GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSK3B | decreases phosphorylation | EXP | | 6480464 | CTD | Glucose results in decreased phosphorylation of GSK3B protein | PMID:23954465 PMID:35385194 | GSK3B | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of GSK3B protein | PMID:35385194 | GSK3B | increases phosphorylation | EXP | | 6480464 | CTD | Glucose results in increased phosphorylation of GSK3B protein | PMID:23690508 | GSK3B | multiple interactions | EXP | | 6480464 | CTD | [[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; [Glucose co-treated with ICG 001] results in decreased phosphorylation of GSK3B protein; Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]; Glucose inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; Panax notoginseng extract inhibits the reaction [[Glucose co-treated with ICG 001] results in decreased phosphorylation of GSK3B protein]; Panax notoginseng extract inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]; Panax notoginseng extract inhibits the reaction [Glucose results in increased expression of GSK3B protein] | PMID:21031461 PMID:22062806 PMID:23954465 PMID:35385194 | GSK3B | decreases phosphorylation | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased phosphorylation of GSK3B protein | PMID:26054749 | GSK3B | increases expression | ISO | Gsk3b (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of GSK3B protein | PMID:31483951 | GSK3B | multiple interactions | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B protein; Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA]]; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]]; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NQO1 mRNA]]; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B mRNA]; MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B protein]; Simvastatin inhibits the reaction [Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein] | PMID:18004065 PMID:29719095 | GSK3B | multiple interactions | ISO | Gsk3b (Mus musculus) | 6480464 | CTD | [Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose; dorsomorphin inhibits the reaction [[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose]; Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]]; RHOA protein promotes the reaction [Glucose results in increased expression of GSK3B protein] | PMID:22180358 PMID:31483951 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |