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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733891
Species: Homo sapiens
RGD Object: Gene
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:76591
Term: (25R)-cholest-5-ene-3beta,26-diol
Definition: A 26-hydroxycholesterol in which the 25-position has R-configuration.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSK3Bincreases phosphorylationEXP 6480464CTD27-hydroxycholesterol results in increased phosphorylation of GSK3B proteinPMID:33131013
GSK3Bmultiple interactionsEXP 6480464CTD27-hydroxycholesterol inhibits the reaction [CTNNB1 protein binds to GSK3B protein]; 27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to GSK3B protein]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [GSK3B protein binds to CTNNB1 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to GSK3B protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of GSK3B protein]; SCIO-469 inhibits the reaction [27-hydroxycholesterol inhibits the reaction [CTNNB1 protein binds to GSK3B protein]]; SCIO-469 inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to GSK3B protein]]; SCIO-469 inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of GSK3B protein]; YWHAH protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of GSK3B protein]PMID:33131013
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