GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSK3B | affects response to substance | EXP | | 6480464 | CTD | GSK3B protein affects the susceptibility to Arsenic Trioxide | PMID:21278055 | GSK3B | decreases phosphorylation | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased phosphorylation of GSK3B protein | PMID:25416439 PMID:32305283 | GSK3B | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of GSK3B mRNA | PMID:22521957 | GSK3B | increases phosphorylation | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of GSK3B protein | PMID:21278055 PMID:25246272 PMID:26966376 PMID:30362509 | GSK3B | multiple interactions | EXP | | 6480464 | CTD | 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; AKT1 protein inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; Arsenic Trioxide inhibits the reaction [Sorafenib results in increased phosphorylation of GSK3B protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein; AS3MT mRNA promotes the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; Deoxyglucose inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; GSK3B protein modified form affects the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; IGF2BP2 protein promotes the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; METTL14 protein promotes the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; Palmitic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; Rosiglitazone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; Sorafenib inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein] | PMID:21278055 PMID:23949314 PMID:25246272 PMID:25416439 PMID:30362509 PMID:32305283 PMID:35226250 | GSK3B | increases phosphorylation | ISO | Gsk3b (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of GSK3B protein | PMID:30362509 | GSK3B | multiple interactions | ISO | Gsk3b (Mus musculus) | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein] | PMID:30362509 PMID:35226250 | | ||||||||||||||||||||||
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