012 Feb;41(2):86-90.
58. Xiao D, etal., PLoS One. 2016 Feb 26;11(2):e0150557. doi: 10.1371/journal.pone.0150557. eCollection 2016.
59. Xiao H, etal., J Neurochem. 2017 Jul;142(2):194-203. doi: 10.1111/jnc.14051. Epub 2017 May 26.
60. Xie CL, etal., Sci Rep. 2016 Mar 21;6:23527. doi: 10.1038/srep23527.
61. Xue M, etal., Biomed Pharmacother. 2017 Oct;94:898-908. doi: 10.1016/j.biopha.2017.08.013. Epub 2017 Aug 12.
62. Yang S, etal., J Cell Biochem. 2018 Feb 2. doi: 10.1002/jcb.26760.
63. Yin Y, etal., Int J Mol Sci. 2013 Aug 12;14(8):16617-37. doi: 10.3390/ijms140816617.
64. Zhao S, etal., Neurol Res. 2012 May;34(4):400-7. doi: 10.1179/1743132812Y.0000000025.
65. Zhou Y, etal., Zhonghua Bing Li Xue Za Zhi. 2015 Nov;44(11):783-7.
Additional References at PubMed
PMID:1181841   PMID:1324914   PMID:1330687   PMID:1333807   PMID:6772446   PMID:7514173   PMID:7566346   PMID:7642555   PMID:7706316   PMID:7980435   PMID:8247524   PMID:8382613  
PMID:8404858   PMID:8524413   PMID:8638126   PMID:8725894   PMID:8764598   PMID:8861947   PMID:8889548   PMID:8999860   PMID:9072970   PMID:9199504   PMID:9271238   PMID:9353289  
PMID:9468292   PMID:9482734   PMID:9546672   PMID:9565682   PMID:9566905   PMID:9570753   PMID:9601641   PMID:9614189   PMID:9731200   PMID:9734785   PMID:9735171   PMID:9736715  
PMID:9771888   PMID:9809441   PMID:9819408   PMID:9832145   PMID:9832503   PMID:10074433   PMID:10090741   PMID:10228155   PMID:10330181   PMID:10330403   PMID:10347142   PMID:10428053  
PMID:10428961   PMID:10481074   PMID:10486203   PMID:10488109   PMID:10523816   PMID:10567568   PMID:10581160   PMID:10587587   PMID:10653665   PMID:10671552   PMID:10753899   PMID:10826493  
PMID:10910956   PMID:10936190   PMID:10966653   PMID:10997338   PMID:11004522   PMID:11035810   PMID:11104755   PMID:11152665   PMID:11166179   PMID:11181841   PMID:11193155   PMID:11251183  
PMID:11311121   PMID:11320080   PMID:11425860   PMID:11427888   PMID:11440715   PMID:11481324   PMID:11483158   PMID:11495916   PMID:11500362   PMID:11524435   PMID:11738041   PMID:11781156  
PMID:11809746   PMID:11812770   PMID:11818547   PMID:11835406   PMID:11877389   PMID:11903055   PMID:11955436   PMID:11967263   PMID:11980723   PMID:11986994   PMID:12000790   PMID:12048243  
PMID:12051714   PMID:12054501   PMID:12063245   PMID:12064478   PMID:12086949   PMID:12095675   PMID:12114015   PMID:12123574   PMID:12130654   PMID:12133000   PMID:12147701   PMID:12162494  
PMID:12167628   PMID:12182887   PMID:12183362   PMID:12226093   PMID:12228224   PMID:12244165   PMID:12364325   PMID:12376533   PMID:12379450   PMID:12387894   PMID:12387897   PMID:12417018  
PMID:12421363   PMID:12434148   PMID:12477932   PMID:12511557   PMID:12527198   PMID:12551948   PMID:12554650   PMID:12584189   PMID:12603528   PMID:12663502   PMID:12761178   PMID:12778079  
PMID:12794074   PMID:12796505   PMID:12808104   PMID:12819195   PMID:12820959   PMID:12829841   PMID:12871932   PMID:12885254   PMID:12900420   PMID:12927815   PMID:12969793   PMID:14518171  
PMID:14520463   PMID:14523002   PMID:14536078   PMID:14550568   PMID:14561750   PMID:14563837   PMID:14612456   PMID:14617795   PMID:14635195   PMID:14636947   PMID:14645548   PMID:14660640  
PMID:14690523   PMID:14691449   PMID:14701753   PMID:14729058   PMID:14729229   PMID:14744935   PMID:14749367   PMID:14985354   PMID:14988008   PMID:14988390   PMID:14991743   PMID:15020233  
PMID:15026145   PMID:15073173   PMID:15132987   PMID:15147888   PMID:15178331   PMID:15178691   PMID:15179015   PMID:15231747   PMID:15252116   PMID:15302935   PMID:15327769   PMID:15345747  
PMID:15351432   PMID:15361837   PMID:15375789   PMID:15379854   PMID:15383283   PMID:15448698   PMID:15456937   PMID:15465828   PMID:15469820   PMID:15470047   PMID:15489334   PMID:15517997  
PMID:15522877   PMID:15542598   PMID:15555766   PMID:15592455   PMID:15609321   PMID:15631989   PMID:15647282   PMID:15652488   PMID:15678105   PMID:15688030   PMID:15719395   PMID:15752768  
PMID:15799972   PMID:15824731   PMID:15829978   PMID:15940626   PMID:15942663   PMID:15951569   PMID:15963640   PMID:15981102   PMID:15993040   PMID:16007092   PMID:16009706   PMID:16027724  
PMID:16039586   PMID:16043125   PMID:16055726   PMID:16076840   PMID:16107342   PMID:16115820   PMID:16123141   PMID:16141410   PMID:16174773   PMID:16188939   PMID:16198352   PMID:16199882  
PMID:16210249   PMID:16247449   PMID:16257959   PMID:16278684   PMID:16282323   PMID:16289845   PMID:16293724   PMID:16315267   PMID:16341242   PMID:16344560   PMID:16365045   PMID:16371352  
PMID:16420965   PMID:16421604   PMID:16428445   PMID:16428884   PMID:16446437   PMID:16462886   PMID:16498402   PMID:16519508   PMID:16528748   PMID:16537926   PMID:16543145   PMID:16543730  
PMID:16551619   PMID:16571670   PMID:16601113   PMID:16611631   PMID:16645641   PMID:16705181   PMID:16753179   PMID:16757548   PMID:16767496   PMID:16787706   PMID:16788573   PMID:16814287  
PMID:16861141   PMID:16882987   PMID:16890161   PMID:16893889   PMID:16912034   PMID:16916907   PMID:16934436   PMID:16936772   PMID:16942622   PMID:16951223   PMID:16959574   PMID:16964243  
PMID:16981698   PMID:16982692   PMID:16984735   PMID:16987250   PMID:16987514   PMID:17016438   PMID:17028556   PMID:17045592   PMID:17046823   PMID:17050006   PMID:17052453   PMID:17072303  
PMID:17078951   PMID:17081983   PMID:17098228   PMID:17107957   PMID:17139249   PMID:17150190   PMID:17159916   PMID:17160944   PMID:17192257   PMID:17215518   PMID:17233643   PMID:17241872  
PMID:17270183   PMID:17273789   PMID:17283049   PMID:17317006   PMID:17318175   PMID:17318191   PMID:17325032   PMID:17353931   PMID:17360711   PMID:17368486   PMID:17387146   PMID:17389597  
PMID:17428466   PMID:17434145   PMID:17437043   PMID:17437044   PMID:17438332   PMID:17475833   PMID:17483602   PMID:17486076   PMID:17510365   PMID:17512525   PMID:17522055   PMID:17562708  
PMID:17565981   PMID:17590240   PMID:17601533   PMID:17609434   PMID:17621172   PMID:17621269   PMID:17628506   PMID:17671694   PMID:17681942   PMID:17697341   PMID:17711861   PMID:17717075  
PMID:17726008   PMID:17908237   PMID:17912008   PMID:17951252   PMID:17972518   PMID:17976739   PMID:17989287   PMID:17990294   PMID:17991736   PMID:17991738   PMID:18029348   PMID:18045539  
PMID:18055457   PMID:18083346   PMID:18156211   PMID:18167338   PMID:18172167   PMID:18178198   PMID:18195729   PMID:18198341   PMID:18201972   PMID:18218855   PMID:18219478   PMID:18221734  
PMID:18223684   PMID:18243662   PMID:18252708   PMID:18263590   PMID:18268107   PMID:18316369   PMID:18316598   PMID:18348280   PMID:18367454   PMID:18391981   PMID:18391982   PMID:18408738  
PMID:18437054   PMID:18450971   PMID:18451303   PMID:18467332   PMID:18500637   PMID:18505846   PMID:18508033   PMID:18552505   PMID:18588978   PMID:18593713   PMID:18602000   PMID:18606491  
PMID:18615589   PMID:18628988   PMID:18632640   PMID:18632848   PMID:18660489   PMID:18676680   PMID:18687691   PMID:18689794   PMID:18708403   PMID:18768676   PMID:18769147   PMID:18782353  
PMID:18786229   PMID:18787224   PMID:18801732   PMID:18804163   PMID:18806775   PMID:18826950   PMID:18829575   PMID:18838540   PMID:18846110   PMID:18852124   PMID:18852354   PMID:18855532  
PMID:18952601   PMID:18955029   PMID:18955053   PMID:18973553   PMID:18991351   PMID:18996102   PMID:18996844   PMID:19003984   PMID:19007860   PMID:19014373   PMID:19022564   PMID:19038973  
PMID:19050253   PMID:19060929   PMID:19061640   PMID:19104043   PMID:19106108   PMID:19107203   PMID:19116273   PMID:19126544   PMID:19131971   PMID:19142874   PMID:19148484   PMID:19156168  
PMID:19170196   PMID:19180470   PMID:19188159   PMID:19190323   PMID:19202075   PMID:19237556   PMID:19249679   PMID:19265551   PMID:19274078   PMID:19289791   PMID:19303846   PMID:19321622  
PMID:19322201   PMID:19323791   PMID:19364825   PMID:19366350   PMID:19401395   PMID:19411070   PMID:19429119   PMID:19429245   PMID:19453261   PMID:19454488   PMID:19457211   PMID:19470470  
PMID:19472218   PMID:19477245   PMID:19481076   PMID:19501118   PMID:19505532   PMID:19527721   PMID:19528467   PMID:19557001   PMID:19573950   PMID:19576224   PMID:19581563   PMID:19584164  
PMID:19607922   PMID:19625176   PMID:19639192   PMID:19656851   PMID:19657367   PMID:19659461   PMID:19681904   PMID:19682504   PMID:19688630   PMID:19692168   PMID:19698783   PMID:19706605  
PMID:19711366   PMID:19713527   PMID:19717166   PMID:19727391   PMID:19751508   PMID:19754670   PMID:19757160   PMID:19759537   PMID:19797085   PMID:19823589   PMID:19830702   PMID:19833727  
PMID:19841191   PMID:19874574   PMID:19882709   PMID:19903789   PMID:19913121   PMID:19995607   PMID:20007971   PMID:20008284   PMID:20015462   PMID:20031160   PMID:20033742   PMID:20039940  
PMID:20080667   PMID:20080974   PMID:20103767   PMID:20106550   PMID:20110283   PMID:20113358   PMID:20127713   PMID:20128690   PMID:20154711   PMID:20159967   PMID:20160451   PMID:20167573  
PMID:20178594   PMID:20190034   PMID:20204404   PMID:20219685   PMID:20226637   PMID:20308328   PMID:20333643   PMID:20351102   PMID:20352103   PMID:20357815   PMID:20368287   PMID:20371704  
PMID:20388706   PMID:20389281   PMID:20399743   PMID:20448354   PMID:20453000   PMID:20454507   PMID:20457218   PMID:20468064   PMID:20484041   PMID:20497256   PMID:20508983   PMID:20510151  
PMID:20525681   PMID:20531236   PMID:20541704   PMID:20561405   PMID:20562859   PMID:20596670   PMID:20599907   PMID:20602615   PMID:20605420   PMID:20615469   PMID:20618448   PMID:20628086  
PMID:20644561   PMID:20647544   PMID:20648061   PMID:20649541   PMID:20679343   PMID:20682308   PMID:20682768   PMID:20709358   PMID:20800594   PMID:20818790   PMID:20831597   PMID:20848477  
PMID:20849862   PMID:20856200   PMID:20864106