GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSK3B | decreases activity | EXP | | 6480464 | CTD | Lithium results in decreased activity of GSK3B protein | PMID:10998351 | GSK3B | increases phosphorylation | EXP | | 6480464 | CTD | Lithium results in increased phosphorylation of GSK3B protein | PMID:15475000 PMID:19440698 | GSK3B | multiple interactions | EXP | | 6480464 | CTD | Lithium inhibits the reaction [GSK3B protein binds to TP53 protein]; Lithium promotes the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]; Magnesium affects the reaction [Lithium results in decreased activity of GSK3B protein] | PMID:10998351 PMID:15475000 PMID:17849503 | GSK3B | decreases activity | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Lithium results in decreased activity of GSK3B protein | PMID:16288908 | GSK3B | decreases activity | ISO | Gsk3b (Mus musculus) | 6480464 | CTD | Lithium results in decreased activity of GSK3B protein | PMID:19621015 | GSK3B | decreases phosphorylation | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Lithium results in decreased phosphorylation of GSK3B protein | PMID:25433145 | GSK3B | increases expression | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Lithium results in increased expression of GSK3B mRNA; Lithium results in increased expression of GSK3B protein | PMID:18296634 PMID:19359144 | GSK3B | increases phosphorylation | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Lithium results in increased phosphorylation of GSK3B protein | PMID:18296634 | GSK3B | multiple interactions | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Lithium results in increased phosphorylation of and results in decreased activity of GSK3B protein | PMID:15950778 PMID:21711903 | GSK3B | multiple interactions | ISO | Gsk3b (Mus musculus) | 6480464 | CTD | [Lithium results in decreased activity of GSK3B protein] which results in increased activity of MTOR protein; [Lithium results in decreased activity of GSK3B protein] which results in increased activity of NFE2L2 protein; Lithium results in increased phosphorylation of and results in decreased activity of GSK3B protein | PMID:17921520 PMID:18619545 PMID:19328817 | |
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