RGD Reference Report - LTP inhibits LTD in the hippocampus via regulation of GSK3beta. - Rat Genome Database

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LTP inhibits LTD in the hippocampus via regulation of GSK3beta.

Authors: Peineau, S  Taghibiglou, C  Bradley, C  Wong, TP  Liu, L  Lu, J  Lo, E  Wu, D  Saule, E  Bouschet, T  Matthews, P  Isaac, JT  Bortolotto, ZA  Wang, YT  Collingridge, GL 
Citation: Peineau S, etal., Neuron. 2007 Mar 1;53(5):703-17.
RGD ID: 1641844
Pubmed: PMID:17329210   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2007.01.029   (Journal Full-text)

Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) and NMDA receptor-dependent long-term depression (LTD). In rat hippocampal slices, GSK3beta inhibitors block the induction of LTD. Furthermore, the activity of GSK3beta is enhanced during LTD via activation of PP1. Conversely, following the induction of LTP, there is inhibition of GSK3beta activity. This regulation of GSK3beta during LTP involves activation of NMDA receptors and the PI3K-Akt pathway and disrupts the ability of synapses to undergo LTD for up to 1 hr. We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gsk3bRatprotein phosphorylation  IDA  RGD 
Gsk3bRatregulation of neuronal synaptic plasticity  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gsk3bRatdendritic spine  IDA  RGD 
Gria1Ratprotein-containing complex  IDA  RGD 
Gria2Ratprotein-containing complex  IDA  RGD 
Gsk3bRatprotein-containing complex  IDA  RGD 

Molecular Function

  

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSK3BHumanlong term depression  ISORGD:7092 RGD 
Gsk3bRatlong term depression  IMP  RGD 
Gsk3bMouselong term depression  ISORGD:7092 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)
Gria2  (glutamate ionotropic receptor AMPA type subunit 2)
Gsk3b  (glycogen synthase kinase 3 beta)

Genes (Mus musculus)
Gsk3b  (glycogen synthase kinase 3 beta)

Genes (Homo sapiens)
GSK3B  (glycogen synthase kinase 3 beta)


Additional Information